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The map label for this gene is patB [H]

Identifier: 110678657

GI number: 110678657

Start: 1286122

End: 1287294

Strand: Reverse

Name: patB [H]

Synonym: RD1_1336

Alternate gene names: 110678657

Gene position: 1287294-1286122 (Counterclockwise)

Preceding gene: 110678662

Following gene: 110678655

Centisome position: 31.15

GC content: 58.91

Gene sequence:

>1173_bases
ATGTCATTCAACGATCCCATCGAACGCCGCGGCACGCACAGCAGCAAATGGGACATGATGGAAACCCTCTTTGATGTCCC
GCAACAAGACGGGATCGCCATGTGGACCGCAGACAGCGACTACGCAACCGCGCCTTGTGTGATCGACGCTTTGCGCCGCG
CGGCAGATCACGGTGTCTTTGGCTATATGCCGGTCCATGATGACTACCTGAATGCCATTCAATGGTGGATGAAAACACGC
CACAACTGGGACATCGACACCTCATGGGCGCTGACATCGCAAGGGTTGGGCAACGCCATCGCGCTCTGCCTTGATGTCTG
GACGGACCCCGGCGCGCGGGTGGTGATTTTCACGCCCGTCTATCACGAGTTTCAGATCAAGATCGAAAAGGCGGGACGCG
AGGCGGTGACCTGTCCGCTCAAACACACAGGCGACACCTATGTGCTTGACCTTGAGGACGCACAATCACGCCTTGATGGC
TCCGAACAGATGCTGATCTGGTGCTCACCGCAAAACCCATCGGGCCGGGTCTGGACGACGGACGAATTGCGCGGGATTGC
GGAGTTTGCTGCGCGCAACGACCTGATCCTTGTGTCCGATGAAATACACCATGATCTGGTGTTTCCCGACCATACCTTTG
TGCCCATGCACATCGCCGCCCCCGAGGTCGAGGATCGCCTGATCGTCCTCACTGCAGCCTCCAAGACCTTCAACATCGCA
GGCCAGCGCACGGGCAACATGATCATCCCGGATGCGAAACTGCGCAAAACGATGCAGAACCGCCTCAATACACTGGATTA
CAAACCCGCCGCACTGAGCCTGCAAATGATCACCGCCGCCTATTCACCCGAAGGCGCCAAATGGGTCGATGCGCAGATCG
AGCACCTTGATCAGAACCGCAGGACCTTTGATGCGGCCATCGCCGACATCCCCGGCGTCATCTCCATGCCGCTGCAGGCG
ACCTATCTGGCCTGGGTCGATTTTTCAGGCACGGGCATGAGCTATGATGAGATATCGCAGCGGGTGCGAAAATCCGCGCG
CATTGCACCCAGTCCCGGACCGGACTTCGGACCGGGCGGTGAAACCTTCCTGCGCTTCAACCTCGCCACGCAACACCACC
GCATCGAGGAGGCCTGCGCCCGCCTGAAAGACGCCTTCAGCGATCTGCAATAG

Upstream 100 bases:

>100_bases
TTTCATTTAGGTCAAGCGCCCGTGCTGTGCAACTGATCTCGGACTTGCGCTCGCCTCGTTTCCCGCTAGCTTGCGCCCGA
AGCACACACAGGAGCACATC

Downstream 100 bases:

>100_bases
GGATCAGCGCGCGTCTTCGATCAGGCCTGCGGGTGCATGCTCGGGCGTTTCAAAATCCAGCGCCGGCGTTCCGCGCACAG
CCGTTGCGCGCTTGAATTCA

Product: aminotransferase, putative

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSFNDPIERRGTHSSKWDMMETLFDVPQQDGIAMWTADSDYATAPCVIDALRRAADHGVFGYMPVHDDYLNAIQWWMKTR
HNWDIDTSWALTSQGLGNAIALCLDVWTDPGARVVIFTPVYHEFQIKIEKAGREAVTCPLKHTGDTYVLDLEDAQSRLDG
SEQMLIWCSPQNPSGRVWTTDELRGIAEFAARNDLILVSDEIHHDLVFPDHTFVPMHIAAPEVEDRLIVLTAASKTFNIA
GQRTGNMIIPDAKLRKTMQNRLNTLDYKPAALSLQMITAAYSPEGAKWVDAQIEHLDQNRRTFDAAIADIPGVISMPLQA
TYLAWVDFSGTGMSYDEISQRVRKSARIAPSPGPDFGPGGETFLRFNLATQHHRIEEACARLKDAFSDLQ

Sequences:

