Click here to switch to the map view.

The map label for this gene is ogt [H]

Identifier: 110634453

GI number: 110634453

Start: 2259985

End: 2260587

Strand: Direct

Name: ogt [H]

Synonym: Meso_2104

Alternate gene names: 110634453

Gene position: 2259985-2260587 (Clockwise)

Preceding gene: 110634451

Following gene: 110634454

Centisome position: 51.22

GC content: 62.19

Gene sequence:

>603_bases
TTGTACCCGAGACGAAGCTATTCCTTGCACCAATCGATTGCGGACTGTCGCCAGATGACCCTTCACCACATCTTTGAGAC
AGCATTCGGCTTCTGCGGCATCGCTTGGAACGAGCGGGGCATCTCCCGTTTCATGCTGCCCATGAGCGCTTCCGAAGCGG
CGGAGGAGCGCATGATGGGCCGCCTCTCCGTTTCCGGTGCGGCGCAGCCCTCAGGCTTCGCACTCGAGGCTGTCGCGGCG
GCGCAACGCTATTTTGCGGGCAGCCATGAAGACTTCTCCGCGTATCCGGTGGATCTTGACGGCATCGATGCTTTCCGGCG
CGCCATTTATCGGACGGCGCGTCAGCTAGGCTACGGGCGGACCACCACCTATGGCGGGCTTGCCGCAGACGCCGGCTTTC
CCAACGCTACACGCGAAACGGGTGTGGCACTCAGCCGCAACCCGGTCCCATTGATTATTCCCTGTCACCGGATTCTCGCC
GCCGGCGGCAAGTTGGGCGGCTTTTCAGCTCCCGGAGGGACCGCTACGAAACAAAAAATGCTCGCGCTGGAAAAAGCTGC
ATCCCCCAACGCGCCGCCGGCTCAGGCGTCCTTCGCGTTTTGA

Upstream 100 bases:

>100_bases
CGTTCACTTTGCCTCCGCGCCCCGAACCTGCATAGCCTATCAGGGAGCCCCGTTCAATTGCGTTTCACCAATACGCCAAC
GCGGGGTGTTTGTTCTTGAT

Downstream 100 bases:

>100_bases
ACAGGCTATCCACAGACTGCCTCGTCCCATCCGCTCCTTTTCTCCTTTTGCACTAACGGCTTGCACGCGAGTCCTCCCAG
GCTTAATCTTAGGTTGTGAT

Product: methylated-DNA--protein-cysteine methyltransferase

Products: NA

Alternate protein names: 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MYPRRSYSLHQSIADCRQMTLHHIFETAFGFCGIAWNERGISRFMLPMSASEAAEERMMGRLSVSGAAQPSGFALEAVAA
AQRYFAGSHEDFSAYPVDLDGIDAFRRAIYRTARQLGYGRTTTYGGLAADAGFPNATRETGVALSRNPVPLIIPCHRILA
AGGKLGGFSAPGGTATKQKMLALEKAASPNAPPAQASFAF

Sequences:

>Translated_200_residues
MYPRRSYSLHQSIADCRQMTLHHIFETAFGFCGIAWNERGISRFMLPMSASEAAEERMMGRLSVSGAAQPSGFALEAVAA
AQRYFAGSHEDFSAYPVDLDGIDAFRRAIYRTARQLGYGRTTTYGGLAADAGFPNATRETGVALSRNPVPLIIPCHRILA
AGGKLGGFSAPGGTATKQKMLALEKAASPNAPPAQASFAF
>Mature_200_residues
MYPRRSYSLHQSIADCRQMTLHHIFETAFGFCGIAWNERGISRFMLPMSASEAAEERMMGRLSVSGAAQPSGFALEAVAA
AQRYFAGSHEDFSAYPVDLDGIDAFRRAIYRTARQLGYGRTTTYGGLAADAGFPNATRETGVALSRNPVPLIIPCHRILA
AGGKLGGFSAPGGTATKQKMLALEKAASPNAPPAQASFAF

Specific function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a sui

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MGMT family [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=79, Percent_Identity=40.5063291139241, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1787596, Length=152, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01035 DNA_binding_1; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 21383; Mature: 21383

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPRRSYSLHQSIADCRQMTLHHIFETAFGFCGIAWNERGISRFMLPMSASEAAEERMMG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHCCCCCHHHHHHHHHHH
RLSVSGAAQPSGFALEAVAAAQRYFAGSHEDFSAYPVDLDGIDAFRRAIYRTARQLGYGR
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
TTTYGGLAADAGFPNATRETGVALSRNPVPLIIPCHRILAAGGKLGGFSAPGGTATKQKM
CCCCCCEECCCCCCCCCHHHCCEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHH
LALEKAASPNAPPAQASFAF
HHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MYPRRSYSLHQSIADCRQMTLHHIFETAFGFCGIAWNERGISRFMLPMSASEAAEERMMG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHCCCCCHHHHHHHHHHH
RLSVSGAAQPSGFALEAVAAAQRYFAGSHEDFSAYPVDLDGIDAFRRAIYRTARQLGYGR
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
TTTYGGLAADAGFPNATRETGVALSRNPVPLIIPCHRILAAGGKLGGFSAPGGTATKQKM
CCCCCCEECCCCCCCCCHHHCCEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHH
LALEKAASPNAPPAQASFAF
HHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]