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The map label for this gene is hutU

Identifier: 110635312

GI number: 110635312

Start: 3242263

End: 3243951

Strand: Reverse

Name: hutU

Synonym: Meso_2983

Alternate gene names: 110635312

Gene position: 3243951-3242263 (Counterclockwise)

Preceding gene: 110635313

Following gene: 110635311

Centisome position: 73.52

GC content: 62.34

Gene sequence:

>1689_bases
ATGAACATGAACCCGCGTCACAACATCCGCGAAATCCGCGCCCCGCGCGGGCCAGAACTCAGCGCGAAGAGCTGGATGAC
CGAAGCGCCACTCCGGATGCTGATGAACAATCTCGATCCGGACGTGGCGGAAAACCCGCATGAACTGGTGGTTTATGGCG
GCATTGGCCGCGCCGCGCGCACCTGGGAAGATTTCGATCGCATTACTGCGGCGCTGAAGACGCTTAGCGAAGAAGAAACC
TTGCTGGTGCAATCCGGCAAGCCTGTCGGCGTGTTCCGCACCCATAAGGATGCCCCGCGCGTGTTGATAGCCAATTCCAA
CCTCGTGCCGCACTGGGCGACCTGGGATCATTTCAACGAGCTGGATAAGAAGGGGCTGGCCATGTACGGCCAGATGACCG
CCGGTTCGTGGATTTATATCGGCACCCAGGGCATCGTGCAGGGCACATACGAAACCTTCGTTGAAGCCGGTCGCCAGCAC
TATGACGGCAATCTCAAGGGCAAGTGGATCCTGACTGGCGGTCTCGGCGGCATGGGCGGCGCGCAGCCGCTCGCCGCTGT
CATGGCGGGTGCCTGCTGCCTTGCCGTCGAGTGCGACGAGACCCGCATCGATTTCCGCCTACGCACCCGTTATGTCGATG
CAAAGGCGAGGACGCTGGACGAGGCGCTGGCCATGATCGACATGTGGACGAAGGCCGGCGAGGCAAAATCCGTCGGGCTG
CTCGGCAATGCCGCCGAAATCTTCCCGGAGCTTGTACGCCGCATGAAGGCGGGCGGCCCGCGCCCGGATATTGTTACCGA
CCAGACCTCCGCGCATGATCCGCGTAATGGTTATCTACCGGTCGGCTGGACGGTCGAGGAAGCCAGGGCGAAGCGTGAGA
GCGACCCGAAATCCGTCGAGATCGCTGCCCGCGCCTCGATGAGGGCACAGGTCGAAGCCATGGTTGCCTTTTGGGACGCC
GGCATCCCGACGCTCGACTACGGCAATAATATCCGCCAGGTCGCCAAGGATGAGGGCCTGGAAAATGCCTTCGCTTTCCC
CGGCTTTGTGCCGGCCTATATTCGCCCGCTTTTCTGCCGCGGCATTGGACCGTTCCGCTGGGCAGCGCTGTCCGGCGATC
CGGAAGATATCTACAAGACCGACGCCAAGGTGAAGGAACTGCTTCCCGACAACAAGCACCTGCACAACTGGCTGGACATG
GCAAAGGAACGCATTTCCTTCCAGGGCCTTCCGGCGCGCATCTGCTGGGTGGGCCTGGGCGACCGCCAGAAGCTTGGCCT
TGCCTTCAACGAGATGGTCCGTAACGGCGAGCTTTCAGCCCCGATCGTCATCGGCCGCGATCATCTCGATTCCGGCTCGG
TCGCCTCGCCGAACCGCGAGACGGAAGCAATGAAGGATGGTTCGGATGCCGTCTCGGATTGGCCATTGCTCAACGCACTG
CTCAACACCGCATCGGGCGCCACCTGGGTGTCGCTGCATCATGGCGGGGGCGTCGGCATGGGCTTTTCGCAGCATGCCGG
CATGGTGATCTGCGCCGACGGCTCTGAAGATGCCAACCGTCGTCTGGAACGGGTTCTGTGGAACGACCCGGCGACCGGCG
TCATGCGCCACGCGGATGCGGGTTACGAAATCGCGGTCGACTGCGCCAAGGAGAAAGGTCTGCGCCTTCCCGGCATTCTC
GGGAACTGA

Upstream 100 bases:

>100_bases
GCGAGAGGGCAGACAACCTGCGCATCCATCTCAAATCCATTTTGACGCGGATCGAACAGATCGCGCTCGGTCTGAAACGC
TAAACAAGGGGAACTTCACC

Downstream 100 bases:

>100_bases
TCCGATGCGCATTCTCCGTGCTGGCGATCATAAGCGCATGCCGTGGAAGAACGGTAAGGGGGAGACGGTGGAAATCGCCG
TCTTTCCGCCCGGCGCATCG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNMNPRHNIREIRAPRGPELSAKSWMTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARTWEDFDRITAALKTLSEEET
LLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWATWDHFNELDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQH
YDGNLKGKWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRIDFRLRTRYVDAKARTLDEALAMIDMWTKAGEAKSVGL
LGNAAEIFPELVRRMKAGGPRPDIVTDQTSAHDPRNGYLPVGWTVEEARAKRESDPKSVEIAARASMRAQVEAMVAFWDA
GIPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDM
AKERISFQGLPARICWVGLGDRQKLGLAFNEMVRNGELSAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNAL
LNTASGATWVSLHHGGGVGMGFSQHAGMVICADGSEDANRRLERVLWNDPATGVMRHADAGYEIAVDCAKEKGLRLPGIL
GN

Sequences:

>Translated_562_residues
MNMNPRHNIREIRAPRGPELSAKSWMTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARTWEDFDRITAALKTLSEEET
LLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWATWDHFNELDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQH
YDGNLKGKWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRIDFRLRTRYVDAKARTLDEALAMIDMWTKAGEAKSVGL
LGNAAEIFPELVRRMKAGGPRPDIVTDQTSAHDPRNGYLPVGWTVEEARAKRESDPKSVEIAARASMRAQVEAMVAFWDA
GIPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDM
AKERISFQGLPARICWVGLGDRQKLGLAFNEMVRNGELSAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNAL
LNTASGATWVSLHHGGGVGMGFSQHAGMVICADGSEDANRRLERVLWNDPATGVMRHADAGYEIAVDCAKEKGLRLPGIL
GN
>Mature_562_residues
MNMNPRHNIREIRAPRGPELSAKSWMTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARTWEDFDRITAALKTLSEEET
LLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWATWDHFNELDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQH
YDGNLKGKWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRIDFRLRTRYVDAKARTLDEALAMIDMWTKAGEAKSVGL
LGNAAEIFPELVRRMKAGGPRPDIVTDQTSAHDPRNGYLPVGWTVEEARAKRESDPKSVEIAARASMRAQVEAMVAFWDA
GIPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDM
AKERISFQGLPARICWVGLGDRQKLGLAFNEMVRNGELSAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNAL
LNTASGATWVSLHHGGGVGMGFSQHAGMVICADGSEDANRRLERVLWNDPATGVMRHADAGYEIAVDCAKEKGLRLPGIL
GN

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=569, Percent_Identity=33.9191564147627, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI260306182, Length=214, Percent_Identity=39.2523364485981, Blast_Score=159, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71997891, Length=557, Percent_Identity=35.7271095152603, Blast_Score=322, Evalue=3e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_MESSB (Q11E20)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675520.1
- ProteinModelPortal:   Q11E20
- SMR:   Q11E20
- STRING:   Q11E20
- GeneID:   4181419
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2983
- NMPDR:   fig|266779.1.peg.1511
- eggNOG:   COG2987
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   MSP266779:MESO_2983-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 61534; Mature: 61534

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 415-415

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMNPRHNIREIRAPRGPELSAKSWMTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAAR
CCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHH
TWEDFDRITAALKTLSEEETLLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWATWDHFNE
HHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHH
LDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYDGNLKGKWILTGGLGGMGG
HHHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
AQPLAAVMAGACCLAVECDETRIDFRLRTRYVDAKARTLDEALAMIDMWTKAGEAKSVGL
HHHHHHHHHCCEEEEEECCCCEEEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCEE
LGNAAEIFPELVRRMKAGGPRPDIVTDQTSAHDPRNGYLPVGWTVEEARAKRESDPKSVE
CCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCEEECCCCHHHHHHHCCCCCCCEE
IAARASMRAQVEAMVAFWDAGIPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCR
EEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
GIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMAKERISFQGLPARICWVGLG
CCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECC
DRQKLGLAFNEMVRNGELSAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNAL
CCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHH
LNTASGATWVSLHHGGGVGMGFSQHAGMVICADGSEDANRRLERVLWNDPATGVMRHADA
HHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCC
GYEIAVDCAKEKGLRLPGILGN
CCEEEEEEHHHCCCCCCCCCCC
>Mature Secondary Structure
MNMNPRHNIREIRAPRGPELSAKSWMTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAAR
CCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHH
TWEDFDRITAALKTLSEEETLLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWATWDHFNE
HHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHH
LDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYDGNLKGKWILTGGLGGMGG
HHHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
AQPLAAVMAGACCLAVECDETRIDFRLRTRYVDAKARTLDEALAMIDMWTKAGEAKSVGL
HHHHHHHHHCCEEEEEECCCCEEEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCEE
LGNAAEIFPELVRRMKAGGPRPDIVTDQTSAHDPRNGYLPVGWTVEEARAKRESDPKSVE
CCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCEEECCCCHHHHHHHCCCCCCCEE
IAARASMRAQVEAMVAFWDAGIPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCR
EEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
GIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMAKERISFQGLPARICWVGLG
CCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECC
DRQKLGLAFNEMVRNGELSAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNAL
CCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHH
LNTASGATWVSLHHGGGVGMGFSQHAGMVICADGSEDANRRLERVLWNDPATGVMRHADA
HHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCC
GYEIAVDCAKEKGLRLPGILGN
CCEEEEEEHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA