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The map label for this gene is alsR [H]

Identifier: 110634658

GI number: 110634658

Start: 2467965

End: 2468948

Strand: Direct

Name: alsR [H]

Synonym: Meso_2313

Alternate gene names: 110634658

Gene position: 2467965-2468948 (Clockwise)

Preceding gene: 110634657

Following gene: 110634670

Centisome position: 55.93

GC content: 61.08

Gene sequence:

>984_bases
ATGAGGCGCCGTCTACCCAAACAGAACAATGATCAGGTCGAGGGTAGTATCCATGCGCGCTCACCCTTGGGGTACCAGAT
TCCGCTCGTGGCACTGATGCAGGCAGCGGCGGTCGCCGAACATCTCAACTTCCGGCACGCGGCAACCGCGCTTGGTGTCA
GTCAGTCCGGCCTCAGCCAGCGCATCAGGCAGTTGGAAGAAGATCTCGGCGTGCTCCTTTTCGAGCGGCGGCATCGCGGT
GTGGCCGTTACCGAAGCGGGTGAGCACTTCCTCAGGCATATCGCGGCCGGCATTGATCAACTCGATCACGCCGTGAAGGT
GGCCGGTATGATTGCTGGCGGTGAGCTTGGCCGACTTCGCATCGGACTCGGCGGCGTTCTGATCTCCCCTGCCCTCGCTG
AACTTCTTGGACGCTTCCGAGAGTCCTATCCTCGCATTGCCGTCGAGATCACGGATGGGCAGCGCGGCGAAGTGCTGCGT
CAGATCCGCGAGAGCCAGCTCGACATCGCCTTCGTGATCGGCGGCGCAGTTGTCCCTGACTGTCATTTGAAACAGCTCTG
GATGGAGCCGCTCGTTGCAGCTCTGCCCGCGCGCCACGACCTTGCCAAGGCGCAGGAGCTGGAATGGGTGGACCTCGCCT
CCGAGACCATCCTTGTGCGACACGACAGGACGGAGCCGCAGGTGCTGAACTGCGTGCTGCACCGCTTCAATGAACACGGA
CTCCAACCAGTCATCCATCGTTTCGATGTCGGGCGGGACACGCTCATGCGGCTGGTGGCAGAGGGATACGGCATTGCACT
GGTGCCGGAATCCGCGACTGCGATCATGGTGCGAGGAGTCGAATTCCGATGCCTCGACGATGAGCCGGAATCAGTTCCCA
TCGCGGCAATCTGGTCTCCCTTCAACAGGAACGTTCCTCACCGCAATTTCCTCGAGATGATGCATCGACGCTGCCGAAAT
GGCGCACCGTCGATCAGGAATTAG

Upstream 100 bases:

>100_bases
TCGGCGGCGAGGAAACGCTTGCGGTAGCCGCGAGCTTCGACCGTCGCACTCTTGCGCGGCTGCGGGAAATGCGGAACTCC
GGCAAGCCCGCGTCCGCGTC

Downstream 100 bases:

>100_bases
CTGCGCCGGCAAGGTTCCTTCGGGCCTTTGCAAAGGCCCGATCGGTCGCCATGAAGCGTTCCAGCATGGGGACAATCAGC
TTGGCCGGGTCCAGAGCAGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MRRRLPKQNNDQVEGSIHARSPLGYQIPLVALMQAAAVAEHLNFRHAATALGVSQSGLSQRIRQLEEDLGVLLFERRHRG
VAVTEAGEHFLRHIAAGIDQLDHAVKVAGMIAGGELGRLRIGLGGVLISPALAELLGRFRESYPRIAVEITDGQRGEVLR
QIRESQLDIAFVIGGAVVPDCHLKQLWMEPLVAALPARHDLAKAQELEWVDLASETILVRHDRTEPQVLNCVLHRFNEHG
LQPVIHRFDVGRDTLMRLVAEGYGIALVPESATAIMVRGVEFRCLDDEPESVPIAAIWSPFNRNVPHRNFLEMMHRRCRN
GAPSIRN

Sequences:

>Translated_327_residues
MRRRLPKQNNDQVEGSIHARSPLGYQIPLVALMQAAAVAEHLNFRHAATALGVSQSGLSQRIRQLEEDLGVLLFERRHRG
VAVTEAGEHFLRHIAAGIDQLDHAVKVAGMIAGGELGRLRIGLGGVLISPALAELLGRFRESYPRIAVEITDGQRGEVLR
QIRESQLDIAFVIGGAVVPDCHLKQLWMEPLVAALPARHDLAKAQELEWVDLASETILVRHDRTEPQVLNCVLHRFNEHG
LQPVIHRFDVGRDTLMRLVAEGYGIALVPESATAIMVRGVEFRCLDDEPESVPIAAIWSPFNRNVPHRNFLEMMHRRCRN
GAPSIRN
>Mature_327_residues
MRRRLPKQNNDQVEGSIHARSPLGYQIPLVALMQAAAVAEHLNFRHAATALGVSQSGLSQRIRQLEEDLGVLLFERRHRG
VAVTEAGEHFLRHIAAGIDQLDHAVKVAGMIAGGELGRLRIGLGGVLISPALAELLGRFRESYPRIAVEITDGQRGEVLR
QIRESQLDIAFVIGGAVVPDCHLKQLWMEPLVAALPARHDLAKAQELEWVDLASETILVRHDRTEPQVLNCVLHRFNEHG
LQPVIHRFDVGRDTLMRLVAEGYGIALVPESATAIMVRGVEFRCLDDEPESVPIAAIWSPFNRNVPHRNFLEMMHRRCRN
GAPSIRN

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=277, Percent_Identity=28.5198555956679, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788887, Length=281, Percent_Identity=29.1814946619217, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI157672245, Length=183, Percent_Identity=30.6010928961749, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI145693105, Length=184, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=29.7297297297297, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=27.5735294117647, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790208, Length=241, Percent_Identity=28.2157676348548, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367136, Length=268, Percent_Identity=27.2388059701493, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789173, Length=165, Percent_Identity=32.1212121212121, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788748, Length=235, Percent_Identity=24.6808510638298, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=301, Percent_Identity=27.2425249169435, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787128, Length=115, Percent_Identity=33.9130434782609, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787589, Length=120, Percent_Identity=34.1666666666667, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36416; Mature: 36416

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRLPKQNNDQVEGSIHARSPLGYQIPLVALMQAAAVAEHLNFRHAATALGVSQSGLSQ
CCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RIRQLEEDLGVLLFERRHRGVAVTEAGEHFLRHIAAGIDQLDHAVKVAGMIAGGELGRLR
HHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEE
IGLGGVLISPALAELLGRFRESYPRIAVEITDGQRGEVLRQIRESQLDIAFVIGGAVVPD
EECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCC
CHLKQLWMEPLVAALPARHDLAKAQELEWVDLASETILVRHDRTEPQVLNCVLHRFNEHG
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCC
LQPVIHRFDVGRDTLMRLVAEGYGIALVPESATAIMVRGVEFRCLDDEPESVPIAAIWSP
HHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCEEEEECCEEEEECCCCCCCCEEEEECC
FNRNVPHRNFLEMMHRRCRNGAPSIRN
CCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRRRLPKQNNDQVEGSIHARSPLGYQIPLVALMQAAAVAEHLNFRHAATALGVSQSGLSQ
CCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RIRQLEEDLGVLLFERRHRGVAVTEAGEHFLRHIAAGIDQLDHAVKVAGMIAGGELGRLR
HHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEE
IGLGGVLISPALAELLGRFRESYPRIAVEITDGQRGEVLRQIRESQLDIAFVIGGAVVPD
EECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCC
CHLKQLWMEPLVAALPARHDLAKAQELEWVDLASETILVRHDRTEPQVLNCVLHRFNEHG
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCC
LQPVIHRFDVGRDTLMRLVAEGYGIALVPESATAIMVRGVEFRCLDDEPESVPIAAIWSP
HHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCEEEEECCEEEEECCCCCCCCEEEEECC
FNRNVPHRNFLEMMHRRCRNGAPSIRN
CCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]