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The map label for this gene is coaBC [H]

Identifier: 110678528

GI number: 110678528

Start: 1162429

End: 1163622

Strand: Direct

Name: coaBC [H]

Synonym: RD1_1200

Alternate gene names: 110678528

Gene position: 1162429-1163622 (Clockwise)

Preceding gene: 110678527

Following gene: 110678529

Centisome position: 28.12

GC content: 61.47

Gene sequence:

>1194_bases
ATGCTGAGCGATAAACACATTCTGCTGATTATTGGTGGCGGGATCGCGGCTTTCAAATCGCTCGATCTGATCCGCCGCCT
GCGCGAGCATGGCGCGGTTGTGACGCCCGTTTTGACCAAGGCGGCCGAAGAATTCGTCACACCACTGTCCGTTTCCGCAC
TGGCGGGCGCGAAAGTATATCGCGACCTGTTTGACCTGACGGATGAGGCCGAGATGGGCCATATCCAGCTTAGCCGGGTT
GCGGACCTTGTCGTTGTGGCGCCTGCGACGGCGGATCTGATGGCCAAGATGGCGCAAGGCCTCGCCAATGATCTGGCCAG
TACGCTGCTGCTGGCAACGGATACGCCTGTGTTGATTGCACCCGCCATGAACGTGCGCATGTGGGAACATGCCGCGACAC
AGCGTAATGCAGTCCGATTGCGCGCGGATGGGGTGCATATGGTGGGGCCGGTTTCCGGCGATATGGCTTGCGGTGAACAT
GGTCCCGGGCGCATGTCCGAGCCGATGGATATTCTGGCGGCCGTGACGGCGCATTTTCAGGACGGACCTTTGCAGGGCAA
ACATATCCTCGTGACGTCCGGTCCAACCCATGAACCCATTGATCCGGTGCGGTATATCGCAAACCGCTCCTCCGGCGCGC
AGGGGGCGGCAATCGCCAGAGCGCTGCATGCATTGGGTGCGAGGGTTTCGTTTGTCACCGGCCCGGCGGATGTGCCGCCC
CCGGCGGGCGTCGATGTGGTGCGGGTTGAGACAGCGCAGCAGATGCTGGACGCGGTGCGTCAATCCCTGCCTGCGGATGC
GGCAGTCTTCGCGGCTGCCGTCGCGGATTGGCGTGTGGCCTGCGCCAGTGACAGCAAACTGAAGAAAACGAGCGGCGCGC
TGCCGGTGCTGACCTTTGCAGAGAACCCGGATATCCTGCACAGCATCTCGCACGCAAAGGACCAGCGCCCGAAACTTGTC
ATCGGTTTTGCCGCCGAAACCGACGATGTGGTGGAAAACGCGACGGCAAAGCGGCTGCGCAAAGGGTGCGACTGGATTGT
TGCAAATGATGTATCGCCCCAGACCGGGATCATGGGGGGGCAGGAGAACGCCGTGACCCTGATAGATGAAAAGGGCGCTG
ACACCTGGCCCAGAATGTCCAAAGACGCAGTGTCGCAACGCCTCGCTGCCCTGATCGCTCAGCGGTTGGCTTAA

Upstream 100 bases:

>100_bases
CGGCAGTCCCTGTGATGCCTTCGCAAAGTAATCCGGGCTGGTGGAAATCAGCGTCTCGCCTTAAAGTCACCCCGTCAGGT
TTCACGATCAAAGGTCCAAG

Downstream 100 bases:

>100_bases
CGGAGGCCATGGCTTTGGTATCCCTGAAACTGCAATGGGCTGACGGGGCCGACACATCGGTGCCGTTGCCTGCCTATGAG
ACATCCGGCGCGGCGGGTGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLSDKHILLIIGGGIAAFKSLDLIRRLREHGAVVTPVLTKAAEEFVTPLSVSALAGAKVYRDLFDLTDEAEMGHIQLSRV
ADLVVVAPATADLMAKMAQGLANDLASTLLLATDTPVLIAPAMNVRMWEHAATQRNAVRLRADGVHMVGPVSGDMACGEH
GPGRMSEPMDILAAVTAHFQDGPLQGKHILVTSGPTHEPIDPVRYIANRSSGAQGAAIARALHALGARVSFVTGPADVPP
PAGVDVVRVETAQQMLDAVRQSLPADAAVFAAAVADWRVACASDSKLKKTSGALPVLTFAENPDILHSISHAKDQRPKLV
IGFAAETDDVVENATAKRLRKGCDWIVANDVSPQTGIMGGQENAVTLIDEKGADTWPRMSKDAVSQRLAALIAQRLA

Sequences:

>Translated_397_residues
MLSDKHILLIIGGGIAAFKSLDLIRRLREHGAVVTPVLTKAAEEFVTPLSVSALAGAKVYRDLFDLTDEAEMGHIQLSRV
ADLVVVAPATADLMAKMAQGLANDLASTLLLATDTPVLIAPAMNVRMWEHAATQRNAVRLRADGVHMVGPVSGDMACGEH
GPGRMSEPMDILAAVTAHFQDGPLQGKHILVTSGPTHEPIDPVRYIANRSSGAQGAAIARALHALGARVSFVTGPADVPP
PAGVDVVRVETAQQMLDAVRQSLPADAAVFAAAVADWRVACASDSKLKKTSGALPVLTFAENPDILHSISHAKDQRPKLV
IGFAAETDDVVENATAKRLRKGCDWIVANDVSPQTGIMGGQENAVTLIDEKGADTWPRMSKDAVSQRLAALIAQRLA
>Mature_397_residues
MLSDKHILLIIGGGIAAFKSLDLIRRLREHGAVVTPVLTKAAEEFVTPLSVSALAGAKVYRDLFDLTDEAEMGHIQLSRV
ADLVVVAPATADLMAKMAQGLANDLASTLLLATDTPVLIAPAMNVRMWEHAATQRNAVRLRADGVHMVGPVSGDMACGEH
GPGRMSEPMDILAAVTAHFQDGPLQGKHILVTSGPTHEPIDPVRYIANRSSGAQGAAIARALHALGARVSFVTGPADVPP
PAGVDVVRVETAQQMLDAVRQSLPADAAVFAAAVADWRVACASDSKLKKTSGALPVLTFAENPDILHSISHAKDQRPKLV
IGFAAETDDVVENATAKRLRKGCDWIVANDVSPQTGIMGGQENAVTLIDEKGADTWPRMSKDAVSQRLAALIAQRLA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=33.5260115606936, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=46.2311557788945, Blast_Score=302, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17560194, Length=191, Percent_Identity=31.9371727748691, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24657262, Length=193, Percent_Identity=29.5336787564767, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41876; Mature: 41876

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDKHILLIIGGGIAAFKSLDLIRRLREHGAVVTPVLTKAAEEFVTPLSVSALAGAKVY
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHH
RDLFDLTDEAEMGHIQLSRVADLVVVAPATADLMAKMAQGLANDLASTLLLATDTPVLIA
HHHHHCCCCCCCCCEEHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHEEHCCCCCEEEE
PAMNVRMWEHAATQRNAVRLRADGVHMVGPVSGDMACGEHGPGRMSEPMDILAAVTAHFQ
CCCCHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
DGPLQGKHILVTSGPTHEPIDPVRYIANRSSGAQGAAIARALHALGARVSFVTGPADVPP
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCC
PAGVDVVRVETAQQMLDAVRQSLPADAAVFAAAVADWRVACASDSKLKKTSGALPVLTFA
CCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCHHHHHCCCCEEEEEC
ENPDILHSISHAKDQRPKLVIGFAAETDDVVENATAKRLRKGCDWIVANDVSPQTGIMGG
CCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
QENAVTLIDEKGADTWPRMSKDAVSQRLAALIAQRLA
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSDKHILLIIGGGIAAFKSLDLIRRLREHGAVVTPVLTKAAEEFVTPLSVSALAGAKVY
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHH
RDLFDLTDEAEMGHIQLSRVADLVVVAPATADLMAKMAQGLANDLASTLLLATDTPVLIA
HHHHHCCCCCCCCCEEHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHEEHCCCCCEEEE
PAMNVRMWEHAATQRNAVRLRADGVHMVGPVSGDMACGEHGPGRMSEPMDILAAVTAHFQ
CCCCHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
DGPLQGKHILVTSGPTHEPIDPVRYIANRSSGAQGAAIARALHALGARVSFVTGPADVPP
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCC
PAGVDVVRVETAQQMLDAVRQSLPADAAVFAAAVADWRVACASDSKLKKTSGALPVLTFA
CCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCHHHHHCCCCEEEEEC
ENPDILHSISHAKDQRPKLVIGFAAETDDVVENATAKRLRKGCDWIVANDVSPQTGIMGG
CCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
QENAVTLIDEKGADTWPRMSKDAVSQRLAALIAQRLA
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA