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The map label for this gene is hemH [H]

Identifier: 110677796

GI number: 110677796

Start: 390239

End: 391282

Strand: Direct

Name: hemH [H]

Synonym: RD1_0401

Alternate gene names: 110677796

Gene position: 390239-391282 (Clockwise)

Preceding gene: 110677795

Following gene: 110677798

Centisome position: 9.44

GC content: 56.32

Gene sequence:

>1044_bases
ATGGCGCGGCCCACACATGCAGAGAGCGACCACCCGGAAGTCGCAAAACCCAAGGTCGGCATTCTGTTGGCAAACCTTGG
GACGCCGGACAATTATGATTACTGGTCGATGCGCCGGTATCTGAACGAATTCCTGTCTGACCGCCGCGTGATCGACTACA
GCCCGTGGATCTGGCAGCCGCTCTTGCAGCTCATCATCCTGTCAAAACGCCCCTTTTCCAGCGGTGCGGCCTATAAATCC
ATCTGGAACGAAGAGGACGGCGAAAGCCCGTTGATGACCATCACCAAGGCGCAGACCAAAAAGGTCAAAGAGGTCATGGC
GCAGCGTCATGGGGACGAGGTCATGGTTGATTTCTGCATGCGCTACGGCAATCCGTCGACCCGGTCAAAAGTTGCGGCCA
TGACGGCCGCAGGATGTCGCAAGATATTGTTTTTCCCACTTTATCCCCATTATGCCGGGGCCACATCCGCCACGGCAAAT
GACGAATTTTTCCGCTCACTGACCTACGAGAAGTGGCAGCCGACCACCCGCACGGTGGACCCGTATTTCGATCGCCCCGA
CTATATCGAAGCGCTGGCGCAGTCGATTGAGCGGGCCTATGCGGGGATGGTCACCAAGCCGGATATTCTGGTGTGCTCGT
ACCATGGCGTGCCGATCCGCTATCTGATGGAGGGCGATCCCTATCATTGTCAGTGCCAGAAAACGACGCGCCTGCTGAAA
GAGCGTTTGGGTTGGGCTGATACGGAAATCACCACCACATTCCAGTCCAAGTTCGGCCCCGAGGAATGGTTGCAGCCCTA
TACCGTAGAGGAAGTGGCAAGACTGGCAGAGGCTGGGAAAAAGAACATCGCCGTCTGCGCGCCTGCATTTTCGGCGGATT
GCATCGAGACGCTGGAAGAGATCAACGAAGAGATCAAGGAAAGCTTTGAAGAGGCAGGCGGCGAGCAGTTCACCTATATT
CCATGCCTCAACGATGATGACGCGCATATCGCGGCGCTGTGCAACACGATCGACGACAACCTGAAGGGTTGGGTTGACAC
GTAA

Upstream 100 bases:

>100_bases
CCGTTGCGTGATTGACCCGAGCCAAAAACCATCTATCTGACGGTCATGGCCTGTAGACAAGGAAAAGAACATGCTGGATA
GCAGCTCCCACGCGAATGCA

Downstream 100 bases:

>100_bases
GCTGGATCACCCCGGAAAATAAAAAAAGGCGGCGCTGAAAAGCACCGCCTCTTTTTAATGCTTGTATTCCTATCAGGAAA
CAGCTGCTGCAACGATAACC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MARPTHAESDHPEVAKPKVGILLANLGTPDNYDYWSMRRYLNEFLSDRRVIDYSPWIWQPLLQLIILSKRPFSSGAAYKS
IWNEEDGESPLMTITKAQTKKVKEVMAQRHGDEVMVDFCMRYGNPSTRSKVAAMTAAGCRKILFFPLYPHYAGATSATAN
DEFFRSLTYEKWQPTTRTVDPYFDRPDYIEALAQSIERAYAGMVTKPDILVCSYHGVPIRYLMEGDPYHCQCQKTTRLLK
ERLGWADTEITTTFQSKFGPEEWLQPYTVEEVARLAEAGKKNIAVCAPAFSADCIETLEEINEEIKESFEEAGGEQFTYI
PCLNDDDAHIAALCNTIDDNLKGWVDT

Sequences:

>Translated_347_residues
MARPTHAESDHPEVAKPKVGILLANLGTPDNYDYWSMRRYLNEFLSDRRVIDYSPWIWQPLLQLIILSKRPFSSGAAYKS
IWNEEDGESPLMTITKAQTKKVKEVMAQRHGDEVMVDFCMRYGNPSTRSKVAAMTAAGCRKILFFPLYPHYAGATSATAN
DEFFRSLTYEKWQPTTRTVDPYFDRPDYIEALAQSIERAYAGMVTKPDILVCSYHGVPIRYLMEGDPYHCQCQKTTRLLK
ERLGWADTEITTTFQSKFGPEEWLQPYTVEEVARLAEAGKKNIAVCAPAFSADCIETLEEINEEIKESFEEAGGEQFTYI
PCLNDDDAHIAALCNTIDDNLKGWVDT
>Mature_346_residues
ARPTHAESDHPEVAKPKVGILLANLGTPDNYDYWSMRRYLNEFLSDRRVIDYSPWIWQPLLQLIILSKRPFSSGAAYKSI
WNEEDGESPLMTITKAQTKKVKEVMAQRHGDEVMVDFCMRYGNPSTRSKVAAMTAAGCRKILFFPLYPHYAGATSATAND
EFFRSLTYEKWQPTTRTVDPYFDRPDYIEALAQSIERAYAGMVTKPDILVCSYHGVPIRYLMEGDPYHCQCQKTTRLLKE
RLGWADTEITTTFQSKFGPEEWLQPYTVEEVARLAEAGKKNIAVCAPAFSADCIETLEEINEEIKESFEEAGGEQFTYIP
CLNDDDAHIAALCNTIDDNLKGWVDT

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=363, Percent_Identity=25.3443526170799, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI60499025, Length=369, Percent_Identity=24.9322493224932, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=42.8125, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=21.8934911242604, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17864156, Length=343, Percent_Identity=27.1137026239067, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24651774, Length=276, Percent_Identity=25.7246376811594, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=29.585798816568, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39509; Mature: 39378

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS01164 COPPER_AMINE_OXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPTHAESDHPEVAKPKVGILLANLGTPDNYDYWSMRRYLNEFLSDRRVIDYSPWIWQP
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHH
LLQLIILSKRPFSSGAAYKSIWNEEDGESPLMTITKAQTKKVKEVMAQRHGDEVMVDFCM
HHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHH
RYGNPSTRSKVAAMTAAGCRKILFFPLYPHYAGATSATANDEFFRSLTYEKWQPTTRTVD
HCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
PYFDRPDYIEALAQSIERAYAGMVTKPDILVCSYHGVPIRYLMEGDPYHCQCQKTTRLLK
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCEEEHHHHHHHHH
ERLGWADTEITTTFQSKFGPEEWLQPYTVEEVARLAEAGKKNIAVCAPAFSADCIETLEE
HHCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
INEEIKESFEEAGGEQFTYIPCLNDDDAHIAALCNTIDDNLKGWVDT
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ARPTHAESDHPEVAKPKVGILLANLGTPDNYDYWSMRRYLNEFLSDRRVIDYSPWIWQP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHH
LLQLIILSKRPFSSGAAYKSIWNEEDGESPLMTITKAQTKKVKEVMAQRHGDEVMVDFCM
HHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHH
RYGNPSTRSKVAAMTAAGCRKILFFPLYPHYAGATSATANDEFFRSLTYEKWQPTTRTVD
HCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
PYFDRPDYIEALAQSIERAYAGMVTKPDILVCSYHGVPIRYLMEGDPYHCQCQKTTRLLK
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCEEEHHHHHHHHH
ERLGWADTEITTTFQSKFGPEEWLQPYTVEEVARLAEAGKKNIAVCAPAFSADCIETLEE
HHCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
INEEIKESFEEAGGEQFTYIPCLNDDDAHIAALCNTIDDNLKGWVDT
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592455 [H]