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The map label for this gene is serS

Identifier: 110634154

GI number: 110634154

Start: 1933321

End: 1934616

Strand: Reverse

Name: serS

Synonym: Meso_1803

Alternate gene names: 110634154

Gene position: 1934616-1933321 (Counterclockwise)

Preceding gene: 110634155

Following gene: 110634153

Centisome position: 43.84

GC content: 63.27

Gene sequence:

>1296_bases
ATGCTCGACATCAGATGGATTCGCGAGAATGCAGACGCCCTCGTTCTCGCGCTGAGGAAGCGTGGGCAGGAAGAGGCTGC
GGCGCGATCCACGGTCGAGGAGGCGATCGCCGCCGATGAGGCGCGCCGAACCCATCTGACGAAACTCCAGGAGGCGCAGG
AGCAACGGAACGCCGCCTCCAAGGAGATTGGCAAGGCCTTGGCCGCCGGCGACAAGGAAAAGGCAGAACGGCTCAAGGCC
GAGGTGGCCGAGCTCAAGGGCTTCATCCAGGACGGCGAGGCGCAGGAACGCGCGCTGGACAACAGGTTGCGCGATCTCCT
CGCGCGAATCCCGAACATTCCGCTGGACGACGTGCCGGTGGGCGCGGACGAGAACGATAATGTGGAGATCCGCAGGGTAG
GAGAGGCGAGGCAGCCTAATTGGGCGAAAGAGCATTTCGAAATCGGCGAGGCGCTCGGCCTCATGGATTTCGAACGTGCA
GCGAAGCTTTCAGGGGCTCGCTTCACCGTACTAACCGGTACGCTCGCCCGCCTCGAACGCGCGCTCGGCCAGTTCATGCT
CGACCTGCATACGACGGAGCACGGCTATACGGAGGTGCAGCCGCCGCTTCTGGTGCGCGATGAGGCGCTGTTCGGAACGG
GACAGCTGCCGAAGTTTGACGAGGATTTGTTCCGCACCACCGATGGGCGCTGGATGATCCCAACCGCCGAAGTCCCGCTC
ACCAATCTCGTGCGCGAGGAAATCCTCGACGGCGAAAAGCTGCCGCTGCGCTACACCGCGCTGACGCCGTGCTTCCGCTC
GGAAGCGGGTTCGGCCGGGCGCGACACGCGTGGCATGCTGCGCCAGCACCAGTTCTACAAGGTCGAGCTGGTGTCGATCA
CCGACGCCGAAAGCGCGCTTGCCGAGCATGAGCGCATGACGGCCTGTGCGGAGGAAGTGCTCAAACGGCTCGGACTGCCT
TTCCGCACCGTTGTGCTGTGCACCGGGGACATGGGTTTCGGCGCGCAGAAGACCTACGACATCGAGGTTTGGCTGCCGGG
CCAGAAGACCTATCGCGAGATTTCATCCTGCTCGGTCTGCGGCGACTTCCAGGCGCGGCGCATGAATGCGCGCTACCGCG
CGGCCGGAGACAAGCAAGCCCGGTTCGTCCATACGTTGAACGGCTCGGGCGTTGCCGTCGGCCGTGCACTCATCGCCGTC
ATGGAGAATTATCAGAACGAGGACGGGAGCATTAGTATTCCCGAAATCCTGCAACCCTATATGGGAGGCCTGAAGAAGAT
CGAAGCAAGGGGCTGA

Upstream 100 bases:

>100_bases
CCCCAGCGGATGCCGGAACGAGCGCAGGCTCGGCCTGATCCCCTCGGCTTGATCTTCTTCCGGGTGGCCCGCAGGCTCAA
CCGACACCCGGAATTGGAAC

Downstream 100 bases:

>100_bases
CGTGCGAATCCTGCTTACCAATGACGACGGCATCCACGCCGAGGGTCTTGCAGTCCTGGAGCGGGTCGCAAGGACGCTTT
CGGACGATGTGTGGGTGGTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLDIRWIRENADALVLALRKRGQEEAAARSTVEEAIAADEARRTHLTKLQEAQEQRNAASKEIGKALAAGDKEKAERLKA
EVAELKGFIQDGEAQERALDNRLRDLLARIPNIPLDDVPVGADENDNVEIRRVGEARQPNWAKEHFEIGEALGLMDFERA
AKLSGARFTVLTGTLARLERALGQFMLDLHTTEHGYTEVQPPLLVRDEALFGTGQLPKFDEDLFRTTDGRWMIPTAEVPL
TNLVREEILDGEKLPLRYTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDAESALAEHERMTACAEEVLKRLGLP
FRTVVLCTGDMGFGAQKTYDIEVWLPGQKTYREISSCSVCGDFQARRMNARYRAAGDKQARFVHTLNGSGVAVGRALIAV
MENYQNEDGSISIPEILQPYMGGLKKIEARG

Sequences:

>Translated_431_residues
MLDIRWIRENADALVLALRKRGQEEAAARSTVEEAIAADEARRTHLTKLQEAQEQRNAASKEIGKALAAGDKEKAERLKA
EVAELKGFIQDGEAQERALDNRLRDLLARIPNIPLDDVPVGADENDNVEIRRVGEARQPNWAKEHFEIGEALGLMDFERA
AKLSGARFTVLTGTLARLERALGQFMLDLHTTEHGYTEVQPPLLVRDEALFGTGQLPKFDEDLFRTTDGRWMIPTAEVPL
TNLVREEILDGEKLPLRYTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDAESALAEHERMTACAEEVLKRLGLP
FRTVVLCTGDMGFGAQKTYDIEVWLPGQKTYREISSCSVCGDFQARRMNARYRAAGDKQARFVHTLNGSGVAVGRALIAV
MENYQNEDGSISIPEILQPYMGGLKKIEARG
>Mature_431_residues
MLDIRWIRENADALVLALRKRGQEEAAARSTVEEAIAADEARRTHLTKLQEAQEQRNAASKEIGKALAAGDKEKAERLKA
EVAELKGFIQDGEAQERALDNRLRDLLARIPNIPLDDVPVGADENDNVEIRRVGEARQPNWAKEHFEIGEALGLMDFERA
AKLSGARFTVLTGTLARLERALGQFMLDLHTTEHGYTEVQPPLLVRDEALFGTGQLPKFDEDLFRTTDGRWMIPTAEVPL
TNLVREEILDGEKLPLRYTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDAESALAEHERMTACAEEVLKRLGLP
FRTVVLCTGDMGFGAQKTYDIEVWLPGQKTYREISSCSVCGDFQARRMNARYRAAGDKQARFVHTLNGSGVAVGRALIAV
MENYQNEDGSISIPEILQPYMGGLKKIEARG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=332, Percent_Identity=35.2409638554217, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI8923421, Length=398, Percent_Identity=31.4070351758794, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI225579074, Length=325, Percent_Identity=33.2307692307692, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=53.4403669724771, Blast_Score=450, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17539260, Length=465, Percent_Identity=30.5376344086021, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=345, Percent_Identity=29.2753623188406, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=32.1995464852608, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=29.7435897435897, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24581334, Length=322, Percent_Identity=35.0931677018634, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17737985, Length=349, Percent_Identity=34.3839541547278, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_MESSB (Q11HC8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674362.1
- ProteinModelPortal:   Q11HC8
- SMR:   Q11HC8
- STRING:   Q11HC8
- GeneID:   4182773
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1803
- NMPDR:   fig|266779.1.peg.3743
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   IRWIREN
- PhylomeDB:   Q11HC8
- BioCyc:   MSP266779:MESO_1803-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48049; Mature: 48049

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRWIRENADALVLALRKRGQEEAAARSTVEEAIAADEARRTHLTKLQEAQEQRNAAS
CCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIGKALAAGDKEKAERLKAEVAELKGFIQDGEAQERALDNRLRDLLARIPNIPLDDVPV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
GADENDNVEIRRVGEARQPNWAKEHFEIGEALGLMDFERAAKLSGARFTVLTGTLARLER
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEHHHHHHHHHH
ALGQFMLDLHTTEHGYTEVQPPLLVRDEALFGTGQLPKFDEDLFRTTDGRWMIPTAEVPL
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCCH
TNLVREEILDGEKLPLRYTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDAESAL
HHHHHHHHCCCCCCCEEEEHHCHHHHHCCCCCCCCHHHHHHHCCEEEEEEEEECCHHHHH
AEHERMTACAEEVLKRLGLPFRTVVLCTGDMGFGAQKTYDIEVWLPGQKTYREISSCSVC
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCC
GDFQARRMNARYRAAGDKQARFVHTLNGSGVAVGRALIAVMENYQNEDGSISIPEILQPY
CCHHHHHHCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLKKIEARG
HCCHHHHCCCC
>Mature Secondary Structure
MLDIRWIRENADALVLALRKRGQEEAAARSTVEEAIAADEARRTHLTKLQEAQEQRNAAS
CCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIGKALAAGDKEKAERLKAEVAELKGFIQDGEAQERALDNRLRDLLARIPNIPLDDVPV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
GADENDNVEIRRVGEARQPNWAKEHFEIGEALGLMDFERAAKLSGARFTVLTGTLARLER
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEHHHHHHHHHH
ALGQFMLDLHTTEHGYTEVQPPLLVRDEALFGTGQLPKFDEDLFRTTDGRWMIPTAEVPL
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCCH
TNLVREEILDGEKLPLRYTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDAESAL
HHHHHHHHCCCCCCCEEEEHHCHHHHHCCCCCCCCHHHHHHHCCEEEEEEEEECCHHHHH
AEHERMTACAEEVLKRLGLPFRTVVLCTGDMGFGAQKTYDIEVWLPGQKTYREISSCSVC
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCC
GDFQARRMNARYRAAGDKQARFVHTLNGSGVAVGRALIAVMENYQNEDGSISIPEILQPY
CCHHHHHHCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLKKIEARG
HCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA