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The map label for this gene is tpa [H]

Identifier: 110678327

GI number: 110678327

Start: 946277

End: 947668

Strand: Reverse

Name: tpa [H]

Synonym: RD1_0981

Alternate gene names: 110678327

Gene position: 947668-946277 (Counterclockwise)

Preceding gene: 110678334

Following gene: 110678324

Centisome position: 22.93

GC content: 59.77

Gene sequence:

>1392_bases
ATGGACGGCAATTTCAATGAAAATGATATCTCCCGCGTCGTCGAAGCAGACCGCGCGCATATCTGGCACCATCTGAGCCA
GCACAAACCTTACGAGACAACAGACCCGCGCATCATTGTCGAAGGCAAGGGCATGAAGGTTTGGGACCAGAAGGGCAAAG
AGCATCTTGATGCCGTCTCCGGTGGGGTCTGGACCGTCAATGTCGGCTATGGCCGCGAACGCATCGCCAACGCCGTGCGG
GACCAGTTGGTCAAGTTGAACTATTTCGCCGGCTCCGCAGGCTCCATCCCCGGTGCCATGTTCGCCGAGCGTCTGATCGA
GAAGATGCCGGGGCTGAGCCGCGTTTATTACTGCAATTCCGGCTCCGAGGCGAATGAAAAAGCCTTCAAGATGGTCCGCC
AGATCGCGCACAAACGCTATGGCGGCAAAAAGCACAAGGTGCTTTATCGCGAGCGTGACTATCACGGCACCACCATTTCC
GCCCTTTCCGCAGGCGGGCAGGACGAACGGAACGCACAATATGGCCCCTTCACGCCCGGTTTCGTGCGCGTGCCCCATTG
CCTTGAATACCGCGCCTTTGAACAGGAAGGGGCGCCACAGGAAAACTACGGTGTCTGGGCGGCGGATCAGATCGAAAAGG
TAATCCTCGCCGAAGGGCCCGATACCGTGGGCGGCCTGTGCCTTGAACCGGTCACTGCAGGTGGCGGGGTGATCACGCCC
CCCGATGGCTACTGGGAGCGTGTGCAGGAAATCTGCCACAAATACGACATCCTGCTGCATATCGACGAGGTCGTATGCGG
CGTCGGTCGGACCGGCACATGGTTCGGCTATCAGCACTACGGCATCCAGCCGGATATGGTCACGATGGCCAAGGGTGTCG
CGTCCGGTTACGCGGCGATCGCCTGCCTTGTGACCAATGAAAAAGTCTTCGACATGTTCAAGGATGACGCCTCGGATCCG
CTGAACTACTTCCGCGACATCTCGACCTTTGGGGGCTGCACGGCGGGTCCGGCAGCTGCGCTGGAAAACCTGTCGATCAT
CGAAGAAGAAGGCCTGCTGGACAACACCACGGAACAGGGGGCCTATATGCTCGACTGTCTGGGCGGCTTGATGGACAAGC
ACAAGATCATCGGCCAGGTGCGCGGCAAGGGGCTGTTCCTCGGTGCCGAACTGGTCGAGGATCGCGACACGCGCAAACCG
GTTGACGAAAGGCTCGCGCAAGCGGTGGTCGCGGACTGCATGCAACAGGGTGTGATCATCGGCGTGACCAACCGCTCTCT
GCCGGGCAAGAACAACACGCTGTGTTTCTCGCCCGCCCTGATCGCCAGCAAGGATGACATTGACCACATCTGCGACGCGG
TGGACGGTGCGCTGTCGCGCGTTTTCGGCTAA

Upstream 100 bases:

>100_bases
GGACCTACTGACAGATGTTAAAATTCTGTCACCTTCTGCTAACCTGTGGCAGCGTGACCGAATCCCACGACACCGAAGCA
CCATACGAGAGGTCTTAATC

Downstream 100 bases:

>100_bases
ATCGCACTCTGCCGGACAATTTGCGCAACGTTACATGAAAAAGCCCCGGCACTGCCGGGGCTTTCCTTTTACCGATGACG
GGACAGTATTTCAGGCCAGC

Product: taurine--pyruvate aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDGNFNENDISRVVEADRAHIWHHLSQHKPYETTDPRIIVEGKGMKVWDQKGKEHLDAVSGGVWTVNVGYGRERIANAVR
DQLVKLNYFAGSAGSIPGAMFAERLIEKMPGLSRVYYCNSGSEANEKAFKMVRQIAHKRYGGKKHKVLYRERDYHGTTIS
ALSAGGQDERNAQYGPFTPGFVRVPHCLEYRAFEQEGAPQENYGVWAADQIEKVILAEGPDTVGGLCLEPVTAGGGVITP
PDGYWERVQEICHKYDILLHIDEVVCGVGRTGTWFGYQHYGIQPDMVTMAKGVASGYAAIACLVTNEKVFDMFKDDASDP
LNYFRDISTFGGCTAGPAAALENLSIIEEEGLLDNTTEQGAYMLDCLGGLMDKHKIIGQVRGKGLFLGAELVEDRDTRKP
VDERLAQAVVADCMQQGVIIGVTNRSLPGKNNTLCFSPALIASKDDIDHICDAVDGALSRVFG

Sequences:

>Translated_463_residues
MDGNFNENDISRVVEADRAHIWHHLSQHKPYETTDPRIIVEGKGMKVWDQKGKEHLDAVSGGVWTVNVGYGRERIANAVR
DQLVKLNYFAGSAGSIPGAMFAERLIEKMPGLSRVYYCNSGSEANEKAFKMVRQIAHKRYGGKKHKVLYRERDYHGTTIS
ALSAGGQDERNAQYGPFTPGFVRVPHCLEYRAFEQEGAPQENYGVWAADQIEKVILAEGPDTVGGLCLEPVTAGGGVITP
PDGYWERVQEICHKYDILLHIDEVVCGVGRTGTWFGYQHYGIQPDMVTMAKGVASGYAAIACLVTNEKVFDMFKDDASDP
LNYFRDISTFGGCTAGPAAALENLSIIEEEGLLDNTTEQGAYMLDCLGGLMDKHKIIGQVRGKGLFLGAELVEDRDTRKP
VDERLAQAVVADCMQQGVIIGVTNRSLPGKNNTLCFSPALIASKDDIDHICDAVDGALSRVFG
>Mature_463_residues
MDGNFNENDISRVVEADRAHIWHHLSQHKPYETTDPRIIVEGKGMKVWDQKGKEHLDAVSGGVWTVNVGYGRERIANAVR
DQLVKLNYFAGSAGSIPGAMFAERLIEKMPGLSRVYYCNSGSEANEKAFKMVRQIAHKRYGGKKHKVLYRERDYHGTTIS
ALSAGGQDERNAQYGPFTPGFVRVPHCLEYRAFEQEGAPQENYGVWAADQIEKVILAEGPDTVGGLCLEPVTAGGGVITP
PDGYWERVQEICHKYDILLHIDEVVCGVGRTGTWFGYQHYGIQPDMVTMAKGVASGYAAIACLVTNEKVFDMFKDDASDP
LNYFRDISTFGGCTAGPAAALENLSIIEEEGLLDNTTEQGAYMLDCLGGLMDKHKIIGQVRGKGLFLGAELVEDRDTRKP
VDERLAQAVVADCMQQGVIIGVTNRSLPGKNNTLCFSPALIASKDDIDHICDAVDGALSRVFG

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=435, Percent_Identity=29.6551724137931, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI37574042, Length=442, Percent_Identity=29.185520361991, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI13994255, Length=477, Percent_Identity=26.2054507337526, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI226442705, Length=442, Percent_Identity=29.4117647058824, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4557809, Length=443, Percent_Identity=24.6049661399549, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442709, Length=376, Percent_Identity=30.8510638297872, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI284507298, Length=342, Percent_Identity=23.9766081871345, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI188536080, Length=390, Percent_Identity=22.5641025641026, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679950, Length=390, Percent_Identity=22.5641025641026, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679946, Length=390, Percent_Identity=22.5641025641026, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788044, Length=435, Percent_Identity=27.3563218390805, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789759, Length=426, Percent_Identity=27.6995305164319, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI145693181, Length=415, Percent_Identity=27.710843373494, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1789016, Length=382, Percent_Identity=30.6282722513089, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=25.6544502617801, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786991, Length=308, Percent_Identity=25, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=28.8888888888889, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=25.6470588235294, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=459, Percent_Identity=27.4509803921569, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25144274, Length=311, Percent_Identity=25.4019292604502, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=154, Percent_Identity=29.8701298701299, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=357, Percent_Identity=28.2913165266106, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=447, Percent_Identity=25.9507829977629, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324386, Length=374, Percent_Identity=26.2032085561497, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161085790, Length=465, Percent_Identity=29.0322580645161, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28574759, Length=469, Percent_Identity=28.7846481876333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21357415, Length=370, Percent_Identity=27.2972972972973, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=28.4382284382284, Blast_Score=135, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 50785; Mature: 50785

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGNFNENDISRVVEADRAHIWHHLSQHKPYETTDPRIIVEGKGMKVWDQKGKEHLDAVS
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHCCHHHHHHHC
GGVWTVNVGYGRERIANAVRDQLVKLNYFAGSAGSIPGAMFAERLIEKMPGLSRVYYCNS
CCEEEEECCCCHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECC
GSEANEKAFKMVRQIAHKRYGGKKHKVLYRERDYHGTTISALSAGGQDERNAQYGPFTPG
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCC
FVRVPHCLEYRAFEQEGAPQENYGVWAADQIEKVILAEGPDTVGGLCLEPVTAGGGVITP
CEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHEECCCCCCCCEEECCCCCCCCEECC
PDGYWERVQEICHKYDILLHIDEVVCGVGRTGTWFGYQHYGIQPDMVTMAKGVASGYAAI
CCHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCEEE
ACLVTNEKVFDMFKDDASDPLNYFRDISTFGGCTAGPAAALENLSIIEEEGLLDNTTEQG
EEEEECHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCC
AYMLDCLGGLMDKHKIIGQVRGKGLFLGAELVEDRDTRKPVDERLAQAVVADCMQQGVII
HHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEE
GVTNRSLPGKNNTLCFSPALIASKDDIDHICDAVDGALSRVFG
EEECCCCCCCCCEEEECCCHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGNFNENDISRVVEADRAHIWHHLSQHKPYETTDPRIIVEGKGMKVWDQKGKEHLDAVS
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHCCHHHHHHHC
GGVWTVNVGYGRERIANAVRDQLVKLNYFAGSAGSIPGAMFAERLIEKMPGLSRVYYCNS
CCEEEEECCCCHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECC
GSEANEKAFKMVRQIAHKRYGGKKHKVLYRERDYHGTTISALSAGGQDERNAQYGPFTPG
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCC
FVRVPHCLEYRAFEQEGAPQENYGVWAADQIEKVILAEGPDTVGGLCLEPVTAGGGVITP
CEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHEECCCCCCCCEEECCCCCCCCEECC
PDGYWERVQEICHKYDILLHIDEVVCGVGRTGTWFGYQHYGIQPDMVTMAKGVASGYAAI
CCHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCEEE
ACLVTNEKVFDMFKDDASDPLNYFRDISTFGGCTAGPAAALENLSIIEEEGLLDNTTEQG
EEEEECHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCC
AYMLDCLGGLMDKHKIIGQVRGKGLFLGAELVEDRDTRKPVDERLAQAVVADCMQQGVII
HHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEE
GVTNRSLPGKNNTLCFSPALIASKDDIDHICDAVDGALSRVFG
EEECCCCCCCCCEEEECCCHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]