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The map label for this gene is hexR [H]

Identifier: 110634222

GI number: 110634222

Start: 2012684

End: 2013559

Strand: Direct

Name: hexR [H]

Synonym: Meso_1872

Alternate gene names: 110634222

Gene position: 2012684-2013559 (Clockwise)

Preceding gene: 110634217

Following gene: 110634223

Centisome position: 45.61

GC content: 57.42

Gene sequence:

>876_bases
TTGAGCACTGATTCAACATTTCTGGACATCCTAAAATCCAGTTTCGATCGCCTGACACGATCGGAGCGGCAGCTGGCCAA
TGCGCTTGTGGCAAATTATCCGATGTCGGCGCTCGGTTCGATCACGACGATCGCCGAGCAAGCATCGGTATCGACTCCGA
CAGTGGTTCGTATGGTCAGGAAACTCGGGTTTAAGGGCTTTCCGGACTTCCAGATGCACATCCATCACGAACTCGAGACC
ACCCTGTCGAACCCCATCGCAAAACACGACAGGTGGACCGCCGACGCCCCGGACGCGCATATCCTAAATCGCTTTGCCGA
CGCGACAATCGCGAACCTGCGAGGGACGCTGTCGGGCATCAGGACGAGCGATTTCGACCGCGCGCGAGATCTTCTCAGGG
AACAGCGCAACCACGTTTACATCGTCGGCGGACGCATCACCAAATCGCTGGCCGAGTACCTTTTCACCCATTGCCAAGTG
ATACGCCCCAATGTCACGCTGATTGCGCCCACTCCCAGCACGTGGCCGCACTATGCCCTCAATATGAGATCTGGCGATGT
CTTGGTGATCTTCGACATCCGGCGCTACGAACGCGAAATCGAGACGCTTAGCCGGATTGCAGCCGAGCGAGGCCTTCATA
CGATCCTCTTCACCGACAGATGGAAATCCCCTGTCGCCAAGACGGCGACGGTCGTCTTTCGCGTGGAAACCGAAGTCCCT
TCGGCATGGGATTCATCGGTCGTCATGCTGTTTGTCGTGGAGGCGCTGATTGAGGCGATACAGAGTTCGGCATGGAAGGC
CACCCGCGACCGGATGAAAGACCTCGAAGGCCTCCTGGAGACGAGCGAGCTGTTTCGAAAGCCGCGTGTGCAATGA

Upstream 100 bases:

>100_bases
TCCCGCGAGTCAACATGGGTTTGAAAAATTCTCTTCACCAATGTTGAGGGAAGCGCGCAGGGATGATACGAAAACCGCGA
AGGATATTGGGACGACCACA

Downstream 100 bases:

>100_bases
CTGGTCCCCACTCGCTATCATCCTGCCCGTAGCAGGCTGGTAAAAGCCGCGCAGTCGCGGCGGTAAAGTTGTCGTCAGGC
TCCGGCGGCGTCTGGTTCTG

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSTDSTFLDILKSSFDRLTRSERQLANALVANYPMSALGSITTIAEQASVSTPTVVRMVRKLGFKGFPDFQMHIHHELET
TLSNPIAKHDRWTADAPDAHILNRFADATIANLRGTLSGIRTSDFDRARDLLREQRNHVYIVGGRITKSLAEYLFTHCQV
IRPNVTLIAPTPSTWPHYALNMRSGDVLVIFDIRRYEREIETLSRIAAERGLHTILFTDRWKSPVAKTATVVFRVETEVP
SAWDSSVVMLFVVEALIEAIQSSAWKATRDRMKDLEGLLETSELFRKPRVQ

Sequences:

>Translated_291_residues
MSTDSTFLDILKSSFDRLTRSERQLANALVANYPMSALGSITTIAEQASVSTPTVVRMVRKLGFKGFPDFQMHIHHELET
TLSNPIAKHDRWTADAPDAHILNRFADATIANLRGTLSGIRTSDFDRARDLLREQRNHVYIVGGRITKSLAEYLFTHCQV
IRPNVTLIAPTPSTWPHYALNMRSGDVLVIFDIRRYEREIETLSRIAAERGLHTILFTDRWKSPVAKTATVVFRVETEVP
SAWDSSVVMLFVVEALIEAIQSSAWKATRDRMKDLEGLLETSELFRKPRVQ
>Mature_290_residues
STDSTFLDILKSSFDRLTRSERQLANALVANYPMSALGSITTIAEQASVSTPTVVRMVRKLGFKGFPDFQMHIHHELETT
LSNPIAKHDRWTADAPDAHILNRFADATIANLRGTLSGIRTSDFDRARDLLREQRNHVYIVGGRITKSLAEYLFTHCQVI
RPNVTLIAPTPSTWPHYALNMRSGDVLVIFDIRRYEREIETLSRIAAERGLHTILFTDRWKSPVAKTATVVFRVETEVPS
AWDSSVVMLFVVEALIEAIQSSAWKATRDRMKDLEGLLETSELFRKPRVQ

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=286, Percent_Identity=25.1748251748252, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 33010; Mature: 32879

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDSTFLDILKSSFDRLTRSERQLANALVANYPMSALGSITTIAEQASVSTPTVVRMVR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
KLGFKGFPDFQMHIHHELETTLSNPIAKHDRWTADAPDAHILNRFADATIANLRGTLSGI
HHCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
RTSDFDRARDLLREQRNHVYIVGGRITKSLAEYLFTHCQVIRPNVTLIAPTPSTWPHYAL
CCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCEEE
NMRSGDVLVIFDIRRYEREIETLSRIAAERGLHTILFTDRWKSPVAKTATVVFRVETEVP
EECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHEEEEEEEECCCC
SAWDSSVVMLFVVEALIEAIQSSAWKATRDRMKDLEGLLETSELFRKPRVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STDSTFLDILKSSFDRLTRSERQLANALVANYPMSALGSITTIAEQASVSTPTVVRMVR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
KLGFKGFPDFQMHIHHELETTLSNPIAKHDRWTADAPDAHILNRFADATIANLRGTLSGI
HHCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
RTSDFDRARDLLREQRNHVYIVGGRITKSLAEYLFTHCQVIRPNVTLIAPTPSTWPHYAL
CCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCEEE
NMRSGDVLVIFDIRRYEREIETLSRIAAERGLHTILFTDRWKSPVAKTATVVFRVETEVP
EECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHEEEEEEEECCCC
SAWDSSVVMLFVVEALIEAIQSSAWKATRDRMKDLEGLLETSELFRKPRVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]