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The map label for this gene is sucC [H]

Identifier: 110678492

GI number: 110678492

Start: 1122758

End: 1123957

Strand: Direct

Name: sucC [H]

Synonym: RD1_1162

Alternate gene names: 110678492

Gene position: 1122758-1123957 (Clockwise)

Preceding gene: 110678491

Following gene: 110678493

Centisome position: 27.17

GC content: 58.08

Gene sequence:

>1200_bases
ATGGATATCCACGAGTACCAAGCGAAAGAAGTTCTTGCTAATTTCGGGGTCGCTGTGCCGGATGGCGCTTTGGCGTACAG
CCCGGAACAGGCATCCTACCGCGCACGCGAGCTCGGCGGTGAAAGATGGGTTGTTAAGGCCCAGATACACGCCGGCGGGC
GCGGCAAGGCGGGCGGCGTAAAAGTCTGTGAAAGCGACGTCGAAATCCAGAAAGCATCCGAAGAGATGTTTGGCAAAAAG
ATGATCACGCATCAGACCGGACCAGAAGGCAAAGGCATCTACCGCGTCTATGTCGAGGCTGCGGTGCCGATAGATCGCGA
GATTTATCTGGGCTTTGTTCTTGATCGTACGACGCAACGGGTCATGATCGTTGCAAGTGCCGAAGGCGGTATGGAGATTG
AAGAAATCTCTGAAAAACGCCCCGAAAGCATCGTTCGGGCGATTGTGGAGCCTGCCGTTGGTCTGCGCGAATTTCAGTGC
CGCCAGATTGCATTCAAATTGGGCGTCGATGCGGGTCTGACACAGCAGATGGTGCGTACCTTGCAAGGCTGTTATCGGGC
TTTTACCGAGCTGGACGCGACCATGGTGGAGATCAACCCTTTGGTCATTACCGCAGACAATCGCGTGATTGCGCTGGATG
CCAAGATGACTTTTGACGACAATGCGTTGTTCCGCCACCCACAGATCAGCGAATTGCGCGACAAATCGCAAGAGGATCCG
CGCGAAAGCCGGGCTGCCGATCGCGGTCTGTCCTATGTCGGTCTGGACGGCAATATCGGCTGCATCGTGAACGGGGCTGG
CCTTGCCATGGCGACGATGGACACGATCAAACTGGCCGGTGGGGAGCCTGCGAATTTCCTCGATATCGGCGGTGGGGCCA
CGCCCGAACGTGTGGCCAAGGCTTTCCGGCTGGTGCTGTCGGACAAGAGCGTGCAGGCGATCTTGGTCAATATCTTTGCA
GGGATCAACCGCTGTGACTGGGTGGCCGAAGGCGTCGTGCAGGCCCTCAGGGAAGTGCAGGTCGATGTGCCCGTGATCGT
GCGACTGGCCGGCACCAATGTGGAGGAAGGGCAGAAGATTCTCGCCCAATCCGGCCTGCCGATCATCCGCGCAACCACTC
TGATGGAAGCCGCCGAGCGCGCGGTCGGTGCGTGGCAGAATGACCTGTCGCAGGGTACAAGAATGAGGGCCGTATCATGA

Upstream 100 bases:

>100_bases
CTTTGATCAGGATGCCGTCTCTAGCGCATTGGATGAGCATTACGGTCAAGCAATCGCCGCCGAATAAAACTGTCATCCGC
GTCTTCTGGGAGGAGCGACC

Downstream 100 bases:

>100_bases
GCATACTTCTTGATAGCGACACCAAAGTCATTGTGCAGGGCATCACCGGCAAGATGGCCCGCTTCCACACCAAGGATATG
CTCGAATACGGCACTAACGT

Product: malate--CoA ligase subunit beta

Products: NA

Alternate protein names: MTK-beta; Malate thiokinase; Malyl-CoA synthetase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MDIHEYQAKEVLANFGVAVPDGALAYSPEQASYRARELGGERWVVKAQIHAGGRGKAGGVKVCESDVEIQKASEEMFGKK
MITHQTGPEGKGIYRVYVEAAVPIDREIYLGFVLDRTTQRVMIVASAEGGMEIEEISEKRPESIVRAIVEPAVGLREFQC
RQIAFKLGVDAGLTQQMVRTLQGCYRAFTELDATMVEINPLVITADNRVIALDAKMTFDDNALFRHPQISELRDKSQEDP
RESRAADRGLSYVGLDGNIGCIVNGAGLAMATMDTIKLAGGEPANFLDIGGGATPERVAKAFRLVLSDKSVQAILVNIFA
GINRCDWVAEGVVQALREVQVDVPVIVRLAGTNVEEGQKILAQSGLPIIRATTLMEAAERAVGAWQNDLSQGTRMRAVS

Sequences:

>Translated_399_residues
MDIHEYQAKEVLANFGVAVPDGALAYSPEQASYRARELGGERWVVKAQIHAGGRGKAGGVKVCESDVEIQKASEEMFGKK
MITHQTGPEGKGIYRVYVEAAVPIDREIYLGFVLDRTTQRVMIVASAEGGMEIEEISEKRPESIVRAIVEPAVGLREFQC
RQIAFKLGVDAGLTQQMVRTLQGCYRAFTELDATMVEINPLVITADNRVIALDAKMTFDDNALFRHPQISELRDKSQEDP
RESRAADRGLSYVGLDGNIGCIVNGAGLAMATMDTIKLAGGEPANFLDIGGGATPERVAKAFRLVLSDKSVQAILVNIFA
GINRCDWVAEGVVQALREVQVDVPVIVRLAGTNVEEGQKILAQSGLPIIRATTLMEAAERAVGAWQNDLSQGTRMRAVS
>Mature_399_residues
MDIHEYQAKEVLANFGVAVPDGALAYSPEQASYRARELGGERWVVKAQIHAGGRGKAGGVKVCESDVEIQKASEEMFGKK
MITHQTGPEGKGIYRVYVEAAVPIDREIYLGFVLDRTTQRVMIVASAEGGMEIEEISEKRPESIVRAIVEPAVGLREFQC
RQIAFKLGVDAGLTQQMVRTLQGCYRAFTELDATMVEINPLVITADNRVIALDAKMTFDDNALFRHPQISELRDKSQEDP
RESRAADRGLSYVGLDGNIGCIVNGAGLAMATMDTIKLAGGEPANFLDIGGGATPERVAKAFRLVLSDKSVQAILVNIFA
GINRCDWVAEGVVQALREVQVDVPVIVRLAGTNVEEGQKILAQSGLPIIRATTLMEAAERAVGAWQNDLSQGTRMRAVS

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=390, Percent_Identity=44.8717948717949, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI157779135, Length=381, Percent_Identity=42.7821522309711, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI294862256, Length=363, Percent_Identity=41.3223140495868, Blast_Score=285, Evalue=5e-77,
Organism=Escherichia coli, GI1786948, Length=384, Percent_Identity=52.34375, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17567829, Length=388, Percent_Identity=43.5567010309278, Blast_Score=324, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI17539378, Length=394, Percent_Identity=43.1472081218274, Blast_Score=323, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6321683, Length=397, Percent_Identity=45.5919395465995, Blast_Score=350, Evalue=3e-97,
Organism=Drosophila melanogaster, GI21356231, Length=394, Percent_Identity=41.6243654822335, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI161078106, Length=393, Percent_Identity=41.4758269720102, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24645208, Length=393, Percent_Identity=41.4758269720102, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI281361397, Length=394, Percent_Identity=41.3705583756345, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI281361395, Length=394, Percent_Identity=41.3705583756345, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI281363475, Length=343, Percent_Identity=25.6559766763848, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363473, Length=343, Percent_Identity=25.6559766763848, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363477, Length=343, Percent_Identity=25.6559766763848, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.9 [H]

Molecular weight: Translated: 43302; Mature: 43302

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIHEYQAKEVLANFGVAVPDGALAYSPEQASYRARELGGERWVVKAQIHAGGRGKAGGV
CCCHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
KVCESDVEIQKASEEMFGKKMITHQTGPEGKGIYRVYVEAAVPIDREIYLGFVLDRTTQR
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEECCCCE
VMIVASAEGGMEIEEISEKRPESIVRAIVEPAVGLREFQCRQIAFKLGVDAGLTQQMVRT
EEEEEECCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHH
LQGCYRAFTELDATMVEINPLVITADNRVIALDAKMTFDDNALFRHPQISELRDKSQEDP
HHHHHHHHHHCCCEEEEECEEEEEECCEEEEEEEEEEECCCCEECCCCHHHHHHCCCCCH
RESRAADRGLSYVGLDGNIGCIVNGAGLAMATMDTIKLAGGEPANFLDIGGGATPERVAK
HHHHHHHCCCEEEECCCCEEEEEECCCEEEEEHHHEEECCCCCCCEEECCCCCCHHHHHH
AFRLVLSDKSVQAILVNIFAGINRCDWVAEGVVQALREVQVDVPVIVRLAGTNVEEGQKI
HHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
LAQSGLPIIRATTLMEAAERAVGAWQNDLSQGTRMRAVS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MDIHEYQAKEVLANFGVAVPDGALAYSPEQASYRARELGGERWVVKAQIHAGGRGKAGGV
CCCHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
KVCESDVEIQKASEEMFGKKMITHQTGPEGKGIYRVYVEAAVPIDREIYLGFVLDRTTQR
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEECCCCE
VMIVASAEGGMEIEEISEKRPESIVRAIVEPAVGLREFQCRQIAFKLGVDAGLTQQMVRT
EEEEEECCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHH
LQGCYRAFTELDATMVEINPLVITADNRVIALDAKMTFDDNALFRHPQISELRDKSQEDP
HHHHHHHHHHCCCEEEEECEEEEEECCEEEEEEEEEEECCCCEECCCCHHHHHHCCCCCH
RESRAADRGLSYVGLDGNIGCIVNGAGLAMATMDTIKLAGGEPANFLDIGGGATPERVAK
HHHHHHHCCCEEEECCCCEEEEEECCCEEEEEHHHEEECCCCCCCEEECCCCCCHHHHHH
AFRLVLSDKSVQAILVNIFAGINRCDWVAEGVVQALREVQVDVPVIVRLAGTNVEEGQKI
HHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
LAQSGLPIIRATTLMEAAERAVGAWQNDLSQGTRMRAVS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]