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The map label for this gene is uvrB [H]

Identifier: 110678580

GI number: 110678580

Start: 1214822

End: 1217020

Strand: Reverse

Name: uvrB [H]

Synonym: RD1_1254

Alternate gene names: 110678580

Gene position: 1217020-1214822 (Counterclockwise)

Preceding gene: 110678582

Following gene: 110678579

Centisome position: 29.45

GC content: 61.26

Gene sequence:

>2199_bases
ATGCCCTACGCACATTCCGACACCACCGAGGCCGTTCTGGCCAACGCTGCACCCGACGTGCGCGCCCGCGAGAAACTGGA
GGGTGGCAAGCGCTTCAAGCTGGCGACCGACTTCGAACCCGCAGGTGACCAGCCCACCGCCATCAAGGAACTCGCTGCCG
GTGTGCTGAGCGGGGAACGCGACCAAGTGCTTCTGGGGGCGACCGGCACGGGCAAGACCTTTACCATGGCCAAGGTGATC
GAGGAAACGCAACGCCCCGCGATCATTCTGGCCCCCAACAAAACCCTCGCTGCCCAGCTCTATGGCGAGTTCAAAGGGTT
CTTTCCCGATAACGCGGTGGAGTATTTCGTCAGCTTCTACGACTACTATCAGCCCGAAGCCTATGTGGCGCGCTCGGATA
CCTACATCGAGAAAGAGAGCCAGATCAACGAACAGATCGACCGCATGCGCCACTCCGCGACACGCGCCCTGCTTGAACGC
GACGACGTGATCATCGTGGCCTCGGTGTCCTGCATCTATGGCATCGGATCGGTGGAAACCTACGGCGCCATGACGCAGGA
CCTCAAGACCGGGCGGATGTATGACCAGCGACAGGTGATGGCGGATCTGGTGGCGCAGCAATACCGCCGCAACGATCAGT
CCTTTCAGCGTGGGTCTTTCCGGGTGCGCGGCGACAGCCTCGAAATCTTTCCCGCCCACCTTGAAGACCGCGCCTGGAAG
TTGTCTTTTTTCGGCGAAGAACTGGAATCTATCACCGAATTCGACCCGCTGACCGGTGAGAAAACCAACACATTCGAGCA
AATCCGCGTTTATGCCAACAGCCACTACGTGACGCCGAAACCCACGATGCAGCAGGCAATCATCAGCATCAAGAAAGAGC
TGCGCACCCGGCTCGATCAACTCGTGGGCGATGGCAAACTGCTCGAAGCGCAGCGGCTGGAGCAGCGCACGAACTTCGAC
CTTGAGATGCTGGAAGCCACGGGCGTGTGCAACGGGATCGAGAACTATTCGCGCTATCTGACCGGTCGCGCACCGGGGGA
GCCGCCCCCCACGCTCTTTGAATTCATCCCCGACAACGCCATCGTCTTTGCCGATGAGAGCCACGTCTCCGTGCCGCAGA
TCGGCGGCATGTACAAAGGCGACTACCGGCGCAAATTCACGCTGGCCGAACACGGGTTCCGCCTGCCTTCCTGCATGGAC
AACCGCCCCCTCAAGTTCGAGGAATGGGACGCCATGCGCCCGCAATCGGTCTTTGTTTCCGCCACGCCCGCCGCCTGGGA
AATGGACCAGACAGGCGGTGTGTTTACCGAACAGATCATCCGCCCCACCGGCCTGATCGACCCGGAAATCGAAATCCGCC
CGGTCGAGATGCAGGTGGACGATCTGCTGGATGAAGTACGCAAGGTGGCCGCCGATGGCTTCCGCACACTGGTCACGACG
CTCACCAAACGCATGGCCGAGGACCTCACCGAATACATGCACGAACAGGGCATCCGCGTGCGCTACATGCACAGCGATAT
CGACACGCTGGAACGCATTGAAATCCTGCGCGATCTGCGGCTGGGTGCCTTTGACGTGCTGATCGGGATCAACCTGCTGC
GCGAAGGTTTGGACATCCCCGAATGTGGGCTGGTGGCGATTCTGGATGCGGATAAGGAAGGCTTCCTGCGCTCTGAAACC
TCACTGATCCAGACCACGGGGCGCGCCGCGCGCAATGCCGAAGGGCGCGTGATCATGTACGCCGACCGCATTACCGGCTC
GATGGAACGCGCGATCGAGGAAACCAACCGCCGCCGCGCCAAACAGATCGCCTATAACGAAAAACACGGCATCACCCCGA
CAACGGTGAAAAAGAACGTCGAGGATATCCTCGCCGGGCTTTACAAAGGCGACACGGACCAATCCCGCGTCACCGCCAAG
ATCGACAAGCAGATGGCGGGCGGCAACCTGCAGGCGGTGCTGGACGGGCTGCGCACGGATATGCGCAAGGCCGCCGAGAA
CCTCGAATTCGAAGAGGCCGCAAGGTTGCGCGACGAAGTCAAACGCCTCGAAGCCGTCGACCTCGCCATCGCCGACGACC
CCATGGCGCGTCAGTATGCAGTGGAAAAAGCCGTGGAAGACAGCGCCAAAGCCTCAGGCCGCAGCACACTGGGCCGCGGC
GGCATGCGCGGCGGGGTGAAGCGGAAGCGGGGGCGTTAA

Upstream 100 bases:

>100_bases
CGTCCCGTTTGCTTTCCTGCCAAAACATGTCAGCAAGCACAGGCACTGGCCTTGATCATGGCGCAGATAAGCGCATCTTG
GCAGGGAAAGAGAGAACCGC

Downstream 100 bases:

>100_bases
ATTTTGATCCTCGCACGCTCTCCTGGAAGGTATGCGCCTTTCTTGTCCCTCCAAACAAAGTCGATCTGCAAACTTTGTTT
CAACGAACGTGCTGATCGAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MPYAHSDTTEAVLANAAPDVRAREKLEGGKRFKLATDFEPAGDQPTAIKELAAGVLSGERDQVLLGATGTGKTFTMAKVI
EETQRPAIILAPNKTLAAQLYGEFKGFFPDNAVEYFVSFYDYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLER
DDVIIVASVSCIYGIGSVETYGAMTQDLKTGRMYDQRQVMADLVAQQYRRNDQSFQRGSFRVRGDSLEIFPAHLEDRAWK
LSFFGEELESITEFDPLTGEKTNTFEQIRVYANSHYVTPKPTMQQAIISIKKELRTRLDQLVGDGKLLEAQRLEQRTNFD
LEMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEFIPDNAIVFADESHVSVPQIGGMYKGDYRRKFTLAEHGFRLPSCMD
NRPLKFEEWDAMRPQSVFVSATPAAWEMDQTGGVFTEQIIRPTGLIDPEIEIRPVEMQVDDLLDEVRKVAADGFRTLVTT
LTKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPECGLVAILDADKEGFLRSET
SLIQTTGRAARNAEGRVIMYADRITGSMERAIEETNRRRAKQIAYNEKHGITPTTVKKNVEDILAGLYKGDTDQSRVTAK
IDKQMAGGNLQAVLDGLRTDMRKAAENLEFEEAARLRDEVKRLEAVDLAIADDPMARQYAVEKAVEDSAKASGRSTLGRG
GMRGGVKRKRGR

Sequences:

>Translated_732_residues
MPYAHSDTTEAVLANAAPDVRAREKLEGGKRFKLATDFEPAGDQPTAIKELAAGVLSGERDQVLLGATGTGKTFTMAKVI
EETQRPAIILAPNKTLAAQLYGEFKGFFPDNAVEYFVSFYDYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLER
DDVIIVASVSCIYGIGSVETYGAMTQDLKTGRMYDQRQVMADLVAQQYRRNDQSFQRGSFRVRGDSLEIFPAHLEDRAWK
LSFFGEELESITEFDPLTGEKTNTFEQIRVYANSHYVTPKPTMQQAIISIKKELRTRLDQLVGDGKLLEAQRLEQRTNFD
LEMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEFIPDNAIVFADESHVSVPQIGGMYKGDYRRKFTLAEHGFRLPSCMD
NRPLKFEEWDAMRPQSVFVSATPAAWEMDQTGGVFTEQIIRPTGLIDPEIEIRPVEMQVDDLLDEVRKVAADGFRTLVTT
LTKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPECGLVAILDADKEGFLRSET
SLIQTTGRAARNAEGRVIMYADRITGSMERAIEETNRRRAKQIAYNEKHGITPTTVKKNVEDILAGLYKGDTDQSRVTAK
IDKQMAGGNLQAVLDGLRTDMRKAAENLEFEEAARLRDEVKRLEAVDLAIADDPMARQYAVEKAVEDSAKASGRSTLGRG
GMRGGVKRKRGR
>Mature_731_residues
PYAHSDTTEAVLANAAPDVRAREKLEGGKRFKLATDFEPAGDQPTAIKELAAGVLSGERDQVLLGATGTGKTFTMAKVIE
ETQRPAIILAPNKTLAAQLYGEFKGFFPDNAVEYFVSFYDYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERD
DVIIVASVSCIYGIGSVETYGAMTQDLKTGRMYDQRQVMADLVAQQYRRNDQSFQRGSFRVRGDSLEIFPAHLEDRAWKL
SFFGEELESITEFDPLTGEKTNTFEQIRVYANSHYVTPKPTMQQAIISIKKELRTRLDQLVGDGKLLEAQRLEQRTNFDL
EMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEFIPDNAIVFADESHVSVPQIGGMYKGDYRRKFTLAEHGFRLPSCMDN
RPLKFEEWDAMRPQSVFVSATPAAWEMDQTGGVFTEQIIRPTGLIDPEIEIRPVEMQVDDLLDEVRKVAADGFRTLVTTL
TKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPECGLVAILDADKEGFLRSETS
LIQTTGRAARNAEGRVIMYADRITGSMERAIEETNRRRAKQIAYNEKHGITPTTVKKNVEDILAGLYKGDTDQSRVTAKI
DKQMAGGNLQAVLDGLRTDMRKAAENLEFEEAARLRDEVKRLEAVDLAIADDPMARQYAVEKAVEDSAKASGRSTLGRGG
MRGGVKRKRGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=58.5074626865672, Blast_Score=781, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 82308; Mature: 82177

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYAHSDTTEAVLANAAPDVRAREKLEGGKRFKLATDFEPAGDQPTAIKELAAGVLSGER
CCCCCCCCHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCC
DQVLLGATGTGKTFTMAKVIEETQRPAIILAPNKTLAAQLYGEFKGFFPDNAVEYFVSFY
CEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
DYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERDDVIIVASVSCIYGIGSVET
HHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHH
YGAMTQDLKTGRMYDQRQVMADLVAQQYRRNDQSFQRGSFRVRGDSLEIFPAHLEDRAWK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCEEEEECCCCCCCEE
LSFFGEELESITEFDPLTGEKTNTFEQIRVYANSHYVTPKPTMQQAIISIKKELRTRLDQ
EHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEECCEEECCCCHHHHHHHHHHHHHHHHHHH
LVGDGKLLEAQRLEQRTNFDLEMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEFIPDNA
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCE
IVFADESHVSVPQIGGMYKGDYRRKFTLAEHGFRLPSCMDNRPLKFEEWDAMRPQSVFVS
EEEECCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ATPAAWEMDQTGGVFTEQIIRPTGLIDPEIEIRPVEMQVDDLLDEVRKVAADGFRTLVTT
ECCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LTKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIP
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
ECGLVAILDADKEGFLRSETSLIQTTGRAARNAEGRVIMYADRITGSMERAIEETNRRRA
CCCEEEEEECCCCCCHHHHHHHHHHHCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
KQIAYNEKHGITPTTVKKNVEDILAGLYKGDTDQSRVTAKIDKQMAGGNLQAVLDGLRTD
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
MRKAAENLEFEEAARLRDEVKRLEAVDLAIADDPMARQYAVEKAVEDSAKASGRSTLGRG
HHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCHHHCCC
GMRGGVKRKRGR
CCCCCCCCCCCC
>Mature Secondary Structure 
PYAHSDTTEAVLANAAPDVRAREKLEGGKRFKLATDFEPAGDQPTAIKELAAGVLSGER
CCCCCCCHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCC
DQVLLGATGTGKTFTMAKVIEETQRPAIILAPNKTLAAQLYGEFKGFFPDNAVEYFVSFY
CEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
DYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERDDVIIVASVSCIYGIGSVET
HHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHH
YGAMTQDLKTGRMYDQRQVMADLVAQQYRRNDQSFQRGSFRVRGDSLEIFPAHLEDRAWK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCEEEEECCCCCCCEE
LSFFGEELESITEFDPLTGEKTNTFEQIRVYANSHYVTPKPTMQQAIISIKKELRTRLDQ
EHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEECCEEECCCCHHHHHHHHHHHHHHHHHHH
LVGDGKLLEAQRLEQRTNFDLEMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEFIPDNA
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCE
IVFADESHVSVPQIGGMYKGDYRRKFTLAEHGFRLPSCMDNRPLKFEEWDAMRPQSVFVS
EEEECCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ATPAAWEMDQTGGVFTEQIIRPTGLIDPEIEIRPVEMQVDDLLDEVRKVAADGFRTLVTT
ECCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LTKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIP
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
ECGLVAILDADKEGFLRSETSLIQTTGRAARNAEGRVIMYADRITGSMERAIEETNRRRA
CCCEEEEEECCCCCCHHHHHHHHHHHCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
KQIAYNEKHGITPTTVKKNVEDILAGLYKGDTDQSRVTAKIDKQMAGGNLQAVLDGLRTD
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
MRKAAENLEFEEAARLRDEVKRLEAVDLAIADDPMARQYAVEKAVEDSAKASGRSTLGRG
HHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCHHHCCC
GMRGGVKRKRGR
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]