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The map label for this gene is rppH [H]

Identifier: 110635777

GI number: 110635777

Start: 3726998

End: 3727513

Strand: Reverse

Name: rppH [H]

Synonym: Meso_3449

Alternate gene names: 110635777

Gene position: 3727513-3726998 (Counterclockwise)

Preceding gene: 110635778

Following gene: 110635768

Centisome position: 84.48

GC content: 58.53

Gene sequence:

>516_bases
ATGACCGCGAAAATAAAGGCAGAGGATCTGCCTTACAGGCCATGCGTGGGCATTATGGTGCTGAACCGTTCCGGGCAGGT
ATGGGCCGGAAGGCGGATTCGCGAAACCGCCAGCGAGACGGATGGCACCACCATGCTGTGGCAGATGCCGCAGGGCGGTA
TCGATCAGAATGAAGATCCGCTTACCGCCGCCCGTCGTGAACTTTATGAGGAAACAGGAATCCGAAGCGTTTCCTTGCTT
GCCGAAGCACCCGAGTGGATCACTTACGACCTGCCTGAGCATTTGGTCGGCAGGGCTCTCAAAGGCCGTTTCCGCGGCCA
GAAGCAGAAATGGTTTGCCTTCCGCTTTGAGGGAGAGGAAAGCGAGATCGCCATCAATCCGCCCCCTGGCGATCACGAAC
CCGAATTCGACGCCTGGGCTTGGAAGCCGATGGAGCAACTGCCAAGGCTGATCGTTCCGTTCAAGCGACAGGTTTATGAG
GAGGTGGTCGCGGCTTTTCGGCACCTGGCCGGGTAG

Upstream 100 bases:

>100_bases
TCGACGCTGTTACGTCCTGGGCGGGTGAGGTCCGGAAACGAGGCGTCGAACTCGTGCCCATTTCCGCCGTGGCCGTTGAT
CCAGAAAGGGGCGAGGGGGG

Downstream 100 bases:

>100_bases
AGCGGCGTCACACCTCCCCTTTTTCGACCGCAGCGAAGCGGAACTGCCGTTACATCATTATCTCTCCCGCGGGGGAGAGA
TAATGATGCCGCTCTACTTC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTAKIKAEDLPYRPCVGIMVLNRSGQVWAGRRIRETASETDGTTMLWQMPQGGIDQNEDPLTAARRELYEETGIRSVSLL
AEAPEWITYDLPEHLVGRALKGRFRGQKQKWFAFRFEGEESEIAINPPPGDHEPEFDAWAWKPMEQLPRLIVPFKRQVYE
EVVAAFRHLAG

Sequences:

>Translated_171_residues
MTAKIKAEDLPYRPCVGIMVLNRSGQVWAGRRIRETASETDGTTMLWQMPQGGIDQNEDPLTAARRELYEETGIRSVSLL
AEAPEWITYDLPEHLVGRALKGRFRGQKQKWFAFRFEGEESEIAINPPPGDHEPEFDAWAWKPMEQLPRLIVPFKRQVYE
EVVAAFRHLAG
>Mature_170_residues
TAKIKAEDLPYRPCVGIMVLNRSGQVWAGRRIRETASETDGTTMLWQMPQGGIDQNEDPLTAARRELYEETGIRSVSLLA
EAPEWITYDLPEHLVGRALKGRFRGQKQKWFAFRFEGEESEIAINPPPGDHEPEFDAWAWKPMEQLPRLIVPFKRQVYEE
VVAAFRHLAG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=161, Percent_Identity=39.1304347826087, Blast_Score=103, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19623; Mature: 19491

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKIKAEDLPYRPCVGIMVLNRSGQVWAGRRIRETASETDGTTMLWQMPQGGIDQNEDP
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCHHHHHHCCCCCCEEEEECCCCCCCCCCCH
LTAARRELYEETGIRSVSLLAEAPEWITYDLPEHLVGRALKGRFRGQKQKWFAFRFEGEE
HHHHHHHHHHHHCCCEEHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCC
SEIAINPPPGDHEPEFDAWAWKPMEQLPRLIVPFKRQVYEEVVAAFRHLAG
CEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAKIKAEDLPYRPCVGIMVLNRSGQVWAGRRIRETASETDGTTMLWQMPQGGIDQNEDP
CCCCCCCCCCCCCCEEEEEECCCCCEEECCHHHHHHCCCCCCEEEEECCCCCCCCCCCH
LTAARRELYEETGIRSVSLLAEAPEWITYDLPEHLVGRALKGRFRGQKQKWFAFRFEGEE
HHHHHHHHHHHHCCCEEHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCC
SEIAINPPPGDHEPEFDAWAWKPMEQLPRLIVPFKRQVYEEVVAAFRHLAG
CEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]