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The map label for this gene is fabF [H]

Identifier: 110634117

GI number: 110634117

Start: 1888058

End: 1889314

Strand: Reverse

Name: fabF [H]

Synonym: Meso_1766

Alternate gene names: 110634117

Gene position: 1889314-1888058 (Counterclockwise)

Preceding gene: 110634118

Following gene: 110634116

Centisome position: 42.82

GC content: 64.44

Gene sequence:

>1257_bases
ATGAGACGCGTCGTCGTCACCGGCGTAGGACTTCTTTCGCCGCTCGGGCTCGGCGCGGAGCACAGCTGGAACAAGCTGCT
TGCCGGCGCGAGCGGGGCGAAGCGCATCGACACATTCGAGGTCGATGATCTGCCCTGCAAGATCGCCAATACGATCCCCC
GCGAAGGCGAGGGCGGATTTGATCCCCAGGCTTTCCTGGAGCCGCGCGAGCTGCGCAAGATCGCAGACTTCGTGGCCTAC
GGAATCGTGGCTGCCGATCAGGCGCTTGCCGATTCGGGCTGGCAGCCGAACACCGAGGAAGAACGCTGCGCGACCGGCGT
TCTCATCGGCTCCGGGATCGGCGGCATCGACGGGATCGCCGAGAACGCGCTGCTTATGCAGGAGCGCGGCCCGCGGCGCA
TCAGCCCGTTCTTCATCCCCGGCAACATCATCAATATGGTCTCCGGTCAGGTGTCGATCCGGCATGGGCTGAAAGGCCCC
AATCACGCTGTCGTCACCGCCTGTTCGACCGGCGCGCACGCCATTGGCGATGCCTCGCGGCTGATCATGTTCGGTGATGC
GGATGTCATGCTGGCGGGCGGCGCGGAATCGCCGGTAACGCGGCTTTCGATTGCCGGCTTTTCTGCCTGCAAGGCACTCT
CCACGAGCTTCAACGATACGCCGGAGAAGGCTTCCCGGCCTTATGACCGTGACCGGGACGGATTCGTCATGGGCGAGGGG
GCCGGCGTGGTGGTGCTCGAGGAACTGGAGCATGCCAAGGCGCGCGGGGCCAGGATCTATGCCGAGGTGGTCGGCTATGG
CCTTTCCGGCGATGCCTATCATATCACTGCGCCGTCGGAAGACGGCGACGGAGCGTTCCGCTGCATGGCGGCGGCGGTGA
AGCGCGCCGGGCTGACTCCGGCCGAGATCGACTATATCAACGCGCACGGCACCTCCACCATGGCCGATACGATCGAGCTC
AAGGCGGTGGAGCGGCTGGTCGGGAATGCCGCCAGCAGGATCTCCATGTCGTCCACCAAATCCTCGATCGGCCATCTTTT
GGGCGCGGCCGGCGCGGCGGAAGCGATTTTCTCGATCCTCGCCATCCGGGACAATGTGGCCCCGCCGACGATCAATCTCG
ACAACCCCGAGGTCGAGACACCGATCGACCTTGTTCCGAACGAGCCGTGCAAGCGCCAGATCGATGTGGCGCTTTCAAAC
TCATTCGGCTTCGGGGGCACGAATGCGTCCCTGGTCTTCCGGCGATACCAAACCTGA

Upstream 100 bases:

>100_bases
AGACGATCCTCACAGTCGGCGACGCTGTGAAGTACATCGAAAAGGCCACAGCCTGAGGCCCAGGCCTTCTGCGCAGCAAG
GACTTGAGGCAATTCAGAAG

Downstream 100 bases:

>100_bases
CCTTTCGGCTTAGATGCCGGAAAAATGACGCTATTCTGCTGCAAATCGTGTAGATGATTCTGCAAACGAGAACATGTTGC
TCGGTAGGGAGATCCGCCTG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRRVVVTGVGLLSPLGLGAEHSWNKLLAGASGAKRIDTFEVDDLPCKIANTIPREGEGGFDPQAFLEPRELRKIADFVAY
GIVAADQALADSGWQPNTEEERCATGVLIGSGIGGIDGIAENALLMQERGPRRISPFFIPGNIINMVSGQVSIRHGLKGP
NHAVVTACSTGAHAIGDASRLIMFGDADVMLAGGAESPVTRLSIAGFSACKALSTSFNDTPEKASRPYDRDRDGFVMGEG
AGVVVLEELEHAKARGARIYAEVVGYGLSGDAYHITAPSEDGDGAFRCMAAAVKRAGLTPAEIDYINAHGTSTMADTIEL
KAVERLVGNAASRISMSSTKSSIGHLLGAAGAAEAIFSILAIRDNVAPPTINLDNPEVETPIDLVPNEPCKRQIDVALSN
SFGFGGTNASLVFRRYQT

Sequences:

>Translated_418_residues
MRRVVVTGVGLLSPLGLGAEHSWNKLLAGASGAKRIDTFEVDDLPCKIANTIPREGEGGFDPQAFLEPRELRKIADFVAY
GIVAADQALADSGWQPNTEEERCATGVLIGSGIGGIDGIAENALLMQERGPRRISPFFIPGNIINMVSGQVSIRHGLKGP
NHAVVTACSTGAHAIGDASRLIMFGDADVMLAGGAESPVTRLSIAGFSACKALSTSFNDTPEKASRPYDRDRDGFVMGEG
AGVVVLEELEHAKARGARIYAEVVGYGLSGDAYHITAPSEDGDGAFRCMAAAVKRAGLTPAEIDYINAHGTSTMADTIEL
KAVERLVGNAASRISMSSTKSSIGHLLGAAGAAEAIFSILAIRDNVAPPTINLDNPEVETPIDLVPNEPCKRQIDVALSN
SFGFGGTNASLVFRRYQT
>Mature_418_residues
MRRVVVTGVGLLSPLGLGAEHSWNKLLAGASGAKRIDTFEVDDLPCKIANTIPREGEGGFDPQAFLEPRELRKIADFVAY
GIVAADQALADSGWQPNTEEERCATGVLIGSGIGGIDGIAENALLMQERGPRRISPFFIPGNIINMVSGQVSIRHGLKGP
NHAVVTACSTGAHAIGDASRLIMFGDADVMLAGGAESPVTRLSIAGFSACKALSTSFNDTPEKASRPYDRDRDGFVMGEG
AGVVVLEELEHAKARGARIYAEVVGYGLSGDAYHITAPSEDGDGAFRCMAAAVKRAGLTPAEIDYINAHGTSTMADTIEL
KAVERLVGNAASRISMSSTKSSIGHLLGAAGAAEAIFSILAIRDNVAPPTINLDNPEVETPIDLVPNEPCKRQIDVALSN
SFGFGGTNASLVFRRYQT

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=52.0481927710843, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI223972627, Length=187, Percent_Identity=45.9893048128342, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI41872631, Length=431, Percent_Identity=25.2900232018561, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=53.3492822966507, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=37.4701670644391, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=37.914691943128, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=42.4812030075188, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=366, Percent_Identity=26.5027322404372, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=362, Percent_Identity=26.5193370165746, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=39.3333333333333, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=47.9809976247031, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19920632, Length=294, Percent_Identity=25.8503401360544, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=294, Percent_Identity=25.8503401360544, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581345, Length=343, Percent_Identity=25.0728862973761, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43863; Mature: 43863

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGVGLLSPLGLGAEHSWNKLLAGASGAKRIDTFEVDDLPCKIANTIPREGEGGF
CCEEEEECCHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCC
DPQAFLEPRELRKIADFVAYGIVAADQALADSGWQPNTEEERCATGVLIGSGIGGIDGIA
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEECCCCCCHHHH
ENALLMQERGPRRISPFFIPGNIINMVSGQVSIRHGLKGPNHAVVTACSTGAHAIGDASR
HCCCEECCCCCCCCCCEEECCHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCE
LIMFGDADVMLAGGAESPVTRLSIAGFSACKALSTSFNDTPEKASRPYDRDRDGFVMGEG
EEEECCCCEEEECCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEECC
AGVVVLEELEHAKARGARIYAEVVGYGLSGDAYHITAPSEDGDGAFRCMAAAVKRAGLTP
CCEEEEHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
AEIDYINAHGTSTMADTIELKAVERLVGNAASRISMSSTKSSIGHLLGAAGAAEAIFSIL
HHEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHCCHHHHHHHHHH
AIRDNVAPPTINLDNPEVETPIDLVPNEPCKRQIDVALSNSFGFGGTNASLVFRRYQT
HHHCCCCCCEEECCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRRVVVTGVGLLSPLGLGAEHSWNKLLAGASGAKRIDTFEVDDLPCKIANTIPREGEGGF
CCEEEEECCHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCC
DPQAFLEPRELRKIADFVAYGIVAADQALADSGWQPNTEEERCATGVLIGSGIGGIDGIA
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEECCCCCCHHHH
ENALLMQERGPRRISPFFIPGNIINMVSGQVSIRHGLKGPNHAVVTACSTGAHAIGDASR
HCCCEECCCCCCCCCCEEECCHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCE
LIMFGDADVMLAGGAESPVTRLSIAGFSACKALSTSFNDTPEKASRPYDRDRDGFVMGEG
EEEECCCCEEEECCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEECC
AGVVVLEELEHAKARGARIYAEVVGYGLSGDAYHITAPSEDGDGAFRCMAAAVKRAGLTP
CCEEEEHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
AEIDYINAHGTSTMADTIELKAVERLVGNAASRISMSSTKSSIGHLLGAAGAAEAIFSIL
HHEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHCCHHHHHHHHHH
AIRDNVAPPTINLDNPEVETPIDLVPNEPCKRQIDVALSNSFGFGGTNASLVFRRYQT
HHHCCCCCCEEECCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]