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The map label for this gene is cpnA [H]

Identifier: 110634653

GI number: 110634653

Start: 2464098

End: 2464895

Strand: Direct

Name: cpnA [H]

Synonym: Meso_2308

Alternate gene names: 110634653

Gene position: 2464098-2464895 (Clockwise)

Preceding gene: 110634651

Following gene: 110634654

Centisome position: 55.84

GC content: 56.77

Gene sequence:

>798_bases
TTGTTCGACTTTAAAGGCAAGGTTTGCCTTGTAACTGGCGCAGGCGGGGAAATTGGCGGAGCGATAGCAGAGAAGCTGGC
TACACTTGGAGGCGCGATCTATTTCTGCGATGTTCAACTACCGCCTGCTCAAGAGCGAGCCAAGGCAATCTCCAAGGATG
CTCATTCGGCGATCGCACTGCAACTCGATGTGTCGAGCGAGGAGAGTTGGGCAAACGCCATCAATGAGGTGCTGGCGCGC
AGCGGTAAACTAGACGTGCTCGTGAACTGCGCCGGTCTCTTTGCCAAAGAGCCAAGCAGCATTCACGACATAGCCTTTGA
GGAATGGCGACGCTTGCACACTGTGAACCTAGATGGCGCCTTCCTGGGAGTACGCGCAGGCGTTCGCGCAATGCGCGAAG
GCGGTGGTGCCATTGTGAACATAGGCTCGGTTGTCAGCTTCTTCGGCGCACGCAGCGGAGTTGCCTATGGCGTAAGCAAA
TCCGCGACCCGCGGCTTAACGCTGCAGGCGGCAGCGAGTTGTCTTTTCGAAAGAATTCCGGTGAGAGTGAACGCAGTCCA
TCCGGGCTATGTGCTAACCGAATCCGCCTTGGCCGGCCTTATGGCAATTCACAAGAATCGCGAAGCCGCAATCGCTGCTT
TTGCGGCCCGAAGCCCTGCCAATCGGGTTATCCATCCTACAGACATTGCGAACAGCGTGGCATTTCTGGCGTCTGACACC
GCGAAAATGATCAACGGCGCCGAGCTATTGGTCGACGACGGCCTTTCTACGCAGATGCCTGGGAAGGCTTTCGCATGA

Upstream 100 bases:

>100_bases
TTCGCGGCCTGCGATTTAGAGCGCAATACGCACAGAATATCCTATTGCGCACACATCGGTCGATCTGCTAGGCGTTCTCG
ATCGGTCATAGGAGGAAAAA

Downstream 100 bases:

>100_bases
GCGCCCCGGAGCAGGTCTTCGTCTTCTGCGTGCTCGATGACGTAGGCACATCATCGCTCGATCGGTACGAATCCTGGCGC
CAAGCTCAGGCAGAGAAGGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MFDFKGKVCLVTGAGGEIGGAIAEKLATLGGAIYFCDVQLPPAQERAKAISKDAHSAIALQLDVSSEESWANAINEVLAR
SGKLDVLVNCAGLFAKEPSSIHDIAFEEWRRLHTVNLDGAFLGVRAGVRAMREGGGAIVNIGSVVSFFGARSGVAYGVSK
SATRGLTLQAAASCLFERIPVRVNAVHPGYVLTESALAGLMAIHKNREAAIAAFAARSPANRVIHPTDIANSVAFLASDT
AKMINGAELLVDDGLSTQMPGKAFA

Sequences:

>Translated_265_residues
MFDFKGKVCLVTGAGGEIGGAIAEKLATLGGAIYFCDVQLPPAQERAKAISKDAHSAIALQLDVSSEESWANAINEVLAR
SGKLDVLVNCAGLFAKEPSSIHDIAFEEWRRLHTVNLDGAFLGVRAGVRAMREGGGAIVNIGSVVSFFGARSGVAYGVSK
SATRGLTLQAAASCLFERIPVRVNAVHPGYVLTESALAGLMAIHKNREAAIAAFAARSPANRVIHPTDIANSVAFLASDT
AKMINGAELLVDDGLSTQMPGKAFA
>Mature_265_residues
MFDFKGKVCLVTGAGGEIGGAIAEKLATLGGAIYFCDVQLPPAQERAKAISKDAHSAIALQLDVSSEESWANAINEVLAR
SGKLDVLVNCAGLFAKEPSSIHDIAFEEWRRLHTVNLDGAFLGVRAGVRAMREGGGAIVNIGSVVSFFGARSGVAYGVSK
SATRGLTLQAAASCLFERIPVRVNAVHPGYVLTESALAGLMAIHKNREAAIAAFAARSPANRVIHPTDIANSVAFLASDT
AKMINGAELLVDDGLSTQMPGKAFA

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=30.9160305343511, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=27.3127753303965, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=27.7992277992278, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=29.0836653386454, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542939, Length=256, Percent_Identity=26.5625, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=27.5193798449612, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4758504, Length=198, Percent_Identity=30.8080808080808, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI66933014, Length=228, Percent_Identity=29.3859649122807, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI83715985, Length=180, Percent_Identity=31.1111111111111, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=29.6153846153846, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=33.203125, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=32.4324324324324, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=29.6875, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=28.2352941176471, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=30.2325581395349, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=29.8449612403101, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=30.8, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=29.3650793650794, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=32.1428571428571, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=30.5882352941176, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=275, Percent_Identity=28, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=267, Percent_Identity=30.7116104868914, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=276, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=257, Percent_Identity=26.8482490272374, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=26.9372693726937, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=28.0155642023346, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=28.7822878228782, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=28.1368821292776, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=270, Percent_Identity=27.037037037037, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=26.5917602996255, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=28.1954887218045, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=27.4809160305344, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=225, Percent_Identity=29.3333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=25.2830188679245, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=258, Percent_Identity=28.2945736434109, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571526, Length=271, Percent_Identity=32.1033210332103, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357041, Length=267, Percent_Identity=32.5842696629214, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=30.7086614173228, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI23397609, Length=269, Percent_Identity=31.5985130111524, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24644339, Length=268, Percent_Identity=31.3432835820896, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=30.46875, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644337, Length=270, Percent_Identity=30, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737361, Length=272, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21355319, Length=262, Percent_Identity=27.8625954198473, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 27607; Mature: 27607

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFKGKVCLVTGAGGEIGGAIAEKLATLGGAIYFCDVQLPPAQERAKAISKDAHSAIAL
CCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCEEEE
QLDVSSEESWANAINEVLARSGKLDVLVNCAGLFAKEPSSIHDIAFEEWRRLHTVNLDGA
EEECCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHEEECCCCH
FLGVRAGVRAMREGGGAIVNIGSVVSFFGARSGVAYGVSKSATRGLTLQAAASCLFERIP
HHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCEECCCCCCCCCEEHHHHHHHHHHHCC
VRVNAVHPGYVLTESALAGLMAIHKNREAAIAAFAARSPANRVIHPTDIANSVAFLASDT
EEEEEECCCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCH
AKMINGAELLVDDGLSTQMPGKAFA
HHHHCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MFDFKGKVCLVTGAGGEIGGAIAEKLATLGGAIYFCDVQLPPAQERAKAISKDAHSAIAL
CCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCEEEE
QLDVSSEESWANAINEVLARSGKLDVLVNCAGLFAKEPSSIHDIAFEEWRRLHTVNLDGA
EEECCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHEEECCCCH
FLGVRAGVRAMREGGGAIVNIGSVVSFFGARSGVAYGVSKSATRGLTLQAAASCLFERIP
HHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCEECCCCCCCCCEEHHHHHHHHHHHCC
VRVNAVHPGYVLTESALAGLMAIHKNREAAIAAFAARSPANRVIHPTDIANSVAFLASDT
EEEEEECCCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCH
AKMINGAELLVDDGLSTQMPGKAFA
HHHHCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]