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The map label for this gene is paaJ [C]

Identifier: 110635833

GI number: 110635833

Start: 3775660

End: 3776829

Strand: Reverse

Name: paaJ [C]

Synonym: Meso_3505

Alternate gene names: 110635833

Gene position: 3776829-3775660 (Counterclockwise)

Preceding gene: 110635834

Following gene: 110635832

Centisome position: 85.59

GC content: 62.05

Gene sequence:

>1170_bases
ATGGGCAAGGCACGGATCGTCGGCTGGGCGCATTCGCTCTTTGGAAAATCGGAACTGGAAGACACCGAGGCGCTGATGGC
CTCCGTCACGACGCCGGCGCTGGCGCATGCCGGTATCGAAGCGGGCGAAGTGGACGGGATTTTCGTCGGCGTCATGAATA
ACGGTTTTTCCAAGCAGGATTTCCAAGGCGCGCTGCTCGCCATGAACAATGAACATCTTGCGCATGTGCCAGCCGTCCGT
CTGGAAAACGCCTGCGCCACCGGCTCTGCCGCGATCTATACGGCAATGGACTTCATCGAATCCGGACGAGGGCGAATCGC
TCTCGTCGTCGGTGCGGAGAAGATGACCAGCACCCCAACCGCGGAGGTGGGCGATATTCTGCTCGGTGCGAGCTTCCGTA
AGGAAGAAGCGGACATAGACGGGGGTTTTGCAGGACTTTTCGCGCGCATTGCGCGGAGTTACTTTCAACGTTACGGCGAC
CGCTCGGAGGAGCTTGCCCTCATCGCCGCCAAGAACCACGCCAACGGCGTCTCTAATCCTTACGCCCATATGCGCCGGGA
TTTCGGCTTCGCTTTCTGCAACACGGTTTCTGAAAAAAACCCCTATGTGGCGGAGCCGCTACGCCGGACAGACTGCTCCC
TCATCTCCGATGGGGCGGCTGCGCTGATTCTGGCGGACGAGGACGCCGCCGCGCAGATGGAGCGGGCGATCGCGTTTCGC
GCCCGGAGTCATGCAAACGACATCCTCGCCTTGAGCCGCCGGGATGCGACCACTTTCGAAGGCGCGCGGCGCGCCTGGGC
GAGAGCGCTGGAAAATGCCGGCGTCTCCCTGCACGACCTGTCGCTCGTGGAAACCCACGACTGCTTTACGATCGCCGAAC
TGATCGAATACGAGGCTATGGGGCTTGCCAAACCTGGAGAGGGCTTTCGCGTTGTGCGGGAAGGGATCGCCGCCAAGGGC
GGAAGACTGCCCGTCAACCCCTCCGGCGGGCTCAAGGCCAAAGGCCATCCGATCGGCGCCACCGGCGTTTCCATGCATAT
CCTGGCCGCCATGCAGCTAATGGGCGAGGCCGGCGATATGCAGATCGCAGGCGCCAAGCTGGCCGGCGTTTTCAACATGG
GCGGGGCGGCCGTGGCCAATTATGTATCGGTGCTCGAGCGCGTAAAATGA

Upstream 100 bases:

>100_bases
TCTGGGCATCTTTTGGCTGATGATCGCACGACCGCCGGAAATCTGGTAGGCTTGGATAAGGCGAAACTGCGCCTATGTTT
CCTGAAAAGGAAGAAGGCAT

Downstream 100 bases:

>100_bases
GCCGGCTGCTGATCACATTCGGGATCGTCCTCGTCGCCGCAGGGCTTCTCTGGCCGCTGATCCAAAAGGCCGGTCTTGGA
AGGCTGCCGGGGGATCTCGC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MGKARIVGWAHSLFGKSELEDTEALMASVTTPALAHAGIEAGEVDGIFVGVMNNGFSKQDFQGALLAMNNEHLAHVPAVR
LENACATGSAAIYTAMDFIESGRGRIALVVGAEKMTSTPTAEVGDILLGASFRKEEADIDGGFAGLFARIARSYFQRYGD
RSEELALIAAKNHANGVSNPYAHMRRDFGFAFCNTVSEKNPYVAEPLRRTDCSLISDGAAALILADEDAAAQMERAIAFR
ARSHANDILALSRRDATTFEGARRAWARALENAGVSLHDLSLVETHDCFTIAELIEYEAMGLAKPGEGFRVVREGIAAKG
GRLPVNPSGGLKAKGHPIGATGVSMHILAAMQLMGEAGDMQIAGAKLAGVFNMGGAAVANYVSVLERVK

Sequences:

>Translated_389_residues
MGKARIVGWAHSLFGKSELEDTEALMASVTTPALAHAGIEAGEVDGIFVGVMNNGFSKQDFQGALLAMNNEHLAHVPAVR
LENACATGSAAIYTAMDFIESGRGRIALVVGAEKMTSTPTAEVGDILLGASFRKEEADIDGGFAGLFARIARSYFQRYGD
RSEELALIAAKNHANGVSNPYAHMRRDFGFAFCNTVSEKNPYVAEPLRRTDCSLISDGAAALILADEDAAAQMERAIAFR
ARSHANDILALSRRDATTFEGARRAWARALENAGVSLHDLSLVETHDCFTIAELIEYEAMGLAKPGEGFRVVREGIAAKG
GRLPVNPSGGLKAKGHPIGATGVSMHILAAMQLMGEAGDMQIAGAKLAGVFNMGGAAVANYVSVLERVK
>Mature_388_residues
GKARIVGWAHSLFGKSELEDTEALMASVTTPALAHAGIEAGEVDGIFVGVMNNGFSKQDFQGALLAMNNEHLAHVPAVRL
ENACATGSAAIYTAMDFIESGRGRIALVVGAEKMTSTPTAEVGDILLGASFRKEEADIDGGFAGLFARIARSYFQRYGDR
SEELALIAAKNHANGVSNPYAHMRRDFGFAFCNTVSEKNPYVAEPLRRTDCSLISDGAAALILADEDAAAQMERAIAFRA
RSHANDILALSRRDATTFEGARRAWARALENAGVSLHDLSLVETHDCFTIAELIEYEAMGLAKPGEGFRVVREGIAAKGG
RLPVNPSGGLKAKGHPIGATGVSMHILAAMQLMGEAGDMQIAGAKLAGVFNMGGAAVANYVSVLERVK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI302344767, Length=322, Percent_Identity=32.2981366459627, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI302344760, Length=322, Percent_Identity=32.2981366459627, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI19923233, Length=322, Percent_Identity=32.2981366459627, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI302344762, Length=316, Percent_Identity=30.6962025316456, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI55956775, Length=279, Percent_Identity=29.0322580645161, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17537653, Length=324, Percent_Identity=29.9382716049383, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24585051, Length=371, Percent_Identity=32.0754716981132, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19921506, Length=371, Percent_Identity=32.0754716981132, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41141; Mature: 41010

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKARIVGWAHSLFGKSELEDTEALMASVTTPALAHAGIEAGEVDGIFVGVMNNGFSKQD
CCCCEEEEHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEEECCCCCCCC
FQGALLAMNNEHLAHVPAVRLENACATGSAAIYTAMDFIESGRGRIALVVGAEKMTSTPT
CCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHCCCCC
AEVGDILLGASFRKEEADIDGGFAGLFARIARSYFQRYGDRSEELALIAAKNHANGVSNP
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
YAHMRRDFGFAFCNTVSEKNPYVAEPLRRTDCSLISDGAAALILADEDAAAQMERAIAFR
HHHHHHHCCHHHHHHHCCCCCCHHCCHHHCCCHHCCCCCEEEEEECCHHHHHHHHHHHHH
ARSHANDILALSRRDATTFEGARRAWARALENAGVSLHDLSLVETHDCFTIAELIEYEAM
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHH
GLAKPGEGFRVVREGIAAKGGRLPVNPSGGLKAKGHPIGATGVSMHILAAMQLMGEAGDM
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
QIAGAKLAGVFNMGGAAVANYVSVLERVK
EEECHHEEHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKARIVGWAHSLFGKSELEDTEALMASVTTPALAHAGIEAGEVDGIFVGVMNNGFSKQD
CCCEEEEHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEEECCCCCCCC
FQGALLAMNNEHLAHVPAVRLENACATGSAAIYTAMDFIESGRGRIALVVGAEKMTSTPT
CCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHCCCCC
AEVGDILLGASFRKEEADIDGGFAGLFARIARSYFQRYGDRSEELALIAAKNHANGVSNP
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
YAHMRRDFGFAFCNTVSEKNPYVAEPLRRTDCSLISDGAAALILADEDAAAQMERAIAFR
HHHHHHHCCHHHHHHHCCCCCCHHCCHHHCCCHHCCCCCEEEEEECCHHHHHHHHHHHHH
ARSHANDILALSRRDATTFEGARRAWARALENAGVSLHDLSLVETHDCFTIAELIEYEAM
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHH
GLAKPGEGFRVVREGIAAKGGRLPVNPSGGLKAKGHPIGATGVSMHILAAMQLMGEAGDM
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
QIAGAKLAGVFNMGGAAVANYVSVLERVK
EEECHHEEHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]