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The map label for this gene is moaE [H]

Identifier: 110634328

GI number: 110634328

Start: 2119719

End: 2120183

Strand: Direct

Name: moaE [H]

Synonym: Meso_1978

Alternate gene names: 110634328

Gene position: 2119719-2120183 (Clockwise)

Preceding gene: 110634327

Following gene: 110634330

Centisome position: 48.04

GC content: 58.92

Gene sequence:

>465_bases
ATGGGCTGCGAGCCCCATATTCGCGTGCAGGCGGAGGATTTCGATCTCGCCGTTGAAATCGATCGGCTGACGGATGGCCG
CAGGGATGTGGGTGCGGTCGTCACCTTCACCGGAAAATGCCGCGATGAAGGCGGTCGCTTGGCAGCACTGGAGCTTGAAC
ACTATCCCGGCATGGCTGAAGCCGAAATGACCCGCATCGCCCGTCAAGCGGCAGAGCGCTGGCAGCTTTCCGGGCTGACC
GTGGTCCACCGTTACGGCAAGATCAGGCCGGGCGAAAACATCGTGCTTGTGGTAACCGCCTCGTCGCACAGGAAAGCAGC
ATTAGAGGCTGCGGATTTCCTGATGGATTATCTGAAGTCGAGAGCGCCTTTTTGGAAAAAGGAGCATCTGACGGATGCCG
GGCCAGGCCAATGGGTGGAAGCCAAGGCGGAAGACGAAAACGCCCTTGAGCGCTGGAAGAAATAA

Upstream 100 bases:

>100_bases
TGATCCGCGTGGCCATCGATCACGAGCATGCTGACCATCAAACGCGATTGCCGTTAGACGGCGAGGTGGCGCTGTTCCCG
CCTATGACGGGAGGGTGAGC

Downstream 100 bases:

>100_bases
GAAAGCCGGGCAGAGCCCGGCTTTCTGCTGAACCTACGGCAGTCAGCCGACGATTTCAGTTTCCGAGAACCAGTAACGAA
TTTCCTGCTCGGCCGTTTCC

Product: molybdopterin synthase subunit MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MGCEPHIRVQAEDFDLAVEIDRLTDGRRDVGAVVTFTGKCRDEGGRLAALELEHYPGMAEAEMTRIARQAAERWQLSGLT
VVHRYGKIRPGENIVLVVTASSHRKAALEAADFLMDYLKSRAPFWKKEHLTDAGPGQWVEAKAEDENALERWKK

Sequences:

>Translated_154_residues
MGCEPHIRVQAEDFDLAVEIDRLTDGRRDVGAVVTFTGKCRDEGGRLAALELEHYPGMAEAEMTRIARQAAERWQLSGLT
VVHRYGKIRPGENIVLVVTASSHRKAALEAADFLMDYLKSRAPFWKKEHLTDAGPGQWVEAKAEDENALERWKK
>Mature_153_residues
GCEPHIRVQAEDFDLAVEIDRLTDGRRDVGAVVTFTGKCRDEGGRLAALELEHYPGMAEAEMTRIARQAAERWQLSGLTV
VHRYGKIRPGENIVLVVTASSHRKAALEAADFLMDYLKSRAPFWKKEHLTDAGPGQWVEAKAEDENALERWKK

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=100, Percent_Identity=37, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787003, Length=152, Percent_Identity=46.0526315789474, Blast_Score=130, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17509279, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356259, Length=140, Percent_Identity=32.8571428571429, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 17331; Mature: 17200

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCEPHIRVQAEDFDLAVEIDRLTDGRRDVGAVVTFTGKCRDEGGRLAALELEHYPGMAE
CCCCCCEEEEECCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCH
AEMTRIARQAAERWQLSGLTVVHRYGKIRPGENIVLVVTASSHRKAALEAADFLMDYLKS
HHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RAPFWKKEHLTDAGPGQWVEAKAEDENALERWKK
CCCCCCHHCCCCCCCCCEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
GCEPHIRVQAEDFDLAVEIDRLTDGRRDVGAVVTFTGKCRDEGGRLAALELEHYPGMAE
CCCCCEEEEECCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCH
AEMTRIARQAAERWQLSGLTVVHRYGKIRPGENIVLVVTASSHRKAALEAADFLMDYLKS
HHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RAPFWKKEHLTDAGPGQWVEAKAEDENALERWKK
CCCCCCHHCCCCCCCCCEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]