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The map label for this gene is uao [H]

Identifier: 110635164

GI number: 110635164

Start: 3077300

End: 3078736

Strand: Reverse

Name: uao [H]

Synonym: Meso_2831

Alternate gene names: 110635164

Gene position: 3078736-3077300 (Counterclockwise)

Preceding gene: 110635169

Following gene: 110635163

Centisome position: 69.77

GC content: 62.28

Gene sequence:

>1437_bases
ATGAGGCGCTATTTCCGGAATATGCGAGGCTACGGAGCCAATCCGCCGAATCCCAAGTGGCCCGGCGGCGCCTATGCGGC
GGTGCAATTCGTCGTCAATTACGAAGAGGGCGGCGAAAACTGTATCCTGCATGGGGATGAGGCATCCGAGGCCTTCCTCT
CGGAGATTGTCGGAGCGCAGCCCTGGCCAGGCATGCGGCACTGGAACATGGAGTCGATTTACGAGTACGGCGCTCGCGTC
GGCTTCTGGCGGCTACACCGCATGTTCACCGAGGCCGAAGTGCCCGTAACCGTCTATGGTGTTGCGACTGCGCTCGCCCG
CTCGCCGGAACAGGTGGCGGCCATGAAGGAGGCATGCTGGGAAATTGCGAGCCACGGGCTTCGCTGGATCGACTATCGCG
CCCATTCGGAAGAGGAGGAACGCAGGGATCTGGATGAAGCCGTGCGGCTGCACACTGAAGTCGTGGGCGAACCGCCGAAA
GGGCTTTATCTTGGGCGTACGTCGGTGAACTCCGTCAAGCTCGCCATCGAGCAGGGCGGGTTCGACTGGATCTCCGATAC
CTATGACGATGACCTGCCTTACTGGCTCGACCACGACGGGCATGGGAAGCCTGCGCGGCCGCAGCTCGTCATCCCATATA
CGCTCGACGCCAATGATATGCGATTTGCCACGCCGCAAGGGTTCAATTCCGGCGACCAGTTCTTTGCCTACCTGAAGGAT
GCGTTTGATACGCTCTATGAAGAGGGAAGGCGCGGCCGGCCGGCCATGATGAGCGTGGGCCTCCATTGCCGGCTGATCGG
CCGGCCGGGGCGGGCGGCCGCGCTCAGGCGCTTCATCGATTATGTAAAAGGCCATGAGAAGGTGTGGCTGCCGCGGCGGA
TGGATATCGCCCGTCATTGGATGGAGCATCACCCCTATCAAGCGCCGACGCTGAGGCCGAGCCGCATGGGGAAAGCGGAG
TTCGTGGAGCGCTTCGGCTCGATTTTCGAGCATTCGCCCTGGATCGCCGAACGGGCCCATGACTTGGAGCTCGGGCCGGC
GCATGACAGCGCCGTGGGCCTTCACAACGCGCTGGCGCGAATGTTCCATTCGGCAGGCGAGGAGGAGCGGCTGGGCGTGC
TGAAGGCGCATCCAGACCTTGCGGGCAAGCTCGCGGCAGCAAAGCGGCTCACGCCGGAATCGGCGAAGGAACAGGCTTCG
GCTGGCCTCGACGCGCTGACGGACGAGGAGCGCGCGCGCTTCACTGACCTCAACACGCGCTACATGGAAAAATTCGGCTT
TCCCTTCATCATTGCCGTCAAGGACAACACGAAGCAAAGCATCCTGCGAGCCTTCGAGACACGTATCGAAAAGGGCCCGG
AAGAGGAGTTCGCTACGGCCTGCGGCCAGGTGGAGCGGATCGCTTATCTGAGGCTCAAGGACATCCTGCCGTCATGA

Upstream 100 bases:

>100_bases
GGTAGAAAGGCTGCAAAAAGACTTTCAAATTTTTTGCAGGGAATAAGCCCGGAAACCTTCGGCTATCGTTGAAAACGAGA
TGAGCGCGGAGAATGCAGAC

Downstream 100 bases:

>100_bases
CCAGAAACTATTACGCGCCCACGGGCGGACACCCGCCACAAACGGATCTTCTTACCGGGAGGGCCGTCTTCACCGAAGCC
TATGCGGTGATTCCCAAGGG

Product: polysaccharide deacetylase

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRRYFRNMRGYGANPPNPKWPGGAYAAVQFVVNYEEGGENCILHGDEASEAFLSEIVGAQPWPGMRHWNMESIYEYGARV
GFWRLHRMFTEAEVPVTVYGVATALARSPEQVAAMKEACWEIASHGLRWIDYRAHSEEEERRDLDEAVRLHTEVVGEPPK
GLYLGRTSVNSVKLAIEQGGFDWISDTYDDDLPYWLDHDGHGKPARPQLVIPYTLDANDMRFATPQGFNSGDQFFAYLKD
AFDTLYEEGRRGRPAMMSVGLHCRLIGRPGRAAALRRFIDYVKGHEKVWLPRRMDIARHWMEHHPYQAPTLRPSRMGKAE
FVERFGSIFEHSPWIAERAHDLELGPAHDSAVGLHNALARMFHSAGEEERLGVLKAHPDLAGKLAAAKRLTPESAKEQAS
AGLDALTDEERARFTDLNTRYMEKFGFPFIIAVKDNTKQSILRAFETRIEKGPEEEFATACGQVERIAYLRLKDILPS

Sequences:

>Translated_478_residues
MRRYFRNMRGYGANPPNPKWPGGAYAAVQFVVNYEEGGENCILHGDEASEAFLSEIVGAQPWPGMRHWNMESIYEYGARV
GFWRLHRMFTEAEVPVTVYGVATALARSPEQVAAMKEACWEIASHGLRWIDYRAHSEEEERRDLDEAVRLHTEVVGEPPK
GLYLGRTSVNSVKLAIEQGGFDWISDTYDDDLPYWLDHDGHGKPARPQLVIPYTLDANDMRFATPQGFNSGDQFFAYLKD
AFDTLYEEGRRGRPAMMSVGLHCRLIGRPGRAAALRRFIDYVKGHEKVWLPRRMDIARHWMEHHPYQAPTLRPSRMGKAE
FVERFGSIFEHSPWIAERAHDLELGPAHDSAVGLHNALARMFHSAGEEERLGVLKAHPDLAGKLAAAKRLTPESAKEQAS
AGLDALTDEERARFTDLNTRYMEKFGFPFIIAVKDNTKQSILRAFETRIEKGPEEEFATACGQVERIAYLRLKDILPS
>Mature_478_residues
MRRYFRNMRGYGANPPNPKWPGGAYAAVQFVVNYEEGGENCILHGDEASEAFLSEIVGAQPWPGMRHWNMESIYEYGARV
GFWRLHRMFTEAEVPVTVYGVATALARSPEQVAAMKEACWEIASHGLRWIDYRAHSEEEERRDLDEAVRLHTEVVGEPPK
GLYLGRTSVNSVKLAIEQGGFDWISDTYDDDLPYWLDHDGHGKPARPQLVIPYTLDANDMRFATPQGFNSGDQFFAYLKD
AFDTLYEEGRRGRPAMMSVGLHCRLIGRPGRAAALRRFIDYVKGHEKVWLPRRMDIARHWMEHHPYQAPTLRPSRMGKAE
FVERFGSIFEHSPWIAERAHDLELGPAHDSAVGLHNALARMFHSAGEEERLGVLKAHPDLAGKLAAAKRLTPESAKEQAS
AGLDALTDEERARFTDLNTRYMEKFGFPFIIAVKDNTKQSILRAFETRIEKGPEEEFATACGQVERIAYLRLKDILPS

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG0726

COG function: function code G; Predicted xylanase/chitin deacetylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Homo sapiens, GI157743280, Length=167, Percent_Identity=37.7245508982036, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 54304; Mature: 54304

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRYFRNMRGYGANPPNPKWPGGAYAAVQFVVNYEEGGENCILHGDEASEAFLSEIVGAQ
CCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCC
PWPGMRHWNMESIYEYGARVGFWRLHRMFTEAEVPVTVYGVATALARSPEQVAAMKEACW
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHHHHH
EIASHGLRWIDYRAHSEEEERRDLDEAVRLHTEVVGEPPKGLYLGRTSVNSVKLAIEQGG
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCC
FDWISDTYDDDLPYWLDHDGHGKPARPQLVIPYTLDANDMRFATPQGFNSGDQFFAYLKD
CCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCHHHHHHHHHH
AFDTLYEEGRRGRPAMMSVGLHCRLIGRPGRAAALRRFIDYVKGHEKVWLPRRMDIARHW
HHHHHHHCCCCCCCHHEECCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
MEHHPYQAPTLRPSRMGKAEFVERFGSIFEHSPWIAERAHDLELGPAHDSAVGLHNALAR
HHHCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
MFHSAGEEERLGVLKAHPDLAGKLAAAKRLTPESAKEQASAGLDALTDEERARFTDLNTR
HHHHCCCHHHCCEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHCCHHHHHHHCCHHH
YMEKFGFPFIIAVKDNTKQSILRAFETRIEKGPEEEFATACGQVERIAYLRLKDILPS
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRYFRNMRGYGANPPNPKWPGGAYAAVQFVVNYEEGGENCILHGDEASEAFLSEIVGAQ
CCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCC
PWPGMRHWNMESIYEYGARVGFWRLHRMFTEAEVPVTVYGVATALARSPEQVAAMKEACW
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHHHHH
EIASHGLRWIDYRAHSEEEERRDLDEAVRLHTEVVGEPPKGLYLGRTSVNSVKLAIEQGG
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCC
FDWISDTYDDDLPYWLDHDGHGKPARPQLVIPYTLDANDMRFATPQGFNSGDQFFAYLKD
CCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCHHHHHHHHHH
AFDTLYEEGRRGRPAMMSVGLHCRLIGRPGRAAALRRFIDYVKGHEKVWLPRRMDIARHW
HHHHHHHCCCCCCCHHEECCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
MEHHPYQAPTLRPSRMGKAEFVERFGSIFEHSPWIAERAHDLELGPAHDSAVGLHNALAR
HHHCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
MFHSAGEEERLGVLKAHPDLAGKLAAAKRLTPESAKEQASAGLDALTDEERARFTDLNTR
HHHHCCCHHHCCEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHCCHHHHHHHCCHHH
YMEKFGFPFIIAVKDNTKQSILRAFETRIEKGPEEEFATACGQVERIAYLRLKDILPS
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]