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The map label for this gene is 110634981

Identifier: 110634981

GI number: 110634981

Start: 2861875

End: 2863911

Strand: Reverse

Name: 110634981

Synonym: Meso_2647

Alternate gene names: NA

Gene position: 2863911-2861875 (Counterclockwise)

Preceding gene: 110634990

Following gene: 110634980

Centisome position: 64.91

GC content: 61.95

Gene sequence:

>2037_bases
ATGCTCAGAATTGGAATTGATATTGGTGGAACGTTCACGGACTTTGCAATTTGGGACGGCCATGCTTCCGGTTATACCGG
CGTCGAAATATTCAAAGTCCCTTCCACGCCGGGCAACTTCCACCTCGGTGTCATCGAAGGGCTGAAGCTGCTGCTCGAAC
GCGGCCGCATCACGGCCGACCAATCCATCATGATCGTTCACGGCACGACGGTCAGCACCAATGCCGTCATCGAACGGAGC
AGCCCGCCCGTTGCGCTGCTCGTCACCAGCGGGTTCCGGGATATTCTCGGCATGGGCCGCCTGAGGATGAACGATCCGAT
CAACCTGTTCGACCGGCGCGCAGAACCGCTCATCCCGCGCAACATGGTCTTCGAGATCGAAGAACGCATGCTGCAGACCG
GCGAGGTGGATATCGAGCTCAATCCCGTACAGCTGATCCGCTCAGCGCGGGCCGCACTGGAGGCCGGAGCGCGGGCGCTG
GCCGTCTGCTTCCTGCACTCCTACCGCAACCCGGCGCACGAGCTGGCCGCCCGCGATATTCTCGTGAAGAAATTCGAAGA
CGTCGAGGTAACCCTCTCGCACGAAATATGGTCCCAGCCTTCTGAATACGAACGGGCCAGCGCCGCGGTTCTGAATGCCT
ATGCCAGTCTTTCGATGAAAGGTTATCTGGCCGAACTGGAAGGCTTTCTTCGGCAAAATCTGAAGAATGCGCGTCTGTTC
ATTTCCAAATCGAACGGCGGCGTGATGGCCTCCAACGAAGCGGGGAGGATGCCGATCCACACGCTGCTGTCCGGACCGGC
GGCCGGCGTCACCGCAGCATGCGCCCTCGGCAACCTGATCGAGGAACCGCAGCTGCTGACCATGGACATGGGCGGTACGA
GCACGGACATCTCCGTCGTCAACAAGGGACAGGCCGTCACGTCCCTTCAGGGCAAGGTGGGCGATTTCCCGCTGATGATG
CCGGTGACCGCGGTCGAAGCCATCGGCGCCGGTGGCGGATCTATCGCCTGGGTCGACGGGAAGGTACTGCATGTCGGTCC
CCGTTCAGCCGGTGCATTTCCCGGGCCAGCCTGTTACGGGCTCGGCGGCACCCAGCCGACGATTTCCGACGCCTACCTGC
TCTGCGGCTATCTTTCGCCCGAACGCCCGCTCGCAGGCCGCCTCAGCTTGAGCGTCGATCTTGCCGCCAAGGCCATGCAA
CCGATCGCGGATGCGCTCGGCATGGATGTGGTCGCTGCCGCCGAAGCCTGCATCACGGTTGCGACCGCCAATATGCTCGC
CAGCGCCTTGCCCTTCATTTCACGTCTCGGGGTTCCCCCGTCCGAACTTACACTGATGTCGTTCGGGGGCGCCGGTGCCA
TCCATGGCGCGCTGCTCGCAGATGAGATCGACATCGGCCGGGTGGTCCTGCCGCGCATGTCGTCGGTCTTCTGCGCCTAT
GGATGCCTCGTCTCCGATCTTCTCTTCGACGTCGTGGAAAGCGTGCAGGGACGTGCGCTCGACAATGAAGTGGTCTTCCA
GGTCTACAAAGGGTTGGAAAAGGACGCCCGGGCCTGGCTCGACGAGCAGGTCGGCGGAAACTTCCTTCCGACCGTCACCC
TCACTTACATAGCCGATGTCCGCTACAAGGGGCAGGCTTTCGACGTGGCGACGGAATTCAGCCTTGAAGGCGATCCGCTT
GCTGCGATCAATGCGGCTTTCCATGTCGAGCACGAGCGGCTCTACGGCCACTCCAGTCCGCAGCTTCCGATCGAGATCCT
GACGCTGCGTCTGCAGATCCGCGGCGCGCTGGAACGCCCGCGCGGCGCGCCTCTGCCGCTTTCGCCTGCGAAGATCGAGC
CGAAGACCCGACGGAAGATCCGGTATGGCGGAAAGAGCTACGACGCGGCCATTTTCGACAAGGCGGCGATGCCGATCGGT
TTCCGCACCTCCGGCCCGGCCATCATCGAGCAGGAAACCATCACCGTTCTCGTTCCTCCCGCGTTCGACGTGACGATCGG
TCGATACGACGACGTCATTCTTGAAAGAAGGGCATAA

Upstream 100 bases:

>100_bases
TGATCCCTGAAAAAAGGTTGGCTAACGTAAGGCCTGCTTCTTGAAGGTCTGTCGGATCCCTCCGGCTGTCCGTCCTCTCG
AATAGTTCAGGATTCTCCGG

Downstream 100 bases:

>100_bases
CAATGGATCCCGTTTTCACCGAAGTGATGAAACACCGTTTTGCAGCGATCGCCGACGAAGCGAGCAATACGGTCTATCGC
ACGGCGTTCACGACCTTCGT

Product: hydantoinase/oxoprolinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MLRIGIDIGGTFTDFAIWDGHASGYTGVEIFKVPSTPGNFHLGVIEGLKLLLERGRITADQSIMIVHGTTVSTNAVIERS
SPPVALLVTSGFRDILGMGRLRMNDPINLFDRRAEPLIPRNMVFEIEERMLQTGEVDIELNPVQLIRSARAALEAGARAL
AVCFLHSYRNPAHELAARDILVKKFEDVEVTLSHEIWSQPSEYERASAAVLNAYASLSMKGYLAELEGFLRQNLKNARLF
ISKSNGGVMASNEAGRMPIHTLLSGPAAGVTAACALGNLIEEPQLLTMDMGGTSTDISVVNKGQAVTSLQGKVGDFPLMM
PVTAVEAIGAGGGSIAWVDGKVLHVGPRSAGAFPGPACYGLGGTQPTISDAYLLCGYLSPERPLAGRLSLSVDLAAKAMQ
PIADALGMDVVAAAEACITVATANMLASALPFISRLGVPPSELTLMSFGGAGAIHGALLADEIDIGRVVLPRMSSVFCAY
GCLVSDLLFDVVESVQGRALDNEVVFQVYKGLEKDARAWLDEQVGGNFLPTVTLTYIADVRYKGQAFDVATEFSLEGDPL
AAINAAFHVEHERLYGHSSPQLPIEILTLRLQIRGALERPRGAPLPLSPAKIEPKTRRKIRYGGKSYDAAIFDKAAMPIG
FRTSGPAIIEQETITVLVPPAFDVTIGRYDDVILERRA

Sequences:

>Translated_678_residues
MLRIGIDIGGTFTDFAIWDGHASGYTGVEIFKVPSTPGNFHLGVIEGLKLLLERGRITADQSIMIVHGTTVSTNAVIERS
SPPVALLVTSGFRDILGMGRLRMNDPINLFDRRAEPLIPRNMVFEIEERMLQTGEVDIELNPVQLIRSARAALEAGARAL
AVCFLHSYRNPAHELAARDILVKKFEDVEVTLSHEIWSQPSEYERASAAVLNAYASLSMKGYLAELEGFLRQNLKNARLF
ISKSNGGVMASNEAGRMPIHTLLSGPAAGVTAACALGNLIEEPQLLTMDMGGTSTDISVVNKGQAVTSLQGKVGDFPLMM
PVTAVEAIGAGGGSIAWVDGKVLHVGPRSAGAFPGPACYGLGGTQPTISDAYLLCGYLSPERPLAGRLSLSVDLAAKAMQ
PIADALGMDVVAAAEACITVATANMLASALPFISRLGVPPSELTLMSFGGAGAIHGALLADEIDIGRVVLPRMSSVFCAY
GCLVSDLLFDVVESVQGRALDNEVVFQVYKGLEKDARAWLDEQVGGNFLPTVTLTYIADVRYKGQAFDVATEFSLEGDPL
AAINAAFHVEHERLYGHSSPQLPIEILTLRLQIRGALERPRGAPLPLSPAKIEPKTRRKIRYGGKSYDAAIFDKAAMPIG
FRTSGPAIIEQETITVLVPPAFDVTIGRYDDVILERRA
>Mature_678_residues
MLRIGIDIGGTFTDFAIWDGHASGYTGVEIFKVPSTPGNFHLGVIEGLKLLLERGRITADQSIMIVHGTTVSTNAVIERS
SPPVALLVTSGFRDILGMGRLRMNDPINLFDRRAEPLIPRNMVFEIEERMLQTGEVDIELNPVQLIRSARAALEAGARAL
AVCFLHSYRNPAHELAARDILVKKFEDVEVTLSHEIWSQPSEYERASAAVLNAYASLSMKGYLAELEGFLRQNLKNARLF
ISKSNGGVMASNEAGRMPIHTLLSGPAAGVTAACALGNLIEEPQLLTMDMGGTSTDISVVNKGQAVTSLQGKVGDFPLMM
PVTAVEAIGAGGGSIAWVDGKVLHVGPRSAGAFPGPACYGLGGTQPTISDAYLLCGYLSPERPLAGRLSLSVDLAAKAMQ
PIADALGMDVVAAAEACITVATANMLASALPFISRLGVPPSELTLMSFGGAGAIHGALLADEIDIGRVVLPRMSSVFCAY
GCLVSDLLFDVVESVQGRALDNEVVFQVYKGLEKDARAWLDEQVGGNFLPTVTLTYIADVRYKGQAFDVATEFSLEGDPL
AAINAAFHVEHERLYGHSSPQLPIEILTLRLQIRGALERPRGAPLPLSPAKIEPKTRRKIRYGGKSYDAAIFDKAAMPIG
FRTSGPAIIEQETITVLVPPAFDVTIGRYDDVILERRA

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=735, Percent_Identity=27.891156462585, Blast_Score=163, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI133901900, Length=728, Percent_Identity=25.8241758241758, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322634, Length=736, Percent_Identity=27.7173913043478, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45550492, Length=727, Percent_Identity=26.2723521320495, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 72576; Mature: 72576

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIGIDIGGTFTDFAIWDGHASGYTGVEIFKVPSTPGNFHLGVIEGLKLLLERGRITAD
CEEEEEECCCCEEEEEEECCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHCCCCCCC
QSIMIVHGTTVSTNAVIERSSPPVALLVTSGFRDILGMGRLRMNDPINLFDRRAEPLIPR
CEEEEEECCEEECCEEEECCCCCEEEEEECCCHHHHCCCCEECCCCHHHHHCCCCCCCCC
NMVFEIEERMLQTGEVDIELNPVQLIRSARAALEAGARALAVCFLHSYRNPAHELAARDI
HHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHH
LVKKFEDVEVTLSHEIWSQPSEYERASAAVLNAYASLSMKGYLAELEGFLRQNLKNARLF
HHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ISKSNGGVMASNEAGRMPIHTLLSGPAAGVTAACALGNLIEEPQLLTMDMGGTSTDISVV
EEECCCCEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
NKGQAVTSLQGKVGDFPLMMPVTAVEAIGAGGGSIAWVDGKVLHVGPRSAGAFPGPACYG
ECCCEEEECCCCCCCCCEEHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCCCCCCCEEC
LGGTQPTISDAYLLCGYLSPERPLAGRLSLSVDLAAKAMQPIADALGMDVVAAAEACITV
CCCCCCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ATANMLASALPFISRLGVPPSELTLMSFGGAGAIHGALLADEIDIGRVVLPRMSSVFCAY
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHH
GCLVSDLLFDVVESVQGRALDNEVVFQVYKGLEKDARAWLDEQVGGNFLPTVTLTYIADV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEEEC
RYKGQAFDVATEFSLEGDPLAAINAAFHVEHERLYGHSSPQLPIEILTLRLQIRGALERP
EECCCEEEEEEEECCCCCCCEEEEHEEEEEHHHHCCCCCCCCCCEEEEEEEEEHHHHCCC
RGAPLPLSPAKIEPKTRRKIRYGGKSYDAAIFDKAAMPIGFRTSGPAIIEQETITVLVPP
CCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECEEEEEECC
AFDVTIGRYDDVILERRA
CCEEEECCCCCCCEECCC
>Mature Secondary Structure
MLRIGIDIGGTFTDFAIWDGHASGYTGVEIFKVPSTPGNFHLGVIEGLKLLLERGRITAD
CEEEEEECCCCEEEEEEECCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHCCCCCCC
QSIMIVHGTTVSTNAVIERSSPPVALLVTSGFRDILGMGRLRMNDPINLFDRRAEPLIPR
CEEEEEECCEEECCEEEECCCCCEEEEEECCCHHHHCCCCEECCCCHHHHHCCCCCCCCC
NMVFEIEERMLQTGEVDIELNPVQLIRSARAALEAGARALAVCFLHSYRNPAHELAARDI
HHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHH
LVKKFEDVEVTLSHEIWSQPSEYERASAAVLNAYASLSMKGYLAELEGFLRQNLKNARLF
HHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ISKSNGGVMASNEAGRMPIHTLLSGPAAGVTAACALGNLIEEPQLLTMDMGGTSTDISVV
EEECCCCEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
NKGQAVTSLQGKVGDFPLMMPVTAVEAIGAGGGSIAWVDGKVLHVGPRSAGAFPGPACYG
ECCCEEEECCCCCCCCCEEHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCCCCCCCEEC
LGGTQPTISDAYLLCGYLSPERPLAGRLSLSVDLAAKAMQPIADALGMDVVAAAEACITV
CCCCCCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ATANMLASALPFISRLGVPPSELTLMSFGGAGAIHGALLADEIDIGRVVLPRMSSVFCAY
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHH
GCLVSDLLFDVVESVQGRALDNEVVFQVYKGLEKDARAWLDEQVGGNFLPTVTLTYIADV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEEEC
RYKGQAFDVATEFSLEGDPLAAINAAFHVEHERLYGHSSPQLPIEILTLRLQIRGALERP
EECCCEEEEEEEECCCCCCCEEEEHEEEEEHHHHCCCCCCCCCCEEEEEEEEEHHHHCCC
RGAPLPLSPAKIEPKTRRKIRYGGKSYDAAIFDKAAMPIGFRTSGPAIIEQETITVLVPP
CCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECEEEEEECC
AFDVTIGRYDDVILERRA
CCEEEECCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]