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The map label for this gene is bla [H]

Identifier: 110634564

GI number: 110634564

Start: 2363072

End: 2363944

Strand: Direct

Name: bla [H]

Synonym: Meso_2215

Alternate gene names: 110634564

Gene position: 2363072-2363944 (Clockwise)

Preceding gene: 110634563

Following gene: 110634566

Centisome position: 53.55

GC content: 63.0

Gene sequence:

>873_bases
ATGATTTCCAGACGTGCCCTGCTCGCCACCTCCGCCTTTTTTACCATGGGCACGGCTTCCGTCCGAGCTTCGGCGCCGCG
ATCGCCAAGCGAGCGTCTTGCCGCATTGGAAAAGAGATCAGGCGGTCGGTTGGGCGTCGCCATTCTCGACACACGAACGG
GGCTGAAGGCGACGCATCGCGCCGATGAGCGTTTTGCCATGTGCAGCACGTTCAAGGCGCTTGCCGCAGCAGCGGTTCTG
GCGCGCGCCGATGCCGGCAAGGAGGATCTGAACCGCCGCATTTCCTACGGAAGGGAAAAACTGATCTTCTGGTCGCCGGT
AACCAAGAATCATGCGGACGGTCCGGGCATGACGCTTGCGGAGCTTTGCGAGGCGGCGGTCACCATGAGCGACAACACCG
CCGGAAATCTTCTGCTGGAGAGCTTGGGGGGGCCTAAGGGACTGACGGCGTTTTTCCGCTCCCTGGGTGATGAGGTCTCG
CGGCTGGACCGTTGGGAACCGGAACTGAACGATGTGCCGCCCGGAGACCTACGCGATACCACGACACCTGAGGCCATGCT
GGGCAGTCTTCGATCGGTCGTTCTTGGAGACGCCCTGTCGCCGAATTCCCGCCAGCGCCTGGCGGGTTGGCTGATTGGTT
GCAAAACCGGCGACAAGCGGCTGCGTGCTGGCTTTCCCGCAGGCTGGACCGTCGGGGACAAAACGGGCACGGGCAGCACC
GTGGCGAGCGATATCGCCGTCGCCTGGGCTCGCAGCGGCGCCACCCTGGTTGTTTCCGCCTATCTCGAAGCACCCCAATT
GCCGGCCCCAAAACGCGACGGAATCTTCAGGGAGATCGGCGAGATCGCCTCGGAAATGGCCGATCTGAACTAA

Upstream 100 bases:

>100_bases
AGTCGCGTTTCGCGACGGCGCTCCATCGCCCTAAATTTGCCCTGAACGCTGTTCTCTCTCCCCGGCACTTTGTCTGATTG
CACCGGAGAGGATTGTTTTC

Downstream 100 bases:

>100_bases
TGCCTGTATTGCTGGATGCGCGTAGTCCTGAGGCCCTGAAGGCCATATTCCTCAATAGACGCTTGCCAGGACAGGAATTC
CTCCACGGTGAGGCGATAGC

Product: beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MISRRALLATSAFFTMGTASVRASAPRSPSERLAALEKRSGGRLGVAILDTRTGLKATHRADERFAMCSTFKALAAAAVL
ARADAGKEDLNRRISYGREKLIFWSPVTKNHADGPGMTLAELCEAAVTMSDNTAGNLLLESLGGPKGLTAFFRSLGDEVS
RLDRWEPELNDVPPGDLRDTTTPEAMLGSLRSVVLGDALSPNSRQRLAGWLIGCKTGDKRLRAGFPAGWTVGDKTGTGST
VASDIAVAWARSGATLVVSAYLEAPQLPAPKRDGIFREIGEIASEMADLN

Sequences:

>Translated_290_residues
MISRRALLATSAFFTMGTASVRASAPRSPSERLAALEKRSGGRLGVAILDTRTGLKATHRADERFAMCSTFKALAAAAVL
ARADAGKEDLNRRISYGREKLIFWSPVTKNHADGPGMTLAELCEAAVTMSDNTAGNLLLESLGGPKGLTAFFRSLGDEVS
RLDRWEPELNDVPPGDLRDTTTPEAMLGSLRSVVLGDALSPNSRQRLAGWLIGCKTGDKRLRAGFPAGWTVGDKTGTGST
VASDIAVAWARSGATLVVSAYLEAPQLPAPKRDGIFREIGEIASEMADLN
>Mature_290_residues
MISRRALLATSAFFTMGTASVRASAPRSPSERLAALEKRSGGRLGVAILDTRTGLKATHRADERFAMCSTFKALAAAAVL
ARADAGKEDLNRRISYGREKLIFWSPVTKNHADGPGMTLAELCEAAVTMSDNTAGNLLLESLGGPKGLTAFFRSLGDEVS
RLDRWEPELNDVPPGDLRDTTTPEAMLGSLRSVVLGDALSPNSRQRLAGWLIGCKTGDKRLRAGFPAGWTVGDKTGTGST
VASDIAVAWARSGATLVVSAYLEAPQLPAPKRDGIFREIGEIASEMADLN

Specific function: Confers high levels of resitance to amoxicillin, benzylpenicillin, piperacillin, ticarcillin and cephalothin. Also hydrolyzes aztreonam at a low level. Not active against ceftazidime, cefotaxime and imipenem [H]

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 30788; Mature: 30788

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRRALLATSAFFTMGTASVRASAPRSPSERLAALEKRSGGRLGVAILDTRTGLKATHR
CCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHH
ADERFAMCSTFKALAAAAVLARADAGKEDLNRRISYGREKLIFWSPVTKNHADGPGMTLA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHH
ELCEAAVTMSDNTAGNLLLESLGGPKGLTAFFRSLGDEVSRLDRWEPELNDVPPGDLRDT
HHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TTPEAMLGSLRSVVLGDALSPNSRQRLAGWLIGCKTGDKRLRAGFPAGWTVGDKTGTGST
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCCCHHHHCCCCCCCCCCCCCCCCCH
VASDIAVAWARSGATLVVSAYLEAPQLPAPKRDGIFREIGEIASEMADLN
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISRRALLATSAFFTMGTASVRASAPRSPSERLAALEKRSGGRLGVAILDTRTGLKATHR
CCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHH
ADERFAMCSTFKALAAAAVLARADAGKEDLNRRISYGREKLIFWSPVTKNHADGPGMTLA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHH
ELCEAAVTMSDNTAGNLLLESLGGPKGLTAFFRSLGDEVSRLDRWEPELNDVPPGDLRDT
HHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TTPEAMLGSLRSVVLGDALSPNSRQRLAGWLIGCKTGDKRLRAGFPAGWTVGDKTGTGST
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCCCHHHHCCCCCCCCCCCCCCCCCH
VASDIAVAWARSGATLVVSAYLEAPQLPAPKRDGIFREIGEIASEMADLN
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA