Click here to switch to the map view.

The map label for this gene is pntAA [H]

Identifier: 110635139

GI number: 110635139

Start: 3051983

End: 3053299

Strand: Reverse

Name: pntAA [H]

Synonym: Meso_2806

Alternate gene names: 110635139

Gene position: 3053299-3051983 (Counterclockwise)

Preceding gene: 110635140

Following gene: 110635138

Centisome position: 69.2

GC content: 64.77

Gene sequence:

>1317_bases
GTGGGACAGACTATCTTTGTGCCCAAGGAGGCGGACACGAACGAGCCGCGCGTCGCCGCATCGCCAGATACGGCGAAACG
GCTTAGCGGGCTCGGTTTCACGGTCATCGTGGAACGTGGCGCGGGGCTCGCCTCACGCATCACGGACGAGGAGTTCGAGA
AGGCCGGCGCCACGCTCGGCGGTGCGGCCGACGCGGCTAAGGCCGATGTGGTCCTGAAGGTCCGCAGGCCCACCGCTTTG
GAACTCAAATCCTACAAGAAGGGCGCCCTGGTGATCGCCACCATGGACCCTTACGGCCATGAGGCCGATGTGGCGGCGAT
GGCCAAGGCCGGAATTTCGGCTTTTGCCATGGAATTCATGCCGCGCATCACGCGCGCGCAATCCATGGACGTGCTCTCCA
GCCAGGCGAACCTCGCCGGCTACCGTGCCGTGATCGATGCGGCGGCCGAATATGACCGGGCGCTTCCAATGATGATGACC
GCGGCGGGTACCGTGCCGGCGGCGAAAGTCTTCGTCATGGGCGCCGGTGTTGCCGGCCTTCAGGCGATTGCAACCGCTAG
GCGGTTGGGAGCGGTGGTTACGGCGACCGACGTGCGCGCGGCCGCGGGCGAGCAGGTGGCTTCGCTTGGGGCCAAATTCA
TCATGACGGACGCGCTCAAGGATGCCTCCGGCCAGGGCGGCTATGCGCGCGAACTGACTGAGGACGAAAGGCGGGCGCAG
GCTGAACTGGTGGCCGAGCACATCGCCAAGCAGGATATCGTGATCACGACAGCGCTTATCCCGGGCCGGCCCGCGCCGCG
GCTGGTGACGGCCGGAATGGTCGCCTCGATGCGGGCGGGATCGGTGATCGTGGATCTTGCGGTCGAGCGCGGCGGTAATG
TCGAGGGCGCGGTGCCCGGCGAAGTGATTACGACGGCCAATGGTGTGAAAATCATCGGTCATCTCAACGTGCCGGGACGG
GTGGCTGCTTCGGCATCGCTGCTTTACGCACGGAATCTCTACGCCTTCCTGGAAACCATGATCGACAAGCAAACGAAGGC
GATGTCGGTCAATTTCGACGACGAGTTGGTGAAGGCGACCCTTCTTGTCCATGACGGAGCGGTGGTGCACCCCAATTTCG
CAGGCGCCACGCCAGCGGCGACACCGAAGCCGTCGCCCTCCGATCCCGAGGTGGAAAAGGCTGCCAAAGGAACGGAACCC
GGCCTCGAGGTTGCGCCAAAAAGGGCGGGGTCGCGCCGCAAGGCCACCGAAAAACCGGCGGCTGAGAGAGCGAAACCCAA
GAAGCCGGCCACGCCTAAGACGGGAGGTGATGCCTAA

Upstream 100 bases:

>100_bases
TTCTCTTCATCCTCATCTGCGCCGTCGGCGCCTGGATTTTGCGGTAATCCACCGTTCGGCCGGGGGGCCACGGGGGACCG
TCCAACAGAGGGAGTTGACG

Downstream 100 bases:

>100_bases
TGGAGCCGAACGCGATCGATCAAGCGCTCGATCAACTGGAGCGCGCAACGGCGAGCGTCCGCGCCGCTTTCGAGAATATG
CAAGCGGAAGGTCTGGCTGA

Product: alanine dehydrogenase/PNT-like

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MGQTIFVPKEADTNEPRVAASPDTAKRLSGLGFTVIVERGAGLASRITDEEFEKAGATLGGAADAAKADVVLKVRRPTAL
ELKSYKKGALVIATMDPYGHEADVAAMAKAGISAFAMEFMPRITRAQSMDVLSSQANLAGYRAVIDAAAEYDRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRAAAGEQVASLGAKFIMTDALKDASGQGGYARELTEDERRAQ
AELVAEHIAKQDIVITTALIPGRPAPRLVTAGMVASMRAGSVIVDLAVERGGNVEGAVPGEVITTANGVKIIGHLNVPGR
VAASASLLYARNLYAFLETMIDKQTKAMSVNFDDELVKATLLVHDGAVVHPNFAGATPAATPKPSPSDPEVEKAAKGTEP
GLEVAPKRAGSRRKATEKPAAERAKPKKPATPKTGGDA

Sequences:

>Translated_438_residues
MGQTIFVPKEADTNEPRVAASPDTAKRLSGLGFTVIVERGAGLASRITDEEFEKAGATLGGAADAAKADVVLKVRRPTAL
ELKSYKKGALVIATMDPYGHEADVAAMAKAGISAFAMEFMPRITRAQSMDVLSSQANLAGYRAVIDAAAEYDRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRAAAGEQVASLGAKFIMTDALKDASGQGGYARELTEDERRAQ
AELVAEHIAKQDIVITTALIPGRPAPRLVTAGMVASMRAGSVIVDLAVERGGNVEGAVPGEVITTANGVKIIGHLNVPGR
VAASASLLYARNLYAFLETMIDKQTKAMSVNFDDELVKATLLVHDGAVVHPNFAGATPAATPKPSPSDPEVEKAAKGTEP
GLEVAPKRAGSRRKATEKPAAERAKPKKPATPKTGGDA
>Mature_437_residues
GQTIFVPKEADTNEPRVAASPDTAKRLSGLGFTVIVERGAGLASRITDEEFEKAGATLGGAADAAKADVVLKVRRPTALE
LKSYKKGALVIATMDPYGHEADVAAMAKAGISAFAMEFMPRITRAQSMDVLSSQANLAGYRAVIDAAAEYDRALPMMMTA
AGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRAAAGEQVASLGAKFIMTDALKDASGQGGYARELTEDERRAQA
ELVAEHIAKQDIVITTALIPGRPAPRLVTAGMVASMRAGSVIVDLAVERGGNVEGAVPGEVITTANGVKIIGHLNVPGRV
AASASLLYARNLYAFLETMIDKQTKAMSVNFDDELVKATLLVHDGAVVHPNFAGATPAATPKPSPSDPEVEKAAKGTEPG
LEVAPKRAGSRRKATEKPAAERAKPKKPATPKTGGDA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=411, Percent_Identity=39.1727493917275, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI122939153, Length=411, Percent_Identity=39.1727493917275, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI1787887, Length=365, Percent_Identity=43.8356164383562, Blast_Score=307, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=360, Percent_Identity=43.6111111111111, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 45300; Mature: 45169

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQTIFVPKEADTNEPRVAASPDTAKRLSGLGFTVIVERGAGLASRITDEEFEKAGATLG
CCCEEEEECCCCCCCCEEECCCCHHHHHCCCCEEEEEECCCCHHHHCCHHHHHHHCCCCC
GAADAAKADVVLKVRRPTALELKSYKKGALVIATMDPYGHEADVAAMAKAGISAFAMEFM
CCCCCCCCEEEEEECCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
PRITRAQSMDVLSSQANLAGYRAVIDAAAEYDRALPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRAAAGEQVASLGAKFIMTDALKDASGQGGYARELTEDERRAQ
HHHHHHHHHCEEEEECHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AELVAEHIAKQDIVITTALIPGRPAPRLVTAGMVASMRAGSVIVDLAVERGGNVEGAVPG
HHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
EVITTANGVKIIGHLNVPGRVAASASLLYARNLYAFLETMIDKQTKAMSVNFDDELVKAT
CEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHEEE
LLVHDGAVVHPNFAGATPAATPKPSPSDPEVEKAAKGTEPGLEVAPKRAGSRRKATEKPA
EEEECCEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
AERAKPKKPATPKTGGDA
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQTIFVPKEADTNEPRVAASPDTAKRLSGLGFTVIVERGAGLASRITDEEFEKAGATLG
CCEEEEECCCCCCCCEEECCCCHHHHHCCCCEEEEEECCCCHHHHCCHHHHHHHCCCCC
GAADAAKADVVLKVRRPTALELKSYKKGALVIATMDPYGHEADVAAMAKAGISAFAMEFM
CCCCCCCCEEEEEECCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
PRITRAQSMDVLSSQANLAGYRAVIDAAAEYDRALPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRAAAGEQVASLGAKFIMTDALKDASGQGGYARELTEDERRAQ
HHHHHHHHHCEEEEECHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AELVAEHIAKQDIVITTALIPGRPAPRLVTAGMVASMRAGSVIVDLAVERGGNVEGAVPG
HHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
EVITTANGVKIIGHLNVPGRVAASASLLYARNLYAFLETMIDKQTKAMSVNFDDELVKAT
CEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHEEE
LLVHDGAVVHPNFAGATPAATPKPSPSDPEVEKAAKGTEPGLEVAPKRAGSRRKATEKPA
EEEECCEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
AERAKPKKPATPKTGGDA
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]