>Translated_390_residues
MSFNDPIERRGTHSSKWDMMETLFDVPQQDGIAMWTADSDYATAPCVIDALRRAADHGVFGYMPVHDDYLNAIQWWMKTR
HNWDIDTSWALTSQGLGNAIALCLDVWTDPGARVVIFTPVYHEFQIKIEKAGREAVTCPLKHTGDTYVLDLEDAQSRLDG
SEQMLIWCSPQNPSGRVWTTDELRGIAEFAARNDLILVSDEIHHDLVFPDHTFVPMHIAAPEVEDRLIVLTAASKTFNIA
GQRTGNMIIPDAKLRKTMQNRLNTLDYKPAALSLQMITAAYSPEGAKWVDAQIEHLDQNRRTFDAAIADIPGVISMPLQA
TYLAWVDFSGTGMSYDEISQRVRKSARIAPSPGPDFGPGGETFLRFNLATQHHRIEEACARLKDAFSDLQ
>Mature_389_residues
SFNDPIERRGTHSSKWDMMETLFDVPQQDGIAMWTADSDYATAPCVIDALRRAADHGVFGYMPVHDDYLNAIQWWMKTRH
NWDIDTSWALTSQGLGNAIALCLDVWTDPGARVVIFTPVYHEFQIKIEKAGREAVTCPLKHTGDTYVLDLEDAQSRLDGS
EQMLIWCSPQNPSGRVWTTDELRGIAEFAARNDLILVSDEIHHDLVFPDHTFVPMHIAAPEVEDRLIVLTAASKTFNIAG
QRTGNMIIPDAKLRKTMQNRLNTLDYKPAALSLQMITAAYSPEGAKWVDAQIEHLDQNRRTFDAAIADIPGVISMPLQAT
YLAWVDFSGTGMSYDEISQRVRKSARIAPSPGPDFGPGGETFLRFNLATQHHRIEEACARLKDAFSDLQ

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=209, Percent_Identity=22.9665071770335, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI56713256, Length=209, Percent_Identity=22.9665071770335, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4507369, Length=363, Percent_Identity=22.8650137741047, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=31.1053984575836, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1788722, Length=365, Percent_Identity=24.1095890410959, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788332, Length=225, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786816, Length=384, Percent_Identity=22.3958333333333, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788627, Length=262, Percent_Identity=23.2824427480916, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567663, Length=300, Percent_Identity=23, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=182, Percent_Identity=24.7252747252747, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=154, Percent_Identity=25.3246753246753, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=154, Percent_Identity=25.3246753246753, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=342, Percent_Identity=21.6374269005848, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573069, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646114, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573067, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573065, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43763; Mature: 43632

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNDPIERRGTHSSKWDMMETLFDVPQQDGIAMWTADSDYATAPCVIDALRRAADHGVF
CCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCE
GYMPVHDDYLNAIQWWMKTRHNWDIDTSWALTSQGLGNAIALCLDVWTDPGARVVIFTPV
EEECCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHEEECCCCCCCEEEEECCC
YHEFQIKIEKAGREAVTCPLKHTGDTYVLDLEDAQSRLDGSEQMLIWCSPQNPSGRVWTT
CEEEEEEEEECCCCEEEECCCCCCCEEEEECHHHHHHCCCCCEEEEEECCCCCCCCEEEH
DELRGIAEFAARNDLILVSDEIHHDLVFPDHTFVPMHIAAPEVEDRLIVLTAASKTFNIA
HHHHHHHHHHCCCCEEEEECCCCCCEECCCCCEEEEEEECCCCCCEEEEEEECCCEEEEC
GQRTGNMIIPDAKLRKTMQNRLNTLDYKPAALSLQMITAAYSPEGAKWVDAQIEHLDQNR
CCCCCCEECCCHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCCCCEEHHHHHHHHHCCC
RTFDAAIADIPGVISMPLQATYLAWVDFSGTGMSYDEISQRVRKSARIAPSPGPDFGPGG
HHHHHHHHCCCCCEECCCEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
ETFLRFNLATQHHRIEEACARLKDAFSDLQ
CEEEEEEECHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFNDPIERRGTHSSKWDMMETLFDVPQQDGIAMWTADSDYATAPCVIDALRRAADHGVF
CCCCCHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCE
GYMPVHDDYLNAIQWWMKTRHNWDIDTSWALTSQGLGNAIALCLDVWTDPGARVVIFTPV
EEECCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHEEECCCCCCCEEEEECCC
YHEFQIKIEKAGREAVTCPLKHTGDTYVLDLEDAQSRLDGSEQMLIWCSPQNPSGRVWTT
CEEEEEEEEECCCCEEEECCCCCCCEEEEECHHHHHHCCCCCEEEEEECCCCCCCCEEEH
DELRGIAEFAARNDLILVSDEIHHDLVFPDHTFVPMHIAAPEVEDRLIVLTAASKTFNIA
HHHHHHHHHHCCCCEEEEECCCCCCEECCCCCEEEEEEECCCCCCEEEEEEECCCEEEEC
GQRTGNMIIPDAKLRKTMQNRLNTLDYKPAALSLQMITAAYSPEGAKWVDAQIEHLDQNR
CCCCCCEECCCHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCCCCEEHHHHHHHHHCCC
RTFDAAIADIPGVISMPLQATYLAWVDFSGTGMSYDEISQRVRKSARIAPSPGPDFGPGG
HHHHHHHHCCCCCEECCCEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
ETFLRFNLATQHHRIEEACARLKDAFSDLQ
CEEEEEEECHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]