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The map label for this gene is argF [H]

Identifier: 110634588

GI number: 110634588

Start: 2393262

End: 2394263

Strand: Reverse

Name: argF [H]

Synonym: Meso_2240

Alternate gene names: 110634588

Gene position: 2394263-2393262 (Counterclockwise)

Preceding gene: 110634589

Following gene: 110634587

Centisome position: 54.26

GC content: 61.08

Gene sequence:

>1002_bases
ATGCCTGTGAATCTCCACGGACGCAGCTTCCTGACGCTGCTCGACTTCACGCCGGACGAGATCCGGTTTCTCCTCAGGCT
CTCCGCCTCGCTGAAGCAGGCCAAATATGGCGGCTACGAACAGCAGCGCCTCAAGGGCAAGAACATCGCCCTCATCTTCG
AAAAGGATTCCACGCGCACGCGAACCGGCTTCGAGGTGGCGGCCTATGACCAGGGCGCGCATGTGACCTATCTCGGCCCC
TCGGGCACGCAGATTGGCCACAAGGAATCCATGAAGGACACGGCTCGCGTGCTCGGCCGTCTTTACGACGCGATCGAGTA
TCGCGGATTTGGGCAGGATCTTGCCGAAGAGCTCGCCTGTCATGCCGGCGTGCCGGTCTATAATGGTTTGACCGACGCGT
TCCACCCGACGCAGATACTGGCGGACTTTCTGACCATGCGCGAATACACGCGCAAGCACCTGTCGGCCGTGTCCTTTGCA
TTCCTTGGCGACGCCGGCAACAATATGGGCAACTCGCTCATGGTCGGTGCGGCGCTCATCGGCATGGACGCTCGGCTTTG
CGGACCCGAGCAGGATTGGCCCGATCCGCAGCTGGTCGACCAGTGCCGCGAAATCGCCGCTCGTACCGGGGGCAGGATCA
CGCTCACCGAGGACATCGAGAAGGCCGTGAAGGGCTGCGACTATGTCTATACGGACGTCTGGGTCTCGATGGGCGAGCCG
CAATCGGTCTGGGCCGAGCGCATCGAACGGCTGACGAAATACCGCGTCACCTCCGAGGTGATGGAGGCGACTGGGAACCC
GCATACGAAGTTCATGCACTGCCTGCCTGCATTCCATAATCGCGAGACCAAGATGGGCGAGAATATCTTCCAGGAGTTCG
GCATCGACTGCATGGAGGTGAGCGAGGAGGTGTTCGAATCCCCCGCATCGGTCGTCTTCGAACAGGCGGAAAATCGCATG
CACACGATCAAGGCCGTCCTCGTCGCGACGATCGGTGGGTAA

Upstream 100 bases:

>100_bases
GTCCCCGGCGCCGAACTTGGGCGCGGCCGCGGCGGCGGGCACTGCATGACCTGCCCGCTCATCCGTGACGCTCTGTAACC
CCTATCAAAGGCCTCGTACC

Downstream 100 bases:

>100_bases
AATGCTGGTCGTCATCGCCCTTGGCGGCAACGCGCTGCTTAAGCGCGGCGAGCCGTTCACCGCCGAGAACCAGCGCGCCA
ACGTGAAGCGCGCGGCGGCG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MPVNLHGRSFLTLLDFTPDEIRFLLRLSASLKQAKYGGYEQQRLKGKNIALIFEKDSTRTRTGFEVAAYDQGAHVTYLGP
SGTQIGHKESMKDTARVLGRLYDAIEYRGFGQDLAEELACHAGVPVYNGLTDAFHPTQILADFLTMREYTRKHLSAVSFA
FLGDAGNNMGNSLMVGAALIGMDARLCGPEQDWPDPQLVDQCREIAARTGGRITLTEDIEKAVKGCDYVYTDVWVSMGEP
QSVWAERIERLTKYRVTSEVMEATGNPHTKFMHCLPAFHNRETKMGENIFQEFGIDCMEVSEEVFESPASVVFEQAENRM
HTIKAVLVATIGG

Sequences:

>Translated_333_residues
MPVNLHGRSFLTLLDFTPDEIRFLLRLSASLKQAKYGGYEQQRLKGKNIALIFEKDSTRTRTGFEVAAYDQGAHVTYLGP
SGTQIGHKESMKDTARVLGRLYDAIEYRGFGQDLAEELACHAGVPVYNGLTDAFHPTQILADFLTMREYTRKHLSAVSFA
FLGDAGNNMGNSLMVGAALIGMDARLCGPEQDWPDPQLVDQCREIAARTGGRITLTEDIEKAVKGCDYVYTDVWVSMGEP
QSVWAERIERLTKYRVTSEVMEATGNPHTKFMHCLPAFHNRETKMGENIFQEFGIDCMEVSEEVFESPASVVFEQAENRM
HTIKAVLVATIGG
>Mature_332_residues
PVNLHGRSFLTLLDFTPDEIRFLLRLSASLKQAKYGGYEQQRLKGKNIALIFEKDSTRTRTGFEVAAYDQGAHVTYLGPS
GTQIGHKESMKDTARVLGRLYDAIEYRGFGQDLAEELACHAGVPVYNGLTDAFHPTQILADFLTMREYTRKHLSAVSFAF
LGDAGNNMGNSLMVGAALIGMDARLCGPEQDWPDPQLVDQCREIAARTGGRITLTEDIEKAVKGCDYVYTDVWVSMGEPQ
SVWAERIERLTKYRVTSEVMEATGNPHTKFMHCLPAFHNRETKMGENIFQEFGIDCMEVSEEVFESPASVVFEQAENRMH
TIKAVLVATIGG

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=330, Percent_Identity=37.5757575757576, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=61.9631901840491, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=59.8187311178248, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI48994908, Length=374, Percent_Identity=26.2032085561497, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI2367364, Length=339, Percent_Identity=26.8436578171091, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=31.7073170731707, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37134; Mature: 37002

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVNLHGRSFLTLLDFTPDEIRFLLRLSASLKQAKYGGYEQQRLKGKNIALIFEKDSTRT
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCC
RTGFEVAAYDQGAHVTYLGPSGTQIGHKESMKDTARVLGRLYDAIEYRGFGQDLAEELAC
CCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HAGVPVYNGLTDAFHPTQILADFLTMREYTRKHLSAVSFAFLGDAGNNMGNSLMVGAALI
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GMDARLCGPEQDWPDPQLVDQCREIAARTGGRITLTEDIEKAVKGCDYVYTDVWVSMGEP
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCEEHHHHHHCCCCC
QSVWAERIERLTKYRVTSEVMEATGNPHTKFMHCLPAFHNRETKMGENIFQEFGIDCMEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHH
SEEVFESPASVVFEQAENRMHTIKAVLVATIGG
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVNLHGRSFLTLLDFTPDEIRFLLRLSASLKQAKYGGYEQQRLKGKNIALIFEKDSTRT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCC
RTGFEVAAYDQGAHVTYLGPSGTQIGHKESMKDTARVLGRLYDAIEYRGFGQDLAEELAC
CCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HAGVPVYNGLTDAFHPTQILADFLTMREYTRKHLSAVSFAFLGDAGNNMGNSLMVGAALI
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GMDARLCGPEQDWPDPQLVDQCREIAARTGGRITLTEDIEKAVKGCDYVYTDVWVSMGEP
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCEEHHHHHHCCCCC
QSVWAERIERLTKYRVTSEVMEATGNPHTKFMHCLPAFHNRETKMGENIFQEFGIDCMEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHH
SEEVFESPASVVFEQAENRMHTIKAVLVATIGG
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA