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The map label for this gene is dnlI [H]

Identifier: 110679112

GI number: 110679112

Start: 1741635

End: 1743233

Strand: Reverse

Name: dnlI [H]

Synonym: RD1_1817

Alternate gene names: 110679112

Gene position: 1743233-1741635 (Counterclockwise)

Preceding gene: 110679113

Following gene: 110679110

Centisome position: 42.18

GC content: 60.41

Gene sequence:

>1599_bases
GTGAAAGAATTCGCAGCGCTTTTCAATGCGATCGACCAGAGCACCAAGACCACCGTCAAAACGGCGGCACTTGCGTCCTA
TTTTGCCAAGGCCCCGAAAGAGGACCGGCTGTGGACAATCGCGCTCTTTTCCGGTCGCAGGCCAAAACGGGCGGTCACAA
CCTCAAAGTTGCGCGAATGGGCAGCGGAAACGGCCGACATTCCCTTGTGGCTCTTCGAGGAAAGCTATCCGATCGTCGGC
GATCTGGCCGAAACGATCGCCTTGGTTCTACCCGACACCACCAGCACGAACGACACACCCCTGTCCGATTGGATCACCGC
CTTGCGCGCCTTGTCAGAGGCGGACGATGCGCAACGCAAAGCCTTCGTGCGGGACGCATGGGCAACCCTCGGCGGCACGG
AGCGTTTTGTGTTCAACAAGTTGATCACCGGCGGTTTTCGCGTTGGGATCAGTCAAAAGCTGATGACCCGCGCGTTGTCA
AAGGCCACGGGCAAGCCCGAAACCGAACTGGCGCATCGCCTGATGGGCAACTGGCACCCGGATGACACCACATGGGACGC
CCTGATCGAGGCGGACGACCCGATGGCGGATGCCTCGCGCCCCTATCCGTTCTACTTGTCCTACGGGCTGGAAGGGGCGG
TTGAAGACCTCGGCAGCCCATCAGACTGGGTTGCGGAATGGAAATGGGACGGCATTCGCGGCCAGTTGATCCTGCGCGAC
GGGCAATATTTCGTGTGGTCGCGCGGCGAGGAGTTGATGACGGACCGCTTTCCGGAACTGGCGCAGGCGGTTGACTTTTT
CCCGGCAGGCACCGTGCTGGATGGCGAATTGCTGGTCTGGGAGGCGGGTGCCGACGCGCCGTCCAGTTTCAATGCGCTGC
AAAAACGGATCGGGCGCAAAACGGTGCCCAAAAAGCTGCTCGCAGAAGCACCTGTCGTGCTGCACGCCTATGATGTGCTG
GAATGGCAGGGCGTGGATATCCGCCAACGCCCCTTTGCGGAACGGCGCGCGATCCTGCAGGACGCCTGCACGGCCCTGCC
GGCAACGGCGCCGGTAAAACAATCCCCCCAGCTTTCGTTTCAAGACTGGGACAGTCTCGCGCAACATCGCGGTGCTGCGC
GCGAGGCACAGGCCGAAGGGGTGATGCTGAAACGCGCCGACAGCCCCTATCTGGTGGGACGCAAAAAGGGGGATTGGTGG
AAATGGAAACTTGATCCACTGACGATTGATGCCGTGATGATCTATGCGCAGGCCGGGCATGGGCGGCGCGCGAATCTCTT
CACCGATTTCACCTTTGCGGTGCGCCATGGCAATGACCTCGTGCCATTCACCAAAGCCTATTCCGGCCTGACCGACGCCG
AATTCCGCGCCATTACCGCTTGGGTGCGTAAAAACACGCTGCAGCGTTTTGGCCCGGTGCGCCAAGTGACGCCGCACCAT
GTCTTTGAAATCGCATTTGAAGGCATTCAGGCCAGCCCACGCCATAAATCCGGCGTGGCGCTGCGCTTTCCCCGCATGGC
GCGGTGGCGACAGGATAAACCCCTGCAAGAGGCCAATACGCTGGATGACCTCAAGCAGATGCTTGAATTATATGGCTAA

Upstream 100 bases:

>100_bases
ATACGGATATCTTTGCCCGCTACCTCAGCGAGAACGGGTGGCATGCGCAGGTGGTTCCCACCGAGTTTGGCGGTGAGAGC
GACGAAAGCGAGGCAGAACC

Downstream 100 bases:

>100_bases
GGCCCAGAGCCTCTGACGAAATACATGGTACACCCAGTACCACGTAACGCATTGAAATCCTTGATTTCAGGCAGCGTTAC
GTGATCGAGGGTTTTCGCAT

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MKEFAALFNAIDQSTKTTVKTAALASYFAKAPKEDRLWTIALFSGRRPKRAVTTSKLREWAAETADIPLWLFEESYPIVG
DLAETIALVLPDTTSTNDTPLSDWITALRALSEADDAQRKAFVRDAWATLGGTERFVFNKLITGGFRVGISQKLMTRALS
KATGKPETELAHRLMGNWHPDDTTWDALIEADDPMADASRPYPFYLSYGLEGAVEDLGSPSDWVAEWKWDGIRGQLILRD
GQYFVWSRGEELMTDRFPELAQAVDFFPAGTVLDGELLVWEAGADAPSSFNALQKRIGRKTVPKKLLAEAPVVLHAYDVL
EWQGVDIRQRPFAERRAILQDACTALPATAPVKQSPQLSFQDWDSLAQHRGAAREAQAEGVMLKRADSPYLVGRKKGDWW
KWKLDPLTIDAVMIYAQAGHGRRANLFTDFTFAVRHGNDLVPFTKAYSGLTDAEFRAITAWVRKNTLQRFGPVRQVTPHH
VFEIAFEGIQASPRHKSGVALRFPRMARWRQDKPLQEANTLDDLKQMLELYG

Sequences:

>Translated_532_residues
MKEFAALFNAIDQSTKTTVKTAALASYFAKAPKEDRLWTIALFSGRRPKRAVTTSKLREWAAETADIPLWLFEESYPIVG
DLAETIALVLPDTTSTNDTPLSDWITALRALSEADDAQRKAFVRDAWATLGGTERFVFNKLITGGFRVGISQKLMTRALS
KATGKPETELAHRLMGNWHPDDTTWDALIEADDPMADASRPYPFYLSYGLEGAVEDLGSPSDWVAEWKWDGIRGQLILRD
GQYFVWSRGEELMTDRFPELAQAVDFFPAGTVLDGELLVWEAGADAPSSFNALQKRIGRKTVPKKLLAEAPVVLHAYDVL
EWQGVDIRQRPFAERRAILQDACTALPATAPVKQSPQLSFQDWDSLAQHRGAAREAQAEGVMLKRADSPYLVGRKKGDWW
KWKLDPLTIDAVMIYAQAGHGRRANLFTDFTFAVRHGNDLVPFTKAYSGLTDAEFRAITAWVRKNTLQRFGPVRQVTPHH
VFEIAFEGIQASPRHKSGVALRFPRMARWRQDKPLQEANTLDDLKQMLELYG
>Mature_532_residues
MKEFAALFNAIDQSTKTTVKTAALASYFAKAPKEDRLWTIALFSGRRPKRAVTTSKLREWAAETADIPLWLFEESYPIVG
DLAETIALVLPDTTSTNDTPLSDWITALRALSEADDAQRKAFVRDAWATLGGTERFVFNKLITGGFRVGISQKLMTRALS
KATGKPETELAHRLMGNWHPDDTTWDALIEADDPMADASRPYPFYLSYGLEGAVEDLGSPSDWVAEWKWDGIRGQLILRD
GQYFVWSRGEELMTDRFPELAQAVDFFPAGTVLDGELLVWEAGADAPSSFNALQKRIGRKTVPKKLLAEAPVVLHAYDVL
EWQGVDIRQRPFAERRAILQDACTALPATAPVKQSPQLSFQDWDSLAQHRGAAREAQAEGVMLKRADSPYLVGRKKGDWW
KWKLDPLTIDAVMIYAQAGHGRRANLFTDFTFAVRHGNDLVPFTKAYSGLTDAEFRAITAWVRKNTLQRFGPVRQVTPHH
VFEIAFEGIQASPRHKSGVALRFPRMARWRQDKPLQEANTLDDLKQMLELYG

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=553, Percent_Identity=23.6889692585895, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985269, Length=348, Percent_Identity=26.1494252873563, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320038, Length=547, Percent_Identity=24.1316270566728, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24762424, Length=495, Percent_Identity=22.8282828282828, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI85815841, Length=354, Percent_Identity=28.2485875706215, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 59797; Mature: 59797

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEFAALFNAIDQSTKTTVKTAALASYFAKAPKEDRLWTIALFSGRRPKRAVTTSKLREW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
AAETADIPLWLFEESYPIVGDLAETIALVLPDTTSTNDTPLSDWITALRALSEADDAQRK
HHHCCCCEEEEECCCCCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AFVRDAWATLGGTERFVFNKLITGGFRVGISQKLMTRALSKATGKPETELAHRLMGNWHP
HHHHHHHHHCCCCHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
DDTTWDALIEADDPMADASRPYPFYLSYGLEGAVEDLGSPSDWVAEWKWDGIRGQLILRD
CCCCHHHEEECCCCCCCCCCCCCEEEECCCCHHHHHCCCCHHHHHEEEECCCCEEEEEEC
GQYFVWSRGEELMTDRFPELAQAVDFFPAGTVLDGELLVWEAGADAPSSFNALQKRIGRK
CCEEEEECCHHHHHHCCHHHHHHHHCCCCCCEECCCEEEEECCCCCCHHHHHHHHHHCHH
TVPKKLLAEAPVVLHAYDVLEWQGVDIRQRPFAERRAILQDACTALPATAPVKQSPQLSF
HCCHHHHHCCCEEEEEEHHHEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
QDWDSLAQHRGAAREAQAEGVMLKRADSPYLVGRKKGDWWKWKLDPLTIDAVMIYAQAGH
HHHHHHHHHCCCHHHHHHCCEEEEECCCCEEEECCCCCEEEEEECCEEEEEEEEEEECCC
GRRANLFTDFTFAVRHGNDLVPFTKAYSGLTDAEFRAITAWVRKNTLQRFGPVRQVTPHH
CCCCCEEEEEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VFEIAFEGIQASPRHKSGVALRFPRMARWRQDKPLQEANTLDDLKQMLELYG
HHHHHHHCCCCCCCCCCCCEEECCHHHHHCCCCCCHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MKEFAALFNAIDQSTKTTVKTAALASYFAKAPKEDRLWTIALFSGRRPKRAVTTSKLREW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
AAETADIPLWLFEESYPIVGDLAETIALVLPDTTSTNDTPLSDWITALRALSEADDAQRK
HHHCCCCEEEEECCCCCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AFVRDAWATLGGTERFVFNKLITGGFRVGISQKLMTRALSKATGKPETELAHRLMGNWHP
HHHHHHHHHCCCCHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
DDTTWDALIEADDPMADASRPYPFYLSYGLEGAVEDLGSPSDWVAEWKWDGIRGQLILRD
CCCCHHHEEECCCCCCCCCCCCCEEEECCCCHHHHHCCCCHHHHHEEEECCCCEEEEEEC
GQYFVWSRGEELMTDRFPELAQAVDFFPAGTVLDGELLVWEAGADAPSSFNALQKRIGRK
CCEEEEECCHHHHHHCCHHHHHHHHCCCCCCEECCCEEEEECCCCCCHHHHHHHHHHCHH
TVPKKLLAEAPVVLHAYDVLEWQGVDIRQRPFAERRAILQDACTALPATAPVKQSPQLSF
HCCHHHHHCCCEEEEEEHHHEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
QDWDSLAQHRGAAREAQAEGVMLKRADSPYLVGRKKGDWWKWKLDPLTIDAVMIYAQAGH
HHHHHHHHHCCCHHHHHHCCEEEEECCCCEEEECCCCCEEEEEECCEEEEEEEEEEECCC
GRRANLFTDFTFAVRHGNDLVPFTKAYSGLTDAEFRAITAWVRKNTLQRFGPVRQVTPHH
CCCCCEEEEEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VFEIAFEGIQASPRHKSGVALRFPRMARWRQDKPLQEANTLDDLKQMLELYG
HHHHHHHCCCCCCCCCCCCEEECCHHHHHCCCCCCHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA