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The map label for this gene is lysC [H]

Identifier: 110635330

GI number: 110635330

Start: 3270221

End: 3271495

Strand: Reverse

Name: lysC [H]

Synonym: Meso_3001

Alternate gene names: 110635330

Gene position: 3271495-3270221 (Counterclockwise)

Preceding gene: 110635332

Following gene: 110635329

Centisome position: 74.14

GC content: 62.9

Gene sequence:

>1275_bases
ATGGCGCGCATCGTGATGAAATTCGGCGGAACCTCCGTCGCCGATCTCGACCGCATCCACAATGTGGCGCGCCATGTCAA
ACGCGAGGTCGAAGCTGGGCACCAGGTGGCTGTGGTGGTCTCGGCCATGTCGGGCAAGACGAATGAGCTTGTCGGCTGGG
TGCAGGGCATGCCGAAGGCGGCCGGCGCCAAATCGCCCTTTTACGACGCGAGAGAATATGACACCGTGGTTGCCTCGGGC
GAGCAGGTGACGAGCGGCCTGCTCGCGATTGCGCTGCAGTCGATCGGGATCGACGCGCGCTCCTGGCAGGGGTGGCAGAT
CCCCATACGCACCGACAACGCCCATGGTGCGGCGCGCATCACGGATATTGACGGCAGCGATATCATAGAGCGCATGGAGC
GCGGGCAGGTGGCTGTGGTCGCCGGGTTCCAGGGGCTCGCCCCCGATAATCGCGTGGCGACGCTCGGGCGCGGCGGGTCT
GATACGAGCGCCGTTGCGGTCGCAGCCGCGCTTCGCGCCGACCGCTGCGACATCTATACGGACGTGGACGGGGTCTATAC
GACCGACCCGCGCATTGAGCCGAGGGCACGGCGGCTGGCGAAGATCTCCTTCGAGGAGATGCTGGAGATGGCCTCGCTCG
GGGCCAAGGTGCTGCAGGTGCGCTCGGTGGAGCTTGCCATGGTGCACAAGGTCAGGACTTTCGTAAGATCGTCATTCGAG
GACCCGGACGCGCCGGGAATGGGCGATTTCGACAATCCGCCCGGCACGCTCATTTGCGACGAGGAAGAAATCGTGGAACA
GCAAGTCGTCACCGGCATTGCCTATGCCAAGGATGAGGCACAGATCTCGCTGCGTCGGGTGGCCGACCGGCCGGGTGTCT
CAGCCGGCATTTTCGGTCCGCTCGCCGAGGCCAACATCAATGTCGACATGATCGTCCAGAACGTCTCGGAGGACGGCTCG
AAGACAGACATCACCTTTACCGTGCCCACGGGGGATGTGGAAAAGGCGCTCAGCGTGCTCGAGAAGGTGCGGGGGACAGT
CGGATTCGACGCCATCCAGTCGGAAGCTGGGCTGGTGAAGGTTTCGGTGATCGGCATCGGCATGCGCAGCCACGCGGGCG
TGGCAGCCACCGCCTTTAGTGCCTTGGCCGAGAAAGGCATCAATATTCGCGCGATCACCACGTCGGAGATAAAAATTTCC
ATACTGATCGACGGACCCTATGCGGAATTGGCCGTCCGGACTTTGCATTCCGTCTACGGTCTGGATAAGCATTAG

Upstream 100 bases:

>100_bases
GCCTTTGGATATTGAGAGCCCGCCGCAGAGCGGCAGCATGGTAACCTCAGATATTCCGCAGGCTAAAGCCTCGCAGTAGC
AAAAGGCCTTTTACACGACC

Downstream 100 bases:

>100_bases
GACAGTTTTCTTTAACCATGCTTTGCGCGCTGCCAGATGGGCCAGCGCCCGCGAAGCTTTGGAGGAAGTCCGATGCGCGA
CATTGGCGGCGGCCCGCGTG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MARIVMKFGGTSVADLDRIHNVARHVKREVEAGHQVAVVVSAMSGKTNELVGWVQGMPKAAGAKSPFYDAREYDTVVASG
EQVTSGLLAIALQSIGIDARSWQGWQIPIRTDNAHGAARITDIDGSDIIERMERGQVAVVAGFQGLAPDNRVATLGRGGS
DTSAVAVAAALRADRCDIYTDVDGVYTTDPRIEPRARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFE
DPDAPGMGDFDNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVADRPGVSAGIFGPLAEANINVDMIVQNVSEDGS
KTDITFTVPTGDVEKALSVLEKVRGTVGFDAIQSEAGLVKVSVIGIGMRSHAGVAATAFSALAEKGINIRAITTSEIKIS
ILIDGPYAELAVRTLHSVYGLDKH

Sequences:

>Translated_424_residues
MARIVMKFGGTSVADLDRIHNVARHVKREVEAGHQVAVVVSAMSGKTNELVGWVQGMPKAAGAKSPFYDAREYDTVVASG
EQVTSGLLAIALQSIGIDARSWQGWQIPIRTDNAHGAARITDIDGSDIIERMERGQVAVVAGFQGLAPDNRVATLGRGGS
DTSAVAVAAALRADRCDIYTDVDGVYTTDPRIEPRARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFE
DPDAPGMGDFDNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVADRPGVSAGIFGPLAEANINVDMIVQNVSEDGS
KTDITFTVPTGDVEKALSVLEKVRGTVGFDAIQSEAGLVKVSVIGIGMRSHAGVAATAFSALAEKGINIRAITTSEIKIS
ILIDGPYAELAVRTLHSVYGLDKH
>Mature_423_residues
ARIVMKFGGTSVADLDRIHNVARHVKREVEAGHQVAVVVSAMSGKTNELVGWVQGMPKAAGAKSPFYDAREYDTVVASGE
QVTSGLLAIALQSIGIDARSWQGWQIPIRTDNAHGAARITDIDGSDIIERMERGQVAVVAGFQGLAPDNRVATLGRGGSD
TSAVAVAAALRADRCDIYTDVDGVYTTDPRIEPRARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFED
PDAPGMGDFDNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVADRPGVSAGIFGPLAEANINVDMIVQNVSEDGSK
TDITFTVPTGDVEKALSVLEKVRGTVGFDAIQSEAGLVKVSVIGIGMRSHAGVAATAFSALAEKGINIRAITTSEIKISI
LIDGPYAELAVRTLHSVYGLDKH

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=30.6079664570231, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1790455, Length=469, Percent_Identity=29.637526652452, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320893, Length=297, Percent_Identity=28.6195286195286, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45180; Mature: 45049

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVMKFGGTSVADLDRIHNVARHVKREVEAGHQVAVVVSAMSGKTNELVGWVQGMPKA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCC
AGAKSPFYDAREYDTVVASGEQVTSGLLAIALQSIGIDARSWQGWQIPIRTDNAHGAARI
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEE
TDIDGSDIIERMERGQVAVVAGFQGLAPDNRVATLGRGGSDTSAVAVAAALRADRCDIYT
EECCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEE
DVDGVYTTDPRIEPRARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFE
CCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPDAPGMGDFDNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVADRPGVSAGIFGP
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
LAEANINVDMIVQNVSEDGSKTDITFTVPTGDVEKALSVLEKVRGTVGFDAIQSEAGLVK
HHHCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEE
VSVIGIGMRSHAGVAATAFSALAEKGINIRAITTSEIKISILIDGPYAELAVRTLHSVYG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHC
LDKH
CCCC
>Mature Secondary Structure 
ARIVMKFGGTSVADLDRIHNVARHVKREVEAGHQVAVVVSAMSGKTNELVGWVQGMPKA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCC
AGAKSPFYDAREYDTVVASGEQVTSGLLAIALQSIGIDARSWQGWQIPIRTDNAHGAARI
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEE
TDIDGSDIIERMERGQVAVVAGFQGLAPDNRVATLGRGGSDTSAVAVAAALRADRCDIYT
EECCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEE
DVDGVYTTDPRIEPRARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFE
CCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPDAPGMGDFDNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVADRPGVSAGIFGP
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
LAEANINVDMIVQNVSEDGSKTDITFTVPTGDVEKALSVLEKVRGTVGFDAIQSEAGLVK
HHHCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEE
VSVIGIGMRSHAGVAATAFSALAEKGINIRAITTSEIKISILIDGPYAELAVRTLHSVYG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHC
LDKH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]