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The map label for this gene is thiD [H]

Identifier: 110634907

GI number: 110634907

Start: 2754965

End: 2755735

Strand: Direct

Name: thiD [H]

Synonym: Meso_2566

Alternate gene names: 110634907

Gene position: 2754965-2755735 (Clockwise)

Preceding gene: 110634906

Following gene: 110634911

Centisome position: 62.44

GC content: 62.78

Gene sequence:

>771_bases
ATGAGTGTCAGGCCGCATGTGCTTGTCGTCGCCGGCTCTGATTCCTCCGGAGGAGCAGGAAACGGCCGCGACATCGAAGT
CCTTGCCAGCCTGGGCGTTAACGCAGCGCTCGCCATTACCGCCGTGACGGCGCAGACGCATAGTCGCGTGGCGGCGGTTG
AACCCATGTCGCCTTCGCTCGTTTCGGCGCAGATGGAAGCTGCGCTGGAAGCAGAGCCCATAGACGCGATCAAGATCGGC
ATGCTCGGGACGAGCGACATAGTGGAGGCAGTCTCGACCGTTCTCCGCAGGCATCTGCCGATTCCCGTCGTCCTCGATCC
CGTGCTCGCCTCCTCCTCTGGAGGACGGCTCATGGAAGAAGCAGGGATTGCCGTGCTGAAGCGTGAACTTCTACCGCTCT
GCCGCCTCGTCACGCCCAATTGGCTGGAGCTTGCCATTCTCGCTGCCACGGTGACCGCAGGGAGTGAGGAAGAGGCGCTT
GATCAAGGCAACTTGCTCCTTGCAAGCGGGTGTCACGCCCTGCTCGTGAAGGGCGGGCATGCGCCGGATAAACGAAATTC
GACAGATATTCTGCTGCGTCGAGGCCATGCGCCGGAACGCTTCGAAGCGCCGCGGCTTGATAGCCGGATGCGCGGCACGG
GTTGCGCGCTCGCCAGTTCCATCGCCGCCGCCTTGGCGCGCGGGCTTTCGCTGGAAGAAAGCATCGCGTTTGGCAAGCGG
AAAGTTTACCACTTATTACGCGAAGCCGATGCCGAGCACCCAGCCGCCTGA

Upstream 100 bases:

>100_bases
CGGCGGCCGTGGTGACGGACATATTGCGCAATTCCAACCCCGAGGCGCGCACACGGGAATGGTTAGAGGCGACCGCATCA
TGGAGGGAAAAAAGCCGAGC

Downstream 100 bases:

>100_bases
TGAGATTTGGTGATAGCGGTCGGCGTCAGCATGATAAATGTTTTAGAACATCTACGCCGGTGAAGAAATATCCGCAAAGA
GGCAGGTGGGCCTCTTCGCG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSVRPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSLVSAQMEAALEAEPIDAIKIG
MLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEEAGIAVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEAL
DQGNLLLASGCHALLVKGGHAPDKRNSTDILLRRGHAPERFEAPRLDSRMRGTGCALASSIAAALARGLSLEESIAFGKR
KVYHLLREADAEHPAA

Sequences:

>Translated_256_residues
MSVRPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSLVSAQMEAALEAEPIDAIKIG
MLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEEAGIAVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEAL
DQGNLLLASGCHALLVKGGHAPDKRNSTDILLRRGHAPERFEAPRLDSRMRGTGCALASSIAAALARGLSLEESIAFGKR
KVYHLLREADAEHPAA
>Mature_255_residues
SVRPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSLVSAQMEAALEAEPIDAIKIGM
LGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEEAGIAVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEALD
QGNLLLASGCHALLVKGGHAPDKRNSTDILLRRGHAPERFEAPRLDSRMRGTGCALASSIAAALARGLSLEESIAFGKRK
VYHLLREADAEHPAA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=248, Percent_Identity=38.7096774193548, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325378, Length=249, Percent_Identity=31.7269076305221, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324997, Length=245, Percent_Identity=33.0612244897959, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324517, Length=245, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 26626; Mature: 26495

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSL
CCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCEEEEEEEEHHHHHCCEEEECCCCCHH
VSAQMEAALEAEPIDAIKIGMLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEE
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHH
AGIAVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEALDQGNLLLASGCHALLVKGGH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCEEEEEECCC
APDKRNSTDILLRRGHAPERFEAPRLDSRMRGTGCALASSIAAALARGLSLEESIAFGKR
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
KVYHLLREADAEHPAA
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SVRPHVLVVAGSDSSGGAGNGRDIEVLASLGVNAALAITAVTAQTHSRVAAVEPMSPSL
CCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCEEEEEEEEHHHHHCCEEEECCCCCHH
VSAQMEAALEAEPIDAIKIGMLGTSDIVEAVSTVLRRHLPIPVVLDPVLASSSGGRLMEE
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHH
AGIAVLKRELLPLCRLVTPNWLELAILAATVTAGSEEEALDQGNLLLASGCHALLVKGGH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCEEEEEECCC
APDKRNSTDILLRRGHAPERFEAPRLDSRMRGTGCALASSIAAALARGLSLEESIAFGKR
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
KVYHLLREADAEHPAA
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]