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The map label for this gene is nuoF2 [H]

Identifier: 110634769

GI number: 110634769

Start: 2603909

End: 2605582

Strand: Reverse

Name: nuoF2 [H]

Synonym: Meso_2428

Alternate gene names: 110634769

Gene position: 2605582-2603909 (Counterclockwise)

Preceding gene: 110634770

Following gene: 110634768

Centisome position: 59.05

GC content: 65.59

Gene sequence:

>1674_bases
ATGACCATGCAGGAAAGGCGGCCACGGGATCGCGGACCCAAGGGGCGGGCGCTCGACGATGCCGCTCTTGCCGAGGTCAG
GACGCTGCTTGGTACACGCGAGCGCCGGCGTGACCTGCTCATTGAGTTCCTGCACCTGATCCAGGATCGTTACGGCTGTC
TTTCGGCGCGGCATCTGCGTGCGCTGGCCGAGGAAATGCGGCTGTCTCAGGCGGAAGTCTATGAAGTGGCGACCTTCTAC
GACCACTTCGACGTGGTGAAGGAAGGAGAGGCGGCGCCGCCGGCGCTGACGATCCGGGTTTGCGATTCGGTAAGCTGCAT
GCTTGCGGGCGCCGAGACGCTCATCGCCGAGTTGCAGGCAGGCGCCGATCCGGCGGCTATCCGTATCATGCGGGCACCCT
GCATGGGGCGCTGCGCCGGGGCGCCCGCCGCCCGCGTCGGAGATCGCGAGGTTGACGGAGCGACTGCCGAGGGCCTGCTT
GGCATGGCGGCTGCCGGCGAGACGGGGGTCAAGGTGCCCGAGTATATCGGGCTCGATGCGTATCGCGGGGCAGGGGGCTA
TCAGCTCCTGCAGAAGATCCGTGAGCGCGCCGTGACCATCGACGCCGTCATAGCCATGCTGGGCGATGCAGGTCTGAGGG
GCCTTGGCGGCGCCGGTTTCCCGGCGGGCAAGAAGTGGCAGATCGTGCGCTCCTATCCCGGCCCGCGCCTGATGTCGATA
AACGGCGACGAGGGTGAGCCCGGCACCTTCAAGGACCGGATTTATCTCGAACGTGATCCCCACCGTACCTTTGAGGGCGC
GCTGATCGCCGCGTATGCGGTGGAGGCCGAGCGGATCTATTTCTACATGCGCGACGAATATCCGGCGGTGCTGGCCATCC
TGCGCGCCGAGATCGCCGCGCTCGAGGCTGCCGGCATTGTTGCGCCGGGCTTTATCGAACTGCGCCGCGGCGCCGGCGCC
TATATCTGCGGCGAGGAGAGCGCGATGCTGGAGAGCATCGAGGGGCGGCGCGGAATGCCGCGCCACAGGCCGCCCTATAT
CGCCGAGGTTGGTCTGTTCGGCCGCCCGACGCTCAACCACAATGTCGAGACGCTGTGGTGGATCCGCGACATCGTCGAGA
AGGGGCCGGACTGGTTCGCCGGCCTCGGCAAGCCGGGCCATCCGGGCGTCCGCTCCTGGTCGGTTTCCGGACGGGTGAAG
GAGCCGGGTGTAAAGCTCGCACCTGCTGGTGTCACTGCGCGTGGGCTGATCGAGGACTATTGCGGCGGCATGGCAGATGG
CCACGAGTTCAAGGCCTATCTTCCCGGCGGGGCCTCCGGTGGTATCCTGCCTGCCGCGCTGGGCGACATCCCGCTCGATT
TCGGCGGCGAACTCGCCAAGCAGGGCTCCTTTGTCGGATCGCATGCGGTCGTGGTGTTCTCGCAGGCGGATAACCTCAAG
GACGTGACCCTCAATCTCATGAACTTCTTCAAACATGAGAGCTGCGGGAAGTGCACGCCTTGCCGGGAGGGAACCGAAAA
GATGGTCACGCTCCTTAAAGAGCCAGGCCCGCTGCGCGAAACCGCGATACGTGACCTGGAAACGGTCATGCGCGACTCAT
CGATCTGCGGCCTCGGCCAGGCCGCGCCCAACCCGGTCAATCACCTCCTGACCCATTTCTGGGATGATCTTTGA

Upstream 100 bases:

>100_bases
GCTCTCGCTGCCGGTGCAGGGAATCATCGTGCCTGATATTCAGCATGCTCGCCCGCTGCAATTGTCGTAAACAGCAACGT
CTTGTTCGGGAGGTGAGGGC

Downstream 100 bases:

>100_bases
TGGCAAACGGCATCACTTTCACGCTCGATGGGAAAACTGTCACCGCCGGTGAGGAGGAGACCATTTGGGACGTCGCCAAG
CGCGAAGGCACGAAGATCCC

Product: respiratory-chain NADH dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MTMQERRPRDRGPKGRALDDAALAEVRTLLGTRERRRDLLIEFLHLIQDRYGCLSARHLRALAEEMRLSQAEVYEVATFY
DHFDVVKEGEAAPPALTIRVCDSVSCMLAGAETLIAELQAGADPAAIRIMRAPCMGRCAGAPAARVGDREVDGATAEGLL
GMAAAGETGVKVPEYIGLDAYRGAGGYQLLQKIRERAVTIDAVIAMLGDAGLRGLGGAGFPAGKKWQIVRSYPGPRLMSI
NGDEGEPGTFKDRIYLERDPHRTFEGALIAAYAVEAERIYFYMRDEYPAVLAILRAEIAALEAAGIVAPGFIELRRGAGA
YICGEESAMLESIEGRRGMPRHRPPYIAEVGLFGRPTLNHNVETLWWIRDIVEKGPDWFAGLGKPGHPGVRSWSVSGRVK
EPGVKLAPAGVTARGLIEDYCGGMADGHEFKAYLPGGASGGILPAALGDIPLDFGGELAKQGSFVGSHAVVVFSQADNLK
DVTLNLMNFFKHESCGKCTPCREGTEKMVTLLKEPGPLRETAIRDLETVMRDSSICGLGQAAPNPVNHLLTHFWDDL

Sequences:

>Translated_557_residues
MTMQERRPRDRGPKGRALDDAALAEVRTLLGTRERRRDLLIEFLHLIQDRYGCLSARHLRALAEEMRLSQAEVYEVATFY
DHFDVVKEGEAAPPALTIRVCDSVSCMLAGAETLIAELQAGADPAAIRIMRAPCMGRCAGAPAARVGDREVDGATAEGLL
GMAAAGETGVKVPEYIGLDAYRGAGGYQLLQKIRERAVTIDAVIAMLGDAGLRGLGGAGFPAGKKWQIVRSYPGPRLMSI
NGDEGEPGTFKDRIYLERDPHRTFEGALIAAYAVEAERIYFYMRDEYPAVLAILRAEIAALEAAGIVAPGFIELRRGAGA
YICGEESAMLESIEGRRGMPRHRPPYIAEVGLFGRPTLNHNVETLWWIRDIVEKGPDWFAGLGKPGHPGVRSWSVSGRVK
EPGVKLAPAGVTARGLIEDYCGGMADGHEFKAYLPGGASGGILPAALGDIPLDFGGELAKQGSFVGSHAVVVFSQADNLK
DVTLNLMNFFKHESCGKCTPCREGTEKMVTLLKEPGPLRETAIRDLETVMRDSSICGLGQAAPNPVNHLLTHFWDDL
>Mature_556_residues
TMQERRPRDRGPKGRALDDAALAEVRTLLGTRERRRDLLIEFLHLIQDRYGCLSARHLRALAEEMRLSQAEVYEVATFYD
HFDVVKEGEAAPPALTIRVCDSVSCMLAGAETLIAELQAGADPAAIRIMRAPCMGRCAGAPAARVGDREVDGATAEGLLG
MAAAGETGVKVPEYIGLDAYRGAGGYQLLQKIRERAVTIDAVIAMLGDAGLRGLGGAGFPAGKKWQIVRSYPGPRLMSIN
GDEGEPGTFKDRIYLERDPHRTFEGALIAAYAVEAERIYFYMRDEYPAVLAILRAEIAALEAAGIVAPGFIELRRGAGAY
ICGEESAMLESIEGRRGMPRHRPPYIAEVGLFGRPTLNHNVETLWWIRDIVEKGPDWFAGLGKPGHPGVRSWSVSGRVKE
PGVKLAPAGVTARGLIEDYCGGMADGHEFKAYLPGGASGGILPAALGDIPLDFGGELAKQGSFVGSHAVVVFSQADNLKD
VTLNLMNFFKHESCGKCTPCREGTEKMVTLLKEPGPLRETAIRDLETVMRDSSICGLGQAAPNPVNHLLTHFWDDL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=373, Percent_Identity=36.7292225201072, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI20149568, Length=369, Percent_Identity=36.8563685636856, Blast_Score=239, Evalue=7e-63,
Organism=Escherichia coli, GI1788620, Length=401, Percent_Identity=38.6533665835411, Blast_Score=256, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17531727, Length=374, Percent_Identity=38.5026737967914, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19920794, Length=371, Percent_Identity=37.466307277628, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI45550452, Length=369, Percent_Identity=34.6883468834688, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24653819, Length=317, Percent_Identity=33.1230283911672, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653817, Length=294, Percent_Identity=31.9727891156463, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 60236; Mature: 60105

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMQERRPRDRGPKGRALDDAALAEVRTLLGTRERRRDLLIEFLHLIQDRYGCLSARHLR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAEEMRLSQAEVYEVATFYDHFDVVKEGEAAPPALTIRVCDSVSCMLAGAETLIAELQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
GADPAAIRIMRAPCMGRCAGAPAARVGDREVDGATAEGLLGMAAAGETGVKVPEYIGLDA
CCCHHHEEEECCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHCCCC
YRGAGGYQLLQKIRERAVTIDAVIAMLGDAGLRGLGGAGFPAGKKWQIVRSYPGPRLMSI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEE
NGDEGEPGTFKDRIYLERDPHRTFEGALIAAYAVEAERIYFYMRDEYPAVLAILRAEIAA
CCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHH
LEAAGIVAPGFIELRRGAGAYICGEESAMLESIEGRRGMPRHRPPYIAEVGLFGRPTLNH
HHHCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
NVETLWWIRDIVEKGPDWFAGLGKPGHPGVRSWSVSGRVKEPGVKLAPAGVTARGLIEDY
CCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHH
CGGMADGHEFKAYLPGGASGGILPAALGDIPLDFGGELAKQGSFVGSHAVVVFSQADNLK
CCCCCCCCCEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCH
DVTLNLMNFFKHESCGKCTPCREGTEKMVTLLKEPGPLRETAIRDLETVMRDSSICGLGQ
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
AAPNPVNHLLTHFWDDL
CCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TMQERRPRDRGPKGRALDDAALAEVRTLLGTRERRRDLLIEFLHLIQDRYGCLSARHLR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAEEMRLSQAEVYEVATFYDHFDVVKEGEAAPPALTIRVCDSVSCMLAGAETLIAELQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
GADPAAIRIMRAPCMGRCAGAPAARVGDREVDGATAEGLLGMAAAGETGVKVPEYIGLDA
CCCHHHEEEECCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHCCCC
YRGAGGYQLLQKIRERAVTIDAVIAMLGDAGLRGLGGAGFPAGKKWQIVRSYPGPRLMSI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEE
NGDEGEPGTFKDRIYLERDPHRTFEGALIAAYAVEAERIYFYMRDEYPAVLAILRAEIAA
CCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHH
LEAAGIVAPGFIELRRGAGAYICGEESAMLESIEGRRGMPRHRPPYIAEVGLFGRPTLNH
HHHCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
NVETLWWIRDIVEKGPDWFAGLGKPGHPGVRSWSVSGRVKEPGVKLAPAGVTARGLIEDY
CCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHH
CGGMADGHEFKAYLPGGASGGILPAALGDIPLDFGGELAKQGSFVGSHAVVVFSQADNLK
CCCCCCCCCEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCH
DVTLNLMNFFKHESCGKCTPCREGTEKMVTLLKEPGPLRETAIRDLETVMRDSSICGLGQ
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
AAPNPVNHLLTHFWDDL
CCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]