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The map label for this gene is yciC [H]

Identifier: 110635175

GI number: 110635175

Start: 3091039

End: 3092103

Strand: Reverse

Name: yciC [H]

Synonym: Meso_2842

Alternate gene names: 110635175

Gene position: 3092103-3091039 (Counterclockwise)

Preceding gene: 110635177

Following gene: 110635174

Centisome position: 70.08

GC content: 60.47

Gene sequence:

>1065_bases
ATGTCCGAACAAAATTCGCAAATCCCGGTCACGGTGCTGACCGGCTATCTCGGCTCCGGCAAGACCACGCTTCTCAACCG
CATCCTGGCGGAAGACCACGGCAAGCGCTATGCCGTGATCGTCAACGAGTTCGGGGAAATCGGCATCGACAACGATCTCA
TCGTCGAATCCGACGAGGAAATCTATGAAATGAACAATGGCTGCGTCTGCTGCACCGTGCGCGGGGATCTCGTGCGCGTC
GTCGAAGGGCTTACCCGGCGCCCCGGCCGGTTCGACGCCATTATCGTCGAGACCACTGGGCTCGCTGACCCGGCGCCGGT
GGCGCAGACCTTTTTCATGGACGACGATGTACGCGCCAAGACCAAGCTTGACGCGGTCGTGGCGCTGGTCGACGCCAAGC
ACCTGCCGCTAAGGCTCAAGGATTCCCGAGAGGCGGCGGACCAGATCGCGTTTGCCGACGTGGTGGTGCTCAACAAGACG
GACCTCGTTTCGCCCGAGGAGCTTGCCACGGTGGAAGCGGCTGTGCGGCAGATCAACCCCAGTGCGCGTATCCACAAAAC
GGAGCGCGCGGGCGTGGCGCTTTCGGACGTGCTCGATCGGGGCGCTTTCGACCTGCAGCGTGCGCTGGATAACGATCCGC
ATTTCCTCGATCATGACGATCCCGATCACGTTTGCGGACCGGATTGCGATCACGATCATCACCACCATCACCATGATCAC
GATCATGACCATCATCATCATGCCCATGGCGGGCTTTCGCCTATCCATGATGTCGGCGTAACCTCCATCTCGCTGCGCGC
GGGCGAAATGGATCCGAAGAAATTCTTTCCATGGATTCAGAAGACAACCCAGATGGACGGGCCGAACATTCTGAGGCTCA
AGGGCATTATCGCGCTCAAGGACGATCCGGATCGGTATGTGGTGCAGGGGGTGCACATGATTGTCGAGGGCGACCATCAG
CGCGCGTGGAAGGAAGGGGAGAAGCGCGAAAGCCGTCTCGTGTTCATCGGCCGCGACCTGGAGACCGAGCGCCTCAAGCG
CACATTCGAGGCTTGCCAGGCCTGA

Upstream 100 bases:

>100_bases
CTTGGTAAGGTTGTAAGGCTGGGCCAACTCCGCTCGTGCAAATCGGGCCGCGGCGTCTTATATGGACGGCAACGATCATC
ATTTGCCCGCGAGGGGATCC

Downstream 100 bases:

>100_bases
TATGCCGACAGTCGCGCCGCTTGATCTTGAAGGCCATTGCATCGCTATAGCCTGGCTCAACAATATTCCTCACTTCGCGC
TGGCCGATGGTGTCGTGCAC

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSEQNSQIPVTVLTGYLGSGKTTLLNRILAEDHGKRYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLVRV
VEGLTRRPGRFDAIIVETTGLADPAPVAQTFFMDDDVRAKTKLDAVVALVDAKHLPLRLKDSREAADQIAFADVVVLNKT
DLVSPEELATVEAAVRQINPSARIHKTERAGVALSDVLDRGAFDLQRALDNDPHFLDHDDPDHVCGPDCDHDHHHHHHDH
DHDHHHHAHGGLSPIHDVGVTSISLRAGEMDPKKFFPWIQKTTQMDGPNILRLKGIIALKDDPDRYVVQGVHMIVEGDHQ
RAWKEGEKRESRLVFIGRDLETERLKRTFEACQA

Sequences:

>Translated_354_residues
MSEQNSQIPVTVLTGYLGSGKTTLLNRILAEDHGKRYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLVRV
VEGLTRRPGRFDAIIVETTGLADPAPVAQTFFMDDDVRAKTKLDAVVALVDAKHLPLRLKDSREAADQIAFADVVVLNKT
DLVSPEELATVEAAVRQINPSARIHKTERAGVALSDVLDRGAFDLQRALDNDPHFLDHDDPDHVCGPDCDHDHHHHHHDH
DHDHHHHAHGGLSPIHDVGVTSISLRAGEMDPKKFFPWIQKTTQMDGPNILRLKGIIALKDDPDRYVVQGVHMIVEGDHQ
RAWKEGEKRESRLVFIGRDLETERLKRTFEACQA
>Mature_353_residues
SEQNSQIPVTVLTGYLGSGKTTLLNRILAEDHGKRYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLVRVV
EGLTRRPGRFDAIIVETTGLADPAPVAQTFFMDDDVRAKTKLDAVVALVDAKHLPLRLKDSREAADQIAFADVVVLNKTD
LVSPEELATVEAAVRQINPSARIHKTERAGVALSDVLDRGAFDLQRALDNDPHFLDHDDPDHVCGPDCDHDHHHHHHDHD
HDHHHHAHGGLSPIHDVGVTSISLRAGEMDPKKFFPWIQKTTQMDGPNILRLKGIIALKDDPDRYVVQGVHMIVEGDHQR
AWKEGEKRESRLVFIGRDLETERLKRTFEACQA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=373, Percent_Identity=35.3887399463807, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI126722884, Length=373, Percent_Identity=35.1206434316354, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI148727351, Length=373, Percent_Identity=35.1206434316354, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI146231952, Length=373, Percent_Identity=35.1206434316354, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI223941779, Length=367, Percent_Identity=33.2425068119891, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI223941776, Length=361, Percent_Identity=34.0720221606648, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI119120938, Length=134, Percent_Identity=47.0149253731343, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI87082430, Length=348, Percent_Identity=30.1724137931034, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788499, Length=182, Percent_Identity=35.1648351648352, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324356, Length=388, Percent_Identity=27.319587628866, Blast_Score=139, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39542; Mature: 39411

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQNSQIPVTVLTGYLGSGKTTLLNRILAEDHGKRYAVIVNEFGEIGIDNDLIVESDEE
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEECCHH
IYEMNNGCVCCTVRGDLVRVVEGLTRRPGRFDAIIVETTGLADPAPVAQTFFMDDDVRAK
HHHCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHEEECCCCCHHH
TKLDAVVALVDAKHLPLRLKDSREAADQIAFADVVVLNKTDLVSPEELATVEAAVRQINP
HHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHCCC
SARIHKTERAGVALSDVLDRGAFDLQRALDNDPHFLDHDDPDHVCGPDCDHDHHHHHHDH
CHHEEEHHHCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DHDHHHHAHGGLSPIHDVGVTSISLRAGEMDPKKFFPWIQKTTQMDGPNILRLKGIIALK
CCCCCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEC
DDPDRYVVQGVHMIVEGDHQRAWKEGEKRESRLVFIGRDLETERLKRTFEACQA
CCCCHHHHHEEEEEEECCHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQNSQIPVTVLTGYLGSGKTTLLNRILAEDHGKRYAVIVNEFGEIGIDNDLIVESDEE
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEECCHH
IYEMNNGCVCCTVRGDLVRVVEGLTRRPGRFDAIIVETTGLADPAPVAQTFFMDDDVRAK
HHHCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHEEECCCCCHHH
TKLDAVVALVDAKHLPLRLKDSREAADQIAFADVVVLNKTDLVSPEELATVEAAVRQINP
HHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHCCC
SARIHKTERAGVALSDVLDRGAFDLQRALDNDPHFLDHDDPDHVCGPDCDHDHHHHHHDH
CHHEEEHHHCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DHDHHHHAHGGLSPIHDVGVTSISLRAGEMDPKKFFPWIQKTTQMDGPNILRLKGIIALK
CCCCCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEC
DDPDRYVVQGVHMIVEGDHQRAWKEGEKRESRLVFIGRDLETERLKRTFEACQA
CCCCHHHHHEEEEEEECCHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]