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The map label for this gene is glcD [H]

Identifier: 110634335

GI number: 110634335

Start: 2127339

End: 2128736

Strand: Reverse

Name: glcD [H]

Synonym: Meso_1985

Alternate gene names: 110634335

Gene position: 2128736-2127339 (Counterclockwise)

Preceding gene: 110634337

Following gene: 110634334

Centisome position: 48.24

GC content: 61.95

Gene sequence:

>1398_bases
ATGAACACAGCCACCATGTTGCGCAACGAGGCCGGGATTGCGGCTGTGCTGGAACGGCTTGCCGCGCGCTTCGGCCCGAA
ACTGCAGACGGGGCTCGCCATCCGCGCTCAGCACGGGCACACAGTCACCTATATTCCCACCCAGGCCCCGGACGGGGTGC
TTTACCCGCAGAACCTGCAGGAGGTGCAGGAGGCGGTCCGGATCTGCGCCGAGTTCCGCGTGCCGATCATTCCCTTCGGG
ACCGGGACGTCGCTGGAGGGCCATGTCAACGCGCCGGCGGGCGGCATTTCCTTCGATATGTCAGAAATGAAGCGCGTGCT
CGCGGTGAACCAGGAAGACCTCGATTGCACCGTGGAAGCAGGCCTCACGCGGGAAGAGCTCAACCAATATCTGAGGGATA
CCGGGCTTTTCTTTCCCATCGATCCGGGCGCCAATGCGAGCCTTGGCGGAATGGCCGCCACGCGTGCGTCCGGCACCAAC
GCCGTGCGTTACGGCACGATGCGCGAGAATGTGCTTTCGCTAACCGCGGTGCTTGCCGACGGGCGTGCCATCACGACGGC
AAGGCGGGCGCGCAAGTCCTCTGCCGGCTACGATCTTACCCGGCTCCTTGTGGGATCGGAAGGCACGCTCGGCATCATCA
CCTCGCTGACGGTGAGGCTTTACGGCATCCCGCCGGCGATTTCCGGAGGGGTTTGTCCCTTCCCGAGCGTGGAGGCGGCA
TGCAACGCCGTGATCATGACGATCCAGATGGGAATTCCGGTGGCGCGGATCGAACTGGTCAATGCGCTGGGAATGCGCGC
CATCAATGGCTATTCCAATCTCGATTATCCCGAAGGTCCATGTCTCTTCGTGGAGTTCCACGGGACGGAATCCGGTGTCC
ATGAACAGGCGGAGATGTTCGGCGAGATCGCTTCCGAGTTTTCGGGTGGTCCATTCGTCTGGACATCGGCGGCCGAGCAA
CGGCAAAAGCTTTGGAAGGCCAGGCACGACTTCCACTGGGCGAGCTTGAAGCTGCGGCCGGGAAAAAAGGCGCTGACCAC
CGATGTGTGCGTGCCGATCTCCCGCCTTGCCGAATGCATTGTCGAGACAGAGGCCGATATCGCCGAAAACGGATTGGTCG
CGCCGATCGTGGGCCATGTGGGTGACGGCAATTTTCATGTATCGATCATTATGGATACGGAAGACCCGGCCGAGATCGAG
CGCGCGCAGGCGTTTGTCGCCCGGCTCAATGCGCGGGCGCTGGCGATGGATGGCACCTGCACGGGCGAACACGGGATCGG
GCAGGGCAAAATGCGTTATCTGGAACAGGAGCACGGGGCAGGGGTTGAGATCATGCGCTCCATCAAGCAAACGCTTGACC
CGCAAGGGATCATGAATCCTGGAAAGATCCTGGCTTGA

Upstream 100 bases:

>100_bases
GGTAAACGAGCGGTTAACAAGCCGCCATTCGGGATGATACTGGACATGGCGGCAAATTGCTGAACACTGAAGGAAGGAGC
CTTCGCGGCCGGAGGAAGAC

Downstream 100 bases:

>100_bases
GTGGCACATAAGCTGACGGCCTGGTGAAATTGTGGCTATGGCGCTCTCGGCAAGCCCCAAGACAGGGAAGGGGAGGTAGG
ACTGGCGCGGCTGTTCGTGA

Product: FAD linked oxidase-like

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNTATMLRNEAGIAAVLERLAARFGPKLQTGLAIRAQHGHTVTYIPTQAPDGVLYPQNLQEVQEAVRICAEFRVPIIPFG
TGTSLEGHVNAPAGGISFDMSEMKRVLAVNQEDLDCTVEAGLTREELNQYLRDTGLFFPIDPGANASLGGMAATRASGTN
AVRYGTMRENVLSLTAVLADGRAITTARRARKSSAGYDLTRLLVGSEGTLGIITSLTVRLYGIPPAISGGVCPFPSVEAA
CNAVIMTIQMGIPVARIELVNALGMRAINGYSNLDYPEGPCLFVEFHGTESGVHEQAEMFGEIASEFSGGPFVWTSAAEQ
RQKLWKARHDFHWASLKLRPGKKALTTDVCVPISRLAECIVETEADIAENGLVAPIVGHVGDGNFHVSIIMDTEDPAEIE
RAQAFVARLNARALAMDGTCTGEHGIGQGKMRYLEQEHGAGVEIMRSIKQTLDPQGIMNPGKILA

Sequences:

>Translated_465_residues
MNTATMLRNEAGIAAVLERLAARFGPKLQTGLAIRAQHGHTVTYIPTQAPDGVLYPQNLQEVQEAVRICAEFRVPIIPFG
TGTSLEGHVNAPAGGISFDMSEMKRVLAVNQEDLDCTVEAGLTREELNQYLRDTGLFFPIDPGANASLGGMAATRASGTN
AVRYGTMRENVLSLTAVLADGRAITTARRARKSSAGYDLTRLLVGSEGTLGIITSLTVRLYGIPPAISGGVCPFPSVEAA
CNAVIMTIQMGIPVARIELVNALGMRAINGYSNLDYPEGPCLFVEFHGTESGVHEQAEMFGEIASEFSGGPFVWTSAAEQ
RQKLWKARHDFHWASLKLRPGKKALTTDVCVPISRLAECIVETEADIAENGLVAPIVGHVGDGNFHVSIIMDTEDPAEIE
RAQAFVARLNARALAMDGTCTGEHGIGQGKMRYLEQEHGAGVEIMRSIKQTLDPQGIMNPGKILA
>Mature_465_residues
MNTATMLRNEAGIAAVLERLAARFGPKLQTGLAIRAQHGHTVTYIPTQAPDGVLYPQNLQEVQEAVRICAEFRVPIIPFG
TGTSLEGHVNAPAGGISFDMSEMKRVLAVNQEDLDCTVEAGLTREELNQYLRDTGLFFPIDPGANASLGGMAATRASGTN
AVRYGTMRENVLSLTAVLADGRAITTARRARKSSAGYDLTRLLVGSEGTLGIITSLTVRLYGIPPAISGGVCPFPSVEAA
CNAVIMTIQMGIPVARIELVNALGMRAINGYSNLDYPEGPCLFVEFHGTESGVHEQAEMFGEIASEFSGGPFVWTSAAEQ
RQKLWKARHDFHWASLKLRPGKKALTTDVCVPISRLAECIVETEADIAENGLVAPIVGHVGDGNFHVSIIMDTEDPAEIE
RAQAFVARLNARALAMDGTCTGEHGIGQGKMRYLEQEHGAGVEIMRSIKQTLDPQGIMNPGKILA

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=444, Percent_Identity=51.8018018018018, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI37595754, Length=467, Percent_Identity=49.2505353319058, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI119964728, Length=428, Percent_Identity=29.6728971962617, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4501993, Length=219, Percent_Identity=32.8767123287671, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1789351, Length=416, Percent_Identity=29.0865384615385, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1787977, Length=496, Percent_Identity=27.4193548387097, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI48994907, Length=458, Percent_Identity=22.0524017467249, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI48994914, Length=267, Percent_Identity=23.2209737827715, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=442, Percent_Identity=46.606334841629, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71992381, Length=442, Percent_Identity=45.0226244343891, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71992392, Length=376, Percent_Identity=49.2021276595745, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17534361, Length=427, Percent_Identity=24.824355971897, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17556096, Length=493, Percent_Identity=23.7322515212982, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320027, Length=483, Percent_Identity=39.1304347826087, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6320023, Length=434, Percent_Identity=26.4976958525346, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320764, Length=438, Percent_Identity=25.3424657534247, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18921117, Length=423, Percent_Identity=27.1867612293144, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24639277, Length=423, Percent_Identity=27.1867612293144, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24639275, Length=423, Percent_Identity=27.1867612293144, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653753, Length=477, Percent_Identity=24.3186582809224, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 49826; Mature: 49826

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTATMLRNEAGIAAVLERLAARFGPKLQTGLAIRAQHGHTVTYIPTQAPDGVLYPQNLQ
CCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHH
EVQEAVRICAEFRVPIIPFGTGTSLEGHVNAPAGGISFDMSEMKRVLAVNQEDLDCTVEA
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCCCEEEEC
GLTREELNQYLRDTGLFFPIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVLAD
CCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCEEEECHHHHHHHHHHHHHHC
GRAITTARRARKSSAGYDLTRLLVGSEGTLGIITSLTVRLYGIPPAISGGVCPFPSVEAA
CCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCHHHH
CNAVIMTIQMGIPVARIELVNALGMRAINGYSNLDYPEGPCLFVEFHGTESGVHEQAEMF
HCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
GEIASEFSGGPFVWTSAAEQRQKLWKARHDFHWASLKLRPGKKALTTDVCVPISRLAECI
HHHHHHCCCCCEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VETEADIAENGLVAPIVGHVGDGNFHVSIIMDTEDPAEIERAQAFVARLNARALAMDGTC
HHCCCHHHHCCCEEEHEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCC
TGEHGIGQGKMRYLEQEHGAGVEIMRSIKQTLDPQGIMNPGKILA
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTATMLRNEAGIAAVLERLAARFGPKLQTGLAIRAQHGHTVTYIPTQAPDGVLYPQNLQ
CCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHH
EVQEAVRICAEFRVPIIPFGTGTSLEGHVNAPAGGISFDMSEMKRVLAVNQEDLDCTVEA
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCCCEEEEC
GLTREELNQYLRDTGLFFPIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVLAD
CCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCEEEECHHHHHHHHHHHHHHC
GRAITTARRARKSSAGYDLTRLLVGSEGTLGIITSLTVRLYGIPPAISGGVCPFPSVEAA
CCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCHHHH
CNAVIMTIQMGIPVARIELVNALGMRAINGYSNLDYPEGPCLFVEFHGTESGVHEQAEMF
HCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
GEIASEFSGGPFVWTSAAEQRQKLWKARHDFHWASLKLRPGKKALTTDVCVPISRLAECI
HHHHHHCCCCCEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VETEADIAENGLVAPIVGHVGDGNFHVSIIMDTEDPAEIERAQAFVARLNARALAMDGTC
HHCCCHHHHCCCEEEHEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCC
TGEHGIGQGKMRYLEQEHGAGVEIMRSIKQTLDPQGIMNPGKILA
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]