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The map label for this gene is rutR [H]

Identifier: 110634391

GI number: 110634391

Start: 2192825

End: 2193460

Strand: Reverse

Name: rutR [H]

Synonym: Meso_2041

Alternate gene names: 110634391

Gene position: 2193460-2192825 (Counterclockwise)

Preceding gene: 110634398

Following gene: 110634390

Centisome position: 49.71

GC content: 62.11

Gene sequence:

>636_bases
ATGTCCAGGACAGGCGCCATCGTGGATGAGCCCGCCAAGCCGAAGCGGACGCGAATCCAGCGTGAAAGGCGTGAACTCAT
CCGGGAGGCGGCTCTTGAGGTTTTCTCGCAGCACGGCTTCCGCGGCTCCACGATCGACCAGATCGCCGAAGCTGCGGGTA
TGTCGAAACCGAACCTGCTCTATTACTTCAAAAGCAAGGAGGCGATCTTCGTCACCCTCATCGACCGGCTGATGGAAGCA
TGGCTGGCGCCCTTGCGGGAGATGAATGCGGACGGCGATCCAGCCACCGAAATCCGCTCCTATATCCGGCGCAAGGTCGA
GATGGCGCGCGACTTCCCGCGCGAAAGCCGGCTGTTCGCCAACGAGATCCTGCAGGGCGCGCCGCGCATCATGCCGCTGC
TCGAAGGCGAGCTGAAGGACCTGGTGGACGAGAAGGCAGAGATCATCCGCCAATGGATTCGGCAGGGGAAGCTAAGGGAG
GCCGACCCCCACCACTTCATCTTCGCCATCTGGGCCACCACCCAGCATTATGCCGATTTCGACGTGCAGGTGCGTGCCGT
GCTGGGACCGGAAAAGGGCGGGGAAAGCCGCTTCGAGGACGCGGCGGCATTTCTGGAGAAGCTGTTTTTGGGGTGA

Upstream 100 bases:

>100_bases
CCAATAGGGCGGTCAAGCGGCATTGTAAGGATTTGCACTTGCCCCCGCGCGTTCCAGTCTGTCAGATGCGACTGTGCCAG
AAGGAGGAAAAATCGGGGAA

Downstream 100 bases:

>100_bases
GATCTCCCTTCCGGAGGGGATAGATTTCTTGGTACAGCAAGAAAGATGACGAATTCGGAGGGTTGTCTCCAAGAGAGTAT
CTTAGGGGAAAAAGTTGGGA

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Rut operon repressor [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSRTGAIVDEPAKPKRTRIQRERRELIREAALEVFSQHGFRGSTIDQIAEAAGMSKPNLLYYFKSKEAIFVTLIDRLMEA
WLAPLREMNADGDPATEIRSYIRRKVEMARDFPRESRLFANEILQGAPRIMPLLEGELKDLVDEKAEIIRQWIRQGKLRE
ADPHHFIFAIWATTQHYADFDVQVRAVLGPEKGGESRFEDAAAFLEKLFLG

Sequences:

>Translated_211_residues
MSRTGAIVDEPAKPKRTRIQRERRELIREAALEVFSQHGFRGSTIDQIAEAAGMSKPNLLYYFKSKEAIFVTLIDRLMEA
WLAPLREMNADGDPATEIRSYIRRKVEMARDFPRESRLFANEILQGAPRIMPLLEGELKDLVDEKAEIIRQWIRQGKLRE
ADPHHFIFAIWATTQHYADFDVQVRAVLGPEKGGESRFEDAAAFLEKLFLG
>Mature_210_residues
SRTGAIVDEPAKPKRTRIQRERRELIREAALEVFSQHGFRGSTIDQIAEAAGMSKPNLLYYFKSKEAIFVTLIDRLMEAW
LAPLREMNADGDPATEIRSYIRRKVEMARDFPRESRLFANEILQGAPRIMPLLEGELKDLVDEKAEIIRQWIRQGKLREA
DPHHFIFAIWATTQHYADFDVQVRAVLGPEKGGESRFEDAAAFLEKLFLG

Specific function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787249, Length=196, Percent_Identity=46.9387755102041, Blast_Score=195, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR019915
- InterPro:   IPR001647
- InterPro:   IPR013573 [H]

Pfam domain/function: PF08362 TetR_C_3; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24286; Mature: 24155

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTGAIVDEPAKPKRTRIQRERRELIREAALEVFSQHGFRGSTIDQIAEAAGMSKPNLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEE
YYFKSKEAIFVTLIDRLMEAWLAPLREMNADGDPATEIRSYIRRKVEMARDFPRESRLFA
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
NEILQGAPRIMPLLEGELKDLVDEKAEIIRQWIRQGKLREADPHHFIFAIWATTQHYADF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECHHHHCCC
DVQVRAVLGPEKGGESRFEDAAAFLEKLFLG
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRTGAIVDEPAKPKRTRIQRERRELIREAALEVFSQHGFRGSTIDQIAEAAGMSKPNLL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEE
YYFKSKEAIFVTLIDRLMEAWLAPLREMNADGDPATEIRSYIRRKVEMARDFPRESRLFA
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
NEILQGAPRIMPLLEGELKDLVDEKAEIIRQWIRQGKLREADPHHFIFAIWATTQHYADF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECHHHHCCC
DVQVRAVLGPEKGGESRFEDAAAFLEKLFLG
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]