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The map label for this gene is xsc [H]

Identifier: 110678323

GI number: 110678323

Start: 941444

End: 943222

Strand: Reverse

Name: xsc [H]

Synonym: RD1_0977

Alternate gene names: 110678323

Gene position: 943222-941444 (Counterclockwise)

Preceding gene: 110678324

Following gene: 110678321

Centisome position: 22.82

GC content: 61.27

Gene sequence:

>1779_bases
ATGAAAATGACCACTGAAGAAGCCTTTGTAAAAACCCTGCAAGCGCATGGTATCGAACACGCCTTCGGGATTATCGGCTC
GGCCATGATGCCGATCTCCGACATTTTCCCCGATGCGGGCATCAAATTCTGGGACTGCGCGCATGAAGGTTCCGCAGGCA
TGATGTCTGACGGTTACACCCGCGCCACCGGCAAAGTGTCGATGATGATCGCGCAGAACGGCCCCGGCATCACCAATTTC
GTGACCGCCGTCAAAACCGCCTACTGGAACCACACGCCGCTTCTGCTCGTGACGCCGCAAGCCGCGAACAAGACCATCGG
TCAGGGCGGTTTTCAGGAAGTCGAACAGATGAAACTCTTCGAGGACATGGTCGCTTATCAGGAAGAGGTGCGCGACCCGA
CCCGTGTGGCCGAGGTCCTGACCCGCGTGATTGCCAAGGCAAAACGCCTCAGCGGCCCGGCGCAGATCAACATCCCGCGT
GATTTCTGGACGCAGGTGGTCGACATCGAAATCCCCGACCCGATTGAATTCGAAGCCTCCCCGGGCGGTGAAAACTCCGT
TGCGCAAGCCGCCGAGATGCTCTCCAACGCCAAGAATCCGGTGATCCTGAACGGGGCGGGCGTGGTCCTGTCAAAAGGCG
GCATCGACGCCTCCCGCCTTCTGGCAGAACGTCTGGATGCCCCCGTCTGCGTGGGCTATCAGCACAATGACGCCTTTCCC
GGCAACCATCCGCTCTTTGCCGGACCACTTGGATACAACGGTTCCAAAGCGGGCATGCAGCTGATCAAGGAAGCCGACGT
GGTTCTGTGCCTCGGCACGCGTCTCAACCCGTTTTCGACCCTGCCCGGCTATGGCATCGACTATTGGCCCGCAGATGCGA
AAATCATTCAGGTGGACATCAACCCCGACCGGATCGGCCTGACCAAGAAGGTCTCGGTCGGGATCGTCGGCGATGCAGCA
AAGGTGGCCAAGGGGATCCTGTCGCAGCTCTCGGACACCGCAGGCGACGAGGGCCGCGAGGCGCGCAAAGCCCATATCGC
CCAGACAAAATCCGCATGGGCGCAGGAGTTGACCTCGCTCACCCACGAGCAGGACGATCCGGGCACCGACTGGAACGTGC
GCGCACGCGCGGCCAAGCCTGACTGGATGAGCCCCCGCATGGCGTGGCGCGCAATCCAGAGCGCGCTGCCGGTGGAGGCG
ATCATTTCATCCGACATCGGCAACAACTGCGCCATCGGCAACGCCTACCCGGCCTTCGAAGAGGGGCGCAAGTATCTCGC
GCCGGGTCTCTTCGGTCCCTGCGGCTACGGCCTGCCCGCCATTGTCGGCGCCAAGATCGGTCAGCCCCATGTGCCGGTTG
TGGGTTTCGCAGGTGACGGGGCCTTTGGCATCGCCGTCAACGAATTGACCGCCATCGGCCGTGGTGAGTGGCCCGCGATC
ACGCAGATCGTGTTCCGCAACTACCAGTGGGGCGCTGAAAAGCGCAACTCGACCCTGTGGTTCGAAGACAACTTCGTCGG
CACCGAGCTTGACGAGGAAGTCTCCTACGCTGGCATCGCCAATGCGTGCGGCCTCAAAGGCGTCGTCGCCCGCACGCAGG
AGGAACTGACAGATGCCCTCAACGAGGCGATCAAGGACCAGATGGAAAACGGCATCACCACGCTGATCGAGGCCATGATC
AATCAGGAACTCGGCGATCCCTTCCGCCGCGACGCGATGAAAAAGCCTGTTCAGGTTGCTGGGATCAGCAAATCCGACAT
GCGTCCACAGACTGTCTGA

Upstream 100 bases:

>100_bases
TGGCTGATCAATCTGGCCCTAACACAATGTAAGCGCATACATTAGATAACAAGCAACCCTAGATTCGCGCATGGATTTCA
CCCCCGGAGGAACACCCGCC

Downstream 100 bases:

>100_bases
TATCGGGTGCATCAAAGCATCCGCATAAAAGGGAACAGGCCGTGAGTGTCTTGCGTGATTTGAAAAATCGCGCCGCCCCA
CGGCCTGCCCACATCGTGAC

Product: sulfoacetaldehyde acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MKMTTEEAFVKTLQAHGIEHAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYTRATGKVSMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPTRVAEVLTRVIAKAKRLSGPAQINIPR
DFWTQVVDIEIPDPIEFEASPGGENSVAQAAEMLSNAKNPVILNGAGVVLSKGGIDASRLLAERLDAPVCVGYQHNDAFP
GNHPLFAGPLGYNGSKAGMQLIKEADVVLCLGTRLNPFSTLPGYGIDYWPADAKIIQVDINPDRIGLTKKVSVGIVGDAA
KVAKGILSQLSDTAGDEGREARKAHIAQTKSAWAQELTSLTHEQDDPGTDWNVRARAAKPDWMSPRMAWRAIQSALPVEA
IISSDIGNNCAIGNAYPAFEEGRKYLAPGLFGPCGYGLPAIVGAKIGQPHVPVVGFAGDGAFGIAVNELTAIGRGEWPAI
TQIVFRNYQWGAEKRNSTLWFEDNFVGTELDEEVSYAGIANACGLKGVVARTQEELTDALNEAIKDQMENGITTLIEAMI
NQELGDPFRRDAMKKPVQVAGISKSDMRPQTV

Sequences:

>Translated_592_residues
MKMTTEEAFVKTLQAHGIEHAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYTRATGKVSMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPTRVAEVLTRVIAKAKRLSGPAQINIPR
DFWTQVVDIEIPDPIEFEASPGGENSVAQAAEMLSNAKNPVILNGAGVVLSKGGIDASRLLAERLDAPVCVGYQHNDAFP
GNHPLFAGPLGYNGSKAGMQLIKEADVVLCLGTRLNPFSTLPGYGIDYWPADAKIIQVDINPDRIGLTKKVSVGIVGDAA
KVAKGILSQLSDTAGDEGREARKAHIAQTKSAWAQELTSLTHEQDDPGTDWNVRARAAKPDWMSPRMAWRAIQSALPVEA
IISSDIGNNCAIGNAYPAFEEGRKYLAPGLFGPCGYGLPAIVGAKIGQPHVPVVGFAGDGAFGIAVNELTAIGRGEWPAI
TQIVFRNYQWGAEKRNSTLWFEDNFVGTELDEEVSYAGIANACGLKGVVARTQEELTDALNEAIKDQMENGITTLIEAMI
NQELGDPFRRDAMKKPVQVAGISKSDMRPQTV
>Mature_592_residues
MKMTTEEAFVKTLQAHGIEHAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYTRATGKVSMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPTRVAEVLTRVIAKAKRLSGPAQINIPR
DFWTQVVDIEIPDPIEFEASPGGENSVAQAAEMLSNAKNPVILNGAGVVLSKGGIDASRLLAERLDAPVCVGYQHNDAFP
GNHPLFAGPLGYNGSKAGMQLIKEADVVLCLGTRLNPFSTLPGYGIDYWPADAKIIQVDINPDRIGLTKKVSVGIVGDAA
KVAKGILSQLSDTAGDEGREARKAHIAQTKSAWAQELTSLTHEQDDPGTDWNVRARAAKPDWMSPRMAWRAIQSALPVEA
IISSDIGNNCAIGNAYPAFEEGRKYLAPGLFGPCGYGLPAIVGAKIGQPHVPVVGFAGDGAFGIAVNELTAIGRGEWPAI
TQIVFRNYQWGAEKRNSTLWFEDNFVGTELDEEVSYAGIANACGLKGVVARTQEELTDALNEAIKDQMENGITTLIEAMI
NQELGDPFRRDAMKKPVQVAGISKSDMRPQTV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=569, Percent_Identity=25.6590509666081, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI21361361, Length=600, Percent_Identity=24.5, Blast_Score=126, Evalue=6e-29,
Organism=Escherichia coli, GI87081685, Length=572, Percent_Identity=25.6993006993007, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1790104, Length=550, Percent_Identity=27.6363636363636, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1787096, Length=562, Percent_Identity=24.3772241992883, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786717, Length=586, Percent_Identity=25.7679180887372, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788716, Length=598, Percent_Identity=24.5819397993311, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17542570, Length=572, Percent_Identity=24.3006993006993, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=596, Percent_Identity=23.993288590604, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17531301, Length=596, Percent_Identity=23.993288590604, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323755, Length=567, Percent_Identity=24.1622574955908, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320816, Length=590, Percent_Identity=22.2033898305085, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI19922626, Length=555, Percent_Identity=24.5045045045045, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017820
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.3.3.15 [H]

Molecular weight: Translated: 63681; Mature: 63681

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMTTEEAFVKTLQAHGIEHAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCCCCCCE
RATGKVSMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLF
ECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
EDMVAYQEEVRDPTRVAEVLTRVIAKAKRLSGPAQINIPRDFWTQVVDIEIPDPIEFEAS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCEEEEEECCCCCCCCCC
PGGENSVAQAAEMLSNAKNPVILNGAGVVLSKGGIDASRLLAERLDAPVCVGYQHNDAFP
CCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCC
GNHPLFAGPLGYNGSKAGMQLIKEADVVLCLGTRLNPFSTLPGYGIDYWPADAKIIQVDI
CCCCEEECCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEC
NPDRIGLTKKVSVGIVGDAAKVAKGILSQLSDTAGDEGREARKAHIAQTKSAWAQELTSL
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
THEQDDPGTDWNVRARAAKPDWMSPRMAWRAIQSALPVEAIISSDIGNNCAIGNAYPAFE
HCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCHH
EGRKYLAPGLFGPCGYGLPAIVGAKIGQPHVPVVGFAGDGAFGIAVNELTAIGRGEWPAI
HCHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEEEHHHHHHCCCCCCHHH
TQIVFRNYQWGAEKRNSTLWFEDNFVGTELDEEVSYAGIANACGLKGVVARTQEELTDAL
HHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NEAIKDQMENGITTLIEAMINQELGDPFRRDAMKKPVQVAGISKSDMRPQTV
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKMTTEEAFVKTLQAHGIEHAFGIIGSAMMPISDIFPDAGIKFWDCAHEGSAGMMSDGYT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCCCCCCE
RATGKVSMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLF
ECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
EDMVAYQEEVRDPTRVAEVLTRVIAKAKRLSGPAQINIPRDFWTQVVDIEIPDPIEFEAS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCEEEEEECCCCCCCCCC
PGGENSVAQAAEMLSNAKNPVILNGAGVVLSKGGIDASRLLAERLDAPVCVGYQHNDAFP
CCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCC
GNHPLFAGPLGYNGSKAGMQLIKEADVVLCLGTRLNPFSTLPGYGIDYWPADAKIIQVDI
CCCCEEECCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEC
NPDRIGLTKKVSVGIVGDAAKVAKGILSQLSDTAGDEGREARKAHIAQTKSAWAQELTSL
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
THEQDDPGTDWNVRARAAKPDWMSPRMAWRAIQSALPVEAIISSDIGNNCAIGNAYPAFE
HCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCHH
EGRKYLAPGLFGPCGYGLPAIVGAKIGQPHVPVVGFAGDGAFGIAVNELTAIGRGEWPAI
HCHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEEEHHHHHHCCCCCCHHH
TQIVFRNYQWGAEKRNSTLWFEDNFVGTELDEEVSYAGIANACGLKGVVARTQEELTDAL
HHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NEAIKDQMENGITTLIEAMINQELGDPFRRDAMKKPVQVAGISKSDMRPQTV
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]