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The map label for this gene is mcl1 [H]

Identifier: 110635866

GI number: 110635866

Start: 3812299

End: 3813231

Strand: Reverse

Name: mcl1 [H]

Synonym: Meso_3538

Alternate gene names: 110635866

Gene position: 3813231-3812299 (Counterclockwise)

Preceding gene: 110635867

Following gene: 110635865

Centisome position: 86.42

GC content: 61.52

Gene sequence:

>933_bases
ATGACCTTGGACCGGATTTCGACACTGCGCAGCATCCTGTTCGTGCCGGGCGCACGACGGGACCTGTTTGCCAAGGCGGA
AGCTACCGGAGCGGACGCCCTCGTCCTGGACCTTGAAGATTCGGTCTCCACAGACATGAAGGGGGAGGCCCGGCAACACG
TCGCCGACGCGTTGGCGAGGTCCGCGCATCGGCTGACATTCGTTCGCATCAACCACCCGTCCTCAGGACTTGTCGATGAG
GATATTTCGGTGCTGGCGCCCCATCCGTCACAAGCGCTAATGGTGCCCAAGGTGGATGATGCCAAGGATCTGCTCGATGT
GGATCGCGCGTTGACCAAGTTTGAACAGCGCGCAGGGCTCGCAAGCGGTGCGATTGGGATCATGATCGTGGTCGAGACGT
GTCTCGGACTGCGCAACATGTTCGAAATTCTGCAGAATATGCCTCGGGTTCGCGGCGCTGGACTTGCCAGCGCGGAGGAG
GGCGACCTGATGATGGACATCGGCGGCTATTGGACGGCGGCGGGAGATGCGCTTGCCTATGCGCGCGGCAAGTTCGTATG
TGACGCCCGCGCGGCGAAAGCGGAATGGCTGGTCGATGGAGCCTTCATGAATCTGGGGAGCGACGATGCCCTGGAGGCAG
AGGTGAGCCGCGCCCGCATGTTAGGCTTCACCGGGAAGATTGCTATCCATCCGCGCCAGGTCCCCGTGATCAATCGCGCC
TTCATGCCAAGCACTGACGAAATCGAGAAGGCCCGCCGGTTGTTGGATGCATACCGCGAAGCAGAAGCGAGGGGGCAAGG
CGCCATCCGCTTCGAAGGCATGATGGTCGATCTTGCGAACGCAAAGCGAGCCGAGCGCATCCTGTCCTTCGCCGCCGCGG
CGGGTGTTCCGGCATCACAACAACACGATGGCTCCAAAGACGAGAAGCGTTGA

Upstream 100 bases:

>100_bases
GGCTACGGCCTTACTGCCGCTTTCTCGGGGCTCGAGCGCGCGATTTTGCGACGCTGGCCGCTTTCGGCTTCGGCCTCATG
AGGATTGGCTGGAGGACTAG

Downstream 100 bases:

>100_bases
AGGATAAGCCAATGCAGAAGCAGGTACGTCGCGTGGTAACGGGTCACAATGCGGCCGGGCGTGCCATCGTCATTTCCGAT
GGTCCTGCGCCATTCGTTCA

Product: HpcH/HpaI aldolase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTLDRISTLRSILFVPGARRDLFAKAEATGADALVLDLEDSVSTDMKGEARQHVADALARSAHRLTFVRINHPSSGLVDE
DISVLAPHPSQALMVPKVDDAKDLLDVDRALTKFEQRAGLASGAIGIMIVVETCLGLRNMFEILQNMPRVRGAGLASAEE
GDLMMDIGGYWTAAGDALAYARGKFVCDARAAKAEWLVDGAFMNLGSDDALEAEVSRARMLGFTGKIAIHPRQVPVINRA
FMPSTDEIEKARRLLDAYREAEARGQGAIRFEGMMVDLANAKRAERILSFAAAAGVPASQQHDGSKDEKR

Sequences:

>Translated_310_residues
MTLDRISTLRSILFVPGARRDLFAKAEATGADALVLDLEDSVSTDMKGEARQHVADALARSAHRLTFVRINHPSSGLVDE
DISVLAPHPSQALMVPKVDDAKDLLDVDRALTKFEQRAGLASGAIGIMIVVETCLGLRNMFEILQNMPRVRGAGLASAEE
GDLMMDIGGYWTAAGDALAYARGKFVCDARAAKAEWLVDGAFMNLGSDDALEAEVSRARMLGFTGKIAIHPRQVPVINRA
FMPSTDEIEKARRLLDAYREAEARGQGAIRFEGMMVDLANAKRAERILSFAAAAGVPASQQHDGSKDEKR
>Mature_309_residues
TLDRISTLRSILFVPGARRDLFAKAEATGADALVLDLEDSVSTDMKGEARQHVADALARSAHRLTFVRINHPSSGLVDED
ISVLAPHPSQALMVPKVDDAKDLLDVDRALTKFEQRAGLASGAIGIMIVVETCLGLRNMFEILQNMPRVRGAGLASAEEG
DLMMDIGGYWTAAGDALAYARGKFVCDARAAKAEWLVDGAFMNLGSDDALEAEVSRARMLGFTGKIAIHPRQVPVINRAF
MPSTDEIEKARRLLDAYREAEARGQGAIRFEGMMVDLANAKRAERILSFAAAAGVPASQQHDGSKDEKR

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=295, Percent_Identity=30.5084745762712, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI87081764, Length=294, Percent_Identity=30.2721088435374, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17557458, Length=281, Percent_Identity=32.0284697508897, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 33534; Mature: 33403

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDRISTLRSILFVPGARRDLFAKAEATGADALVLDLEDSVSTDMKGEARQHVADALAR
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
SAHRLTFVRINHPSSGLVDEDISVLAPHPSQALMVPKVDDAKDLLDVDRALTKFEQRAGL
HHHEEEEEEEECCCCCCCCCCCCEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCC
ASGAIGIMIVVETCLGLRNMFEILQNMPRVRGAGLASAEEGDLMMDIGGYWTAAGDALAY
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEECCCCHHHH
ARGKFVCDARAAKAEWLVDGAFMNLGSDDALEAEVSRARMLGFTGKIAIHPRQVPVINRA
HCCCEEECCCCCCHHHEEEHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCEECCC
FMPSTDEIEKARRLLDAYREAEARGQGAIRFEGMMVDLANAKRAERILSFAAAAGVPASQ
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCC
QHDGSKDEKR
CCCCCCCCCC
>Mature Secondary Structure 
TLDRISTLRSILFVPGARRDLFAKAEATGADALVLDLEDSVSTDMKGEARQHVADALAR
CHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
SAHRLTFVRINHPSSGLVDEDISVLAPHPSQALMVPKVDDAKDLLDVDRALTKFEQRAGL
HHHEEEEEEEECCCCCCCCCCCCEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCC
ASGAIGIMIVVETCLGLRNMFEILQNMPRVRGAGLASAEEGDLMMDIGGYWTAAGDALAY
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEECCCCHHHH
ARGKFVCDARAAKAEWLVDGAFMNLGSDDALEAEVSRARMLGFTGKIAIHPRQVPVINRA
HCCCEEECCCCCCHHHEEEHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCEECCC
FMPSTDEIEKARRLLDAYREAEARGQGAIRFEGMMVDLANAKRAERILSFAAAAGVPASQ
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCC
QHDGSKDEKR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA