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The map label for this gene is hdaH [H]

Identifier: 110678513

GI number: 110678513

Start: 1146200

End: 1147300

Strand: Reverse

Name: hdaH [H]

Synonym: RD1_1183

Alternate gene names: 110678513

Gene position: 1147300-1146200 (Counterclockwise)

Preceding gene: 110678514

Following gene: 110678512

Centisome position: 27.76

GC content: 61.58

Gene sequence:

>1101_bases
ATGAGCACCGGCTTTTTCTGGGATGAGCAGTGTTTTTGGCATGCAGGCGGAAACTATGCCTCCACCCTGCCGATTGGGGG
GCTGGTGCAGCCGCTGAACGCGACCGGCCTGCCCGAAACACAGGAAGCAAAGCGCCGCCTGAAGAACCTGATGGATGTCA
CCGGCCTGTCGAATGATCTGGATGTGCGCCGCGCGCCAATGGCGACGCGTGAGGATTTGCTGCGCGTGCATCCGGCCTCG
TACCTCGATGAGTTCAAACGCCTGTCAGATGCAGGCGGCGGTGAACTTGGCCGACGCACACCCTTTGCCACCGGGGGGTA
TGAGATCGCGTCGCTTTCTGCCGGGCTGGTTGTCGCCGCTGTTGATGCCGTCGTGAGCGGCGATCTGGAAAACGCCTATG
CCCTGTCGCGCCCGCCGGGCCATCACTGCCTGCCCGACTATCCAAACGGGTTTTGCCTGCTGGCCAATATCGCCATCGCC
ATCGAAGCCGCGCAGGCCAAGGGGTTTGCGAAACGTGTCGTTGTTCTGGACTGGGATGTGCACCACGGCAATGGCACCGA
AGCGATCTATTATGACCGCCCGGACGTGCTGACGATCTCTCTGCATCAGGAGGGCAACTACCCGCTCGACACCGGAGGTA
TCGCTGATCGCGGCACGGGCGATGGTGTGGGCTACAACCTGAATCTGCCCCTCATCGCCGGCACCGGGCATACCGGATAC
CTACATGCGATGGACACGATCGTTCTGCCACAAATCGCGGCGTTCAAACCCGATCTGATCGTCGTCGCCTGTGGATATGA
CGCAAGCGCCATTGATCCCCTTGCGCGGATGCTGGCCACGGCGGAGACCTTTCGCAAGCTGACCGAACGCATCAAAACCG
CCGCGCAGGAACACTGTGACGGGCGTTTGGTGCTCGCGCATGAAGGCGGCTATTCCGAGGTCTACGTCCCGTTCTGCGGC
CATGCCACGCTCGAAGCGCTTTCGGGCAGTGACAAAACAGCCCCCGACCCCTTGGCCGAGACATTGCGCGTGCGCCAACC
GAGCGCCCGCTTTGATGCCTTCATCAGGGGTGAAATCGACCATCTGGCCAGCCAACTCTAA

Upstream 100 bases:

>100_bases
AAACAGGCATGTTGGCAACGGCGTCTGCGCAGAAAATGGCGCGTGGACTTTTCCCGGCGGCTGCTTCACTCTGCTGGCGG
ACAATGAACGAGAGAAAGAT

Downstream 100 bases:

>100_bases
CCTGCAGGACACCCATGCCCGACCCAAACCCCAATGCACTGGACTTTTTGCTGACGCGCCGCTCGAGACCGGCCAAGACC
CTGCAGGCCCCCGCGCCGGA

Product: histone deacetylase family protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSTGFFWDEQCFWHAGGNYASTLPIGGLVQPLNATGLPETQEAKRRLKNLMDVTGLSNDLDVRRAPMATREDLLRVHPAS
YLDEFKRLSDAGGGELGRRTPFATGGYEIASLSAGLVVAAVDAVVSGDLENAYALSRPPGHHCLPDYPNGFCLLANIAIA
IEAAQAKGFAKRVVVLDWDVHHGNGTEAIYYDRPDVLTISLHQEGNYPLDTGGIADRGTGDGVGYNLNLPLIAGTGHTGY
LHAMDTIVLPQIAAFKPDLIVVACGYDASAIDPLARMLATAETFRKLTERIKTAAQEHCDGRLVLAHEGGYSEVYVPFCG
HATLEALSGSDKTAPDPLAETLRVRQPSARFDAFIRGEIDHLASQL

Sequences:

>Translated_366_residues
MSTGFFWDEQCFWHAGGNYASTLPIGGLVQPLNATGLPETQEAKRRLKNLMDVTGLSNDLDVRRAPMATREDLLRVHPAS
YLDEFKRLSDAGGGELGRRTPFATGGYEIASLSAGLVVAAVDAVVSGDLENAYALSRPPGHHCLPDYPNGFCLLANIAIA
IEAAQAKGFAKRVVVLDWDVHHGNGTEAIYYDRPDVLTISLHQEGNYPLDTGGIADRGTGDGVGYNLNLPLIAGTGHTGY
LHAMDTIVLPQIAAFKPDLIVVACGYDASAIDPLARMLATAETFRKLTERIKTAAQEHCDGRLVLAHEGGYSEVYVPFCG
HATLEALSGSDKTAPDPLAETLRVRQPSARFDAFIRGEIDHLASQL
>Mature_365_residues
STGFFWDEQCFWHAGGNYASTLPIGGLVQPLNATGLPETQEAKRRLKNLMDVTGLSNDLDVRRAPMATREDLLRVHPASY
LDEFKRLSDAGGGELGRRTPFATGGYEIASLSAGLVVAAVDAVVSGDLENAYALSRPPGHHCLPDYPNGFCLLANIAIAI
EAAQAKGFAKRVVVLDWDVHHGNGTEAIYYDRPDVLTISLHQEGNYPLDTGGIADRGTGDGVGYNLNLPLIAGTGHTGYL
HAMDTIVLPQIAAFKPDLIVVACGYDASAIDPLARMLATAETFRKLTERIKTAAQEHCDGRLVLAHEGGYSEVYVPFCGH
ATLEALSGSDKTAPDPLAETLRVRQPSARFDAFIRGEIDHLASQL

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI153085395, Length=248, Percent_Identity=37.0967741935484, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI13128864, Length=316, Percent_Identity=32.2784810126582, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI30795204, Length=247, Percent_Identity=36.8421052631579, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI17158039, Length=247, Percent_Identity=36.8421052631579, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI30795202, Length=247, Percent_Identity=36.8421052631579, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI20070354, Length=255, Percent_Identity=36.078431372549, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI148539870, Length=259, Percent_Identity=34.7490347490347, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI169234807, Length=259, Percent_Identity=34.7490347490347, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI62750349, Length=257, Percent_Identity=34.6303501945525, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI62750347, Length=257, Percent_Identity=34.6303501945525, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI226529806, Length=255, Percent_Identity=33.7254901960784, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI293336691, Length=295, Percent_Identity=27.1186440677966, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI13128860, Length=340, Percent_Identity=26.1764705882353, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI8923769, Length=255, Percent_Identity=25.8823529411765, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13128862, Length=250, Percent_Identity=26, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262073092, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262073088, Length=175, Percent_Identity=30.2857142857143, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=307, Percent_Identity=32.2475570032573, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17540332, Length=307, Percent_Identity=32.2475570032573, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI193206283, Length=307, Percent_Identity=32.2475570032573, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI193209491, Length=232, Percent_Identity=35.3448275862069, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508561, Length=294, Percent_Identity=30.2721088435374, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=264, Percent_Identity=32.5757575757576, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17561978, Length=294, Percent_Identity=27.891156462585, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=225, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25154020, Length=213, Percent_Identity=27.2300469483568, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25154022, Length=251, Percent_Identity=25.0996015936255, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324307, Length=288, Percent_Identity=32.9861111111111, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6321244, Length=238, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=277, Percent_Identity=25.9927797833935, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325141, Length=311, Percent_Identity=26.6881028938907, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325325, Length=204, Percent_Identity=25.4901960784314, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281360899, Length=335, Percent_Identity=32.2388059701493, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24642142, Length=335, Percent_Identity=32.2388059701493, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24642144, Length=335, Percent_Identity=32.2388059701493, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24642146, Length=337, Percent_Identity=32.0474777448071, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI281360799, Length=322, Percent_Identity=32.6086956521739, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24641720, Length=322, Percent_Identity=32.6086956521739, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI281360801, Length=322, Percent_Identity=32.6086956521739, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24657891, Length=267, Percent_Identity=28.8389513108614, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24644244, Length=236, Percent_Identity=25.4237288135593, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39310; Mature: 39179

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGFFWDEQCFWHAGGNYASTLPIGGLVQPLNATGLPETQEAKRRLKNLMDVTGLSNDL
CCCCCEECCCEEEECCCCEECCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
DVRRAPMATREDLLRVHPASYLDEFKRLSDAGGGELGRRTPFATGGYEIASLSAGLVVAA
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCCCHHHHH
VDAVVSGDLENAYALSRPPGHHCLPDYPNGFCLLANIAIAIEAAQAKGFAKRVVVLDWDV
HHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEEEHHHHCCCEEEEEEEEEEE
HHGNGTEAIYYDRPDVLTISLHQEGNYPLDTGGIADRGTGDGVGYNLNLPLIAGTGHTGY
ECCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCC
LHAMDTIVLPQIAAFKPDLIVVACGYDASAIDPLARMLATAETFRKLTERIKTAAQEHCD
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRLVLAHEGGYSEVYVPFCGHATLEALSGSDKTAPDPLAETLRVRQPSARFDAFIRGEID
CEEEEEECCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHEECCCHH
HLASQL
HHHHCC
>Mature Secondary Structure 
STGFFWDEQCFWHAGGNYASTLPIGGLVQPLNATGLPETQEAKRRLKNLMDVTGLSNDL
CCCCEECCCEEEECCCCEECCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
DVRRAPMATREDLLRVHPASYLDEFKRLSDAGGGELGRRTPFATGGYEIASLSAGLVVAA
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCCCHHHHH
VDAVVSGDLENAYALSRPPGHHCLPDYPNGFCLLANIAIAIEAAQAKGFAKRVVVLDWDV
HHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEEEHHHHCCCEEEEEEEEEEE
HHGNGTEAIYYDRPDVLTISLHQEGNYPLDTGGIADRGTGDGVGYNLNLPLIAGTGHTGY
ECCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCC
LHAMDTIVLPQIAAFKPDLIVVACGYDASAIDPLARMLATAETFRKLTERIKTAAQEHCD
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRLVLAHEGGYSEVYVPFCGHATLEALSGSDKTAPDPLAETLRVRQPSARFDAFIRGEID
CEEEEEECCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHEECCCHH
HLASQL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA