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The map label for this gene is uvrC

Identifier: 110634325

GI number: 110634325

Start: 2116842

End: 2118803

Strand: Direct

Name: uvrC

Synonym: Meso_1975

Alternate gene names: 110634325

Gene position: 2116842-2118803 (Clockwise)

Preceding gene: 110634324

Following gene: 110634326

Centisome position: 47.97

GC content: 61.77

Gene sequence:

>1962_bases
TTGAACGCGGCAGATCTCGGCAACACGATCATAAGCGCAGAAGATTCAACCTTGGAATGGGACCGCGCCGGCACGGAAAC
GGCCGCCACAGGTGTGGAGGTGATTCAGGCCGTCGTGAAACGGCTTCCAAACGCGCCCGGCGTCTACCGCATGGTGAATA
CCGAGGGCGATGTGCTTTACGTGGGCAAGGCACGCAGCCTGAAGAAGCGGGTCACGAACTATGCCCAGGGACGTGGGCAT
TCGAACCGCATCGAGCGGATGATCCGCGAGACCGCGACGATGGAGTTCGTCGTCACGCGCACCGAGACGGAAGCGCTGCT
CCTCGAGGCCAATCTCATCAAGCGATTGCGTCCGCGCTTTAACGTGCTGATGCGGGACGACAAGTCCTTTCCGTATATCC
TGCTGACGGGGAACCATCCGGCTCCAGGCATTTTCAAGCATCGAGGTGCGCGGTCGCGCAGAGGCGATTACTTCGGGCCG
TTTGCGTCCGCTGGCGCGGTAGGACGGACGATAAACTCACTGCAAAGAGCGTTCCTGCTGCGCACTTGCACCGATTCGGT
TTTCGAAAGCCGCACGCGGCCTTGCCTTCTCTACCAGATCAAGCGCTGCTCCGGCCCCTGCACGAGAGAGATCAGCGTTG
AGGACTACGCCACGCTCGTGAAGGAGGCGAAGGACTTTCTTTCTGGCCGCTCGAGCACGGTAAAGGCGGAGATCGCCACC
GCGATGCAAGAGGCCTCTCAGGCGCTCGATTTCGAACGCGCCGCGATCTATCGCGACCGCCTTGCCGCCCTGAGCCATGT
GCAAAGCCACCAGGGCATCAATCCGCAGGGATTGGAAGAGGCGGACGTCTTTGCAATCCATCAGGAAGGCGGTCAGACCT
GCATCCAGGTCTTCTTCTTCCGTACCGGCCAGAACTGGGGCAACCGGGCCTATTTCCCGAAAGCGGACCCGGCGCTCGGC
CACGGAGAGGTGCTGGGTTCCTTCCTGGCACAGTTTTACGACGACAAGCCGTGCCCGCGATTGATCCTCCTCTCCCATCC
CGTCGAGGATCAAGACCTTTTGGCCGAAGCGCTCTCGGCCCGCGCGGGACGCAAGGTGCAGGTCTCAGTTCCGGCGCGGG
GGGAGAAGAAGGACCTGACCGATCACGCCCTGCAGAATGCGCGCGAAGCGTTGGGAAGGCGCCTTGCGGAAACATCGTCA
CAAGCGCGGCTGCTTGAGGGGCTTGCAGAGACTTTCGGCCTGGAGGCCGCGCCACGGCGGATCGAGGTCTACGACAATTC
GCACATCATGGGCACCAACGCGGTGGGCGCGATGATCGTGGCGGGTCCGGAAGGGTTTGTGAAGAACCAGTATCGAAAGT
TCAATATCCGCTCGGCGGAGATCACGCCGGGCGACGATTTCGGCATGATGCGCGAGGTGATGCAACGGCGCTTCGCCCGC
CTCATCAAAGAGCAAGGTCTGCCGGGCAATGGCAGCGAGGCAGAAGATTCCGACGCTTCCTTCCCCGCCTGGCCTGATCT
CATTTTGATCGACGGTGGCCAAGGCCAGATGTCGGCCGTCCGCCAAATACTGGACGATCTCGGCATCGCCGATCTCGTCA
CCGCCATAGGTGTCGCAAAAGGCGTTGACCGCGACGCCGGGCGCGAGCGCTTCTTCATGGAGGGCCGCCCCCCCTTTACG
CTGCCGCCGAGGGACCCCGTCCTCTATTTCGTGCAGCGGCTAAGGGATGAAGCGCACCGCTTCGCCATCGGTTCGCACCG
CGCGCGCCGCAAGAAGGAGATGGTGAAAAACCCTCTCGATGAGATTGCCGGAATCGGCCCTGGCCGAAAGCGGGCTCTTC
TTCATCACTTCGGCACCGCCAAGGCAGTCAGCCGGGCGGCGGTCGAAGACCTGATGGAGGTGGGCGGCATATCGGAATCC
ATAGCCCGGCTGATTTACAATCACTTTCATGAGAGTGGCTAG

Upstream 100 bases:

>100_bases
CGATTCGCTATCTATGGGAGACACCCTCCATCACTGGGCAGATGATTGCCCTCGATGGCGGGAAGCATCTCACATGGAAC
GACTTAAGTGGAGACGCGTC

Downstream 100 bases:

>100_bases
TGACCAGCCGCTTGACCGCGGTCTACCTGGTCTGATTTGACTAGGCCGACAATGAGCCAGCAATCCATGTCGCAACAACG
CGCCTTCAACCTTCCAAACC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MNAADLGNTIISAEDSTLEWDRAGTETAATGVEVIQAVVKRLPNAPGVYRMVNTEGDVLYVGKARSLKKRVTNYAQGRGH
SNRIERMIRETATMEFVVTRTETEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGNHPAPGIFKHRGARSRRGDYFGP
FASAGAVGRTINSLQRAFLLRTCTDSVFESRTRPCLLYQIKRCSGPCTREISVEDYATLVKEAKDFLSGRSSTVKAEIAT
AMQEASQALDFERAAIYRDRLAALSHVQSHQGINPQGLEEADVFAIHQEGGQTCIQVFFFRTGQNWGNRAYFPKADPALG
HGEVLGSFLAQFYDDKPCPRLILLSHPVEDQDLLAEALSARAGRKVQVSVPARGEKKDLTDHALQNAREALGRRLAETSS
QARLLEGLAETFGLEAAPRRIEVYDNSHIMGTNAVGAMIVAGPEGFVKNQYRKFNIRSAEITPGDDFGMMREVMQRRFAR
LIKEQGLPGNGSEAEDSDASFPAWPDLILIDGGQGQMSAVRQILDDLGIADLVTAIGVAKGVDRDAGRERFFMEGRPPFT
LPPRDPVLYFVQRLRDEAHRFAIGSHRARRKKEMVKNPLDEIAGIGPGRKRALLHHFGTAKAVSRAAVEDLMEVGGISES
IARLIYNHFHESG

Sequences:

>Translated_653_residues
MNAADLGNTIISAEDSTLEWDRAGTETAATGVEVIQAVVKRLPNAPGVYRMVNTEGDVLYVGKARSLKKRVTNYAQGRGH
SNRIERMIRETATMEFVVTRTETEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGNHPAPGIFKHRGARSRRGDYFGP
FASAGAVGRTINSLQRAFLLRTCTDSVFESRTRPCLLYQIKRCSGPCTREISVEDYATLVKEAKDFLSGRSSTVKAEIAT
AMQEASQALDFERAAIYRDRLAALSHVQSHQGINPQGLEEADVFAIHQEGGQTCIQVFFFRTGQNWGNRAYFPKADPALG
HGEVLGSFLAQFYDDKPCPRLILLSHPVEDQDLLAEALSARAGRKVQVSVPARGEKKDLTDHALQNAREALGRRLAETSS
QARLLEGLAETFGLEAAPRRIEVYDNSHIMGTNAVGAMIVAGPEGFVKNQYRKFNIRSAEITPGDDFGMMREVMQRRFAR
LIKEQGLPGNGSEAEDSDASFPAWPDLILIDGGQGQMSAVRQILDDLGIADLVTAIGVAKGVDRDAGRERFFMEGRPPFT
LPPRDPVLYFVQRLRDEAHRFAIGSHRARRKKEMVKNPLDEIAGIGPGRKRALLHHFGTAKAVSRAAVEDLMEVGGISES
IARLIYNHFHESG
>Mature_653_residues
MNAADLGNTIISAEDSTLEWDRAGTETAATGVEVIQAVVKRLPNAPGVYRMVNTEGDVLYVGKARSLKKRVTNYAQGRGH
SNRIERMIRETATMEFVVTRTETEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGNHPAPGIFKHRGARSRRGDYFGP
FASAGAVGRTINSLQRAFLLRTCTDSVFESRTRPCLLYQIKRCSGPCTREISVEDYATLVKEAKDFLSGRSSTVKAEIAT
AMQEASQALDFERAAIYRDRLAALSHVQSHQGINPQGLEEADVFAIHQEGGQTCIQVFFFRTGQNWGNRAYFPKADPALG
HGEVLGSFLAQFYDDKPCPRLILLSHPVEDQDLLAEALSARAGRKVQVSVPARGEKKDLTDHALQNAREALGRRLAETSS
QARLLEGLAETFGLEAAPRRIEVYDNSHIMGTNAVGAMIVAGPEGFVKNQYRKFNIRSAEITPGDDFGMMREVMQRRFAR
LIKEQGLPGNGSEAEDSDASFPAWPDLILIDGGQGQMSAVRQILDDLGIADLVTAIGVAKGVDRDAGRERFFMEGRPPFT
LPPRDPVLYFVQRLRDEAHRFAIGSHRARRKKEMVKNPLDEIAGIGPGRKRALLHHFGTAKAVSRAAVEDLMEVGGISES
IARLIYNHFHESG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=620, Percent_Identity=38.8709677419355, Blast_Score=440, Evalue=1e-124,
Organism=Escherichia coli, GI1788037, Length=200, Percent_Identity=28, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_MESSB (Q11GV7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674533.1
- ProteinModelPortal:   Q11GV7
- STRING:   Q11GV7
- GeneID:   4182581
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1975
- NMPDR:   fig|266779.1.peg.570
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q11GV7
- ProtClustDB:   PRK00558
- BioCyc:   MSP266779:MESO_1975-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 72245; Mature: 72245

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAADLGNTIISAEDSTLEWDRAGTETAATGVEVIQAVVKRLPNAPGVYRMVNTEGDVLY
CCCHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEE
VGKARSLKKRVTNYAQGRGHSNRIERMIRETATMEFVVTRTETEALLLEANLIKRLRPRF
ECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHCHHH
NVLMRDDKSFPYILLTGNHPAPGIFKHRGARSRRGDYFGPFASAGAVGRTINSLQRAFLL
CEEEECCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHH
RTCTDSVFESRTRPCLLYQIKRCSGPCTREISVEDYATLVKEAKDFLSGRSSTVKAEIAT
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AMQEASQALDFERAAIYRDRLAALSHVQSHQGINPQGLEEADVFAIHQEGGQTCIQVFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
RTGQNWGNRAYFPKADPALGHGEVLGSFLAQFYDDKPCPRLILLSHPVEDQDLLAEALSA
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
RAGRKVQVSVPARGEKKDLTDHALQNAREALGRRLAETSSQARLLEGLAETFGLEAAPRR
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IEVYDNSHIMGTNAVGAMIVAGPEGFVKNQYRKFNIRSAEITPGDDFGMMREVMQRRFAR
EEEECCCEEEECCCCCEEEEECCCHHHHCCHHEECCEECCCCCCCCHHHHHHHHHHHHHH
LIKEQGLPGNGSEAEDSDASFPAWPDLILIDGGQGQMSAVRQILDDLGIADLVTAIGVAK
HHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHH
GVDRDAGRERFFMEGRPPFTLPPRDPVLYFVQRLRDEAHRFAIGSHRARRKKEMVKNPLD
CCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
EIAGIGPGRKRALLHHFGTAKAVSRAAVEDLMEVGGISESIARLIYNHFHESG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAADLGNTIISAEDSTLEWDRAGTETAATGVEVIQAVVKRLPNAPGVYRMVNTEGDVLY
CCCHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEE
VGKARSLKKRVTNYAQGRGHSNRIERMIRETATMEFVVTRTETEALLLEANLIKRLRPRF
ECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHCHHH
NVLMRDDKSFPYILLTGNHPAPGIFKHRGARSRRGDYFGPFASAGAVGRTINSLQRAFLL
CEEEECCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHH
RTCTDSVFESRTRPCLLYQIKRCSGPCTREISVEDYATLVKEAKDFLSGRSSTVKAEIAT
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AMQEASQALDFERAAIYRDRLAALSHVQSHQGINPQGLEEADVFAIHQEGGQTCIQVFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
RTGQNWGNRAYFPKADPALGHGEVLGSFLAQFYDDKPCPRLILLSHPVEDQDLLAEALSA
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
RAGRKVQVSVPARGEKKDLTDHALQNAREALGRRLAETSSQARLLEGLAETFGLEAAPRR
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IEVYDNSHIMGTNAVGAMIVAGPEGFVKNQYRKFNIRSAEITPGDDFGMMREVMQRRFAR
EEEECCCEEEECCCCCEEEEECCCHHHHCCHHEECCEECCCCCCCCHHHHHHHHHHHHHH
LIKEQGLPGNGSEAEDSDASFPAWPDLILIDGGQGQMSAVRQILDDLGIADLVTAIGVAK
HHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHH
GVDRDAGRERFFMEGRPPFTLPPRDPVLYFVQRLRDEAHRFAIGSHRARRKKEMVKNPLD
CCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
EIAGIGPGRKRALLHHFGTAKAVSRAAVEDLMEVGGISESIARLIYNHFHESG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA