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The map label for this gene is rhtB [H]

Identifier: 110635195

GI number: 110635195

Start: 3113464

End: 3114105

Strand: Reverse

Name: rhtB [H]

Synonym: Meso_2862

Alternate gene names: 110635195

Gene position: 3114105-3113464 (Counterclockwise)

Preceding gene: 110635196

Following gene: 110635187

Centisome position: 70.58

GC content: 57.94

Gene sequence:

>642_bases
ATGAATTTCATTCCGGATACCGCAATAATCCTGCAATTTGCGATAGCGGTTATTGTGCTGGCGATCACGCCTGGTCCCGA
TATGACGCTTTTTGTCGGCCGTGCGCTCTCGCAGGGCAGGGCGGCGGGCTTCGCCTGCATGTTCGGTGCCATGACAGGGA
TCGTGATCCACACCATACTGGTTGCGCTTGGCTTATCCGCACTGCTCGTGGCTTCGCCCACGGCATTCTGGATCTTGAAG
ATCTTCGGCGCGGGTTACCTGGTCTGGCTTGCCTGGCAGGCGATCCGCCATGGCTCGGCCTTCAATCCGGACGCAAAGGC
AAGCAATAAGGCCTCGCTGTTCAAGAACTGGGCCACCGGGCTCGGCATCAACCTGCTCAATCCGAAGATAATCCTCTTCT
TCATGACCTTCCTGCCGCAATTCGTCACGCCCAGCGATCCGCACGCGCCCGGCAAACTGTTCTTCCTCGGCGTGCTTTTC
ATTCCGTTATCGCTACCGATTACCGCACCGATGGTGATTGCGGCGGACAAATTCGCCGGGCTGCTGCGCAAAAGTCCCAC
GATCACCCGCGTGGTGGATTACCTTTTCGCCGGTGTGTTCTCGGCTTTCGCGCTGAAAATCCTCACGGCGCAGACGAGGT
AA

Upstream 100 bases:

>100_bases
TGGATGGCGGGCAAGGCGCGCTTCGGCAGAATGGCGGCATGGGCCTAGGCCAGAGTGAAGAGTGGCGCTAAATTGCGCCG
CTCACCAGTAAGAGGCATTC

Downstream 100 bases:

>100_bases
ACCCTTCCCGGTGGATCAGCCGGCGAACGGCCGGATCCGCCAGCCCGGTCAGTGGACCTCCGTGAGGTCCTTCGCAATTG
CCTCAATCAGCCTGTCGAAA

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MNFIPDTAIILQFAIAVIVLAITPGPDMTLFVGRALSQGRAAGFACMFGAMTGIVIHTILVALGLSALLVASPTAFWILK
IFGAGYLVWLAWQAIRHGSAFNPDAKASNKASLFKNWATGLGINLLNPKIILFFMTFLPQFVTPSDPHAPGKLFFLGVLF
IPLSLPITAPMVIAADKFAGLLRKSPTITRVVDYLFAGVFSAFALKILTAQTR

Sequences:

>Translated_213_residues
MNFIPDTAIILQFAIAVIVLAITPGPDMTLFVGRALSQGRAAGFACMFGAMTGIVIHTILVALGLSALLVASPTAFWILK
IFGAGYLVWLAWQAIRHGSAFNPDAKASNKASLFKNWATGLGINLLNPKIILFFMTFLPQFVTPSDPHAPGKLFFLGVLF
IPLSLPITAPMVIAADKFAGLLRKSPTITRVVDYLFAGVFSAFALKILTAQTR
>Mature_213_residues
MNFIPDTAIILQFAIAVIVLAITPGPDMTLFVGRALSQGRAAGFACMFGAMTGIVIHTILVALGLSALLVASPTAFWILK
IFGAGYLVWLAWQAIRHGSAFNPDAKASNKASLFKNWATGLGINLLNPKIILFFMTFLPQFVTPSDPHAPGKLFFLGVLF
IPLSLPITAPMVIAADKFAGLLRKSPTITRVVDYLFAGVFSAFALKILTAQTR

Specific function: Conducts the efflux of homoserine and homoserine lactone [H]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=190, Percent_Identity=30.5263157894737, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788099, Length=205, Percent_Identity=25.3658536585366, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22853; Mature: 22853

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFIPDTAIILQFAIAVIVLAITPGPDMTLFVGRALSQGRAAGFACMFGAMTGIVIHTIL
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VALGLSALLVASPTAFWILKIFGAGYLVWLAWQAIRHGSAFNPDAKASNKASLFKNWATG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
LGINLLNPKIILFFMTFLPQFVTPSDPHAPGKLFFLGVLFIPLSLPITAPMVIAADKFAG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LLRKSPTITRVVDYLFAGVFSAFALKILTAQTR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFIPDTAIILQFAIAVIVLAITPGPDMTLFVGRALSQGRAAGFACMFGAMTGIVIHTIL
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VALGLSALLVASPTAFWILKIFGAGYLVWLAWQAIRHGSAFNPDAKASNKASLFKNWATG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
LGINLLNPKIILFFMTFLPQFVTPSDPHAPGKLFFLGVLFIPLSLPITAPMVIAADKFAG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LLRKSPTITRVVDYLFAGVFSAFALKILTAQTR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]