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The map label for this gene is ahcY

Identifier: 110677854

GI number: 110677854

Start: 452305

End: 453693

Strand: Direct

Name: ahcY

Synonym: RD1_0465

Alternate gene names: 110677854

Gene position: 452305-453693 (Clockwise)

Preceding gene: 110677851

Following gene: 110677855

Centisome position: 10.94

GC content: 56.73

Gene sequence:

>1389_bases
GTGACCAAAGACTTCATCGTAAAAGATATTGCCCTTGCCGAGTTTGGCCGCAAAGAGCTTGATATTGCCGAAACCGAAAT
GCCGGGGCTGATGGCCTTGCGCGCGGAATATGGCGACAGCAAGCCGCTGGCCGGTGCGCGCATTGTCGGCTCGCTGCACA
TGACGATCCAGACGGCAGTTCTGATCGAAACGCTTGTTGCCTTGGGTGCCGATGTCCGCTGGGCGTCCTGCAATATCTTT
TCGACGCAGGACCACGCGGCGGCGGCCATCGCGGCGGGCGGGACGCCTGTTTTCGCGATCAAGGGTCAGTCGCTGGAAGA
GCATTGGGATTACCTCGACCGGTCGTTCATGTTTGAGGATGGTCCCAACCTTATCCTTGACGATGGCGGTGATGCGACCC
TCTATGTTCTGCTTGGTGCCCGTGCCGAGGCGGGTGAAGAGATTATCCCCGTGCCCACATCCGAAGAGGAAGAGGCCATC
AAGGCGCAGATCAAGAAGCGCATGGCGGCGTCTCCCGGTTGGTTCACGAAAGTGCGTGATCAGATCAAAGGTGTCAGCGA
AGAGACGACAACTGGCGTTCACCGTCTCTATGACCTCGTCAAGCAGGGGCAATTGCCATTCCCTGCGATCAATGTGAATG
ATTCTGTCACCAAGTCGAAGTTTGACAACAAATACGGCTGCAAGGAATCGCTGGTGGATGGTATCCGCCGCGCCACGGAT
ACGATGATGGCGGGCAAGGTTGCCGTGGTAATGGGCTACGGCGATGTGGGCAAAGGCTCCGCTGCCAGTCTGCGCGGTGC
CGGTGCCCGCGTAAAAGTCACCGAAGTGGACCCGATTTGCGCGCTGCAAGCCGCCATGGACGGTTTCGAGGTTGTCCTGC
TCGAAGATGTGGTGGGATCGGCGGATATCTTTATCACGACGACGGGCAACAAGGACGTGATCCGCATCGAGCATATGCGT
GCGATGAAAGACATGGCGATCGTTGGCAACATTGGTCACTTTGACAATGAAATTCAGGTTGCTGCCCTCAAGAACCACAA
GTGGACCAATATCAAAGAACAGGTAGACATGATCGAGATGCCGAATGGCAATCGTCTCATTCTGCTTTCTGAGGGGCGCT
TGCTGAACCTCGGGAACGCGACCGGGCACCCGTCCTTCGTGATGTCCGCGTCCTTTACCAATCAGGTGCTGGCGCAGATC
GAACTGTGGACCCGTGCGGATGCGTATGACAACGAGGTCTACATTCTGCCCAAACATCTGGATGAAAAGGTCGCACGTTT
GCACCTTGACCGGATCGGTGTGAAACTGACCCCGCTTGACCCGGAGCAAGCGGCATATATCGGCGTGAAACCCGAAGGTC
CCTTCAAGCCGGAACACTACCGGTACTGA

Upstream 100 bases:

>100_bases
AAAGAGGATGTGGACAATTGCTGGCATTCGTTCTGTTGCAGCGCCCTGCAACGGGTGGTAGAGCAGCGGCAAAGATCATT
CAGAGCCTCGGAGTGCACGC

Downstream 100 bases:

>100_bases
TTAAAAACCGGTATGCGACCAGATCGGGCGACGCTGTTTGCGTTGCCCGGAACGGCGCGCGGATACTCCATGGATCGGGA
GATTCCGCCTATGGGGAAAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTKDFIVKDIALAEFGRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAVLIETLVALGADVRWASCNIF
STQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFEDGPNLILDDGGDATLYVLLGARAEAGEEIIPVPTSEEEEAI
KAQIKKRMAASPGWFTKVRDQIKGVSEETTTGVHRLYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD
TMMAGKVAVVMGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGSADIFITTTGNKDVIRIEHMR
AMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMPNGNRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQI
ELWTRADAYDNEVYILPKHLDEKVARLHLDRIGVKLTPLDPEQAAYIGVKPEGPFKPEHYRY

Sequences:

>Translated_462_residues
MTKDFIVKDIALAEFGRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAVLIETLVALGADVRWASCNIF
STQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFEDGPNLILDDGGDATLYVLLGARAEAGEEIIPVPTSEEEEAI
KAQIKKRMAASPGWFTKVRDQIKGVSEETTTGVHRLYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD
TMMAGKVAVVMGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGSADIFITTTGNKDVIRIEHMR
AMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMPNGNRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQI
ELWTRADAYDNEVYILPKHLDEKVARLHLDRIGVKLTPLDPEQAAYIGVKPEGPFKPEHYRY
>Mature_461_residues
TKDFIVKDIALAEFGRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAVLIETLVALGADVRWASCNIFS
TQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFEDGPNLILDDGGDATLYVLLGARAEAGEEIIPVPTSEEEEAIK
AQIKKRMAASPGWFTKVRDQIKGVSEETTTGVHRLYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT
MMAGKVAVVMGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGSADIFITTTGNKDVIRIEHMRA
MKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMPNGNRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIE
LWTRADAYDNEVYILPKHLDEKVARLHLDRIGVKLTPLDPEQAAYIGVKPEGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=461, Percent_Identity=57.9175704989154, Blast_Score=500, Evalue=1e-141,
Organism=Homo sapiens, GI239937451, Length=439, Percent_Identity=57.630979498861, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=50.5376344086022, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=50.9677419354839, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=50.9677419354839, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=50.5376344086022, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=48.9270386266094, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=57.2043010752688, Blast_Score=506, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=56.3674321503132, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=58.6580086580087, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=48.9270386266094, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.3239740820734, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.2164502164502, Blast_Score=420, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_ROSDO (Q9ZNA5)

Other databases:

- EMBL:   AB020211
- EMBL:   CP000362
- RefSeq:   YP_680861.1
- ProteinModelPortal:   Q9ZNA5
- SMR:   Q9ZNA5
- STRING:   Q9ZNA5
- GeneID:   4198145
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_0465
- NMPDR:   fig|375451.6.peg.438
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q9ZNA5
- ProtClustDB:   PRK05476
- BioCyc:   RDEN375451:RD1_0465-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 50485; Mature: 50354

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 55-55 BINDING 128-128 BINDING 188-188 BINDING 218-218 BINDING 222-222 BINDING 223-223 BINDING 275-275 BINDING 310-310 BINDING 376-376

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDFIVKDIALAEFGRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAV
CCCHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHH
LIETLVALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFED
HHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCEEECC
GPNLILDDGGDATLYVLLGARAEAGEEIIPVPTSEEEEAIKAQIKKRMAASPGWFTKVRD
CCCEEEECCCCEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
QIKGVSEETTTGVHRLYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD
HHCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
TMMAGKVAVVMGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGS
HHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEECCCCC
ADIFITTTGNKDVIRIEHMRAMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEM
CEEEEEECCCCCEEEEHHHHHHHHHHEEECCCCCCCCEEEEEECCCCCCCHHHHHHEEEC
PNGNRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTRADAYDNEVYILPKHL
CCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHHHHHHEECCCCCCCEEEEECCHH
DEKVARLHLDRIGVKLTPLDPEQAAYIGVKPEGPFKPEHYRY
HHHHHHHHHHHCCEEEECCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TKDFIVKDIALAEFGRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAV
CCHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHH
LIETLVALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFED
HHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCEEECC
GPNLILDDGGDATLYVLLGARAEAGEEIIPVPTSEEEEAIKAQIKKRMAASPGWFTKVRD
CCCEEEECCCCEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
QIKGVSEETTTGVHRLYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD
HHCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
TMMAGKVAVVMGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGS
HHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEECCCCC
ADIFITTTGNKDVIRIEHMRAMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEM
CEEEEEECCCCCEEEEHHHHHHHHHHEEECCCCCCCCEEEEEECCCCCCCHHHHHHEEEC
PNGNRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTRADAYDNEVYILPKHL
CCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHHHHHHEECCCCCCCEEEEECCHH
DEKVARLHLDRIGVKLTPLDPEQAAYIGVKPEGPFKPEHYRY
HHHHHHHHHHHCCEEEECCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA