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The map label for this gene is pdhR [H]

Identifier: 110678648

GI number: 110678648

Start: 1275919

End: 1276704

Strand: Reverse

Name: pdhR [H]

Synonym: RD1_1326

Alternate gene names: 110678648

Gene position: 1276704-1275919 (Counterclockwise)

Preceding gene: 110678651

Following gene: 110678642

Centisome position: 30.89

GC content: 61.58

Gene sequence:

>786_bases
ATGCCATTTCGCCCCGTCGTTTCTGAAAAACTGTCGATTGCCGTGGTGCATCAGATCGAAGAGTTGATCCTGCGCGGCAT
CCTGTTGCCCGATGAACGGCTGCCTGCGGAACGGGAACTGGCGGAACGGCTCTGCGTGTCCCGGCCCAGCCTGCGCGAAG
CCATCGGGCTCTTGCAGGACAAGGGTCTGTTGACGACCAGAGCCGGTGCGGGTGTCTACGTGGCGGATGTTCTGGGGTCC
GCGTTTTCCCCGGCCCTCGTCGAGCTTTTCGCCCGTCATGACAGGGCAAAATTCGACTACCTCTCCTTCCGCCGAGACAT
GGAGGGGCTGGCCGCAGAACGGGCGACGCGGCTGGCGTCTGAAACCGATCTGCGCGTGGTGCAGGAAATTTTCGATCAGA
TGGAAGTCGCCCATGGCAAGCGCAATCCTGAAAACGATGCGCATCTGGATGCGAAATTCCATATGGCGATCATAGAAGCC
AGCCACAACGTGGTCATGCTGCACATGATGCGCTCCATGTATCAATTGCTGCGCGAGGGCGTGTTCTACAACCGGCAGGT
CATATTCAAACAGCGCACGACCCGCAGCGTGCTGCTGGACCAGCACCGTGCGATCAACACCGCCCTGCAAGCCCGGGATG
GCGCCGGGGCGCGCGCCGCCGTGGCCGCACATCTCGACTACATCGAAACCTCGCTGCGCGATGACGTCAGGGCCGCCGAA
AACGAAGAGACGGCGCAGCGTCGTCTGGATCACGTCAAGGAAACGGGGCGTGCAACCGGGCGCTAG

Upstream 100 bases:

>100_bases
TGAGGGGGCAACCGCTGGCCCATGGACACCAAAGGCCGCACGTAAACCGTTTGCCGCAACCGCATTTTGGTCATATCATT
TTACCAGTAAGGAGATTCCA

Downstream 100 bases:

>100_bases
CGCTGCGGCCAAAGCGGCGTGCGAAAAGCGTCACTCACCTGCCGTGGCCTGAACGCGCGAGGTGACATTGGGTGTTTGCC
TCTCGTCCCACGCCATAACG

Product: pyruvate dehydrogenase complex repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MPFRPVVSEKLSIAVVHQIEELILRGILLPDERLPAERELAERLCVSRPSLREAIGLLQDKGLLTTRAGAGVYVADVLGS
AFSPALVELFARHDRAKFDYLSFRRDMEGLAAERATRLASETDLRVVQEIFDQMEVAHGKRNPENDAHLDAKFHMAIIEA
SHNVVMLHMMRSMYQLLREGVFYNRQVIFKQRTTRSVLLDQHRAINTALQARDGAGARAAVAAHLDYIETSLRDDVRAAE
NEETAQRRLDHVKETGRATGR

Sequences:

>Translated_261_residues
MPFRPVVSEKLSIAVVHQIEELILRGILLPDERLPAERELAERLCVSRPSLREAIGLLQDKGLLTTRAGAGVYVADVLGS
AFSPALVELFARHDRAKFDYLSFRRDMEGLAAERATRLASETDLRVVQEIFDQMEVAHGKRNPENDAHLDAKFHMAIIEA
SHNVVMLHMMRSMYQLLREGVFYNRQVIFKQRTTRSVLLDQHRAINTALQARDGAGARAAVAAHLDYIETSLRDDVRAAE
NEETAQRRLDHVKETGRATGR
>Mature_260_residues
PFRPVVSEKLSIAVVHQIEELILRGILLPDERLPAERELAERLCVSRPSLREAIGLLQDKGLLTTRAGAGVYVADVLGSA
FSPALVELFARHDRAKFDYLSFRRDMEGLAAERATRLASETDLRVVQEIFDQMEVAHGKRNPENDAHLDAKFHMAIIEAS
HNVVMLHMMRSMYQLLREGVFYNRQVIFKQRTTRSVLLDQHRAINTALQARDGAGARAAVAAHLDYIETSLRDDVRAAEN
EETAQRRLDHVKETGRATGR

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=36.7521367521368, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790032, Length=232, Percent_Identity=34.051724137931, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789353, Length=235, Percent_Identity=30.2127659574468, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1790780, Length=216, Percent_Identity=31.9444444444444, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI87082208, Length=211, Percent_Identity=26.5402843601896, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29460; Mature: 29329

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFRPVVSEKLSIAVVHQIEELILRGILLPDERLPAERELAERLCVSRPSLREAIGLLQD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHC
KGLLTTRAGAGVYVADVLGSAFSPALVELFARHDRAKFDYLSFRRDMEGLAAERATRLAS
CCCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ETDLRVVQEIFDQMEVAHGKRNPENDAHLDAKFHMAIIEASHNVVMLHMMRSMYQLLREG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHC
VFYNRQVIFKQRTTRSVLLDQHRAINTALQARDGAGARAAVAAHLDYIETSLRDDVRAAE
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NEETAQRRLDHVKETGRATGR
CHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PFRPVVSEKLSIAVVHQIEELILRGILLPDERLPAERELAERLCVSRPSLREAIGLLQD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHC
KGLLTTRAGAGVYVADVLGSAFSPALVELFARHDRAKFDYLSFRRDMEGLAAERATRLAS
CCCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ETDLRVVQEIFDQMEVAHGKRNPENDAHLDAKFHMAIIEASHNVVMLHMMRSMYQLLREG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHC
VFYNRQVIFKQRTTRSVLLDQHRAINTALQARDGAGARAAVAAHLDYIETSLRDDVRAAE
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NEETAQRRLDHVKETGRATGR
CHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]