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The map label for this gene is hmgA [H]

Identifier: 110634797

GI number: 110634797

Start: 2631339

End: 2632697

Strand: Direct

Name: hmgA [H]

Synonym: Meso_2456

Alternate gene names: 110634797

Gene position: 2631339-2632697 (Clockwise)

Preceding gene: 110634795

Following gene: 110634798

Centisome position: 59.63

GC content: 61.3

Gene sequence:

>1359_bases
ATGAATGTCGAGAACCTATCTTTGCAGACTCAAAAAACCGACCGGCCGGAGAGCGCTATCCAGCCAGGCTACATGTCAGG
TTTCGGCAATGGTTTTGAGACCGAAGCCCTCCCCGGCGCGCTTCCCATCGGCCGCAACTCGCCGCAGAAGTGCTCATACG
GCCTTTATGCGGAACAGCTCAGCGGATCGCCCTTCACCGCGCCGCGGACCACCAACGAGCGCTCCTGGCTCTACCGCATA
AGGCCGACCGTGACGCATTGGGGCCAGTTCCAGAAGGCCGATATCGGGCTTTGGCGAACAGCGCCAGCGCAGGAGGTCGA
GGTGCCGATCGCCCCGATGCGCTGGGACCCGATCCCGCTTCCCAGCGAAAAGGTATCATTCATAGATGGCGTGCGAACAA
TCACCACCGCCGGCGACGCGGGAACGCAGGCCGGCATGGGCGCGCATGTCTATCTCATCACCCGCTCGATGGTGGACGAA
TACTTCTACAATGCCGACGGCGAAATGCTGTTTGTGCCCCAAGAGGGCAGCCTGCGCATTTGCACCGAGTTCGGCATCAT
CGACATCGAGCCCGGTGAAATCGCGGTGATCCCCCGCGGCGTGAAGATCCGGGTGGAACTCACCGGCGGCCCCGCACGCG
GCTATCTCTGCGAGAACTACGGCGGCGCCTTCACCCTGCCCGAGCGCGGCCCCATCGGCGCCAACTGCCTGGCCAACCCG
CGCGATTTTCTGACACCCGTCGCAGCATACGAGGACAGGGACACGCCTTCCAGGATGTATGTGAAATGGGGCGGCTCTCT
CTGGACAGCCGAGATGGACCACTCGCCCCTCGATGTCGTCGCGTGGCATGGCAATTATGCGCCCTACAAATACGACCTGC
GGCGCTACTCGCCGGTGGGACCGATCCTGTACGACCATGCCGATCCGTCGATCTTCACCGTGCTCACCTCGCCCTCGGAA
ACACCCGGCACCGCCAATGTCGATTTCGTGATCTTCCCCGACCGTTGGCTTGTGACGGAAAACACCTTCCGGCCGCCGTG
GTACCACATGAACGTGATGAGCGAATTCATGGGGCTGATCTACGGCGTCTATGACGCGAAGACCGGCGGCGGCTTCGTTC
CTGGCGGCATATCCCTCCACAACACCATGCTGCCGCACGGACCCGACGTGGACGCCTTCGAAAAGGCAAGCAACGTCGAG
TTGAAGCCACATAAGCTGGAGGGCACGCTGGCATTCATGTTCGAGACGCGGTTCCCGCAGAAGGTGACGGCCTTTGCCGC
CCAAACAGAAGCGTTCCAAAAGGACTATGGAGCTTACGGCCATAAGCTCAAGAAGCACTTCAATCCGAACGAGCGATAG

Upstream 100 bases:

>100_bases
GAGACGGTAGGGCAGGAACTGTTCGAGATGAAGCTTGGCCATCATGTTGATAGTTACAAAAACGACAGTTACATTTGCAA
CAAAGTTAGGAGAACCCATC

Downstream 100 bases:

>100_bases
GCTTCGAATAGCCACTGCGGCCTAGAGCCCGCGGCTTCATCTTGTTAATGTTCTGCGTTCGCCGGAACAAACATGGATGG
AAAGCTCGGATTCGATGCCG

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MNVENLSLQTQKTDRPESAIQPGYMSGFGNGFETEALPGALPIGRNSPQKCSYGLYAEQLSGSPFTAPRTTNERSWLYRI
RPTVTHWGQFQKADIGLWRTAPAQEVEVPIAPMRWDPIPLPSEKVSFIDGVRTITTAGDAGTQAGMGAHVYLITRSMVDE
YFYNADGEMLFVPQEGSLRICTEFGIIDIEPGEIAVIPRGVKIRVELTGGPARGYLCENYGGAFTLPERGPIGANCLANP
RDFLTPVAAYEDRDTPSRMYVKWGGSLWTAEMDHSPLDVVAWHGNYAPYKYDLRRYSPVGPILYDHADPSIFTVLTSPSE
TPGTANVDFVIFPDRWLVTENTFRPPWYHMNVMSEFMGLIYGVYDAKTGGGFVPGGISLHNTMLPHGPDVDAFEKASNVE
LKPHKLEGTLAFMFETRFPQKVTAFAAQTEAFQKDYGAYGHKLKKHFNPNER

Sequences:

>Translated_452_residues
MNVENLSLQTQKTDRPESAIQPGYMSGFGNGFETEALPGALPIGRNSPQKCSYGLYAEQLSGSPFTAPRTTNERSWLYRI
RPTVTHWGQFQKADIGLWRTAPAQEVEVPIAPMRWDPIPLPSEKVSFIDGVRTITTAGDAGTQAGMGAHVYLITRSMVDE
YFYNADGEMLFVPQEGSLRICTEFGIIDIEPGEIAVIPRGVKIRVELTGGPARGYLCENYGGAFTLPERGPIGANCLANP
RDFLTPVAAYEDRDTPSRMYVKWGGSLWTAEMDHSPLDVVAWHGNYAPYKYDLRRYSPVGPILYDHADPSIFTVLTSPSE
TPGTANVDFVIFPDRWLVTENTFRPPWYHMNVMSEFMGLIYGVYDAKTGGGFVPGGISLHNTMLPHGPDVDAFEKASNVE
LKPHKLEGTLAFMFETRFPQKVTAFAAQTEAFQKDYGAYGHKLKKHFNPNER
>Mature_452_residues
MNVENLSLQTQKTDRPESAIQPGYMSGFGNGFETEALPGALPIGRNSPQKCSYGLYAEQLSGSPFTAPRTTNERSWLYRI
RPTVTHWGQFQKADIGLWRTAPAQEVEVPIAPMRWDPIPLPSEKVSFIDGVRTITTAGDAGTQAGMGAHVYLITRSMVDE
YFYNADGEMLFVPQEGSLRICTEFGIIDIEPGEIAVIPRGVKIRVELTGGPARGYLCENYGGAFTLPERGPIGANCLANP
RDFLTPVAAYEDRDTPSRMYVKWGGSLWTAEMDHSPLDVVAWHGNYAPYKYDLRRYSPVGPILYDHADPSIFTVLTSPSE
TPGTANVDFVIFPDRWLVTENTFRPPWYHMNVMSEFMGLIYGVYDAKTGGGFVPGGISLHNTMLPHGPDVDAFEKASNVE
LKPHKLEGTLAFMFETRFPQKVTAFAAQTEAFQKDYGAYGHKLKKHFNPNER

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=438, Percent_Identity=51.5981735159817, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17507969, Length=431, Percent_Identity=51.9721577726218, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24583650, Length=436, Percent_Identity=49.3119266055046, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 50254; Mature: 50254

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVENLSLQTQKTDRPESAIQPGYMSGFGNGFETEALPGALPIGRNSPQKCSYGLYAEQL
CCCCCCEEEECCCCCCHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
SGSPFTAPRTTNERSWLYRIRPTVTHWGQFQKADIGLWRTAPAQEVEVPIAPMRWDPIPL
CCCCCCCCCCCCCCCEEEEECCCHHCCCCEEECCCCEEECCCCCCEECCCCCCCCCCCCC
PSEKVSFIDGVRTITTAGDAGTQAGMGAHVYLITRSMVDEYFYNADGEMLFVPQEGSLRI
CCHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEHHHHHHHHCCCCCCEEEEECCCCEEE
CTEFGIIDIEPGEIAVIPRGVKIRVELTGGPARGYLCENYGGAFTLPERGPIGANCLANP
EEECCEEEECCCCEEEEECCEEEEEEECCCCCCCEEEECCCCEEECCCCCCCCCCCCCCC
RDFLTPVAAYEDRDTPSRMYVKWGGSLWTAEMDHSPLDVVAWHGNYAPYKYDLRRYSPVG
HHHHCHHHHCCCCCCCCEEEEEECCEEEEEECCCCCCEEEEECCCCCCEEEEHHHCCCCC
PILYDHADPSIFTVLTSPSETPGTANVDFVIFPDRWLVTENTFRPPWYHMNVMSEFMGLI
CEEEECCCCCEEEEEECCCCCCCCCCEEEEEECCEEEEECCCCCCCEEEHHHHHHHHHHH
YGVYDAKTGGGFVPGGISLHNTMLPHGPDVDAFEKASNVELKPHKLEGTLAFMFETRFPQ
HHHEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCEECCCEEEEEEECCCCH
KVTAFAAQTEAFQKDYGAYGHKLKKHFNPNER
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNVENLSLQTQKTDRPESAIQPGYMSGFGNGFETEALPGALPIGRNSPQKCSYGLYAEQL
CCCCCCEEEECCCCCCHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
SGSPFTAPRTTNERSWLYRIRPTVTHWGQFQKADIGLWRTAPAQEVEVPIAPMRWDPIPL
CCCCCCCCCCCCCCCEEEEECCCHHCCCCEEECCCCEEECCCCCCEECCCCCCCCCCCCC
PSEKVSFIDGVRTITTAGDAGTQAGMGAHVYLITRSMVDEYFYNADGEMLFVPQEGSLRI
CCHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEHHHHHHHHCCCCCCEEEEECCCCEEE
CTEFGIIDIEPGEIAVIPRGVKIRVELTGGPARGYLCENYGGAFTLPERGPIGANCLANP
EEECCEEEECCCCEEEEECCEEEEEEECCCCCCCEEEECCCCEEECCCCCCCCCCCCCCC
RDFLTPVAAYEDRDTPSRMYVKWGGSLWTAEMDHSPLDVVAWHGNYAPYKYDLRRYSPVG
HHHHCHHHHCCCCCCCCEEEEEECCEEEEEECCCCCCEEEEECCCCCCEEEEHHHCCCCC
PILYDHADPSIFTVLTSPSETPGTANVDFVIFPDRWLVTENTFRPPWYHMNVMSEFMGLI
CEEEECCCCCEEEEEECCCCCCCCCCEEEEEECCEEEEECCCCCCCEEEHHHHHHHHHHH
YGVYDAKTGGGFVPGGISLHNTMLPHGPDVDAFEKASNVELKPHKLEGTLAFMFETRFPQ
HHHEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCEECCCEEEEEEECCCCH
KVTAFAAQTEAFQKDYGAYGHKLKKHFNPNER
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]