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The map label for this gene is prs [H]

Identifier: 110634504

GI number: 110634504

Start: 2306092

End: 2307024

Strand: Direct

Name: prs [H]

Synonym: Meso_2155

Alternate gene names: 110634504

Gene position: 2306092-2307024 (Clockwise)

Preceding gene: 110634503

Following gene: 110634506

Centisome position: 52.26

GC content: 61.09

Gene sequence:

>933_bases
ATGAAGCTTTTTGCGGGCAATTCCAACCGGGTGCTGGCCGAGGCCATTGCCCGCTACCTCAACATTTCACTCGGCAAGGC
GATGGTCCGCCGTTTCGCAGATCAGGAGATCTTTGTCGAAATCCAGGAGAATGTGCGCGGCGAGGACGTTTTCGTCCTGC
AGTCCACCTCCTATCCGGCGAACGATCACCTGATGGAACTGCTCATCATGATCGACGCATTCCGCCGCTCCTCGGCCCGC
CGCATCACGGCAGTGCTTCCCTATTTCGGCTATGCGCGGCAGGACCGCCGCACTTCGGGCCGCACTCCGATCTCCGCCAA
GCTGGTGGCAAATCTGATTACCCAGGCCGGCGCCGACCGCGTGCTGACGCTTGACCTCCATGCCGGCCAGATCCAGGGGT
TCTTCGATATTCCGACGGACAATCTCTACGCGGTGCCGGTCATGGCGCGTGACGTGAAGGCCCATTACAAGCTTGAAAAC
GTGATGGTCGTTTCCCCCGATGTCGGCGGCGTCGTGCGCGCCCGCGCGCTCGCCAAGCGCATCGATGCCCCGCTCGCCAT
CGTCGACAAGCGCCGCGACCGTCCCGGCGAGTCGGAGGTGATGAACGTCATCGGCGACGTTCATGGCCGGGATTGCCTGC
TGATCGATGATATCGTCGATTCCGGCGGCACGCTCTGCAACGCTGCCGAAGCACTGATCGCCAATGGAGCGACGAGCGTT
ACGGCCTATATCACCCATGGCGTGCTCTCGGGCGGAGCCGTGGCAAGGATCACCGGTTCGAAGCTCAAGGAACTGGTGAT
AACGGACTCCATTCAGCCGACCTCGTCGGTGGAAGCCGCCCATAATATCCGCGCCATAACGATCGCCGACCTAATCGGAG
AGGCAATCTCGCGGACGGCTTCGGAAGAATCGGTTTCGAGCCTTTTCAACTAA

Upstream 100 bases:

>100_bases
GCCGCACCAAACGAAGTGTGTATCGGCTATTCGCCCTTGCAATCATTGGCAACGCCGCTAAAAGCCCGGATTGAAACGTG
GCGTCGGCCGGGATCACTCC

Downstream 100 bases:

>100_bases
GACATTACTCGATCGCCGCGCCGCGCTCGGCCAGGAGAGACCGCAGGATGGAGCGGTGGCAGCGCGCTTCATCTTCGCAA
TAGCAGCCGATCGAGAAATC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKLFAGNSNRVLAEAIARYLNISLGKAMVRRFADQEIFVEIQENVRGEDVFVLQSTSYPANDHLMELLIMIDAFRRSSAR
RITAVLPYFGYARQDRRTSGRTPISAKLVANLITQAGADRVLTLDLHAGQIQGFFDIPTDNLYAVPVMARDVKAHYKLEN
VMVVSPDVGGVVRARALAKRIDAPLAIVDKRRDRPGESEVMNVIGDVHGRDCLLIDDIVDSGGTLCNAAEALIANGATSV
TAYITHGVLSGGAVARITGSKLKELVITDSIQPTSSVEAAHNIRAITIADLIGEAISRTASEESVSSLFN

Sequences:

>Translated_310_residues
MKLFAGNSNRVLAEAIARYLNISLGKAMVRRFADQEIFVEIQENVRGEDVFVLQSTSYPANDHLMELLIMIDAFRRSSAR
RITAVLPYFGYARQDRRTSGRTPISAKLVANLITQAGADRVLTLDLHAGQIQGFFDIPTDNLYAVPVMARDVKAHYKLEN
VMVVSPDVGGVVRARALAKRIDAPLAIVDKRRDRPGESEVMNVIGDVHGRDCLLIDDIVDSGGTLCNAAEALIANGATSV
TAYITHGVLSGGAVARITGSKLKELVITDSIQPTSSVEAAHNIRAITIADLIGEAISRTASEESVSSLFN
>Mature_310_residues
MKLFAGNSNRVLAEAIARYLNISLGKAMVRRFADQEIFVEIQENVRGEDVFVLQSTSYPANDHLMELLIMIDAFRRSSAR
RITAVLPYFGYARQDRRTSGRTPISAKLVANLITQAGADRVLTLDLHAGQIQGFFDIPTDNLYAVPVMARDVKAHYKLEN
VMVVSPDVGGVVRARALAKRIDAPLAIVDKRRDRPGESEVMNVIGDVHGRDCLLIDDIVDSGGTLCNAAEALIANGATSV
TAYITHGVLSGGAVARITGSKLKELVITDSIQPTSSVEAAHNIRAITIADLIGEAISRTASEESVSSLFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=45.9807073954984, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=45.6310679611651, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.3376205787781, Blast_Score=291, Evalue=4e-79,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=45.1923076923077, Blast_Score=287, Evalue=7e-78,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=34.5029239766082, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=32.5581395348837, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI310128524, Length=141, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=141, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=141, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=141, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=54.6623794212219, Blast_Score=348, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=44.0514469453376, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=44.0514469453376, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=44.0514469453376, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.0129449838188, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=34.5132743362832, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=44.1935483870968, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=43.7299035369775, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=44.8717948717949, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=42.3469387755102, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=43.0232558139535, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=45.3376205787781, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=42.2155688622754, Blast_Score=270, Evalue=8e-73,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=31.6239316239316, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=31.6239316239316, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=31.6239316239316, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=31.6239316239316, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45552010, Length=370, Percent_Identity=31.0810810810811, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24651462, Length=370, Percent_Identity=31.0810810810811, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24651464, Length=370, Percent_Identity=31.0810810810811, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33532; Mature: 33532

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFAGNSNRVLAEAIARYLNISLGKAMVRRFADQEIFVEIQENVRGEDVFVLQSTSYPA
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHCCCCCEEEEEECCCCCC
NDHLMELLIMIDAFRRSSARRITAVLPYFGYARQDRRTSGRTPISAKLVANLITQAGADR
HHHHHHHHHHHHHHHCCCCHHEEEEHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCE
VLTLDLHAGQIQGFFDIPTDNLYAVPVMARDVKAHYKLENVMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEEEEEHHHHHHHHEEECEEEEECCCCCHHHHHHHHHHH
IDAPLAIVDKRRDRPGESEVMNVIGDVHGRDCLLIDDIVDSGGTLCNAAEALIANGATSV
HCCCEEEHHCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHCCCCCHHHHHHHHHHCCCCHH
TAYITHGVLSGGAVARITGSKLKELVITDSIQPTSSVEAAHNIRAITIADLIGEAISRTA
HHHHHHHHHCCCCEEEECHHHHHHHHEECCCCCCCHHHHHHCEEEEHHHHHHHHHHHHCC
SEESVSSLFN
CHHHHHHHCC
>Mature Secondary Structure
MKLFAGNSNRVLAEAIARYLNISLGKAMVRRFADQEIFVEIQENVRGEDVFVLQSTSYPA
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHCCCCCEEEEEECCCCCC
NDHLMELLIMIDAFRRSSARRITAVLPYFGYARQDRRTSGRTPISAKLVANLITQAGADR
HHHHHHHHHHHHHHHCCCCHHEEEEHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCE
VLTLDLHAGQIQGFFDIPTDNLYAVPVMARDVKAHYKLENVMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEEEEEHHHHHHHHEEECEEEEECCCCCHHHHHHHHHHH
IDAPLAIVDKRRDRPGESEVMNVIGDVHGRDCLLIDDIVDSGGTLCNAAEALIANGATSV
HCCCEEEHHCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHCCCCCHHHHHHHHHHCCCCHH
TAYITHGVLSGGAVARITGSKLKELVITDSIQPTSSVEAAHNIRAITIADLIGEAISRTA
HHHHHHHHHCCCCEEEECHHHHHHHHEECCCCCCCHHHHHHCEEEEHHHHHHHHHHHHCC
SEESVSSLFN
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]