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The map label for this gene is garR [H]

Identifier: 110634857

GI number: 110634857

Start: 2694819

End: 2695697

Strand: Reverse

Name: garR [H]

Synonym: Meso_2516

Alternate gene names: 110634857

Gene position: 2695697-2694819 (Counterclockwise)

Preceding gene: 110634858

Following gene: 110634856

Centisome position: 61.09

GC content: 62.23

Gene sequence:

>879_bases
TTGCCCGCGCTCGCCTTCATCGGAGCCGGGGTTATGGGGCGGCCCATGATTGCGAATCTTCGCAAAGCCGGCTTCGCCCT
CAAGGCATACGACCGGAGCCCTGCGGCGCTGGAAAACCTGCGCAGCGACGGCGTCACTGTCGCGGATAGCCTGGCGGCGG
CGGTTGCCGGTGCGGACGTGGTGGTGACGATGCTTCCGGATACGCCGCACGTACAAAGCGTTCTGCTCGGCGAGGATGGG
ATCGGAACGTTGCTGCCCACCGGAACCCTCGTTATCGACATGAGTACGATCTCGGCCTCCGGGATCCGCGCCATCGGGCA
GGATCTGGCCAGTCGGGGTGTGGATCTAGTGGATGCCCCGGTCAGCGGCGGCGTAAGAGGCGCGATCGCGGGAGAGCTGT
CAATCATGTGCGGCGGCTCCCCTGAGGCGTTCGCCAAGGCACGGCCAGTGCTCGAGGGGATGGGAACCACCATCATTCAT
GCGGGCGACCTGGGGATGGGCCAGGTGTTCAAGATGTGCAACCAGCTTATGGTGGGGGTGCATATTCAAGCCATGTGCGA
AGCCTTTGCGCTCTGCCGCGCGCAGGGAGGTGATCTGAACCTTCTGCGGGAAACACTAATGGGCGGTGCAGCCGGGTCGT
GGATGCTCGAAAATCTCGGGCCTCAGGTAATTGCCAAAGATGATTCCGCAGGGTTCCGCATTGACCTGCAGCTCAAGGAT
CTTCGTCTGGCGGGAGAGGCGGCATTCGAGAAGGGCCTGCCCCTTCCGGGCCTTGCAATGGCAACGTCACTTTATCTCGA
AGCACGTGCACATGGCGAAGGATCGAACGGCAACCAGGCCATGTTCCGTACCTATGACCGTCTTACCAACCAGGCATGA

Upstream 100 bases:

>100_bases
TCATCATTCCCGTGTCGGCCGCACTGTCGATCCTCTTTATCCTCGAAAACCAACTAACAAGTACGAAAGCACCAACATGA
CAGAACCCGAGGTCAGTTCA

Downstream 100 bases:

>100_bases
TCGCCGGACCGCGGCCCCCAACAATTTCGACAGGAATTTCGCATGAAAATCATTATTGGCTCAGATCACGCAGGTTATCC
TCTCAAGGCCGATATCATCT

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MPALAFIGAGVMGRPMIANLRKAGFALKAYDRSPAALENLRSDGVTVADSLAAAVAGADVVVTMLPDTPHVQSVLLGEDG
IGTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVDAPVSGGVRGAIAGELSIMCGGSPEAFAKARPVLEGMGTTIIH
AGDLGMGQVFKMCNQLMVGVHIQAMCEAFALCRAQGGDLNLLRETLMGGAAGSWMLENLGPQVIAKDDSAGFRIDLQLKD
LRLAGEAAFEKGLPLPGLAMATSLYLEARAHGEGSNGNQAMFRTYDRLTNQA

Sequences:

>Translated_292_residues
MPALAFIGAGVMGRPMIANLRKAGFALKAYDRSPAALENLRSDGVTVADSLAAAVAGADVVVTMLPDTPHVQSVLLGEDG
IGTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVDAPVSGGVRGAIAGELSIMCGGSPEAFAKARPVLEGMGTTIIH
AGDLGMGQVFKMCNQLMVGVHIQAMCEAFALCRAQGGDLNLLRETLMGGAAGSWMLENLGPQVIAKDDSAGFRIDLQLKD
LRLAGEAAFEKGLPLPGLAMATSLYLEARAHGEGSNGNQAMFRTYDRLTNQA
>Mature_291_residues
PALAFIGAGVMGRPMIANLRKAGFALKAYDRSPAALENLRSDGVTVADSLAAAVAGADVVVTMLPDTPHVQSVLLGEDGI
GTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVDAPVSGGVRGAIAGELSIMCGGSPEAFAKARPVLEGMGTTIIHA
GDLGMGQVFKMCNQLMVGVHIQAMCEAFALCRAQGGDLNLLRETLMGGAAGSWMLENLGPQVIAKDDSAGFRIDLQLKDL
RLAGEAAFEKGLPLPGLAMATSLYLEARAHGEGSNGNQAMFRTYDRLTNQA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=287, Percent_Identity=31.7073170731707, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=24.468085106383, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI145693186, Length=283, Percent_Identity=39.5759717314488, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=36.4583333333333, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=36.140350877193, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=31.1188811188811, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788341, Length=279, Percent_Identity=24.3727598566308, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17557316, Length=273, Percent_Identity=33.6996336996337, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24655230, Length=297, Percent_Identity=32.3232323232323, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19922568, Length=297, Percent_Identity=32.3232323232323, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30108; Mature: 29977

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALAFIGAGVMGRPMIANLRKAGFALKAYDRSPAALENLRSDGVTVADSLAAAVAGADV
CCCHHHHCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHCCCCE
VVTMLPDTPHVQSVLLGEDGIGTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVDAP
EEEECCCCCCHHEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECC
VSGGVRGAIAGELSIMCGGSPEAFAKARPVLEGMGTTIIHAGDLGMGQVFKMCNQLMVGV
CCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
HIQAMCEAFALCRAQGGDLNLLRETLMGGAAGSWMLENLGPQVIAKDDSAGFRIDLQLKD
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCEEEEEEEEC
LRLAGEAAFEKGLPLPGLAMATSLYLEARAHGEGSNGNQAMFRTYDRLTNQA
EEHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PALAFIGAGVMGRPMIANLRKAGFALKAYDRSPAALENLRSDGVTVADSLAAAVAGADV
CCHHHHCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHCCCCE
VVTMLPDTPHVQSVLLGEDGIGTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVDAP
EEEECCCCCCHHEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECC
VSGGVRGAIAGELSIMCGGSPEAFAKARPVLEGMGTTIIHAGDLGMGQVFKMCNQLMVGV
CCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
HIQAMCEAFALCRAQGGDLNLLRETLMGGAAGSWMLENLGPQVIAKDDSAGFRIDLQLKD
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCEEEEEEEEC
LRLAGEAAFEKGLPLPGLAMATSLYLEARAHGEGSNGNQAMFRTYDRLTNQA
EEHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]