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The map label for this gene is dnaA

Identifier: 110677616

GI number: 110677616

Start: 204958

End: 206322

Strand: Direct

Name: dnaA

Synonym: RD1_0208

Alternate gene names: 110677616

Gene position: 204958-206322 (Clockwise)

Preceding gene: 110677615

Following gene: 110677617

Centisome position: 4.96

GC content: 57.07

Gene sequence:

>1365_bases
ATGACGAAAGAACAATGGGGTCAGTTACAGCAGAGACTGCTCAAAACGGTTGGTCAGAACAATTACAAAAACTGGATCGA
ACCGATTGAGTTCGGCAGCACACAGGATGGTGTGGCAACTTTTGAGGTGCCAACAAATTTTCTGGGCAATTATGTCAGCC
AGAATTTCGCGGATCTGATTTTGCATGAGGTCCGGCAGGAGGATCCGGCGGTGCGTCGGTTGCGCTTTGCGGTGCCGTCG
CATGTGAATGCCACCACGAAACCCGCGCGTCCGGCACAGGCGACCGCCCCGCGCGCGCCGGCTGAGAAAACACCGCGCAG
CACGCTGAGCACGGCGCCACTGGATGCGCGGTTCACCTTTGACAACTTCATTGTCGGCAAACCGAATGAACTGGCCCACG
CCGCCGCCAAGCGCGTTGCCGAAGGCGGCCCCGTCACCTTTAATCCGTTGTTCCTCTACGGCGGTGTGGGCTTGGGTAAA
ACGCACCTGATGCACGCCATTGCGCATGAATTGCGCCTGCGCCGGCCGGAAATGAATGTGCTCTACCTGTCGGCAGAACA
ATTCATGTACCGCTTCGTTCAGGCCCTGCGCGACCGCAAGATGATGGATTTCAAGGAAATCTTTCGATCCGTTGACGTGC
TGATGGTCGATGATGTGCAATTCATCGCGGGCAAAGGCAGCACGCAGGAAGAGTTCTTTCACACTTTCAACGCGCTTGTG
GATCAGAACAAGCAGATCATCATTTCGGGCGATCGCGCACCGGGTGAAATCAAGGACATGGAAGAGCGTGTCAAATCGCG
CCTGCAATGTGGGCTTGTGGTCGATCTGCACCCGACCGATTACGAATTGCGGCTTGGCATTTTGCAAAGCAAGGTGGAAC
AGCAACGCAAGAACTACCCCGGCCTTGATATTTCGGACGGGGTTCTGGAATTCCTTGCGCATCGGATTTCGACCAATGTG
CGGGTGCTTGAGGGCGCGCTGACACGCCTGTGTGCCTTTGCGTCCCTGGTGGGGCGCGAGATCGACATGGAACTGACGCA
GGATTGTCTGTCTGACGTGTTGCGCGCCTCCGAGCGCAAGATCACCGTCGAGGAAATTCAGCGCAAGGTCTCGGATCACT
ACAACATCCGCCTGTCGGACATGATCGGACCCAAGCGGTTGCGCTCATATGCGCGGCCCCGGCAGGTTGCCATGTATCTG
AGCAAAAAGATGACGTCGCGCTCCCTGCCTGAAATCGGCCGCCGCTTTGGCGGGCGCGATCACACGACGGTCATGCATGG
TGTAAAACGCATCGAAGAGCTCAAGATTCAGGACGGGCAGATCGCCGAAGACCTCGAATTGCTGCGCCGCGCGCTGGAAG
AGTGA

Upstream 100 bases:

>100_bases
GGAAGGGCTTGGCGGAGCCTTGGGCGATGAGTGGTGTGTGGGGACCGGTCTTTCGGTGAAAGGCTGTGGCATAGAAAAGC
TTAAGGAACGCAGGTCGAAG

Downstream 100 bases:

>100_bases
CAAAAAGAGGTCTGCGCGCCCTCATCTGGCCTGCAGACCTTGACGCCCTGCCGTTATCCTACGACAAATCCACAAAACGC
TTGTGAAGTCGGCCAAACAG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTKEQWGQLQQRLLKTVGQNNYKNWIEPIEFGSTQDGVATFEVPTNFLGNYVSQNFADLILHEVRQEDPAVRRLRFAVPS
HVNATTKPARPAQATAPRAPAEKTPRSTLSTAPLDARFTFDNFIVGKPNELAHAAAKRVAEGGPVTFNPLFLYGGVGLGK
THLMHAIAHELRLRRPEMNVLYLSAEQFMYRFVQALRDRKMMDFKEIFRSVDVLMVDDVQFIAGKGSTQEEFFHTFNALV
DQNKQIIISGDRAPGEIKDMEERVKSRLQCGLVVDLHPTDYELRLGILQSKVEQQRKNYPGLDISDGVLEFLAHRISTNV
RVLEGALTRLCAFASLVGREIDMELTQDCLSDVLRASERKITVEEIQRKVSDHYNIRLSDMIGPKRLRSYARPRQVAMYL
SKKMTSRSLPEIGRRFGGRDHTTVMHGVKRIEELKIQDGQIAEDLELLRRALEE

Sequences:

>Translated_454_residues
MTKEQWGQLQQRLLKTVGQNNYKNWIEPIEFGSTQDGVATFEVPTNFLGNYVSQNFADLILHEVRQEDPAVRRLRFAVPS
HVNATTKPARPAQATAPRAPAEKTPRSTLSTAPLDARFTFDNFIVGKPNELAHAAAKRVAEGGPVTFNPLFLYGGVGLGK
THLMHAIAHELRLRRPEMNVLYLSAEQFMYRFVQALRDRKMMDFKEIFRSVDVLMVDDVQFIAGKGSTQEEFFHTFNALV
DQNKQIIISGDRAPGEIKDMEERVKSRLQCGLVVDLHPTDYELRLGILQSKVEQQRKNYPGLDISDGVLEFLAHRISTNV
RVLEGALTRLCAFASLVGREIDMELTQDCLSDVLRASERKITVEEIQRKVSDHYNIRLSDMIGPKRLRSYARPRQVAMYL
SKKMTSRSLPEIGRRFGGRDHTTVMHGVKRIEELKIQDGQIAEDLELLRRALEE
>Mature_453_residues
TKEQWGQLQQRLLKTVGQNNYKNWIEPIEFGSTQDGVATFEVPTNFLGNYVSQNFADLILHEVRQEDPAVRRLRFAVPSH
VNATTKPARPAQATAPRAPAEKTPRSTLSTAPLDARFTFDNFIVGKPNELAHAAAKRVAEGGPVTFNPLFLYGGVGLGKT
HLMHAIAHELRLRRPEMNVLYLSAEQFMYRFVQALRDRKMMDFKEIFRSVDVLMVDDVQFIAGKGSTQEEFFHTFNALVD
QNKQIIISGDRAPGEIKDMEERVKSRLQCGLVVDLHPTDYELRLGILQSKVEQQRKNYPGLDISDGVLEFLAHRISTNVR
VLEGALTRLCAFASLVGREIDMELTQDCLSDVLRASERKITVEEIQRKVSDHYNIRLSDMIGPKRLRSYARPRQVAMYLS
KKMTSRSLPEIGRRFGGRDHTTVMHGVKRIEELKIQDGQIAEDLELLRRALEE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=478, Percent_Identity=39.7489539748954, Blast_Score=347, Evalue=7e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_ROSDO (Q16DK6)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_680623.1
- ProteinModelPortal:   Q16DK6
- SMR:   Q16DK6
- STRING:   Q16DK6
- GeneID:   4198158
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_0208
- NMPDR:   fig|375451.6.peg.195
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- PhylomeDB:   Q16DK6
- ProtClustDB:   PRK00149
- BioCyc:   RDEN375451:RD1_0208-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51672; Mature: 51541

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEQWGQLQQRLLKTVGQNNYKNWIEPIEFGSTQDGVATFEVPTNFLGNYVSQNFADLI
CCHHHHHHHHHHHHHHHCCCCHHHHHCHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
LHEVRQEDPAVRRLRFAVPSHVNATTKPARPAQATAPRAPAEKTPRSTLSTAPLDARFTF
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEE
DNFIVGKPNELAHAAAKRVAEGGPVTFNPLFLYGGVGLGKTHLMHAIAHELRLRRPEMNV
CCEECCCCHHHHHHHHHHHHCCCCEEECHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCE
LYLSAEQFMYRFVQALRDRKMMDFKEIFRSVDVLMVDDVQFIAGKGSTQEEFFHTFNALV
EEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHCCCCCCHHHHHHHHHHHH
DQNKQIIISGDRAPGEIKDMEERVKSRLQCGLVVDLHPTDYELRLGILQSKVEQQRKNYP
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
GLDISDGVLEFLAHRISTNVRVLEGALTRLCAFASLVGREIDMELTQDCLSDVLRASERK
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
ITVEEIQRKVSDHYNIRLSDMIGPKRLRSYARPRQVAMYLSKKMTSRSLPEIGRRFGGRD
CCHHHHHHHHHHCCCEEEHHCCCHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHCCCCC
HTTVMHGVKRIEELKIQDGQIAEDLELLRRALEE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKEQWGQLQQRLLKTVGQNNYKNWIEPIEFGSTQDGVATFEVPTNFLGNYVSQNFADLI
CHHHHHHHHHHHHHHHCCCCHHHHHCHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
LHEVRQEDPAVRRLRFAVPSHVNATTKPARPAQATAPRAPAEKTPRSTLSTAPLDARFTF
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEE
DNFIVGKPNELAHAAAKRVAEGGPVTFNPLFLYGGVGLGKTHLMHAIAHELRLRRPEMNV
CCEECCCCHHHHHHHHHHHHCCCCEEECHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCE
LYLSAEQFMYRFVQALRDRKMMDFKEIFRSVDVLMVDDVQFIAGKGSTQEEFFHTFNALV
EEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHCCCCCCHHHHHHHHHHHH
DQNKQIIISGDRAPGEIKDMEERVKSRLQCGLVVDLHPTDYELRLGILQSKVEQQRKNYP
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
GLDISDGVLEFLAHRISTNVRVLEGALTRLCAFASLVGREIDMELTQDCLSDVLRASERK
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
ITVEEIQRKVSDHYNIRLSDMIGPKRLRSYARPRQVAMYLSKKMTSRSLPEIGRRFGGRD
CCHHHHHHHHHHCCCEEEHHCCCHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHCCCCC
HTTVMHGVKRIEELKIQDGQIAEDLELLRRALEE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA