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The map label for this gene is proA

Identifier: 110635784

GI number: 110635784

Start: 3733434

End: 3734720

Strand: Reverse

Name: proA

Synonym: Meso_3456

Alternate gene names: 110635784

Gene position: 3734720-3733434 (Counterclockwise)

Preceding gene: 110635785

Following gene: 110635783

Centisome position: 84.64

GC content: 61.93

Gene sequence:

>1287_bases
ATGTTGCAGGTGCGTGAGCCGTCGGAGCACGATATCGTTACCCTCATGGCAGAGCTTGGCAGGCGCGGCCGTGCTGCTGC
CCGGCCGCTCGCCGTTGCGAGCACGGAACGGAAAAACGCAGCCCTCCTCGCCATGGCCGAGGCTCTTGAGGCAAACACGG
GCAGGATTCTCGCGGCCAATAAAACCGACATGGAGAAGGGAGAGGCCGCCGGTCTTTCCGCCGCCATTCTCGACCGGTTG
AAGCTCGACGAGAAGCGAGTCAGGGCAATTGCCGAGGGAATACGCGCCATCGCCGATCTTGATGATCCGGTCGGAACGGT
GATCGCCGAATGGGATCGGCCGAATGGTCTCCATATCGAGCGCGTGCGCACGCCGCTCGGCGTCATCGGCGTTATCTATG
AAAGCCGGCCCAATGTGACAGCAGATGCTGGCGCGCTCTGCCTGAAGGCAGGCAATGCGGTGATCCTCCGTGGCGGTTCC
GATTCGGCCGCTTCGTCCGCGGCGATCCATTCCTGTCTCGTTGAAGGATTGCGAAAGGCGGGCCTTCCCGAGGATGCGAT
CCAGCGCGTGCCGGTTACCGATCGTGAAGCGGTAGGCGAGATGCTGAGGGGCTTGGGCGGTAATCTTGACGTGATCGTCC
CGCGCGGCGGGCGCAGCCTCGTGGAGCGGGTCCAGAATGAAGCGCGCGTGCCGGTCTTTGCCCATCTCGAAGGCATCTGC
CATCTATACGTGGACCGCTCTGCCAAGCTCGACATGGCCGTGGCACTTGCCCTTAATGCAAAGATGCGGCGAACAGGCGT
ATGCGGAGCTGCCGAGACGCTGCTTGTCGACCGCGCGGTGGCTGGTACCCACCTGGTGCCGATTTTGGAGGCACTGGCAG
CAGCGGGCTGCGAGATCCGTGGCGGCGAAGATGTACGGGCGCGCTTCCCCTCGGCGATCTCCGCAAGTGAGGAAGATTGG
CGCACGGAATATCTGGATGCGATCATCTCCGTTAAACTGGTGGATGGCGTCTTCGAAGCGATCGAGCATATAGGGACCTA
TTCCTCGCATCATACGGAGGCGATCGTGGCGGAAGATCCCGTTGCTGTGCAGCGTTTTCTTAATGAGATCGACTCCGCCA
TCCTTCTCCACAATGCCTCCACTCAATTTGCCGACGGTGGCGAGTTCGGCATGGGCGCGGAGATCGGCATCGCGACGGGC
AAGATGCATGCGCGCGGACCCGTTGGTGTTGAGCAACTCACCTCCTTCAAATACCGCGTGCATGGCAGCGGCCAAACGAG
GCCCTGA

Upstream 100 bases:

>100_bases
ATCCTGGGTTACGAAGCGCGAGCGGCCATGGTGCACCGGGACGACCTGGTCCTTTCCGGGCCTACTGGCGAGCTCATGGA
TCGCAAGGTGGAAGGAATCG

Downstream 100 bases:

>100_bases
GGGAATGCTTTCAGGCGGGGAAGACGTAGCGGCGCATTATTTGCGCATGCCCTTTGCCGAAAAGGATATGACGGTGGGCC
TGTTCGGCGGCTCCTTCAAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLQVREPSEHDIVTLMAELGRRGRAAARPLAVASTERKNAALLAMAEALEANTGRILAANKTDMEKGEAAGLSAAILDRL
KLDEKRVRAIAEGIRAIADLDDPVGTVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGS
DSAASSAAIHSCLVEGLRKAGLPEDAIQRVPVTDREAVGEMLRGLGGNLDVIVPRGGRSLVERVQNEARVPVFAHLEGIC
HLYVDRSAKLDMAVALALNAKMRRTGVCGAAETLLVDRAVAGTHLVPILEALAAAGCEIRGGEDVRARFPSAISASEEDW
RTEYLDAIISVKLVDGVFEAIEHIGTYSSHHTEAIVAEDPVAVQRFLNEIDSAILLHNASTQFADGGEFGMGAEIGIATG
KMHARGPVGVEQLTSFKYRVHGSGQTRP

Sequences:

>Translated_428_residues
MLQVREPSEHDIVTLMAELGRRGRAAARPLAVASTERKNAALLAMAEALEANTGRILAANKTDMEKGEAAGLSAAILDRL
KLDEKRVRAIAEGIRAIADLDDPVGTVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGS
DSAASSAAIHSCLVEGLRKAGLPEDAIQRVPVTDREAVGEMLRGLGGNLDVIVPRGGRSLVERVQNEARVPVFAHLEGIC
HLYVDRSAKLDMAVALALNAKMRRTGVCGAAETLLVDRAVAGTHLVPILEALAAAGCEIRGGEDVRARFPSAISASEEDW
RTEYLDAIISVKLVDGVFEAIEHIGTYSSHHTEAIVAEDPVAVQRFLNEIDSAILLHNASTQFADGGEFGMGAEIGIATG
KMHARGPVGVEQLTSFKYRVHGSGQTRP
>Mature_428_residues
MLQVREPSEHDIVTLMAELGRRGRAAARPLAVASTERKNAALLAMAEALEANTGRILAANKTDMEKGEAAGLSAAILDRL
KLDEKRVRAIAEGIRAIADLDDPVGTVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGS
DSAASSAAIHSCLVEGLRKAGLPEDAIQRVPVTDREAVGEMLRGLGGNLDVIVPRGGRSLVERVQNEARVPVFAHLEGIC
HLYVDRSAKLDMAVALALNAKMRRTGVCGAAETLLVDRAVAGTHLVPILEALAAAGCEIRGGEDVRARFPSAISASEEDW
RTEYLDAIISVKLVDGVFEAIEHIGTYSSHHTEAIVAEDPVAVQRFLNEIDSAILLHNASTQFADGGEFGMGAEIGIATG
KMHARGPVGVEQLTSFKYRVHGSGQTRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=409, Percent_Identity=38.1418092909535, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI62912457, Length=409, Percent_Identity=38.1418092909535, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=40.6862745098039, Blast_Score=310, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=35.421686746988, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=35.421686746988, Blast_Score=248, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=33.7209302325581, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=34.6246973365617, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_MESSB (Q11CP8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675992.1
- ProteinModelPortal:   Q11CP8
- SMR:   Q11CP8
- STRING:   Q11CP8
- GeneID:   4181697
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3456
- NMPDR:   fig|266779.1.peg.1074
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- ProtClustDB:   PRK00197
- BioCyc:   MSP266779:MESO_3456-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45414; Mature: 45414

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQVREPSEHDIVTLMAELGRRGRAAARPLAVASTERKNAALLAMAEALEANTGRILAAN
CCCCCCCCCCHHHHHHHHHCCCCCHHHCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEC
KTDMEKGEAAGLSAAILDRLKLDEKRVRAIAEGIRAIADLDDPVGTVIAEWDRPNGLHIE
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCHH
RVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAASSAAIHSCLVEGLRKA
HHHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHC
GLPEDAIQRVPVTDREAVGEMLRGLGGNLDVIVPRGGRSLVERVQNEARVPVFAHLEGIC
CCCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHE
HLYVDRSAKLDMAVALALNAKMRRTGVCGAAETLLVDRAVAGTHLVPILEALAAAGCEIR
EEEECCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
GGEDVRARFPSAISASEEDWRTEYLDAIISVKLVDGVFEAIEHIGTYSSHHTEAIVAEDP
CCCHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCH
VAVQRFLNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRV
HHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEE
HGSGQTRP
ECCCCCCC
>Mature Secondary Structure
MLQVREPSEHDIVTLMAELGRRGRAAARPLAVASTERKNAALLAMAEALEANTGRILAAN
CCCCCCCCCCHHHHHHHHHCCCCCHHHCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEC
KTDMEKGEAAGLSAAILDRLKLDEKRVRAIAEGIRAIADLDDPVGTVIAEWDRPNGLHIE
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCHH
RVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAASSAAIHSCLVEGLRKA
HHHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHC
GLPEDAIQRVPVTDREAVGEMLRGLGGNLDVIVPRGGRSLVERVQNEARVPVFAHLEGIC
CCCHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHE
HLYVDRSAKLDMAVALALNAKMRRTGVCGAAETLLVDRAVAGTHLVPILEALAAAGCEIR
EEEECCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
GGEDVRARFPSAISASEEDWRTEYLDAIISVKLVDGVFEAIEHIGTYSSHHTEAIVAEDP
CCCHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCH
VAVQRFLNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRV
HHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEE
HGSGQTRP
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA