Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 110634097

GI number: 110634097

Start: 1865662

End: 1867077

Strand: Reverse

Name: degP [H]

Synonym: Meso_1746

Alternate gene names: 110634097

Gene position: 1867077-1865662 (Counterclockwise)

Preceding gene: 110634098

Following gene: 110634094

Centisome position: 42.31

GC content: 61.02

Gene sequence:

>1416_bases
ATGCGCGCGCCGCAAACCGGCATTCGTCCGCAGCACGGGCCCGACTCCGTCGCCGATCTGGCTGAAAACCTGCTAAAGGC
CGTCGTCAACATCTCGACCTCCCAGAATGGCGGCTCGCGACGCGGACGCGTTCCTATGCCACGGTTGCCGGAAGGCTCGC
CCTTTGAGGAGTATTTCGGCGAATTCTTCGACGGTGAAGGAGGCCAGCCACGTACCCCAGGACCTGGCGCTTCGCTGGGG
TCTGGCTTTGTGATTGATGGCGAGGAAGGGATCATTGTCACCAACAATCACGTTATCGTGGATGCCGACGAAATCACTGT
AAATTTCTCGGACGGCTCCGCGCGGAAGGCTGAGCTTGTGGGCGTCGACACGAAGACGGACCTTGCGGTCCTCAAGATCG
ACCCTGAGGGCGCGGCGTTGTCGGAGGTTCATTTCGGCGATTCCGAGACGATGAGAATCGGCGACTGGGTGATGGCGATC
GGCAATCCGTTCGGGTTTGGGGGGTCCGTGACCGTCGGAATCATCTCGGCGCGCAACCGGCAGATCGGGTCGGGCCCCTA
TGACGACTACATCCAAACCGACGCGGCCATTAACCGCGGCAATTCCGGCGGGCCACTCTTTAACATGGCGGGAGAGGTAA
TCGGTATCAACACCGCCATCATTTCCCCTTCGGGCGGCTCCATCGGCATCGGCTTTGCCATCCCCTCGAACCTGGCGCTC
AACGTCGTCGGCCAGCTTCGGGAATTCGGCGAGACGCGGCGTGGCTGGCTGGGCGTGCGCATTCAGCCCGTCACGGATGA
GATTGCCGAAAGTCTGGGCCTAGATGAGGCGGCGGGCGTTCTGGTGAGCGGGATCGAGAAGGGTGGACCGGCCGACAATG
GCCTCTTGCAGGCGGGCGATATCATTGTCGGCTTCAATGGCACCAAGGTCGCGGATGACCGCCAACTGCGCCGGTTGGTG
GCGGAAAGCGGAGTCGGCAAAGAGATCGATCTCGAGATCCTCCGTAAGGGGGAGCGGGAAACCGTTAAAGTGACGCTGGG
ACGCCTGGAAGAGGAAAGCCAGCCGGCATCCGATACACAGGGCGAGGACACCGAGGAGGAGGGCTCACCCCTCGCTTCAG
CCCAACTGTTGGGAATGACGATCAAGGAGTTGGACGAGGAAGGCCGCAGTCAGTTCAACTTGCCGGAAGACGTAACGGGC
GTGCTTGTCGCGGAAGTGGAAGCAAATTCCGCCGCCGCCGAGCAGGGCATTCAACCCGGTGACGTGATCGTGGAAATAGC
ACTCCAGTCGGTATCTTCGCCTCAGGATGTGCTCGACGAGGTGGAAGCGCTGAAGCAGCAGGGACGCAAGAACGCCCTCC
TCATGCTCTCTTCAAAATCGGGCGAGCTGCGTTTCGTTACGCTAAGGATGAACTGA

Upstream 100 bases:

>100_bases
TCCCGAGCAGCCCGCCCAGCCTGAAGGCAGCCCCGAACAGCTGCCTGCGCCCGGCGGGGACACGGAGCTTCTGCCGGTGC
CGGATACCGGCACACAGGGA

Downstream 100 bases:

>100_bases
ACGCCGCCAGTCTGCGGAGGCGATTCGGTAAAGGACGTGACGCTTGAGCCACGGATGGGTGTCGGGCACGCCGGGGTGAT
CGAAGTCCCCGCCAACGATC

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MRAPQTGIRPQHGPDSVADLAENLLKAVVNISTSQNGGSRRGRVPMPRLPEGSPFEEYFGEFFDGEGGQPRTPGPGASLG
SGFVIDGEEGIIVTNNHVIVDADEITVNFSDGSARKAELVGVDTKTDLAVLKIDPEGAALSEVHFGDSETMRIGDWVMAI
GNPFGFGGSVTVGIISARNRQIGSGPYDDYIQTDAAINRGNSGGPLFNMAGEVIGINTAIISPSGGSIGIGFAIPSNLAL
NVVGQLREFGETRRGWLGVRIQPVTDEIAESLGLDEAAGVLVSGIEKGGPADNGLLQAGDIIVGFNGTKVADDRQLRRLV
AESGVGKEIDLEILRKGERETVKVTLGRLEEESQPASDTQGEDTEEEGSPLASAQLLGMTIKELDEEGRSQFNLPEDVTG
VLVAEVEANSAAAEQGIQPGDVIVEIALQSVSSPQDVLDEVEALKQQGRKNALLMLSSKSGELRFVTLRMN

Sequences:

>Translated_471_residues
MRAPQTGIRPQHGPDSVADLAENLLKAVVNISTSQNGGSRRGRVPMPRLPEGSPFEEYFGEFFDGEGGQPRTPGPGASLG
SGFVIDGEEGIIVTNNHVIVDADEITVNFSDGSARKAELVGVDTKTDLAVLKIDPEGAALSEVHFGDSETMRIGDWVMAI
GNPFGFGGSVTVGIISARNRQIGSGPYDDYIQTDAAINRGNSGGPLFNMAGEVIGINTAIISPSGGSIGIGFAIPSNLAL
NVVGQLREFGETRRGWLGVRIQPVTDEIAESLGLDEAAGVLVSGIEKGGPADNGLLQAGDIIVGFNGTKVADDRQLRRLV
AESGVGKEIDLEILRKGERETVKVTLGRLEEESQPASDTQGEDTEEEGSPLASAQLLGMTIKELDEEGRSQFNLPEDVTG
VLVAEVEANSAAAEQGIQPGDVIVEIALQSVSSPQDVLDEVEALKQQGRKNALLMLSSKSGELRFVTLRMN
>Mature_471_residues
MRAPQTGIRPQHGPDSVADLAENLLKAVVNISTSQNGGSRRGRVPMPRLPEGSPFEEYFGEFFDGEGGQPRTPGPGASLG
SGFVIDGEEGIIVTNNHVIVDADEITVNFSDGSARKAELVGVDTKTDLAVLKIDPEGAALSEVHFGDSETMRIGDWVMAI
GNPFGFGGSVTVGIISARNRQIGSGPYDDYIQTDAAINRGNSGGPLFNMAGEVIGINTAIISPSGGSIGIGFAIPSNLAL
NVVGQLREFGETRRGWLGVRIQPVTDEIAESLGLDEAAGVLVSGIEKGGPADNGLLQAGDIIVGFNGTKVADDRQLRRLV
AESGVGKEIDLEILRKGERETVKVTLGRLEEESQPASDTQGEDTEEEGSPLASAQLLGMTIKELDEEGRSQFNLPEDVTG
VLVAEVEANSAAAEQGIQPGDVIVEIALQSVSSPQDVLDEVEALKQQGRKNALLMLSSKSGELRFVTLRMN

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=246, Percent_Identity=37.8048780487805, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI22129776, Length=261, Percent_Identity=35.2490421455939, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI24308541, Length=246, Percent_Identity=34.9593495934959, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI7019477, Length=289, Percent_Identity=34.2560553633218, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1786356, Length=468, Percent_Identity=35.8974358974359, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1789629, Length=419, Percent_Identity=36.9928400954654, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=39.7810218978102, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324206, Length=352, Percent_Identity=25.8522727272727, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24646839, Length=305, Percent_Identity=34.4262295081967, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49566; Mature: 49566

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPQTGIRPQHGPDSVADLAENLLKAVVNISTSQNGGSRRGRVPMPRLPEGSPFEEYFG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
EFFDGEGGQPRTPGPGASLGSGFVIDGEEGIIVTNNHVIVDADEITVNFSDGSARKAELV
HHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCEEEEECCEEEEEECCCCCCEEEEE
GVDTKTDLAVLKIDPEGAALSEVHFGDSETMRIGDWVMAIGNPFGFGGSVTVGIISARNR
ECCCCCCEEEEEECCCCCEEEEEECCCCCCEEECEEEEEECCCCCCCCEEEEEEEEECCC
QIGSGPYDDYIQTDAAINRGNSGGPLFNMAGEVIGINTAIISPSGGSIGIGFAIPSNLAL
CCCCCCCHHHHHCCHHHCCCCCCCCHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCHHH
NVVGQLREFGETRRGWLGVRIQPVTDEIAESLGLDEAAGVLVSGIEKGGPADNGLLQAGD
HHHHHHHHHHHHHCCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEECC
IIVGFNGTKVADDRQLRRLVAESGVGKEIDLEILRKGERETVKVTLGRLEEESQPASDTQ
EEEECCCCCCCCHHHHHHHHHHCCCCCEECHHHHHCCCCCEEEEEEEHHCCCCCCCCCCC
GEDTEEEGSPLASAQLLGMTIKELDEEGRSQFNLPEDVTGVLVAEVEANSAAAEQGIQPG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHCCCCC
DVIVEIALQSVSSPQDVLDEVEALKQQGRKNALLMLSSKSGELRFVTLRMN
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEC
>Mature Secondary Structure
MRAPQTGIRPQHGPDSVADLAENLLKAVVNISTSQNGGSRRGRVPMPRLPEGSPFEEYFG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
EFFDGEGGQPRTPGPGASLGSGFVIDGEEGIIVTNNHVIVDADEITVNFSDGSARKAELV
HHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCEEEEECCEEEEEECCCCCCEEEEE
GVDTKTDLAVLKIDPEGAALSEVHFGDSETMRIGDWVMAIGNPFGFGGSVTVGIISARNR
ECCCCCCEEEEEECCCCCEEEEEECCCCCCEEECEEEEEECCCCCCCCEEEEEEEEECCC
QIGSGPYDDYIQTDAAINRGNSGGPLFNMAGEVIGINTAIISPSGGSIGIGFAIPSNLAL
CCCCCCCHHHHHCCHHHCCCCCCCCHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCHHH
NVVGQLREFGETRRGWLGVRIQPVTDEIAESLGLDEAAGVLVSGIEKGGPADNGLLQAGD
HHHHHHHHHHHHHCCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEECC
IIVGFNGTKVADDRQLRRLVAESGVGKEIDLEILRKGERETVKVTLGRLEEESQPASDTQ
EEEECCCCCCCCHHHHHHHHHHCCCCCEECHHHHHCCCCCEEEEEEEHHCCCCCCCCCCC
GEDTEEEGSPLASAQLLGMTIKELDEEGRSQFNLPEDVTGVLVAEVEANSAAAEQGIQPG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHCCCCC
DVIVEIALQSVSSPQDVLDEVEALKQQGRKNALLMLSSKSGELRFVTLRMN
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]