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The map label for this gene is gyaR [H]

Identifier: 110635151

GI number: 110635151

Start: 3066508

End: 3067476

Strand: Reverse

Name: gyaR [H]

Synonym: Meso_2818

Alternate gene names: 110635151

Gene position: 3067476-3066508 (Counterclockwise)

Preceding gene: 110635154

Following gene: 110635150

Centisome position: 69.52

GC content: 61.92

Gene sequence:

>969_bases
ATGCCTGATGAAACCCGAGACATCACCATTCTCGTTGCCGGAAAGTTGCATCCGCATGCGGTAAGCCGCATCGGCGAGCA
TTTCCGGATGCTGCGTGTGGATCGTTGCGATCCCGCCCTGTTGACCGAGGCGATGAAACAGAATGTTCTCGGCATAGCCG
CGACGGGAGGGGTCAGCGCCGCCTTCATGGACGCGTTGCCACATTTGCAGATCATCGCCATTTTTGGTGTCGGCTACGAT
TCGGTAGATGCCGTCCATGCCGCGGAGAAGGGCGTGATGGTGACGAACACGCCGGACGTTCTGACGGATGAAGTCGCGGA
TGCGGCGATCGGCCTGCTCATCAATACAGTGCGTGAGTTACCCCGGGCGGAGAAATATCTGCGCGACGGGCGCTGGCACC
GTGAGGGACCATATCCGCTCACGCGAGCCAGTTTGCGCGGACGCAGCGTCGGGATCTTCGGCATGGGCCGGATAGGCCGC
GCCGTCGCGCGGCGCATAGAAGCCTTCGGCCTGCCGGTGAGCTATCACAACCGTCGCAAGGTGGAAGACGTGCCCTACAC
ATATTACCCCACGCTTGTTGGCCTCGCAGAAGCGGTGGATACGCTGATCTCGATCGCTCCGGGGGGAACGGGCACGGACA
AGGCGGTGGATGCGCAGGTGCTGCGGGCGCTTGGACCGAACGGTGTCTTCCTCAATGTGGGGCGCGGCAGCACCGTCGAC
GAGGAGGCGCTTGTCGCGGCGCTTCGGGACGGCACGATCCTGGCAGCGGGGCTGGACGTTTTTGCGGACGAGCCAAATGT
GCCGGAGGCGCTTCTTGGCTGCGAAAACGCCTGCCTTCTTCCTCACGTGGCTTCGGCTTCCGCCCACACGCGGCAGGCGA
TGGCGGATCTTGTAGCAGACAATCTGCTCTCCTGGTTTACCCAAGGAAAACCGCTGACACCGGTAATGGAGACAGCTCAG
GTAAAATAG

Upstream 100 bases:

>100_bases
TCGTCAAGCCCGGAAGGGCAACCGCTTTACTTTTGCGTCTTCACACCGTTCAGATAATCGGGTGTGATTCGGTGCGCGGA
CCATCGTTGAGACTCTGTCA

Downstream 100 bases:

>100_bases
TGAAGGCTGAGAATCGTTCGAGTCATATTATGGCCAATTAATTTTTATTAACGATTAGCCTTAATGATGCTGATACGAAA
TTCAGAACGGGGCAAAAGAT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MPDETRDITILVAGKLHPHAVSRIGEHFRMLRVDRCDPALLTEAMKQNVLGIAATGGVSAAFMDALPHLQIIAIFGVGYD
SVDAVHAAEKGVMVTNTPDVLTDEVADAAIGLLINTVRELPRAEKYLRDGRWHREGPYPLTRASLRGRSVGIFGMGRIGR
AVARRIEAFGLPVSYHNRRKVEDVPYTYYPTLVGLAEAVDTLISIAPGGTGTDKAVDAQVLRALGPNGVFLNVGRGSTVD
EEALVAALRDGTILAAGLDVFADEPNVPEALLGCENACLLPHVASASAHTRQAMADLVADNLLSWFTQGKPLTPVMETAQ
VK

Sequences:

>Translated_322_residues
MPDETRDITILVAGKLHPHAVSRIGEHFRMLRVDRCDPALLTEAMKQNVLGIAATGGVSAAFMDALPHLQIIAIFGVGYD
SVDAVHAAEKGVMVTNTPDVLTDEVADAAIGLLINTVRELPRAEKYLRDGRWHREGPYPLTRASLRGRSVGIFGMGRIGR
AVARRIEAFGLPVSYHNRRKVEDVPYTYYPTLVGLAEAVDTLISIAPGGTGTDKAVDAQVLRALGPNGVFLNVGRGSTVD
EEALVAALRDGTILAAGLDVFADEPNVPEALLGCENACLLPHVASASAHTRQAMADLVADNLLSWFTQGKPLTPVMETAQ
VK
>Mature_321_residues
PDETRDITILVAGKLHPHAVSRIGEHFRMLRVDRCDPALLTEAMKQNVLGIAATGGVSAAFMDALPHLQIIAIFGVGYDS
VDAVHAAEKGVMVTNTPDVLTDEVADAAIGLLINTVRELPRAEKYLRDGRWHREGPYPLTRASLRGRSVGIFGMGRIGRA
VARRIEAFGLPVSYHNRRKVEDVPYTYYPTLVGLAEAVDTLISIAPGGTGTDKAVDAQVLRALGPNGVFLNVGRGSTVDE
EALVAALRDGTILAAGLDVFADEPNVPEALLGCENACLLPHVASASAHTRQAMADLVADNLLSWFTQGKPLTPVMETAQV
K

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=34.1176470588235, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI23308577, Length=262, Percent_Identity=29.3893129770992, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=29.3172690763052, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=29.3172690763052, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI61743967, Length=213, Percent_Identity=29.1079812206573, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4557497, Length=213, Percent_Identity=29.1079812206573, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI145580575, Length=248, Percent_Identity=29.4354838709677, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI87082289, Length=302, Percent_Identity=32.7814569536424, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=27.2413793103448, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=240, Percent_Identity=25.4166666666667, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=238, Percent_Identity=26.890756302521, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=274, Percent_Identity=31.7518248175182, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=23.8670694864048, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=23.2628398791541, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=302, Percent_Identity=23.1788079470199, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571528, Length=267, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI45552429, Length=263, Percent_Identity=31.5589353612167, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551003, Length=263, Percent_Identity=31.5589353612167, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=31.3207547169811, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=31.3207547169811, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574284, Length=255, Percent_Identity=31.3725490196078, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574286, Length=325, Percent_Identity=29.8461538461538, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=31.2977099236641, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI62472511, Length=251, Percent_Identity=29.8804780876494, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19921140, Length=245, Percent_Identity=25.3061224489796, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34414; Mature: 34283

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDETRDITILVAGKLHPHAVSRIGEHFRMLRVDRCDPALLTEAMKQNVLGIAATGGVSA
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCHHH
AFMDALPHLQIIAIFGVGYDSVDAVHAAEKGVMVTNTPDVLTDEVADAAIGLLINTVREL
HHHHHCCCEEEEEEEECCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
PRAEKYLRDGRWHREGPYPLTRASLRGRSVGIFGMGRIGRAVARRIEAFGLPVSYHNRRK
HHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
VEDVPYTYYPTLVGLAEAVDTLISIAPGGTGTDKAVDAQVLRALGPNGVFLNVGRGSTVD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCC
EEALVAALRDGTILAAGLDVFADEPNVPEALLGCENACLLPHVASASAHTRQAMADLVAD
HHHHHHHHCCCEEEEECCHHHCCCCCCCHHHHCCCCCEECCCHHCCHHHHHHHHHHHHHH
NLLSWFTQGKPLTPVMETAQVK
HHHHHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure 
PDETRDITILVAGKLHPHAVSRIGEHFRMLRVDRCDPALLTEAMKQNVLGIAATGGVSA
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCHHH
AFMDALPHLQIIAIFGVGYDSVDAVHAAEKGVMVTNTPDVLTDEVADAAIGLLINTVREL
HHHHHCCCEEEEEEEECCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
PRAEKYLRDGRWHREGPYPLTRASLRGRSVGIFGMGRIGRAVARRIEAFGLPVSYHNRRK
HHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
VEDVPYTYYPTLVGLAEAVDTLISIAPGGTGTDKAVDAQVLRALGPNGVFLNVGRGSTVD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCC
EEALVAALRDGTILAAGLDVFADEPNVPEALLGCENACLLPHVASASAHTRQAMADLVAD
HHHHHHHHCCCEEEEECCHHHCCCCCCCHHHHCCCCCEECCCHHCCHHHHHHHHHHHHHH
NLLSWFTQGKPLTPVMETAQVK
HHHHHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA