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The map label for this gene is alkJ [C]

Identifier: 110678888

GI number: 110678888

Start: 1503197

End: 1504837

Strand: Reverse

Name: alkJ [C]

Synonym: RD1_1582

Alternate gene names: 110678888

Gene position: 1504837-1503197 (Counterclockwise)

Preceding gene: 110678892

Following gene: 110678886

Centisome position: 36.41

GC content: 61.43

Gene sequence:

>1641_bases
ATGCAGGAGGTTTTCGACTACATCATCGTGGGGGGCGGGTCGTCGGGCTGCGTGATGGCCGCCCGGTTGAGCGAGGACAA
AAACACCTCTGTCTTGCTGTTAGAGGCGGGCGGTCCTGACCGTAACCCATTGTTTCATATACCTGCAGGCTTTGCGAGGA
TGACCAAGGGCATCGCATCATGGGGGTGGTCCACCGTGCCCCAGAAAGGGCTGAACGGTCGGTCGCTCTGGTATACGCAG
GCCAAGGTCATCGGCGGCGGCTCTTCGATCAACGCGCAGATCTATACGCGGGGCAATCCGCATGACTACGACAATTGGGC
AGAACACCACGGCTGTCGCGGATGGAGCTATCGCGAAGTTCTACCGTATTTCAAGCGCTCCGAAGGCAATGAGGTCTTTT
CCGACCTGTATCACGGTCAGGACGGTCCCCTTGGTGTATCAAAGCCGCGCGGTGCGCTGCCCATCTGCACGGCATTTATT
GAGGCCGCGCAGGAATGGGGCCTTGCGCATAACCCTGATTTCAACGGGATGCGGCAGGAAGGCTGCGGGTTTTACCAACT
GACGCAACGCGACGCGCGTCGTTCCTCCACCGCGCGGGCTTTCCTGAAACCGGCCCAGACACGCGCAAACCTGACCGTGC
GCACGCGCGCAGAAGTGTCGCGTATCAAGCTTGAGGGACACAAGGCAATCGGGGTTCTTCTGCGCCACAACGGTGCTGAT
CTGCTGATCCGTGCGGACCGCGAAGTGATCGTCACAGCCGGCGCCATCGGATCACCCCGCCTGTTGATGTATTCAGGCAT
TGGCCCCGCGGATCATCTGCGCAGTGTCGGCATTGACGTTGCGCTGGATGTGCCCGGTGTCGGGTCAAACCTGCAGGATC
ACCTCGACCTTTGCACGATATCGCAATGCACCGGGCGGCATACCTACGACGGAGCCGACCGCATTGATCGCACGCTGTTG
GCGGGTTTGCGCTATTATCTGACAAGGACCGGACCTGCCACGGCATCGCTGTTTGAAACGGGGGGCTTTGGCTATGCCGA
TCCGAACGCGCCCTACCCCGACCTTCAGTTTCACCTCGGCCAAGGATCGGGCATTGAGAAAGGGATCGTCAGGATAAAAG
GCGCGGGCGTGACGCTCAACAGTGCCTTGATCCGCCCGAGATCACGCGGGTCCGTGCGGCTCGCGTCCTCCGATCCCACT
GTGCCGCCCCTGATTGACCCGAATTTCTGGGGTGACCCCCATGACCGGGAGATGTCGTTAAGAGGTCTGGAGATCGCCCG
CGAGATCATGGCGCAACCTGCACTGTCGAAATACGTTGCAACCGAGGTCTTGCCCGGACCCGGCACCACCAAAGAGGACC
TGCTGCGCTATGCGATCAGAATTGCCAAAACCGACCACCACCCCGTCGGGACCTGTCGGATGGGAACGGGCCCCGATGCT
GTTGTCGACCCGGCGCTGCGCGTGATCGGGGCGTGCGGGCTGCGGGTCTGCGACGCGTCCATCATGCCCCGGATCAATGC
GTCAAATACCAATGCGCCCACGATCATGATTGGCGAAAAAGCCTCGGACATGGTGCGGGGCCTTGCACCGCTGCCTGCGG
CGGACTTGCCAGTGAGGGGCGAGGCGAGCGCACCGCCGTAA

Upstream 100 bases:

>100_bases
ACCGCAGTTCATCGCGCAATTTCGAGCGCGCAGGTTGACATCTTGCGGACAGCCAGGTCTTACTGATGTAACCAAACAGT
TACAAAAACAAGGGCCAGGG

Downstream 100 bases:

>100_bases
GGGGTGACGCCCGCGCAGGTCAACGCGTGGAATCATGGCACAGTGAAGTCAAGAACCCGCCCGTTGACCTTGCCAGCCGC
GATGATGAGGGCCGCCGGAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: SDH [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MQEVFDYIIVGGGSSGCVMAARLSEDKNTSVLLLEAGGPDRNPLFHIPAGFARMTKGIASWGWSTVPQKGLNGRSLWYTQ
AKVIGGGSSINAQIYTRGNPHDYDNWAEHHGCRGWSYREVLPYFKRSEGNEVFSDLYHGQDGPLGVSKPRGALPICTAFI
EAAQEWGLAHNPDFNGMRQEGCGFYQLTQRDARRSSTARAFLKPAQTRANLTVRTRAEVSRIKLEGHKAIGVLLRHNGAD
LLIRADREVIVTAGAIGSPRLLMYSGIGPADHLRSVGIDVALDVPGVGSNLQDHLDLCTISQCTGRHTYDGADRIDRTLL
AGLRYYLTRTGPATASLFETGGFGYADPNAPYPDLQFHLGQGSGIEKGIVRIKGAGVTLNSALIRPRSRGSVRLASSDPT
VPPLIDPNFWGDPHDREMSLRGLEIAREIMAQPALSKYVATEVLPGPGTTKEDLLRYAIRIAKTDHHPVGTCRMGTGPDA
VVDPALRVIGACGLRVCDASIMPRINASNTNAPTIMIGEKASDMVRGLAPLPAADLPVRGEASAPP

Sequences:

>Translated_546_residues
MQEVFDYIIVGGGSSGCVMAARLSEDKNTSVLLLEAGGPDRNPLFHIPAGFARMTKGIASWGWSTVPQKGLNGRSLWYTQ
AKVIGGGSSINAQIYTRGNPHDYDNWAEHHGCRGWSYREVLPYFKRSEGNEVFSDLYHGQDGPLGVSKPRGALPICTAFI
EAAQEWGLAHNPDFNGMRQEGCGFYQLTQRDARRSSTARAFLKPAQTRANLTVRTRAEVSRIKLEGHKAIGVLLRHNGAD
LLIRADREVIVTAGAIGSPRLLMYSGIGPADHLRSVGIDVALDVPGVGSNLQDHLDLCTISQCTGRHTYDGADRIDRTLL
AGLRYYLTRTGPATASLFETGGFGYADPNAPYPDLQFHLGQGSGIEKGIVRIKGAGVTLNSALIRPRSRGSVRLASSDPT
VPPLIDPNFWGDPHDREMSLRGLEIAREIMAQPALSKYVATEVLPGPGTTKEDLLRYAIRIAKTDHHPVGTCRMGTGPDA
VVDPALRVIGACGLRVCDASIMPRINASNTNAPTIMIGEKASDMVRGLAPLPAADLPVRGEASAPP
>Mature_546_residues
MQEVFDYIIVGGGSSGCVMAARLSEDKNTSVLLLEAGGPDRNPLFHIPAGFARMTKGIASWGWSTVPQKGLNGRSLWYTQ
AKVIGGGSSINAQIYTRGNPHDYDNWAEHHGCRGWSYREVLPYFKRSEGNEVFSDLYHGQDGPLGVSKPRGALPICTAFI
EAAQEWGLAHNPDFNGMRQEGCGFYQLTQRDARRSSTARAFLKPAQTRANLTVRTRAEVSRIKLEGHKAIGVLLRHNGAD
LLIRADREVIVTAGAIGSPRLLMYSGIGPADHLRSVGIDVALDVPGVGSNLQDHLDLCTISQCTGRHTYDGADRIDRTLL
AGLRYYLTRTGPATASLFETGGFGYADPNAPYPDLQFHLGQGSGIEKGIVRIKGAGVTLNSALIRPRSRGSVRLASSDPT
VPPLIDPNFWGDPHDREMSLRGLEIAREIMAQPALSKYVATEVLPGPGTTKEDLLRYAIRIAKTDHHPVGTCRMGTGPDA
VVDPALRVIGACGLRVCDASIMPRINASNTNAPTIMIGEKASDMVRGLAPLPAADLPVRGEASAPP

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=546, Percent_Identity=40.8424908424908, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1786503, Length=554, Percent_Identity=40.4332129963899, Blast_Score=357, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=35.3571428571429, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24642055, Length=577, Percent_Identity=37.0883882149047, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24642042, Length=565, Percent_Identity=37.1681415929204, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24642048, Length=584, Percent_Identity=36.8150684931507, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI45551458, Length=565, Percent_Identity=36.6371681415929, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI45549471, Length=565, Percent_Identity=36.6371681415929, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24642039, Length=560, Percent_Identity=37.5, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24642059, Length=566, Percent_Identity=36.3957597173145, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=36.7595818815331, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24650267, Length=578, Percent_Identity=35.4671280276817, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI18859995, Length=570, Percent_Identity=36.140350877193, Blast_Score=280, Evalue=3e-75,
Organism=Drosophila melanogaster, GI18859993, Length=572, Percent_Identity=37.5874125874126, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24642035, Length=571, Percent_Identity=34.8511383537653, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=32.9710144927536, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24642051, Length=578, Percent_Identity=32.0069204152249, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24645930, Length=573, Percent_Identity=27.5741710296684, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24642057, Length=581, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.32 [H]

Molecular weight: Translated: 58771; Mature: 58771

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEVFDYIIVGGGSSGCVMAARLSEDKNTSVLLLEAGGPDRNPLFHIPAGFARMTKGIAS
CCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEEECCCCHHHHHHHHHH
WGWSTVPQKGLNGRSLWYTQAKVIGGGSSINAQIYTRGNPHDYDNWAEHHGCRGWSYREV
CCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHCCCCCCCHHHH
LPYFKRSEGNEVFSDLYHGQDGPLGVSKPRGALPICTAFIEAAQEWGLAHNPDFNGMRQE
HHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
GCGFYQLTQRDARRSSTARAFLKPAQTRANLTVRTRAEVSRIKLEGHKAIGVLLRHNGAD
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCEEEEEEEECCCE
LLIRADREVIVTAGAIGSPRLLMYSGIGPADHLRSVGIDVALDVPGVGSNLQDHLDLCTI
EEEECCCEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
SQCTGRHTYDGADRIDRTLLAGLRYYLTRTGPATASLFETGGFGYADPNAPYPDLQFHLG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEC
QGSGIEKGIVRIKGAGVTLNSALIRPRSRGSVRLASSDPTVPPLIDPNFWGDPHDREMSL
CCCCCCCCEEEEECCCEEECHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHH
RGLEIAREIMAQPALSKYVATEVLPGPGTTKEDLLRYAIRIAKTDHHPVGTCRMGTGPDA
HHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCH
VVDPALRVIGACGLRVCDASIMPRINASNTNAPTIMIGEKASDMVRGLAPLPAADLPVRG
HHHHHHHHHHHCCHHEECHHHCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCCCCC
EASAPP
CCCCCC
>Mature Secondary Structure
MQEVFDYIIVGGGSSGCVMAARLSEDKNTSVLLLEAGGPDRNPLFHIPAGFARMTKGIAS
CCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEEECCCCHHHHHHHHHH
WGWSTVPQKGLNGRSLWYTQAKVIGGGSSINAQIYTRGNPHDYDNWAEHHGCRGWSYREV
CCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHCCCCCCCHHHH
LPYFKRSEGNEVFSDLYHGQDGPLGVSKPRGALPICTAFIEAAQEWGLAHNPDFNGMRQE
HHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
GCGFYQLTQRDARRSSTARAFLKPAQTRANLTVRTRAEVSRIKLEGHKAIGVLLRHNGAD
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCEEEEEEEECCCE
LLIRADREVIVTAGAIGSPRLLMYSGIGPADHLRSVGIDVALDVPGVGSNLQDHLDLCTI
EEEECCCEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
SQCTGRHTYDGADRIDRTLLAGLRYYLTRTGPATASLFETGGFGYADPNAPYPDLQFHLG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEC
QGSGIEKGIVRIKGAGVTLNSALIRPRSRGSVRLASSDPTVPPLIDPNFWGDPHDREMSL
CCCCCCCCEEEEECCCEEECHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHH
RGLEIAREIMAQPALSKYVATEVLPGPGTTKEDLLRYAIRIAKTDHHPVGTCRMGTGPDA
HHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCH
VVDPALRVIGACGLRVCDASIMPRINASNTNAPTIMIGEKASDMVRGLAPLPAADLPVRG
HHHHHHHHHHHCCHHEECHHHCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCCCCC
EASAPP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023923 [H]