Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 110677735

GI number: 110677735

Start: 321157

End: 322920

Strand: Direct

Name: ilvD [H]

Synonym: RD1_0332

Alternate gene names: 110677735

Gene position: 321157-322920 (Clockwise)

Preceding gene: 110677729

Following gene: 110677740

Centisome position: 7.77

GC content: 62.07

Gene sequence:

>1764_bases
ATGTCCAGCCAGCGCTTTGATAAATCCAAGCTGCCCAGCCGCCATGTGACCGAGGGACCCTCACGGGCGCCGCATCGGTC
CTACTATTACGCGATGGGCATGACGGAGGAAGAAATCCATCAACCGCTTGTTGGCGTGGCCACTTGCTGGAACGAGGCCG
CCCCCTGCAACATCGCGCTGAACCGCCAGGCGCAATCGGTCAAGATGGGCGTGAAACGCGAAAGCGGCACGCCACGTGAA
TTCACCACCATCACCGTCACCGACGGCATCGCGATGGGCCACGAGGGCATGCGGTCGTCACTGGCGTCACGCGAGGCAAT
TGCCGATACGGTGGAACTGACCATGCGCGGGCATTGCTATGACGCACTTGTGGGGCTGGCGGGCTGCGACAAATCCCTGC
CGGGCATGATGATGGCGATGATCCGTCTGAATGTGCCATCGGTTTTCCTTTATGGCGGGTCAATCCTGCCGGGACGTGCG
CCCAAGGGGGCGTCGGTGCCTGCCGAATACGCCGACCGCGACCTGACCGTTCAGGACATGTTCGAAGCTGTTGGGCATCA
ACAGAACGGCACCCTGAGCGAGGCAGAACTCGAAGTGCTCGAACGCGTCGCCTGCCCTTCTGCCGGGGCTTGTGGCGGGC
AGTTTACCGCCAACACCATGGCCTGTGTATCCGAGGCCATCGGTCTGGCGTTGCCCAATTCCGCCGGGGCACCTGCGCCG
TACGAATCCCGCGACGCCTATGCCGAAGCCTCGGGTGCGGCGGTCATGAACCTGATCGAAAAGAACATCCGTGCGCGCGA
CATCTGCACGCGGGAGGCCTTCGAGAATGCCGCGCGCATCGTCGCTTGTACGGGCGGGTCGACCAACGCCGGTCTGCACC
TGCCTGCCATGGCGCATGAAGCGGGCATCGATTTCTTCCTCGAAGACGTCTGCGAGATCTTCCGCGACACGCCCTATTTC
GTCGATCTGAAACCGGGCGGGCAGTATGTCGCCAAGGACATGTACGAAGCCGGCGGCGTGCCCGTGGTAATGAAAGAGCT
GCGCAAGGCAGGCCTGTTGCACGAGGACTGCATGACCGTCACCGGCTATTCCATCGGCGAGGAACTGGACAAGGTCAGCC
TTGAGGCGGATGGCCGAGTTGTCTATCCGATTGAAACACCGCTGTCGAAAACCGGTGGCGTCGTCGGCCTCAAGGGCAAC
CTTGCCCCCGAAGGAGCCATCGTGAAAATCGCCGGAATGGAGCCGCAGCATTTGCTGTTCACCGGCCCTGCGCGAATCTT
TGAGTGTGAGCAGGACGCGTTTGAAGCCGTCCAGAACCGCACCTACAAAGAGGGCGATGTCTTTGTCATCCGCAACGAGG
GCCCTGCTGGCGGCCCCGGCATGCGCGAGATGCTGGCAACGACGGCGGCGCTTTCGGGTCAGGGCATGGGCAAGAAAGTC
GCGCTGATCACGGATGGACGTTTCTCGGGGGCGACACGCGGGTTCTGCGTCGGCCATGTGGGTCCCGAGGCCGCGCACGG
AGGCCCCATCGCCTTGCTCAAGGATGGCGATATGATCACGCTTAACGCGATCGAGGGGACCATCACCGTCGATGTGTCCG
ACGAGGAGATGGCCGAGCGTAAAGCCAATTGGAAAGGGGCGCGTCCAACGATCTATGGTGCTGGTGCCTTGTGGAAATAC
GCGCAACTTGTGGGGCCAACCTATCTCGGGGCCGTGACCCATCCGGGCGGTAAAGACGAAGGCCACGCGTACATGGAACT
GTAA

Upstream 100 bases:

>100_bases
AATACAAGGACGCATCTGCGCGCTGCCGATACGCTTGAGCCTTGCGGCCCGCAGGGCGGTTGGCTATGCCTGACAGAGGT
TTTTGTTACGGAGAAACACC

Downstream 100 bases:

>100_bases
AGCACTTTGCCTGTGATCTCGATCACAGGTGGCTGCCTTTCGCTTCGGGCGCGCGTCTTGCGATACGAATGCCCAGGATA
CAACGAAAAAGCCTCACGCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MSSQRFDKSKLPSRHVTEGPSRAPHRSYYYAMGMTEEEIHQPLVGVATCWNEAAPCNIALNRQAQSVKMGVKRESGTPRE
FTTITVTDGIAMGHEGMRSSLASREAIADTVELTMRGHCYDALVGLAGCDKSLPGMMMAMIRLNVPSVFLYGGSILPGRA
PKGASVPAEYADRDLTVQDMFEAVGHQQNGTLSEAELEVLERVACPSAGACGGQFTANTMACVSEAIGLALPNSAGAPAP
YESRDAYAEASGAAVMNLIEKNIRARDICTREAFENAARIVACTGGSTNAGLHLPAMAHEAGIDFFLEDVCEIFRDTPYF
VDLKPGGQYVAKDMYEAGGVPVVMKELRKAGLLHEDCMTVTGYSIGEELDKVSLEADGRVVYPIETPLSKTGGVVGLKGN
LAPEGAIVKIAGMEPQHLLFTGPARIFECEQDAFEAVQNRTYKEGDVFVIRNEGPAGGPGMREMLATTAALSGQGMGKKV
ALITDGRFSGATRGFCVGHVGPEAAHGGPIALLKDGDMITLNAIEGTITVDVSDEEMAERKANWKGARPTIYGAGALWKY
AQLVGPTYLGAVTHPGGKDEGHAYMEL

Sequences:

>Translated_587_residues
MSSQRFDKSKLPSRHVTEGPSRAPHRSYYYAMGMTEEEIHQPLVGVATCWNEAAPCNIALNRQAQSVKMGVKRESGTPRE
FTTITVTDGIAMGHEGMRSSLASREAIADTVELTMRGHCYDALVGLAGCDKSLPGMMMAMIRLNVPSVFLYGGSILPGRA
PKGASVPAEYADRDLTVQDMFEAVGHQQNGTLSEAELEVLERVACPSAGACGGQFTANTMACVSEAIGLALPNSAGAPAP
YESRDAYAEASGAAVMNLIEKNIRARDICTREAFENAARIVACTGGSTNAGLHLPAMAHEAGIDFFLEDVCEIFRDTPYF
VDLKPGGQYVAKDMYEAGGVPVVMKELRKAGLLHEDCMTVTGYSIGEELDKVSLEADGRVVYPIETPLSKTGGVVGLKGN
LAPEGAIVKIAGMEPQHLLFTGPARIFECEQDAFEAVQNRTYKEGDVFVIRNEGPAGGPGMREMLATTAALSGQGMGKKV
ALITDGRFSGATRGFCVGHVGPEAAHGGPIALLKDGDMITLNAIEGTITVDVSDEEMAERKANWKGARPTIYGAGALWKY
AQLVGPTYLGAVTHPGGKDEGHAYMEL
>Mature_586_residues
SSQRFDKSKLPSRHVTEGPSRAPHRSYYYAMGMTEEEIHQPLVGVATCWNEAAPCNIALNRQAQSVKMGVKRESGTPREF
TTITVTDGIAMGHEGMRSSLASREAIADTVELTMRGHCYDALVGLAGCDKSLPGMMMAMIRLNVPSVFLYGGSILPGRAP
KGASVPAEYADRDLTVQDMFEAVGHQQNGTLSEAELEVLERVACPSAGACGGQFTANTMACVSEAIGLALPNSAGAPAPY
ESRDAYAEASGAAVMNLIEKNIRARDICTREAFENAARIVACTGGSTNAGLHLPAMAHEAGIDFFLEDVCEIFRDTPYFV
DLKPGGQYVAKDMYEAGGVPVVMKELRKAGLLHEDCMTVTGYSIGEELDKVSLEADGRVVYPIETPLSKTGGVVGLKGNL
APEGAIVKIAGMEPQHLLFTGPARIFECEQDAFEAVQNRTYKEGDVFVIRNEGPAGGPGMREMLATTAALSGQGMGKKVA
LITDGRFSGATRGFCVGHVGPEAAHGGPIALLKDGDMITLNAIEGTITVDVSDEEMAERKANWKGARPTIYGAGALWKYA
QLVGPTYLGAVTHPGGKDEGHAYMEL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=576, Percent_Identity=38.0208333333333, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI2367371, Length=500, Percent_Identity=34, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1786464, Length=506, Percent_Identity=36.1660079051383, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788157, Length=474, Percent_Identity=30.8016877637131, Blast_Score=188, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=565, Percent_Identity=43.8938053097345, Blast_Score=432, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62367; Mature: 62235

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQRFDKSKLPSRHVTEGPSRAPHRSYYYAMGMTEEEIHQPLVGVATCWNEAAPCNIAL
CCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHHHHHHCCCCCCCEEEE
NRQAQSVKMGVKRESGTPREFTTITVTDGIAMGHEGMRSSLASREAIADTVELTMRGHCY
CCCHHHHHHCCCCCCCCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHEECCCHH
DALVGLAGCDKSLPGMMMAMIRLNVPSVFLYGGSILPGRAPKGASVPAEYADRDLTVQDM
HHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCCHHHCCCCCCHHHH
FEAVGHQQNGTLSEAELEVLERVACPSAGACGGQFTANTMACVSEAIGLALPNSAGAPAP
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCEECCCCCCCCCC
YESRDAYAEASGAAVMNLIEKNIRARDICTREAFENAARIVACTGGSTNAGLHLPAMAHE
CCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEECCHHHHH
AGIDFFLEDVCEIFRDTPYFVDLKPGGQYVAKDMYEAGGVPVVMKELRKAGLLHEDCMTV
HCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHEE
TGYSIGEELDKVSLEADGRVVYPIETPLSKTGGVVGLKGNLAPEGAIVKIAGMEPQHLLF
CCCHHHHHHHHEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEE
TGPARIFECEQDAFEAVQNRTYKEGDVFVIRNEGPAGGPGMREMLATTAALSGQGMGKKV
ECCHHEEECCHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEE
ALITDGRFSGATRGFCVGHVGPEAAHGGPIALLKDGDMITLNAIEGTITVDVSDEEMAER
EEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECEEEEEEECHHHHHHH
KANWKGARPTIYGAGALWKYAQLVGPTYLGAVTHPGGKDEGHAYMEL
HCCCCCCCCEEEECHHHHHHHHHHCCHHCCEECCCCCCCCCCEEEEC
>Mature Secondary Structure 
SSQRFDKSKLPSRHVTEGPSRAPHRSYYYAMGMTEEEIHQPLVGVATCWNEAAPCNIAL
CCCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHHHHHHCCCCCCCEEEE
NRQAQSVKMGVKRESGTPREFTTITVTDGIAMGHEGMRSSLASREAIADTVELTMRGHCY
CCCHHHHHHCCCCCCCCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHEECCCHH
DALVGLAGCDKSLPGMMMAMIRLNVPSVFLYGGSILPGRAPKGASVPAEYADRDLTVQDM
HHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCCHHHCCCCCCHHHH
FEAVGHQQNGTLSEAELEVLERVACPSAGACGGQFTANTMACVSEAIGLALPNSAGAPAP
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCEECCCCCCCCCC
YESRDAYAEASGAAVMNLIEKNIRARDICTREAFENAARIVACTGGSTNAGLHLPAMAHE
CCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEECCHHHHH
AGIDFFLEDVCEIFRDTPYFVDLKPGGQYVAKDMYEAGGVPVVMKELRKAGLLHEDCMTV
HCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHEE
TGYSIGEELDKVSLEADGRVVYPIETPLSKTGGVVGLKGNLAPEGAIVKIAGMEPQHLLF
CCCHHHHHHHHEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEE
TGPARIFECEQDAFEAVQNRTYKEGDVFVIRNEGPAGGPGMREMLATTAALSGQGMGKKV
ECCHHEEECCHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEE
ALITDGRFSGATRGFCVGHVGPEAAHGGPIALLKDGDMITLNAIEGTITVDVSDEEMAER
EEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECEEEEEEECHHHHHHH
KANWKGARPTIYGAGALWKYAQLVGPTYLGAVTHPGGKDEGHAYMEL
HCCCCCCCCEEEECHHHHHHHHHHCCHHCCEECCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA