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The map label for this gene is pdxY [H]

Identifier: 110635553

GI number: 110635553

Start: 3493565

End: 3494467

Strand: Reverse

Name: pdxY [H]

Synonym: Meso_3224

Alternate gene names: 110635553

Gene position: 3494467-3493565 (Counterclockwise)

Preceding gene: 110635554

Following gene: 110635552

Centisome position: 79.2

GC content: 63.12

Gene sequence:

>903_bases
ATGACGGGCGAAATTGGGAGAAATGCCGGCGGCGCGCGCGCCGTTATTGTCGTGTCGAGCCACGTGGCAAGGGGGTCCGT
CGGCAACCGGGCTTCCGTCTTTGCGCTGGAGGCTCTTGGGCATCCGGTCTGGGCCGTCCCGACCGTTATTCTGCCGTGGC
ATCCCGGCCATGGGCGGGCGACGCGCATTGTGCCGCCTGCTGCGGATTTTGCGGCTCTGATGCGCGATCTGGAAAATGCC
GCATGGCTCGGGGAGGTTGCGGCGGTGCTCACCGGTTATCTGGGAGAGGCATCACAGGCTGATGCCGTCGCTTCACTGGT
GCGCGCGGTAAAGAAGAGAAATCCAAAGGCCTTCTATGTCTGCGATCCCATCATGGGAGATAAGGGAGGGCTTTACGTAC
CGGAGGCGACGGCCGCTGCCATCCGGGATGTGCTGCTGCCGATTGCGGATGTAGCGACGCCGAATCTCTATGAGCTTGCC
TGGATCGCGGGCCGTGATCTCGATACCCTCGAGGATGCCATGGCGGCGGCGGCAAGGGCGGGTCCTTCGGAAATGCTGGT
CACATCCTCCCCCGCTTCCGCTCCGGATCGCATCGCTAACCTGCTGCTTACGCCTCAAAATGCATATCTGGCGGAGCACC
AAGCCATCGAGAATCCGACCAAAGGGCCGGGTGACCTCATGGCCGCGCTCTACACGGCTTGGCTCCTGAAAGGGCTGGCG
CCTGGCGAGGCTTTGCAACGAGCAACGGCATCGGTTCTCGAAGCATTGGCTCGGGCGGGCAGACGCGGCGCCGACGAATT
GATGCTGGAGACGGATGCTTCGAGCCTCTCGGAGCCGGCCGCCGCGGTGGAACTTCGCAAGCTGGCGCTGCCAGGGAATA
ATTTTCCGGAGCGAGGCCTTTAA

Upstream 100 bases:

>100_bases
GGACCGAGATCTGGGGCCGGCGCATTGCGCGCGTGCTCGCCCTCGTGGCTGTCATAATCTTGATCGGCTGGCTTATTCTT
CTCCTCTGGGGCAACGGGCC

Downstream 100 bases:

>100_bases
CCTGACGCTTGCCCAGCCGTTTAATCCCGGTTATTCGCAATGGCATGGTGCATCTTCCTGAACGGCTTTTGGCCGGATAT
CGTAACTTCATGGCCGGGCG

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTGEIGRNAGGARAVIVVSSHVARGSVGNRASVFALEALGHPVWAVPTVILPWHPGHGRATRIVPPAADFAALMRDLENA
AWLGEVAAVLTGYLGEASQADAVASLVRAVKKRNPKAFYVCDPIMGDKGGLYVPEATAAAIRDVLLPIADVATPNLYELA
WIAGRDLDTLEDAMAAAARAGPSEMLVTSSPASAPDRIANLLLTPQNAYLAEHQAIENPTKGPGDLMAALYTAWLLKGLA
PGEALQRATASVLEALARAGRRGADELMLETDASSLSEPAAAVELRKLALPGNNFPERGL

Sequences:

>Translated_300_residues
MTGEIGRNAGGARAVIVVSSHVARGSVGNRASVFALEALGHPVWAVPTVILPWHPGHGRATRIVPPAADFAALMRDLENA
AWLGEVAAVLTGYLGEASQADAVASLVRAVKKRNPKAFYVCDPIMGDKGGLYVPEATAAAIRDVLLPIADVATPNLYELA
WIAGRDLDTLEDAMAAAARAGPSEMLVTSSPASAPDRIANLLLTPQNAYLAEHQAIENPTKGPGDLMAALYTAWLLKGLA
PGEALQRATASVLEALARAGRRGADELMLETDASSLSEPAAAVELRKLALPGNNFPERGL
>Mature_299_residues
TGEIGRNAGGARAVIVVSSHVARGSVGNRASVFALEALGHPVWAVPTVILPWHPGHGRATRIVPPAADFAALMRDLENAA
WLGEVAAVLTGYLGEASQADAVASLVRAVKKRNPKAFYVCDPIMGDKGGLYVPEATAAAIRDVLLPIADVATPNLYELAW
IAGRDLDTLEDAMAAAARAGPSEMLVTSSPASAPDRIANLLLTPQNAYLAEHQAIENPTKGPGDLMAALYTAWLLKGLAP
GEALQRATASVLEALARAGRRGADELMLETDASSLSEPAAAVELRKLALPGNNFPERGL

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=242, Percent_Identity=31.8181818181818, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1788758, Length=260, Percent_Identity=33.4615384615385, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787924, Length=286, Percent_Identity=30.4195804195804, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17507759, Length=276, Percent_Identity=29.7101449275362, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17507757, Length=286, Percent_Identity=28.6713286713287, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320806, Length=189, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324354, Length=239, Percent_Identity=27.6150627615063, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553007, Length=232, Percent_Identity=29.7413793103448, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 31257; Mature: 31126

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGEIGRNAGGARAVIVVSSHVARGSVGNRASVFALEALGHPVWAVPTVILPWHPGHGRA
CCCCCCCCCCCCEEEEEEECHHHCCCCCCCHHHEEHHHHCCCHHCCCEEEEECCCCCCCE
TRIVPPAADFAALMRDLENAAWLGEVAAVLTGYLGEASQADAVASLVRAVKKRNPKAFYV
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEE
CDPIMGDKGGLYVPEATAAAIRDVLLPIADVATPNLYELAWIAGRDLDTLEDAMAAAARA
ECCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHHHC
GPSEMLVTSSPASAPDRIANLLLTPQNAYLAEHQAIENPTKGPGDLMAALYTAWLLKGLA
CCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
PGEALQRATASVLEALARAGRRGADELMLETDASSLSEPAAAVELRKLALPGNNFPERGL
CHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCHHHHHCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TGEIGRNAGGARAVIVVSSHVARGSVGNRASVFALEALGHPVWAVPTVILPWHPGHGRA
CCCCCCCCCCCEEEEEEECHHHCCCCCCCHHHEEHHHHCCCHHCCCEEEEECCCCCCCE
TRIVPPAADFAALMRDLENAAWLGEVAAVLTGYLGEASQADAVASLVRAVKKRNPKAFYV
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEE
CDPIMGDKGGLYVPEATAAAIRDVLLPIADVATPNLYELAWIAGRDLDTLEDAMAAAARA
ECCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHHHC
GPSEMLVTSSPASAPDRIANLLLTPQNAYLAEHQAIENPTKGPGDLMAALYTAWLLKGLA
CCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
PGEALQRATASVLEALARAGRRGADELMLETDASSLSEPAAAVELRKLALPGNNFPERGL
CHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCHHHHHCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]