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The map label for this gene is hutU [H]

Identifier: 110634886

GI number: 110634886

Start: 2727019

End: 2728662

Strand: Reverse

Name: hutU [H]

Synonym: Meso_2545

Alternate gene names: 110634886

Gene position: 2728662-2727019 (Counterclockwise)

Preceding gene: 110634887

Following gene: 110634885

Centisome position: 61.84

GC content: 63.99

Gene sequence:

>1644_bases
GTGACCAGACCCCCTCTACCGATCCAGGCCCAGCGCGGCCCTCAGCTTCGCTGTAAGGGCTGGCGGCAGGAAGCAATCCT
GAGATTGCTCGAGAACAATCTCGAAAATGCGGAGAACCCCGCTGAGCTCGTCATCTATATGAGTTGGGCAAAGGCCGCCC
GCGACTGGAAGAGCTTTGACCAGGCCGTGGCCGCCCTCAAGGAACTCGAGATCGACCAGACGCTCGTGATGCAATCGGGC
CGGCCGGTAGGCCGCTTTCCATCGCAGAACACGACGCCCCTGGTGCTGATGGCGAACGGCAACGTCGTCGGCGCGTGGTC
TGATGACGATTCCTTCCGCGCGCTGGCTGATAAGGGCCTGACGATCAAGCCCGGCATGACGGCGGCGGCATGGCAGTATA
TCGGCAGCCAGGGCATTCTGCAGGGCACCTATGAAACCTTCTCCAGCGTCGGTAGAAAGCATTTTGGCGGTTCACTGGCC
GGTCGACTGATCGTATCCGCGGGCTGTGGCGGCATGAGCGGTGCGCAGCCGCTGGCCGGCAAACTCGCCGGAGCCGCGAT
CCTCGTGGTCGAGGCCGATGAGGGCCGGATACGCCGCCGCATCGATACAGGCTACTGCGAGCGCATGACCGCCGATCTCG
ACGAGGCGCTCGCCTGGCTGAATGAAGCCCGTGACGCACGGATCGGCTGTTCGGTGGGGCTCGTCGGCAATATCGCGGCC
GTGCTGCCTACACTCCTCGAACGCGGCATCATACCCGATGTGGTGACCGACCAGACGATGGCCGATCCGGTGAACGGCTA
TGTCCCGCTCGGCATGACCGTCGAAGAGGTTGCCGCGCTGCGCAAGAGCGCCCCCGAAATCCTCAAGCAGCGCTCCAACG
AAACGCTGCTTATTCATGTCGGCGCGATGCTCGAAATGCAGAAGCGCGGCGCGGTGGTATTCGAGTATGGCAATGCGCTG
CGCCGGTACGCCAGGGACGCCGGCCTTGATGGTTCCTTCGGCTTCGGCTCGTTTATCGACCTTTATATCCGGCCGCTCTT
TTGCGAGGGCATCGGCCCGTTCCGCTGGATCGCGGTCTCCGGCGATCCTTCGGACATCCATCGCATCGACGATCTGATCC
TGGAGATGTTCCCGTCCGACCACCGCATCGTCAGCTGGATCAGGATGGCGCGCGAGCATGTCAAGTTCACAGGCCTGCCG
GCGCGAATTGGTTGGCTGGGCCTGGGCGAGCGCAAGAGGCTGGCCCTGGCCGTGAACGACCTGGTGGCCAAGGGTGCGCT
GGCGGGGCCAATCGCCTTCACGCGAGACCACCTCGATTCCGGTTCAGCGACGTTGCCTTACCGCGAGACGGAAAACATGC
TGGACGGCTCCGACGCGATTTCCGACTGGCCGTTGCTCAACGCCTTGCTGAACTGCGCTTCGGGAGCCGACCTGATTGCG
CTGCACTCGGGCGGCAGTGCGATGCAATCGGCGGGGGTGACTACCGTCGCCACTGGCACGGCCGAGGATGCAGCCCGGCT
GGCCAGGGTGATGGACAACGACACCGCCATTGGTGTGTTGCGCCATGCCTCGGCCGGCTACGAAACAGCGAAGCAGCTGG
CGCGCGAGACCGGGATCGGCATAGCGGAGCAGCTTCAGACCTGA

Upstream 100 bases:

>100_bases
GCAATGCGCCGCAGGCGCCGGAGTGCTGCTGGAAGCGTTGATCCGCATCGACGCAGCACTGGAACATTGAGTTGGCTTGT
ATGGCTGCAAGGAGGTTCGC

Downstream 100 bases:

>100_bases
TCGCCGGCCGCGTCTGCCGGGGGGTTTCCAACGAAAGGACTTCAAACAGCATGAGCGATTTCGACGTCGTCGTGACTGGA
CGTGTGGTTACGACGGACCG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTRPPLPIQAQRGPQLRCKGWRQEAILRLLENNLENAENPAELVIYMSWAKAARDWKSFDQAVAALKELEIDQTLVMQSG
RPVGRFPSQNTTPLVLMANGNVVGAWSDDDSFRALADKGLTIKPGMTAAAWQYIGSQGILQGTYETFSSVGRKHFGGSLA
GRLIVSAGCGGMSGAQPLAGKLAGAAILVVEADEGRIRRRIDTGYCERMTADLDEALAWLNEARDARIGCSVGLVGNIAA
VLPTLLERGIIPDVVTDQTMADPVNGYVPLGMTVEEVAALRKSAPEILKQRSNETLLIHVGAMLEMQKRGAVVFEYGNAL
RRYARDAGLDGSFGFGSFIDLYIRPLFCEGIGPFRWIAVSGDPSDIHRIDDLILEMFPSDHRIVSWIRMAREHVKFTGLP
ARIGWLGLGERKRLALAVNDLVAKGALAGPIAFTRDHLDSGSATLPYRETENMLDGSDAISDWPLLNALLNCASGADLIA
LHSGGSAMQSAGVTTVATGTAEDAARLARVMDNDTAIGVLRHASAGYETAKQLARETGIGIAEQLQT

Sequences:

>Translated_547_residues
MTRPPLPIQAQRGPQLRCKGWRQEAILRLLENNLENAENPAELVIYMSWAKAARDWKSFDQAVAALKELEIDQTLVMQSG
RPVGRFPSQNTTPLVLMANGNVVGAWSDDDSFRALADKGLTIKPGMTAAAWQYIGSQGILQGTYETFSSVGRKHFGGSLA
GRLIVSAGCGGMSGAQPLAGKLAGAAILVVEADEGRIRRRIDTGYCERMTADLDEALAWLNEARDARIGCSVGLVGNIAA
VLPTLLERGIIPDVVTDQTMADPVNGYVPLGMTVEEVAALRKSAPEILKQRSNETLLIHVGAMLEMQKRGAVVFEYGNAL
RRYARDAGLDGSFGFGSFIDLYIRPLFCEGIGPFRWIAVSGDPSDIHRIDDLILEMFPSDHRIVSWIRMAREHVKFTGLP
ARIGWLGLGERKRLALAVNDLVAKGALAGPIAFTRDHLDSGSATLPYRETENMLDGSDAISDWPLLNALLNCASGADLIA
LHSGGSAMQSAGVTTVATGTAEDAARLARVMDNDTAIGVLRHASAGYETAKQLARETGIGIAEQLQT
>Mature_546_residues
TRPPLPIQAQRGPQLRCKGWRQEAILRLLENNLENAENPAELVIYMSWAKAARDWKSFDQAVAALKELEIDQTLVMQSGR
PVGRFPSQNTTPLVLMANGNVVGAWSDDDSFRALADKGLTIKPGMTAAAWQYIGSQGILQGTYETFSSVGRKHFGGSLAG
RLIVSAGCGGMSGAQPLAGKLAGAAILVVEADEGRIRRRIDTGYCERMTADLDEALAWLNEARDARIGCSVGLVGNIAAV
LPTLLERGIIPDVVTDQTMADPVNGYVPLGMTVEEVAALRKSAPEILKQRSNETLLIHVGAMLEMQKRGAVVFEYGNALR
RYARDAGLDGSFGFGSFIDLYIRPLFCEGIGPFRWIAVSGDPSDIHRIDDLILEMFPSDHRIVSWIRMAREHVKFTGLPA
RIGWLGLGERKRLALAVNDLVAKGALAGPIAFTRDHLDSGSATLPYRETENMLDGSDAISDWPLLNALLNCASGADLIAL
HSGGSAMQSAGVTTVATGTAEDAARLARVMDNDTAIGVLRHASAGYETAKQLARETGIGIAEQLQT

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=569, Percent_Identity=31.4586994727592, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI260306182, Length=629, Percent_Identity=28.7758346581876, Blast_Score=238, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71997891, Length=539, Percent_Identity=30.9833024118738, Blast_Score=250, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 58862; Mature: 58731

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPPLPIQAQRGPQLRCKGWRQEAILRLLENNLENAENPAELVIYMSWAKAARDWKSFD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHH
QAVAALKELEIDQTLVMQSGRPVGRFPSQNTTPLVLMANGNVVGAWSDDDSFRALADKGL
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHCCCC
TIKPGMTAAAWQYIGSQGILQGTYETFSSVGRKHFGGSLAGRLIVSAGCGGMSGAQPLAG
EECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCCCHHH
KLAGAAILVVEADEGRIRRRIDTGYCERMTADLDEALAWLNEARDARIGCSVGLVGNIAA
HCCCEEEEEEECCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VLPTLLERGIIPDVVTDQTMADPVNGYVPLGMTVEEVAALRKSAPEILKQRSNETLLIHV
HHHHHHHCCCCCCHHCCCHHCCCCCCCEECCCCHHHHHHHHHCCHHHHHHCCCCEEEEEE
GAMLEMQKRGAVVFEYGNALRRYARDAGLDGSFGFGSFIDLYIRPLFCEGIGPFRWIAVS
CHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
GDPSDIHRIDDLILEMFPSDHRIVSWIRMAREHVKFTGLPARIGWLGLGERKRLALAVND
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHCCEECCCCCCCHHHHHHH
LVAKGALAGPIAFTRDHLDSGSATLPYRETENMLDGSDAISDWPLLNALLNCASGADLIA
HHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEE
LHSGGSAMQSAGVTTVATGTAEDAARLARVMDNDTAIGVLRHASAGYETAKQLARETGIG
EECCCCHHHHCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCC
IAEQLQT
HHHHHCC
>Mature Secondary Structure 
TRPPLPIQAQRGPQLRCKGWRQEAILRLLENNLENAENPAELVIYMSWAKAARDWKSFD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHH
QAVAALKELEIDQTLVMQSGRPVGRFPSQNTTPLVLMANGNVVGAWSDDDSFRALADKGL
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHCCCC
TIKPGMTAAAWQYIGSQGILQGTYETFSSVGRKHFGGSLAGRLIVSAGCGGMSGAQPLAG
EECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCCCHHH
KLAGAAILVVEADEGRIRRRIDTGYCERMTADLDEALAWLNEARDARIGCSVGLVGNIAA
HCCCEEEEEEECCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VLPTLLERGIIPDVVTDQTMADPVNGYVPLGMTVEEVAALRKSAPEILKQRSNETLLIHV
HHHHHHHCCCCCCHHCCCHHCCCCCCCEECCCCHHHHHHHHHCCHHHHHHCCCCEEEEEE
GAMLEMQKRGAVVFEYGNALRRYARDAGLDGSFGFGSFIDLYIRPLFCEGIGPFRWIAVS
CHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
GDPSDIHRIDDLILEMFPSDHRIVSWIRMAREHVKFTGLPARIGWLGLGERKRLALAVND
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHCCEECCCCCCCHHHHHHH
LVAKGALAGPIAFTRDHLDSGSATLPYRETENMLDGSDAISDWPLLNALLNCASGADLIA
HHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEE
LHSGGSAMQSAGVTTVATGTAEDAARLARVMDNDTAIGVLRHASAGYETAKQLARETGIG
EECCCCHHHHCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCC
IAEQLQT
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA