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The map label for this gene is pntB [H]

Identifier: 110635137

GI number: 110635137

Start: 3050159

End: 3051556

Strand: Reverse

Name: pntB [H]

Synonym: Meso_2804

Alternate gene names: 110635137

Gene position: 3051556-3050159 (Counterclockwise)

Preceding gene: 110635138

Following gene: 110635136

Centisome position: 69.16

GC content: 60.01

Gene sequence:

>1398_bases
GTGAGCGCCAATCTCGCCTCTTTCCTCTATCTTGTCTCCGGCATCCTATTCATCCTGGCGCTGCGCGGCCTTTCGCACCC
CACCACCAGCCGCCAAGGCAATTTCTATGGCATGGTCGGCATGGCGATTGCCATTGTGACCACGCTTTTGCTGACGACGC
CTACGCCGGGCGGCTTCCTGCTCATCCTTGCAGGGCTTGCAATCGGCGGCGGTGTGGGCGCGGTAACCGCGCGGCGCATC
GCCATGACGGCAATGCCGCAGCTCGTTGCCGCCTTCCATAGCCTGGTGGGCCTTGCCGCCGTCATGGTGGCTGCCGCTGC
TCTTTACTCGCCCGAAAGCTTCGGTATCGGCGAAGTGGGCGCTATTCATGCGCAGGCGCTGGTGGAAATGTCCCTTGGTG
TGGCGATCGGCGCCATCACCTTCACCGGTTCGATCATCGCCTTCCTGAAGCTGGATGGCCGCATGTCGGGAAAACCCATT
CTGCTTCCTGGGCGCCATCCGCTCAATGCTGCAATCGGCATTGCGCTTGTCGTGCTCATCGCGATGCTGGTGGTGACGCA
GAGCCATACGATTTTCTGGCTCATCGTGATCCTGTCGCTCATTCTGGGTGTTCTCATCATTGTCCCGATCGGCGGCGCGG
ACATGCCGGTCGTTGTGTCGATGCTCAACTCCTATTCGGGGTGGGCGGCAGCCGGAATTGGCTTCACGCTCGGCAATCTG
GCGCTCATCATCACCGGTGCTCTGGTCGGTTCCTCGGGTGCGATCCTGTCCTACATCATGTGCAAGGGCATGAACCGCTC
CTTCATCTCCGTGATCCTCGGAGGCTTCGGCGGGGAGACAGCGGCGGCAGTGGATGACGGCATCGAACGTACGGTCAAGC
AGGGTTCGGCTGACGATGCGGCCTATCTGATGATGAACGCGCAGAAAGTCATCATCGTACCGGGCTATGGCATGGCAGTC
GCCCAGGCCCAGCATGCGCTGCGCGAAATGGCAGACAAGCTGAAGGCCAATGGGGTCGAGGTGAAATATGCCATTCATCC
GGTGGCGGGCCGCATGCCCGGCCATATGAATGTGCTGCTTGCGGAAGCCCAGGTGCCCTATGACGAGGTGTTCGAGCTGG
AGGACATCAATTCCGAGTTCGCCCAGGCCGACGTAGCTTATGTCATCGGCGCGAATGACGTTACCAACCCTGCGGCACGG
GACGACAAGTCCTCACCCATTTACGGTATGCCGATCCTAGATGTCGACAAGGCGCGTACCTGCCTTTTTGTGAAGCGCTC
GCTCGGTTCCGGCTATGCAGGTATCGACAATACGCTGTTCTACAAGGACGGCACGATGATGCTGCTCGGCGACGCCAAGA
AGATGACCGAAGACATCGTCAAGGCGATGGATCACTAG

Upstream 100 bases:

>100_bases
TTCGGCTTCGTTGCCCTGGTGCTCGCCTCGGTGAACATCTTCGGCGGTTTCCTGGTAACCCAGCGCATGCTGGCGATGTA
CAAGAAGAAGGAAAAGTGAC

Downstream 100 bases:

>100_bases
CGGTTACCGCGCCATGGTTCGAACCATGCAAGAAAAGCCCGGCCTTGCGCCGGGCTTTTCGCCTTTGTAGCCGCCTCGAA
ATGCTGCCCTAGATAGGCTG

Product: NAD(P) transhydrogenase, beta subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSANLASFLYLVSGILFILALRGLSHPTTSRQGNFYGMVGMAIAIVTTLLLTTPTPGGFLLILAGLAIGGGVGAVTARRI
AMTAMPQLVAAFHSLVGLAAVMVAAAALYSPESFGIGEVGAIHAQALVEMSLGVAIGAITFTGSIIAFLKLDGRMSGKPI
LLPGRHPLNAAIGIALVVLIAMLVVTQSHTIFWLIVILSLILGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAVDDGIERTVKQGSADDAAYLMMNAQKVIIVPGYGMAV
AQAQHALREMADKLKANGVEVKYAIHPVAGRMPGHMNVLLAEAQVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAAR
DDKSSPIYGMPILDVDKARTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEDIVKAMDH

Sequences:

>Translated_465_residues
MSANLASFLYLVSGILFILALRGLSHPTTSRQGNFYGMVGMAIAIVTTLLLTTPTPGGFLLILAGLAIGGGVGAVTARRI
AMTAMPQLVAAFHSLVGLAAVMVAAAALYSPESFGIGEVGAIHAQALVEMSLGVAIGAITFTGSIIAFLKLDGRMSGKPI
LLPGRHPLNAAIGIALVVLIAMLVVTQSHTIFWLIVILSLILGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAVDDGIERTVKQGSADDAAYLMMNAQKVIIVPGYGMAV
AQAQHALREMADKLKANGVEVKYAIHPVAGRMPGHMNVLLAEAQVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAAR
DDKSSPIYGMPILDVDKARTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEDIVKAMDH
>Mature_464_residues
SANLASFLYLVSGILFILALRGLSHPTTSRQGNFYGMVGMAIAIVTTLLLTTPTPGGFLLILAGLAIGGGVGAVTARRIA
MTAMPQLVAAFHSLVGLAAVMVAAAALYSPESFGIGEVGAIHAQALVEMSLGVAIGAITFTGSIIAFLKLDGRMSGKPIL
LPGRHPLNAAIGIALVVLIAMLVVTQSHTIFWLIVILSLILGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNLA
LIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAVDDGIERTVKQGSADDAAYLMMNAQKVIIVPGYGMAVA
QAQHALREMADKLKANGVEVKYAIHPVAGRMPGHMNVLLAEAQVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAARD
DKSSPIYGMPILDVDKARTCLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEDIVKAMDH

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=459, Percent_Identity=47.276688453159, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI122939153, Length=459, Percent_Identity=47.276688453159, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1787886, Length=468, Percent_Identity=52.1367521367521, Blast_Score=458, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17550456, Length=460, Percent_Identity=45.6521739130435, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48414; Mature: 48283

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANLASFLYLVSGILFILALRGLSHPTTSRQGNFYGMVGMAIAIVTTLLLTTPTPGGFL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHH
LILAGLAIGGGVGAVTARRIAMTAMPQLVAAFHSLVGLAAVMVAAAALYSPESFGIGEVG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AIHAQALVEMSLGVAIGAITFTGSIIAFLKLDGRMSGKPILLPGRHPLNAAIGIALVVLI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHH
AMLVVTQSHTIFWLIVILSLILGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAVDDGIERTVKQGSADDA
HHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
AYLMMNAQKVIIVPGYGMAVAQAQHALREMADKLKANGVEVKYAIHPVAGRMPGHMNVLL
EEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEE
AEAQVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAARDDKSSPIYGMPILDVDKART
EECCCCHHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCEECCCCHH
CLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEDIVKAMDH
HHHHHHHCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SANLASFLYLVSGILFILALRGLSHPTTSRQGNFYGMVGMAIAIVTTLLLTTPTPGGFL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHH
LILAGLAIGGGVGAVTARRIAMTAMPQLVAAFHSLVGLAAVMVAAAALYSPESFGIGEVG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AIHAQALVEMSLGVAIGAITFTGSIIAFLKLDGRMSGKPILLPGRHPLNAAIGIALVVLI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHH
AMLVVTQSHTIFWLIVILSLILGVLIIVPIGGADMPVVVSMLNSYSGWAAAGIGFTLGNL
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
ALIITGALVGSSGAILSYIMCKGMNRSFISVILGGFGGETAAAVDDGIERTVKQGSADDA
HHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
AYLMMNAQKVIIVPGYGMAVAQAQHALREMADKLKANGVEVKYAIHPVAGRMPGHMNVLL
EEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEE
AEAQVPYDEVFELEDINSEFAQADVAYVIGANDVTNPAARDDKSSPIYGMPILDVDKART
EECCCCHHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCEECCCCHH
CLFVKRSLGSGYAGIDNTLFYKDGTMMLLGDAKKMTEDIVKAMDH
HHHHHHHCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]