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The map label for this gene is aroE

Identifier: 110677832

GI number: 110677832

Start: 428041

End: 428874

Strand: Direct

Name: aroE

Synonym: RD1_0438

Alternate gene names: 110677832

Gene position: 428041-428874 (Clockwise)

Preceding gene: 110677831

Following gene: 110677833

Centisome position: 10.36

GC content: 57.31

Gene sequence:

>834_bases
ATGAGCATGACAAAAATTCCGCTCGCGGGTGTCATGGGTGCGCCCATTGCGCACTCAAAGTCGCCGCAGCTTCACCGGCA
TTGGTTGGAAACCTATGGCATAAGCGGTTTCTACGTTCCGATGGAGGTGAAAGCGGCGGACGTTGAACATGTCTTGCGCA
CTTTGCCCAAAATGGGCTTTGTCGGATTGAATGTAACACTGCCGCATAAGGAAGCGGTGTTGAAACTCGCTGATCAAATC
ACAGACCGCGCCAGACTGATCGGTGCTGCGAACACGTTGACCTTTGGCAAGGACGGCGAAATCCATGCGGACAACACAGA
CGGCTACGGGTTTCTCGAAAATCTCAGATCAGGCGCAACTGATTGGACGCCCTCACAAGGCCCCGCGGTGGTGTTGGGTG
CCGGTGGTGCCGCGCGTGCAGTGATCGTCGCCCTGCTGGATGCCGGTGTGCCGGAAATCATCCTGACCAACAGGACCCGC
GCCCGATCAGATCAGTTGCAGTCGGATTTTGGCAATCGCGTGCGGGTGATGGACTGGACGCAGATCTCGGGCGTGCTTCA
CGAGGCGCAGCTTCTGGTCAACACAACGTCTTTGGGCATGGTCGGTAAACCGGAAATGGAAGCGTCGCTGGACGGGTTGC
AGGCGCATACCACAGTCACCGACCTTGTGTATAACCCATTGAAAACACGTCTGCTTGAGGTAGCAGAGGAAAAAGGTTGC
GTGACTGTCGACGGGCTGGGGATGCTGTTACATCAAGGCGTTCCGGGATTTGAGCGCTGGTTTGGTCGGCGACCGGATGT
CACAGATGCCACGCGCGCAGCGGTGCTCGGGTGA

Upstream 100 bases:

>100_bases
TGCGGTTGTTTTCACGTATCGACGGCGATTATTTCACGGTACTGGGGTTGCCGCTGCTTGAACTGCTGTCTTACCTTGCC
TTACGCGGAGACTTACCAAG

Downstream 100 bases:

>100_bases
CGTTCAAACTCGGTCTCACAGGCTCCATCGGCATGGGTAAATCCACCACGGCACAGCTTTTTGTGGAACTTGGCTGCGCG
CTTTGGGATGCGGATGCGGC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSMTKIPLAGVMGAPIAHSKSPQLHRHWLETYGISGFYVPMEVKAADVEHVLRTLPKMGFVGLNVTLPHKEAVLKLADQI
TDRARLIGAANTLTFGKDGEIHADNTDGYGFLENLRSGATDWTPSQGPAVVLGAGGAARAVIVALLDAGVPEIILTNRTR
ARSDQLQSDFGNRVRVMDWTQISGVLHEAQLLVNTTSLGMVGKPEMEASLDGLQAHTTVTDLVYNPLKTRLLEVAEEKGC
VTVDGLGMLLHQGVPGFERWFGRRPDVTDATRAAVLG

Sequences:

>Translated_277_residues
MSMTKIPLAGVMGAPIAHSKSPQLHRHWLETYGISGFYVPMEVKAADVEHVLRTLPKMGFVGLNVTLPHKEAVLKLADQI
TDRARLIGAANTLTFGKDGEIHADNTDGYGFLENLRSGATDWTPSQGPAVVLGAGGAARAVIVALLDAGVPEIILTNRTR
ARSDQLQSDFGNRVRVMDWTQISGVLHEAQLLVNTTSLGMVGKPEMEASLDGLQAHTTVTDLVYNPLKTRLLEVAEEKGC
VTVDGLGMLLHQGVPGFERWFGRRPDVTDATRAAVLG
>Mature_276_residues
SMTKIPLAGVMGAPIAHSKSPQLHRHWLETYGISGFYVPMEVKAADVEHVLRTLPKMGFVGLNVTLPHKEAVLKLADQIT
DRARLIGAANTLTFGKDGEIHADNTDGYGFLENLRSGATDWTPSQGPAVVLGAGGAARAVIVALLDAGVPEIILTNRTRA
RSDQLQSDFGNRVRVMDWTQISGVLHEAQLLVNTTSLGMVGKPEMEASLDGLQAHTTVTDLVYNPLKTRLLEVAEEKGCV
TVDGLGMLLHQGVPGFERWFGRRPDVTDATRAAVLG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=35.2490421455939, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787983, Length=274, Percent_Identity=33.5766423357664, Blast_Score=128, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320332, Length=265, Percent_Identity=27.9245283018868, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_ROSDO (Q16CZ0)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_680839.1
- ProteinModelPortal:   Q16CZ0
- SMR:   Q16CZ0
- STRING:   Q16CZ0
- GeneID:   4198333
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_0438
- NMPDR:   fig|375451.6.peg.414
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   GHYIPMD
- PhylomeDB:   Q16CZ0
- ProtClustDB:   PRK00258
- BioCyc:   RDEN375451:RD1_0438-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29809; Mature: 29677

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTKIPLAGVMGAPIAHSKSPQLHRHWLETYGISGFYVPMEVKAADVEHVLRTLPKMGF
CCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHCCCE
VGLNVTLPHKEAVLKLADQITDRARLIGAANTLTFGKDGEIHADNTDGYGFLENLRSGAT
EEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCHHHHHHHHCCCC
DWTPSQGPAVVLGAGGAARAVIVALLDAGVPEIILTNRTRARSDQLQSDFGNRVRVMDWT
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCEEEEEEHH
QISGVLHEAQLLVNTTSLGMVGKPEMEASLDGLQAHTTVTDLVYNPLKTRLLEVAEEKGC
HHHHHHHHHHHEEEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VTVDGLGMLLHQGVPGFERWFGRRPDVTDATRAAVLG
EEECHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SMTKIPLAGVMGAPIAHSKSPQLHRHWLETYGISGFYVPMEVKAADVEHVLRTLPKMGF
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHCCCE
VGLNVTLPHKEAVLKLADQITDRARLIGAANTLTFGKDGEIHADNTDGYGFLENLRSGAT
EEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCHHHHHHHHCCCC
DWTPSQGPAVVLGAGGAARAVIVALLDAGVPEIILTNRTRARSDQLQSDFGNRVRVMDWT
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCEEEEEEHH
QISGVLHEAQLLVNTTSLGMVGKPEMEASLDGLQAHTTVTDLVYNPLKTRLLEVAEEKGC
HHHHHHHHHHHEEEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VTVDGLGMLLHQGVPGFERWFGRRPDVTDATRAAVLG
EEECHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA