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The map label for this gene is iclR [H]

Identifier: 110635635

GI number: 110635635

Start: 3574494

End: 3575303

Strand: Reverse

Name: iclR [H]

Synonym: Meso_3307

Alternate gene names: 110635635

Gene position: 3575303-3574494 (Counterclockwise)

Preceding gene: 110635640

Following gene: 110635634

Centisome position: 81.03

GC content: 61.11

Gene sequence:

>810_bases
GTGCAACTACCTGTCCGCCGCCGTGGCCGCCCAAAGAGCGGCAGAAACGAGCCGCCGGGCTCAAACATACAGGCGCTCGA
CCGGGCGCTTGATGTGGTGGAGGCGCTCGCCTCCCATGACGGGATGACCCTTACCGAACTTTCCGATCATCTCCGGCAGT
CGGCGGCAACCATGTATCGCGTTCTGTCGACACTGGAGCGACGCCAGTATGTGGAGATCAACCCCGAGCGTCAGGAATGG
TTCATCGGCCCTGAGGCATTCCGCCTGGGTTCGGCCTTCCTGCGGCGCACCAATATCGTCGAGAGCAGCCGGTCGATCAT
GCGGGACCTCATGGCGCGGACCGGCGAGACCTCCAATCTGGGGATCGAGCGTGACGGCGATGTTCTCTTTGTCAGCCAGG
TTGAAACGCATGAGACAATCCGCGCATTTTTTCCGCCCGGCACCCGATCGCCACTGCATGCTTCCGGTATCGGGAAGGCT
TTGCTGAGCGCTTTCGACGACGAAAGGCTGGAGGCATTCATTAATAGAGCGCGGTTCATCCGCTTCACCGACAAGACGGT
GGCCAATGCAGACCAACTGCGAGAAGCGGTGCGCCAAACGCGCGGGCAAGGCTATTCGCTGGATGACGAGGAGCGGACAA
TCGGCATGCGCTGTGTAGCCGCCGCCATTTTCAACAGCTACGGCGAGGCGGTTGCTGGAATATCGGTATCCGGCCCGACC
ATCAGGCTGCCTGACTCCAAGGTTCGCGAGATCGGGCAGTGGGTGGTTGAGGCCGCAAACGAAATTTCACGACGGCTCGG
TGCGAGATAG

Upstream 100 bases:

>100_bases
CTTTTTGGTATGCAAAGCAGCAGCCTATATTTTTTCATTGTGCGCAATCGAATTTCATGATGATTTTTTGTCTGAAGGCA
AACCAAACTGGAGTGCTCTC

Downstream 100 bases:

>100_bases
TTGATATTGCGTATCATCGCATTCGCGATAGAGCTCCTTCTGCAGCGTCTTGTATTACGCGCCGGTCGTGCTTATATGGC
GATGATCGATCTTGTTTGCT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MQLPVRRRGRPKSGRNEPPGSNIQALDRALDVVEALASHDGMTLTELSDHLRQSAATMYRVLSTLERRQYVEINPERQEW
FIGPEAFRLGSAFLRRTNIVESSRSIMRDLMARTGETSNLGIERDGDVLFVSQVETHETIRAFFPPGTRSPLHASGIGKA
LLSAFDDERLEAFINRARFIRFTDKTVANADQLREAVRQTRGQGYSLDDEERTIGMRCVAAAIFNSYGEAVAGISVSGPT
IRLPDSKVREIGQWVVEAANEISRRLGAR

Sequences:

>Translated_269_residues
MQLPVRRRGRPKSGRNEPPGSNIQALDRALDVVEALASHDGMTLTELSDHLRQSAATMYRVLSTLERRQYVEINPERQEW
FIGPEAFRLGSAFLRRTNIVESSRSIMRDLMARTGETSNLGIERDGDVLFVSQVETHETIRAFFPPGTRSPLHASGIGKA
LLSAFDDERLEAFINRARFIRFTDKTVANADQLREAVRQTRGQGYSLDDEERTIGMRCVAAAIFNSYGEAVAGISVSGPT
IRLPDSKVREIGQWVVEAANEISRRLGAR
>Mature_269_residues
MQLPVRRRGRPKSGRNEPPGSNIQALDRALDVVEALASHDGMTLTELSDHLRQSAATMYRVLSTLERRQYVEINPERQEW
FIGPEAFRLGSAFLRRTNIVESSRSIMRDLMARTGETSNLGIERDGDVLFVSQVETHETIRAFFPPGTRSPLHASGIGKA
LLSAFDDERLEAFINRARFIRFTDKTVANADQLREAVRQTRGQGYSLDDEERTIGMRCVAAAIFNSYGEAVAGISVSGPT
IRLPDSKVREIGQWVVEAANEISRRLGAR

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=264, Percent_Identity=35.6060606060606, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1786715, Length=267, Percent_Identity=34.0823970037453, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788131, Length=246, Percent_Identity=28.4552845528455, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786468, Length=246, Percent_Identity=29.6747967479675, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788581, Length=249, Percent_Identity=28.1124497991968, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1790752, Length=250, Percent_Identity=23.6, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789999, Length=257, Percent_Identity=24.5136186770428, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30072; Mature: 30072

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPVRRRGRPKSGRNEPPGSNIQALDRALDVVEALASHDGMTLTELSDHLRQSAATMYR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VLSTLERRQYVEINPERQEWFIGPEAFRLGSAFLRRTNIVESSRSIMRDLMARTGETSNL
HHHHHHHHCEEECCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GIERDGDVLFVSQVETHETIRAFFPPGTRSPLHASGIGKALLSAFDDERLEAFINRARFI
CCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHE
RFTDKTVANADQLREAVRQTRGQGYSLDDEERTIGMRCVAAAIFNSYGEAVAGISVSGPT
EECCHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IRLPDSKVREIGQWVVEAANEISRRLGAR
EECCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLPVRRRGRPKSGRNEPPGSNIQALDRALDVVEALASHDGMTLTELSDHLRQSAATMYR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VLSTLERRQYVEINPERQEWFIGPEAFRLGSAFLRRTNIVESSRSIMRDLMARTGETSNL
HHHHHHHHCEEECCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GIERDGDVLFVSQVETHETIRAFFPPGTRSPLHASGIGKALLSAFDDERLEAFINRARFI
CCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHE
RFTDKTVANADQLREAVRQTRGQGYSLDDEERTIGMRCVAAAIFNSYGEAVAGISVSGPT
EECCHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IRLPDSKVREIGQWVVEAANEISRRLGAR
EECCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]