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The map label for this gene is parC [H]

Identifier: 110678712

GI number: 110678712

Start: 1335179

End: 1337476

Strand: Direct

Name: parC [H]

Synonym: RD1_1393

Alternate gene names: 110678712

Gene position: 1335179-1337476 (Clockwise)

Preceding gene: 110678705

Following gene: 110678714

Centisome position: 32.3

GC content: 60.18

Gene sequence:

>2298_bases
ATGAACGATGTCAGCGACACAAAACCGGTAGACCTTTCCGAACCATTGCGCCGCGCGCTTGGCGAGCGGTATCTGACCTA
TGCGCTGAGCACGATCATGCATCGTGCGCTGCCCGATGCGCGTGATGGTCTCAAGCCCGTGCATCGCCGGATCCTGTATG
CGATGCGCGAATTGCGCTTGTCTTCTACCGGCGGTTTCCGCAAGTCCGCCAAGATTTCGGGCGACGTGATGGGCAACTAT
CACCCGCATGGGGACGCCGCGATTTACGACGCGATGGCCCGCCTCGCGCAGGATTTCAACGTCCGCTATCCGCTGGTCGA
CGGGCAGGGGAATTTTGGCAATATCGACGGCGATAACCCCGCCGCCAGCCGCTACACCGAAGCGCGCATGACCGCCGTTG
CCGAGGCGATGCTGGAAGGGCTGAACGAGAATGCGGTCGATTTTCGTGAGAACTACGACGGCACGCTGACCGAGCCGGTG
GTTTTGCCCGCGCAGTTCCCGAATTTGCTGGCGAACGGGTCCAGCGGCATCGCCGTGGGGATGGCCACCAACATCCCGCC
CCACAACATCGCCGAACTGTGTGACGCCTGTATTCACCTCATCAAAACGCCCGATGCGCGCGATGACACCTTGTTGAAAT
ATGTGCCCGGACCGGACTTCCCGACCGGTGGTGTGATCGTGGAGCCGCCGGAAAACATCGCGCAGGCCTATCGTACGGGC
AAGGGCGGGTTTCGTCTGCGCTGCCGTTGGGAGGTGGAGGACCTGGGCCGGGGTCAATGGCAGATCGTGGTCACCGAAAT
CCCCTATCAGGTGCAGAAATCCAAGCTGATCGAAAAGATCGCGGAGCTTATTCAGACCAAGAAAATCCCGATCCTCGCGG
ATGTGCGTGACGAATCCGCCGATGACATCCGGATGATCATTGAGCCGCGTTCCCGGTCGGTTGATCCGGATGTGCTGATG
GGGATGTTGTTTCGCAACTGCGATCTTGAGGTGCGGTTTTCGCTGAACATGAACGTGCTGATTGACGGCGTGACGCCCAA
GGTTTGTTCGATGAAAGAGGTGTTGCAGGCCTTCCTTGATCATCGGCAGGAAGTCTTGCAGCGGCGCTCAACGCATCGTC
TGGAAAAGATCGACCACCGTCTTGAGGTGCTTGAAGGGTTCATCATCGCCTTTCTGAACCTTGATCGCGTGATTGACATC
ATCCGCTATGATGACGATCCCAAGGCGGCTTTGATGGCCGAGGATTGGGGCCGCGATCACCCGCGTGCTCTCAATGAGGC
GGATTATGTACCGCCAGTGTCGACGGATGATGTGACGCTGACCGAGGTGCAGGCCGAGGCCATTTTGAATATGCGGTTGC
GGTCTTTGCGCCGTCTTGAGGAAATGGAACTGGTGCGTGAGCAGGAGGCCCTGATGGAAGAGCGCGCCGGGCTGGAGGAC
CTTTTGGAAAATCCCGGTCTGCAATGGGCCAGCATCACCGAGCAATTGCGCGCGACCAAGAAACAGTTCGGCAAGGACTG
GGACGGCGGTGCGCGCCGCACCACATTCTCCGAGGCTGCGGTGATCGAAGACGTGCCCATCGAGGCGATGATCGACCGCG
AGCCGATCACGGTCGTTTGCTCGCAAATGGGATGGGTGCGCGCAATGACGGGCCACATCGACCTCGGGCGGGAGTTGAAA
TTCAAGGATGGCGACGGGCCGCGCTTTATCTTCCATGCGGAAACCACGGATCGTTTGCTGGTGTTTGGATCGAACGGGCG
GTTTTATACGGTCTCCGCCTCCAGCCTGCCGGGCGGTCGGGGCATGGGAGAGCCGCTGCGCTTGATGATTGATCTGCCCA
ATGAGGCGGAAATCGTCACAATTCTTACCCATGCGCCTGATCGCAAGCTGTTGGTCGCGTCCTCCGCGGGTGATGGTTTT
GTCGTGCCCGAAGCAGATGTCGTGGCCCAGACCCGGACGGGCAAACAGGTGCTGAACGTGCGCGGCGATACGCGTGCGAT
GATCTGCAAACCGGTGAATGGGGATACAGTGGCCGTCGTCGGTGAAAACCGCAAGGTTCTGGTCTTCCCGCTTGAGGATC
TGCCTGAAATGGGCCGGGGCAAAGGTGTCCGTTTGCAAAAGTACAAAGACGGCGGGCTGTCCGATGCGACGACCTTCATG
CGCGCGGAAGGGCTCAGCTGGCTGGACCCGGCAGGGCGTACCCGCAGCGAAACGGACCTCGCCGAATGGACGGGAAAACG
CGCCACGGCGGGCCGGATGGCGCCGCGCGGTTTCCCGCGCGACAACAAGTTCACCTAG

Upstream 100 bases:

>100_bases
AATTGACCAGTCAAGGCCCCGCAGCCCGGTGCCGCCATGCAATCACAGGTGTTGTCAATCGGCGCTTGTTCCCTGCTTGT
GGCCCCGCTAAACAAAGCCG

Downstream 100 bases:

>100_bases
ACCGGTTCAGCCATCAACCAGACGCCGCCTTCGGGGCGCAGCGTGATGACCATCACAGGCTTTGGATCGCGGCCTTTCAC
CGGTGTAAAACGGAACCGTG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MNDVSDTKPVDLSEPLRRALGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMRELRLSSTGGFRKSAKISGDVMGNY
HPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNPAASRYTEARMTAVAEAMLEGLNENAVDFRENYDGTLTEPV
VLPAQFPNLLANGSSGIAVGMATNIPPHNIAELCDACIHLIKTPDARDDTLLKYVPGPDFPTGGVIVEPPENIAQAYRTG
KGGFRLRCRWEVEDLGRGQWQIVVTEIPYQVQKSKLIEKIAELIQTKKIPILADVRDESADDIRMIIEPRSRSVDPDVLM
GMLFRNCDLEVRFSLNMNVLIDGVTPKVCSMKEVLQAFLDHRQEVLQRRSTHRLEKIDHRLEVLEGFIIAFLNLDRVIDI
IRYDDDPKAALMAEDWGRDHPRALNEADYVPPVSTDDVTLTEVQAEAILNMRLRSLRRLEEMELVREQEALMEERAGLED
LLENPGLQWASITEQLRATKKQFGKDWDGGARRTTFSEAAVIEDVPIEAMIDREPITVVCSQMGWVRAMTGHIDLGRELK
FKDGDGPRFIFHAETTDRLLVFGSNGRFYTVSASSLPGGRGMGEPLRLMIDLPNEAEIVTILTHAPDRKLLVASSAGDGF
VVPEADVVAQTRTGKQVLNVRGDTRAMICKPVNGDTVAVVGENRKVLVFPLEDLPEMGRGKGVRLQKYKDGGLSDATTFM
RAEGLSWLDPAGRTRSETDLAEWTGKRATAGRMAPRGFPRDNKFT

Sequences:

>Translated_765_residues
MNDVSDTKPVDLSEPLRRALGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMRELRLSSTGGFRKSAKISGDVMGNY
HPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNPAASRYTEARMTAVAEAMLEGLNENAVDFRENYDGTLTEPV
VLPAQFPNLLANGSSGIAVGMATNIPPHNIAELCDACIHLIKTPDARDDTLLKYVPGPDFPTGGVIVEPPENIAQAYRTG
KGGFRLRCRWEVEDLGRGQWQIVVTEIPYQVQKSKLIEKIAELIQTKKIPILADVRDESADDIRMIIEPRSRSVDPDVLM
GMLFRNCDLEVRFSLNMNVLIDGVTPKVCSMKEVLQAFLDHRQEVLQRRSTHRLEKIDHRLEVLEGFIIAFLNLDRVIDI
IRYDDDPKAALMAEDWGRDHPRALNEADYVPPVSTDDVTLTEVQAEAILNMRLRSLRRLEEMELVREQEALMEERAGLED
LLENPGLQWASITEQLRATKKQFGKDWDGGARRTTFSEAAVIEDVPIEAMIDREPITVVCSQMGWVRAMTGHIDLGRELK
FKDGDGPRFIFHAETTDRLLVFGSNGRFYTVSASSLPGGRGMGEPLRLMIDLPNEAEIVTILTHAPDRKLLVASSAGDGF
VVPEADVVAQTRTGKQVLNVRGDTRAMICKPVNGDTVAVVGENRKVLVFPLEDLPEMGRGKGVRLQKYKDGGLSDATTFM
RAEGLSWLDPAGRTRSETDLAEWTGKRATAGRMAPRGFPRDNKFT
>Mature_765_residues
MNDVSDTKPVDLSEPLRRALGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMRELRLSSTGGFRKSAKISGDVMGNY
HPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNPAASRYTEARMTAVAEAMLEGLNENAVDFRENYDGTLTEPV
VLPAQFPNLLANGSSGIAVGMATNIPPHNIAELCDACIHLIKTPDARDDTLLKYVPGPDFPTGGVIVEPPENIAQAYRTG
KGGFRLRCRWEVEDLGRGQWQIVVTEIPYQVQKSKLIEKIAELIQTKKIPILADVRDESADDIRMIIEPRSRSVDPDVLM
GMLFRNCDLEVRFSLNMNVLIDGVTPKVCSMKEVLQAFLDHRQEVLQRRSTHRLEKIDHRLEVLEGFIIAFLNLDRVIDI
IRYDDDPKAALMAEDWGRDHPRALNEADYVPPVSTDDVTLTEVQAEAILNMRLRSLRRLEEMELVREQEALMEERAGLED
LLENPGLQWASITEQLRATKKQFGKDWDGGARRTTFSEAAVIEDVPIEAMIDREPITVVCSQMGWVRAMTGHIDLGRELK
FKDGDGPRFIFHAETTDRLLVFGSNGRFYTVSASSLPGGRGMGEPLRLMIDLPNEAEIVTILTHAPDRKLLVASSAGDGF
VVPEADVVAQTRTGKQVLNVRGDTRAMICKPVNGDTVAVVGENRKVLVFPLEDLPEMGRGKGVRLQKYKDGGLSDATTFM
RAEGLSWLDPAGRTRSETDLAEWTGKRATAGRMAPRGFPRDNKFT

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=688, Percent_Identity=40.5523255813954, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1788562, Length=649, Percent_Identity=40.3697996918336, Blast_Score=443, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17535065, Length=498, Percent_Identity=23.6947791164659, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=503, Percent_Identity=23.6580516898608, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=390, Percent_Identity=25.1282051282051, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17136538, Length=217, Percent_Identity=27.6497695852535, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85240; Mature: 85240

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVSDTKPVDLSEPLRRALGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMRELRL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHH
SSTGGFRKSAKISGDVMGNYHPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
AASRYTEARMTAVAEAMLEGLNENAVDFRENYDGTLTEPVVLPAQFPNLLANGSSGIAVG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEECCCCCHHHCCCCCCEEEE
MATNIPPHNIAELCDACIHLIKTPDARDDTLLKYVPGPDFPTGGVIVEPPENIAQAYRTG
EECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCHHHHHHHHCC
KGGFRLRCRWEVEDLGRGQWQIVVTEIPYQVQKSKLIEKIAELIQTKKIPILADVRDESA
CCCEEEEEEEEHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
DDIRMIIEPRSRSVDPDVLMGMLFRNCDLEVRFSLNMNVLIDGVTPKVCSMKEVLQAFLD
CCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCHHHHHHHHHHHHH
HRQEVLQRRSTHRLEKIDHRLEVLEGFIIAFLNLDRVIDIIRYDDDPKAALMAEDWGRDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHCCCCC
PRALNEADYVPPVSTDDVTLTEVQAEAILNMRLRSLRRLEEMELVREQEALMEERAGLED
CCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLENPGLQWASITEQLRATKKQFGKDWDGGARRTTFSEAAVIEDVPIEAMIDREPITVVC
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEECCCCCEEECCCCHHHHH
SQMGWVRAMTGHIDLGRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTVSASSLPGGR
HHCCHHEEEECCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCC
GMGEPLRLMIDLPNEAEIVTILTHAPDRKLLVASSAGDGFVVPEADVVAQTRTGKQVLNV
CCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCEECCCHHHHEECCCCHHHEEC
RGDTRAMICKPVNGDTVAVVGENRKVLVFPLEDLPEMGRGKGVRLQKYKDGGLSDATTFM
CCCCEEEEEECCCCCEEEEEECCCEEEEEECHHCCCCCCCCCEEEEEECCCCCCHHHHHH
RAEGLSWLDPAGRTRSETDLAEWTGKRATAGRMAPRGFPRDNKFT
HHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDVSDTKPVDLSEPLRRALGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMRELRL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHH
SSTGGFRKSAKISGDVMGNYHPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
AASRYTEARMTAVAEAMLEGLNENAVDFRENYDGTLTEPVVLPAQFPNLLANGSSGIAVG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEECCCCCHHHCCCCCCEEEE
MATNIPPHNIAELCDACIHLIKTPDARDDTLLKYVPGPDFPTGGVIVEPPENIAQAYRTG
EECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCHHHHHHHHCC
KGGFRLRCRWEVEDLGRGQWQIVVTEIPYQVQKSKLIEKIAELIQTKKIPILADVRDESA
CCCEEEEEEEEHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
DDIRMIIEPRSRSVDPDVLMGMLFRNCDLEVRFSLNMNVLIDGVTPKVCSMKEVLQAFLD
CCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCHHHHHHHHHHHHH
HRQEVLQRRSTHRLEKIDHRLEVLEGFIIAFLNLDRVIDIIRYDDDPKAALMAEDWGRDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHCCCCC
PRALNEADYVPPVSTDDVTLTEVQAEAILNMRLRSLRRLEEMELVREQEALMEERAGLED
CCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLENPGLQWASITEQLRATKKQFGKDWDGGARRTTFSEAAVIEDVPIEAMIDREPITVVC
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEECCCCCEEECCCCHHHHH
SQMGWVRAMTGHIDLGRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTVSASSLPGGR
HHCCHHEEEECCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCC
GMGEPLRLMIDLPNEAEIVTILTHAPDRKLLVASSAGDGFVVPEADVVAQTRTGKQVLNV
CCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCEECCCHHHHEECCCCHHHEEC
RGDTRAMICKPVNGDTVAVVGENRKVLVFPLEDLPEMGRGKGVRLQKYKDGGLSDATTFM
CCCCEEEEEECCCCCEEEEEECCCEEEEEECHHCCCCCCCCCEEEEEECCCCCCHHHHHH
RAEGLSWLDPAGRTRSETDLAEWTGKRATAGRMAPRGFPRDNKFT
HHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]